Molecular Mechanisms of Endoplasmic Reticulum Stress and Protein Homeostasis in Diseases
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 92
Editor
Interests: oxidative stress; neurodegenerative diseases; misfolding protein; corrector; inflammation; ER stress; calcium homeostasis; proteostasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Maintaining protein homeostasis (proteostasis) is fundamental for cellular survival, and its disruption is a defining hallmark of numerous human pathologies. The endoplasmic reticulum (ER) serves as the primary hub for protein folding and quality control; however, physiological demands, environmental insults, or genetic mutations can overwhelm its capacity, triggering ER stress. To counteract this, cells activate the Unfolded Protein Response (UPR), an intricate adaptive network that modulates translation, transcription, and degradation pathways. While initially protective, chronic or unresolved UPR signaling transitions into a pathological driver, leading to cellular dysfunction, inflammation, and cell death.
This Special Issue aims to provide a comprehensive, holistic overview of the molecular mechanisms underlying ER stress and its profound impact on proteostasis in disease contexts. The scope of this collection spans from basic organelle biology to translational medicine, welcoming original research and comprehensive reviews that explore UPR signaling dynamics, protein quality control networks (including ER-associated degradation and ER-phagy), and the critical functional correlation between ER stress and mitochondrial dysfunction. By investigating these pathways across various disease models—such as neurodegeneration, diabetes, cardiovascular disorders, and cancer—this issue seeks to highlight novel therapeutic interventions, including chemical chaperones and small-molecule modulators, capable of restoring proteostatic balance.
We look forward to receiving your contributions.
Dr. Michela Pecoraro
Guest Editor
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Keywords
- endoplasmic reticulum stress
- unfolded protein response (UPR)
- protein homeostasis
- mitochondria-ER crosstalk
- ERAD
- proteotoxicity
- neurodegeneration
- translational therapeutics
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