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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Products in Health and Disease: Mechanisms, Therapeutic Applications, and Emerging Challenges

edited by

Hee-Geun Jo

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1153 | Submission Open

Keywords: herbal medicine; network pharmacology; multi-omics; microbiome; synergistic effects; multi-target; drug discovery; natural products

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms of Abiotic and Biotic Stress Tolerance in Crops

edited by

Abdullah Shalmani

and

Adnan Iqbal

submission deadline 31 Dec 2026 | 1 articles | Viewed by 898 | Submission Open

Keywords: stress tolerance; molecular mechanisms; omics approaches; transcriptional regulation; multi-stress resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Regulation of Insect Adaptation

edited by

Lianxi Xing

submission deadline 31 Dec 2026 | 1 articles | Viewed by 841 | Submission Open

Keywords: insect adaptation; molecular regulation; cross-scale phenotyping; gene networks; phenotypic plasticity; ecological genomics; physiological mechanisms; epigenetics

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Natural Polyphenols in Cardiovascular Disease Prevention: Molecular Mechanisms and Therapeutic Perspectives

edited by

Pasquale Perrone

submission deadline 31 Dec 2026 | 1 articles | Viewed by 806 | Submission Open

Keywords: polyphenols; phytochemicals; cardiovascular diseases; cardiovascular; protective

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms of Fruit Development, Stress Response, and Quality Formation in Horticultural Crops

edited by

Rahat Sharif

submission deadline 31 Dec 2026 | 1 articles | Viewed by 749 | Submission Open

Keywords: phytohormones; fruit development; abiotic stress; pathogen resistance; epigenetics; metabolic pathways; postharvest biology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Perspectives on the Development, Physiological Functions, and Reproduction of Aquatic Organisms

edited by

Mingzhe Yuan

submission deadline 31 Dec 2026 | 1 articles | Viewed by 713 | Submission Open

Keywords: molecular toxicology; environmental stressors; gene expression regulation; aquatic organism adaptation; epigenetic responses

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Biomarker Discovery in Neurodegenerative Disorders

edited by

George P. Paraskevas

submission deadline 31 Dec 2026 | Viewed by 439 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; cerebrospinal fluid (CSF) biomarkers; positron emission tomography (PET); seeding amplification assay (SAA); plasma biomarkers

(This special issue belongs to the Section Molecular Medicine)

Allergic Diseases: Molecular Pathways and Pathogenesis

edited by

Jing Gao

submission deadline 31 Dec 2026 | Viewed by 400 | Submission Open

Keywords: allergic diseases; allergic responses; allergic inflammation; immune response; genetics and susceptibility

(This special issue belongs to the Section Molecular Medicine)

Molecular Biology and Biochemistry of Cannabis: Exploring the Genetic and Metabolic Pathways

edited by Craig M. Schluttenhofer

submission deadline 31 Dec 2026 | Viewed by 366 | Submission Open

Keywords: cannabis sativa; molecular biology; phytochemical pathways; cannabinoid receptors; genomics; neurobiology; immunomodulation; plant–microbe interactions

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advancements in Dendrimer Technology: From Molecular Biology Applications to Therapeutic Innovations

edited by

Jørn Bolstad Christensen

and

Julien Rossignol

submission deadline 31 Dec 2026 | Viewed by 326 | Submission Open

Keywords: dendrimers; molecular biology applications; therapeutic innovations; nanomedicine; drug delivery

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Efficacy and Applications of Synthetic and Natural Plant Compounds

edited by

Julius Liobikas

submission deadline 31 Dec 2026 | 1 articles | Viewed by 319 | Submission Open

Keywords: synthetic bioactive compounds; phytochemicals; plant metabolites; metabolic regulation; signaling pathways; cell death; anticancer effects; antibacterial and antifungal activity; anti-inflammatory effects; health promoting effects

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Biomedical Technology and Brain Metabolism

edited by Jennifer M. Lynch

submission deadline 31 Dec 2026 | Viewed by 312 | Submission Open

Keywords: biomedical optics; brain metabolism; optical neuroimaging; cerebral blood flow; near-infrared spectroscopy; diffuse correlation spectroscopy; neurocritical care; noninvasive monitoring; optical biomarkers; brain health

(This special issue belongs to the Section Molecular Medicine)

Molecular Research on Novel Anticancer Drugs: From Structure to Molecular Targets

edited by

Magdalena Mizerska-Kowalska

and

Roman Paduch

submission deadline 31 Dec 2026 | Viewed by 292 | Submission Open

Keywords: cancer therapy; anticancer agents; natural sources; drug design; drug repurposing; drug synthesis; molecular mechanisms

