Molecular Dialogues: Signaling Networks of the Aging Nervous System

Dear Colleagues,

This Special Issue centers on the molecular logic through which the nervous system ages, emphasizing how signaling networks are remodeled over time and how these changes influence neural resilience or vulnerability. The contributions examine age-dependent alterations in intracellular and intercellular communication, focusing on signaling pathways built around ions, neurotransmitters, bioactive lipids, redox mediators, and metabolic intermediates. Special emphasis is placed on calcium handling, mitochondrial–cytosolic crosstalk, and the coupling between energy metabolism and signal transduction. These molecular dialogues regulate synaptic maintenance, neuroglial interactions, stress responses, and decisions governing cellular adaptation, senescence, or death. The issue highlights how cumulative molecular dysregulation, rather than isolated defects, drives functional decline, chronic inflammation, and susceptibility to neurodegeneration during aging. By integrating experimental data with mechanistic and conceptual perspectives, this collection seeks to define core signaling nodes and molecular circuits that shape the aging nervous system, offering a framework for identifying targets capable of modulating neural aging and delaying age-associated neurological disease.

Dr. Hercules Rezende Freitas
Guest Editor

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