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  • Review
  • Open Access
21 Citations
18,022 Views
21 Pages

Haemophilia A: A Review of Clinical Manifestations, Treatment, Mutations, and the Development of Inhibitors

  • Samuel Sarmiento Doncel,
  • Gina Alejandra Díaz Mosquera,
  • Javier Mauricio Cortes,
  • Carol Agudelo Rico,
  • Francisco Javier Meza Cadavid and
  • Ronald Guillermo Peláez

16 February 2023

The purpose of this narrative review was to provide an overview that allows readers to improve their understanding of hemophilia A, which is considered a genetic disease with a high impact on the quality of life of people who suffer from it is consid...

  • Review
  • Open Access
15 Citations
17,650 Views
16 Pages

Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective

  • Daniel Martínez-Carballeira,
  • Ángel Bernardo,
  • Alberto Caro,
  • Inmaculada Soto and
  • Laura Gutiérrez

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated decrease in the platelet count and an increased risk of bleeding. The pathogenesis is complex, affecting multiple components of the immune system and causing both per...

  • Article
  • Open Access
9 Citations
11,085 Views
11 Pages

Reticulocyte Hemoglobin as a Screening Test for Iron Deficiency Anemia: A New Cut-Off

  • Abdullah I. Aedh,
  • Mohamed S. M. Khalil,
  • Alaa S. Abd-Elkader,
  • Mohamed M. El-Khawanky,
  • Hamdan M. Alshehri,
  • Amr Hussein,
  • Ali A. Lafi Alghamdi and
  • Abdulkarim Hasan

14 March 2023

Introduction: Latent iron deficiency (LID), in which iron stores in the body are depleted without incidental anemia, poses a key diagnostic challenge. Reticulocyte hemoglobin content (Ret-Hb) is directly correlated with the functionally available iro...

  • Review
  • Open Access
2 Citations
9,638 Views
14 Pages

Most patients with diffuse large B-cell lymphoma (DLBCL) are >65 years of age, with the number of patients expected to increase in the coming years. A comprehensive geriatric assessment that carefully evaluates fitness status and comorbidities is...

  • Review
  • Open Access
5 Citations
9,177 Views
15 Pages

Neutropenia in Childhood—A Narrative Review and Practical Diagnostic Approach

  • Georgios Katsaras,
  • Silouani Koutsi,
  • Evdokia Psaroulaki,
  • Dimitra Gouni and
  • Pelagia Tsitsani

Neutropenia refers to a decrease in the absolute neutrophil count according to age and race norms and poses a common concern in pediatric practice. Neutrophils serve as host defenders and act crucially in acute inflammation procedures. In this narrat...

  • Case Report
  • Open Access
6 Citations
8,939 Views
8 Pages

26 April 2023

Androgen usage has widely increased in recent times via prescribed and unprescribed means. Testosterone is a popular androgen taken by both athletes and the general population. While there is some evidence of androgens being thrombogenic, we report o...

  • Review
  • Open Access
14 Citations
8,582 Views
12 Pages

Oral Manifestations: A Warning-Sign in Children with Hematological Disease Acute Lymphocytic Leukemia

  • Sandra Clara Soares,
  • Louis J. D. Roux,
  • Ana Rita Castro,
  • Cristina Cardoso Silva,
  • Rita Rodrigues,
  • Viviana M. P. Macho,
  • Fátima Silva and
  • Céu Costa

24 August 2023

Acute lymphocytic leukemia (ALL) is the most frequent form of all childhood leukemias, mostly affecting children between 2 and 4 years old. Oral symptoms, such as mouth ulcers, mucositis, xerostomia, Herpes or Candidiasis, gingival enlargement and bl...

  • Review
  • Open Access
40 Citations
8,564 Views
11 Pages

18 April 2024

Menin inhibitors are new and promising agents currently in clinical development that target the HOX/MEIS1 transcriptional program which is critical for leukemogenesis in histone-lysine N-methyltransferase 2A-rearranged (KMT2Ar) and in NPM1-mutated (N...

  • Case Report
  • Open Access
7,088 Views
8 Pages

Anemia Due to Unexpected Zinc-Induced Copper Deficiency

  • Nicholas Chun,
  • Shehla Aman,
  • Dan Xu,
  • Jun Wang,
  • Craig Zuppan and
  • Albert Kheradpour

Anemia due to acquired copper deficiency is most commonly the result of malabsorption or dietary deficiency. However, it can occasionally be due to excess zinc intake, which impairs the absorption of copper. Copper deficiency may result in vacuolated...

  • Review
  • Open Access
4 Citations
6,932 Views
13 Pages

Gene Therapy: A Revolutionary Step in Treating Thalassemia

  • Jhancy Malay,
  • Rasha Aziz Attia Salama,
  • Ghania Shehzad Alam Qureshi,
  • Ali Raafat Ali Ahmed Ammar,
  • Gayatri Janardhan,
  • Maryam Safdar and
  • Hesham Amin Hamdy Elshamy

21 October 2024

Beta thalassemia is an inherited blood disorder that results in inefficient erythropoiesis due to genetic mutation that leads to the reduction or absence of the hemoglobin beta-globulin protein. Approximately 8.5% of UAE residents suffer from β-...

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Hematol. Rep. - ISSN 2038-8330