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular and Cellular Mechanisms of Cardiac Repair and Regeneration

edited by

Xiaoxin Chen

and Marco P. De Leon

submission deadline 31 Dec 2026 | Viewed by 253 | Submission Open

Keywords: cardiac regeneration; cardiomyocyte proliferation; oxygen signaling; metabolic reprogramming; angiogenesis; cardiomyocyte migration; evolutionary regeneration biology; spatial transcriptomics; single-cell omics; regenerative cardiovascular biology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanism of HPV’s Involvement in Cancers, 2nd Edition

edited by Xuesong Wen

submission deadline 31 Dec 2026 | Viewed by 232 | Submission Open

Keywords: HPV; HPV carcinogenesis; viral interaction; HPV genotyping; head and neck cancer; immune balance; cervical cancer

(This special issue belongs to the Section Molecular Medicine)

Advanced Molecular Biology Contributions of USA Researchers

edited by

Dumitru Iacobas

and Dekai Zhang

submission deadline 31 Dec 2026 | Viewed by 154 | Submission Open

Keywords: molecular biology; molecular biophysics; molecular cell biology; molecular genetics and genomics; molecular immunology; molecular informatics; molecular microbiology; molecular neurobiology; molecular oncology; molecular pharmacology; molecular pathology; molecular physiology; molecular radiation biology; molecular reproductive biology; molecular zoology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms of Animal Viral Infection and Host Immune Regulation

edited by Yun Zhang

submission deadline 31 Dec 2026 | Viewed by 138 | Submission Open

Keywords: animal virus; zoonotic viruses; viral entry and replication; innate immunity; adaptive immunity; antiviral strategies

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Applications of Phage Infection and Host Resistance

edited by Rajnikant Sharma

submission deadline 31 Dec 2026 | Viewed by 121 | Submission Open

Keywords: bacteriophages; phage therapy; phage–host interactions; bacterial host resistance; antimicrobial resistance; biotechnology applications

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms in Lung Diseases: From Pathogenesis to Therapeutic Targets

edited by Hugo Hyung Bok Yoo

submission deadline 31 Dec 2026 | Viewed by 109 | Submission Open

Keywords: lung diseases; molecular mechanisms; pulmonary biomarkers; chronic obstructive pulmonary disease; pulmonary hypertension; pulmonary embolism; interstitial lung disease; airway remodeling; pulmonary vascular disease; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Antiviral Drug Target Discovery and Design

edited by

Dongwei Kang

and Huajun Zhao

submission deadline 31 Dec 2026 | Viewed by 108 | Submission Open

Keywords: antiviral; drug discovery; drug resistance; immune and pharmacological mechanisms; immunotherapy; immunopathology; vaccines and adjuvants

(This special issue belongs to the Section Molecular Pharmacology)

Rewiring the Injured Brain: Synaptic Plasticity and Circuit Modulation After Stroke and Brain Injury

edited by

Xiaofei Wei

submission deadline 31 Dec 2026 | Viewed by 98 | Submission Open

Keywords: stroke; brain injury; synaptic plasticity; neuronal circuit modulation; neural circuit remodeling; neuroinflammation; neurorepair; molecular mechanisms; neuroplasticity; neuromodulation

(This special issue belongs to the Section Molecular Medicine)

Molecular Advances in Cholesterol and Lipid Metabolism

edited by

Lilian Costa Beber

and Hemelin Farias

submission deadline 31 Dec 2026 | Viewed by 93 | Submission Open

Keywords: molecular biology; cholesterol intracellular metabolism; molecular signaling; inflammation; molecular pathophysiology; therapeutic applications; immunity; endothelial dysfunction; diabetes; cognition

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

DNA Methylation in Cancer—Biomarkers and Therapeutic Targets

edited by

Susan Logotheti

submission deadline 31 Dec 2026 | Viewed by 90 | Submission Open

Keywords: DNA methylation; epigenetics; cancer biomarkers; tumor heterogeneity; precision oncology; epigenetic therapy; microarrays

(This special issue belongs to the Section Molecular Medicine)

Environmental Stress and Toxicology in Aquaculture: A Molecular Perspective

edited by

Peng Luo

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1427 | Submission Open

Keywords: aquatic toxicology; molecular physiology; environmental stress; gene expression; oxidative stress; heavy metals; detoxification mechanisms; omics; immune response; aquaculture

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Epigenetic Mechanisms at the Crossroads of Aging and Neuroinflammation

edited by Vicki Maltby

submission deadline 25 Jan 2027 | Viewed by 61 | Submission Open

Keywords: epigenetic; aging; neuroinflammation; microglial activation; astrocyte reprogramming; chromatin remodeling; DNA methylation; histone modifications; non-coding RNAs; neurodegeneration

