Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 562
Special Issue Editors
Interests: interstitial lung diseases; IPF; hypersensitivity pneumonitis; patients advocacy; patients related outcomes
Special Issues, Collections and Topics in MDPI journals
Interests: sarcoidosis; hypersensitivity pneumonitis; interstitial lung diseases; COVID-19 lung disease; pulmonary hypertension; mycobacterial lung diseases; pericardial diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pulmonary hypertension (PH) is a common complication of interstitial lung diseases (ILDs). The pathophysiology of PH associated with ILDs (PH-ILDs) is complex and includes pulmonary endothelium disfunction and pre-capillary vessel remodeling similar to that seen in pulmonary arteria hypertension (PAH). In the majority of ILDs, the patient’s PH remains mild; however, it can escalate severely in a small proportion of the patients. Worsening PH significantly degrades patients’ symptoms, quality of life, and survival. Unfortunately, treatment options for PH-ILDs are limited, with only one medication targeting pulmonary vasculature approved for use in this group of patients—inhaled Treprostinil. A better understanding of many issues regarding PH-ILDs is necessary to improve patient management and outcomes. Some of them include alterations in pathways on molecular and cellular level, the identification of patients at risk of severe PH, the role of PAH-targeted medication and the real risk of hypoxemia with their use, or the role of antifibrotic treatment. Therefore, we invite researchers focusing on both basic and clinical sciences to share their thoughts and results from conducted studies. We look forward to receiving your contribution.
Dr. Katarzyna B. Lewandowska
Prof. Dr. Monika Szturmowicz
Guest Editors
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Keywords
- pulmonary hypertension
- interstitial lung disease
- lung fibrosis
- pulmonary hemodynamics
- pulmonary function testing
- pathogenesis
- prognosis
- survival
- treatment
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