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Molecular Biology Methods in Hepatology Research, 2nd Edition

edited by

Ralf Weiskirchen

and

Dileep G. Nair

submission deadline 31 Jan 2027 | 5 articles | Viewed by 10625 | Submission Open

Keywords: hepatic diseases; molecular biology methods; single-cell genomics; single-cell proteomics; hepatic organoids; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Advances in Drug Design and Drug Discovery

edited by

Arjun Singh

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5520 | Submission Open

Keywords: drug discovery; drug design; artificial intelligence; structure-based drug design; omics; biologics; precision medicine; drug repurposing

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biology in Drug Design and Precision Therapy, 2nd Edition

edited by

Cristina Manuela Dragoi

Ion-Bogdan Dumitrescu

and

Alina Crenguta Nicolae

submission deadline 31 Jan 2027 | 6 articles | Viewed by 4640 | Submission Open

Keywords: molecular biology; drug design; molecular targets; disease mechanisms; structural biology; computational chemistry; pharmacology; precision medicine; molecular pathways; personalized therapy; drug research

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Pharmacological Underlying Cardiorenal Diseases

edited by

Caterina Carollo

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3506 | Submission Open

Keywords: hypertension; cardio-renal syndromes; heart failure; chronic kidney disease; hemodialysis; periotenal dialysis

(This special issue belongs to the Section Molecular Medicine)

Neuropituitary Hormones in Metabolic Disorders

edited by

Claudia Camerino

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3431 | Submission Open

Keywords: oxytocin; vasopressin; thermoregulation; obesity; Prader–Willi syndrome; autism spectrum disorder; anorexia nervosa; craniopharyngioma; metabolic disorders; hypothalamic pituitary disorders; oxytocin-deficiency; vasopressin-deficiency

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Future Challenges of Targeted Therapy of Cancers, 3rd Edition

edited by

Simona Gurzu

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3144 | Submission Open

Keywords: biomarkers; tumor tissue; individualized therapy; gene profile; epithelial–mesenchymal transition; immunotherapy; angiogenesis; metastases; oncology; pathology

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in Plant Stress Tolerance, 2nd Edition

edited by

Sajid Ali

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1706 | Submission Open

Keywords: plant stress tolerance; molecular mechanisms; stress-responsive gene; signal transduction pathways; epigenetic modifications; phytohormones (ethylene, ABA, SA, JA); reactive oxygen species (ROS); plant–microbe interactions; microbial plant bio-stimulants; omics approaches (genomics, transcriptomics, proteomics, and metabolomics)

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Targets in Bone Biology and Cancer

edited by

Alberto Hidalgo-Bravo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1627 | Submission Open

Keywords: bone health; molecular mechanisms; cancer biology; bone cancer; cancer therapeutics

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights, Biomarkers, and Clinical Diagnosis in Cancer Biology and Treatment

edited by

Po-Ming Chen

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1423 | Submission Open

Keywords: cancer biomarkers; precision medicine; prevention; prognosis; diagnosis

(This special issue belongs to the Section Molecular Medicine)

Emerging Trends in Nanobiotechnology and Nanomedicine

edited by

Eduardo Ricci Junior

and

Ana Paula Dos Santos Matos

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1121 | Submission Open

Keywords: bionanotechnology; nanocarriers; cancer; infectious diseases; drug delivery; bioavailability

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Cerebrovascular Diseases: From Pathogenesis to Treatment, 2nd Edition

edited by

Adrià Arboix

Teresa Gasull

and Francisco Purroy

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1016 | Submission Open

Keywords: stroke; ischemic; hemorrhagic; neuronal death; molecular mechanisms; inflammation; epigenetics; ischemic tolerance; ferroptosis; free radicals; treatment

(This special issue belongs to the Section Molecular Medicine)

New Discoveries and Mechanistic Insights in Future Cancer Therapies

edited by

Yi-Chiang Hsu

submission deadline 31 Jan 2027 | Viewed by 664 | Submission Open

Keywords: cancer therapeutics; tumor antigens; vaccine; nanotechnology

(This special issue belongs to the Section Molecular Medicine)

Molecular Dialogues: Signaling Networks of the Aging Nervous System

edited by

Hercules Rezende Freitas

submission deadline 31 Jan 2027 | 1 articles | Viewed by 518 | Submission Open

Keywords: neuroglial signaling; molecular signal transduction; calcium dynamics; bioactive lipids; neuroinflammation; neural metabolism; cell–cell communication

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Biomaterials for Disease Diagnosis and Therapy: Emerging Molecular Innovations and Applications

edited by Md Tipu Sultan

submission deadline 31 Jan 2027 | Viewed by 441 | Submission Open

Keywords: biomaterials; disease diagnosis; nanoparticles; hydrogels; scaffolds; bio 3D printing; bioink; biosensors; drug delivery; tissue engineering; biocompatibility; translational medicine; cancer; neurodegenerative disorders; disease model; 3D-printed microfluidic devices; organ on a chip; 3D-printed medical devices

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Research and Recent Advances in Caenorhabditis elegans

edited by

Boopathi Balasubramaniam

submission deadline 31 Jan 2027 | Viewed by 266 | Submission Open

Keywords: C. elegans; molecular biology; biochemistry; microbiology; omics; genetics; host-pathogen interactions; signaling pathways; innate immunity; functional genomics

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms of Liver Diseases and Potential Therapeutic Targets

edited by

Milena Veskovic

and

Dušan Mladenović

submission deadline 31 Jan 2027 | Viewed by 259 | Submission Open

Keywords: pathophysiology; molecular mechanism; metabolism; nutrition; biomarkers; liver; insulin resistance

(This special issue belongs to the Section Molecular Medicine)

Molecular Approaches and Innovations for Human and Veterinary Vaccines

edited by Attila Farsang

submission deadline 31 Jan 2027 | Viewed by 245 | Submission Open

Keywords: vaccines; vaccinology; immunology mechanisms; vaccine vectors; gene vaccines; infection; host–pathogen interactions and responses

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Regulatory Factors and Signaling Pathways Controlling Ovarian Development and Function

edited by Jing Xu, Fuhua Xu and So-Youn Kim

submission deadline 31 Jan 2027 | Viewed by 157 | Submission Open

Keywords: ovarian follicle; corpus luteum; ovarian vasculature; oocyte; granulosa cells; ovarian immune cells; oogenesis; folliculogenesis; luteinization; steroidogenesis

(This special issue belongs to the Section Molecular Medicine)

Design, Synthesis, and Bioactivity of Organic Compounds

edited by

Beata Morak-Młodawska

and

Zuzanna Rzepka

submission deadline 31 Jan 2027 | Viewed by 149 | Submission Open

Keywords: organic synthesis of bioactive compounds; structural analysis; biological activity and its mechanisms; pharmacokinetic analysis of a potential drug; lipophilicity; molecular modeling

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Targeted Cancer Therapy: Action Mechanisms and Novel Biomarkers

edited by Mario Uccello and

Elena V. Svirshchevskaya

submission deadline 31 Jan 2027 | Viewed by 111 | Submission Open

Keywords: targeted cancer therapy; biomarkers; mechanisms of action; treatment resistance; precision oncology; translational oncology; tumour microenvironment; immunotherapy; biomarker-driven therapy; cancer biology

(This special issue belongs to the Section Molecular Medicine)

Molecular Engineering, Design, and Delivery Strategies for Protein, Peptide and Enzyme Therapeutics

edited by

Suman Basak

submission deadline 31 Jan 2027 | Viewed by 111 | Submission Open

Keywords: protein therapeutics; peptide therapeutics; enzyme therapeutics; biologics; molecular engineering; drug delivery; bioconjugation; nanomedicine; computational modeling; precision medicine

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Mechanisms of Neuronal Signaling in Brain Development and Plasticity

edited by

George Ayoub

submission deadline 31 Jan 2027 | Viewed by 95 | Submission Open

Keywords: neurodevelopment; cellular/molecular signaling; autism; ADHD; neuronal plasticity; nutritional factors

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innovations in Nanomedicine and Bio-Nanotechnology

edited by

Karthik Gourishetti

and Rajwinder Kaur

submission deadline 31 Jan 2027 | Viewed by 95 | Submission Open

Keywords: molecular biology; nanomedicine; targeted drug delivery; gene regulation; molecular signaling; extracellular vesicles; intracellular trafficking; molecular therapeutics; bio-nanotechnology; clinical translation

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Endoplasmic Reticulum Stress and Protein Homeostasis in Diseases

edited by

Michela Pecoraro

submission deadline 31 Jan 2027 | Viewed by 91 | Submission Open

Keywords: endoplasmic reticulum stress; unfolded protein response (UPR); protein homeostasis; mitochondria-ER crosstalk; ERAD; proteotoxicity; neurodegeneration; translational therapeutics

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Developments in Molecular Pharmacology in Portugal

edited by

Vanessa Mateus

Maryam Malmir

and

Sergio Faloni de Andrade

submission deadline 31 Jan 2027 | Viewed by 87 | Submission Open

Keywords: molecular pharmacology; signaling pathways; inflammation; drug discovery; in vivo models; drug mechanisms; molecular targets; pharmacodynamics; translational research; biomarkers

(This special issue belongs to the Section Molecular Pharmacology)

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