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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Animal Metabolism: Pathophysiological Implications in Tumor Progression

edited by

Cristian Gabriel Torres Mendoza

submission deadline 31 Jan 2026 | Viewed by 56 | Submission Open

Keywords: animal cancer metabolism; animal tumor diseases; Warburg effect; drug-resistance; therapeutic targets

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innovative Approaches in Bone and Cartilage Regeneration: From Stem Cells to Organoids

edited by

Maria Giovanna Rizzo

submission deadline 31 Jan 2026 | Viewed by 54 | Submission Open

Keywords: bone and cartilage biology; physiology; molecular biology; nutraceuticals; regenerative medicine

(This special issue belongs to the Section Molecular Medicine)

Pharmacological Activities and Mechanisms of Action of Natural Products, 2nd Edition

edited by

Shining Loo

Antony Kam

and Lee Simon Ming-Yuen

submission deadline 31 Jan 2026 | Viewed by 36 | Submission Open

Keywords: natural products; pharmacological activity; molecular mechanisms; therapeutic targets; structure– activity relationships; protein– ligand interactions; cell signaling pathways; enzyme inhibition/activation; molecular targets

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms and Therapeutic Approaches in Fibrosis and Tissue Remodeling

edited by Pulin Che

submission deadline 31 Jan 2026 | Viewed by 35 | Submission Open

Keywords: fibrosis; tissue remodeling; biomarkers; molecular pathways; translational medicine; therapeutic strategies

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Treatment of Kidney Diseases

edited by Junyi Zhu

submission deadline 10 Feb 2026 | Viewed by 47 | Submission Open

Keywords: nephrotic syndrome; kidney disease; kidney injury

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Omics Approaches in Plant Stress Tolerance

edited by

Dipali Srivastava

and

Romit Seth

submission deadline 15 Feb 2026 | Viewed by 56 | Submission Open

Keywords: environmental stress; gene regulation; transcriptomics; molecular pathways; stress tolerance; genetic engineering; CRISP; molecular biology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of the Neuro-Musculoskeletal System

edited by

Adriano Polican Ciena

submission deadline 20 Feb 2026 | Viewed by 80 | Submission Open

Keywords: morphology; molecular biology; microscopy; neuromuscular junction; myotendinous junction

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Hyperlipidemia and Molecular Mechanism in Human and Animals

edited by

Kyuhyung Choi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2351 | Submission Open

Keywords: hyperlipidemia; diabetes mellitus; Cushing’ s disease; pancreatitis; gall bladder mucoceles

(This special issue belongs to the Section Molecular Medicine)

The Modulatory Effects of Plants with Therapeutic Potential in Neuropsychiatric Disorder

edited by

Alin Ciobica

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2153 | Submission Open

Keywords: plant biodiversity; antioxidant effects; therapeutic potential; neuropsychiatric disorders; oxidative stress markers; inflammatory markers

(This special issue belongs to the Section Molecular Pharmacology)

Hormonal Regulation in Germ Cell Development

edited by

Kwan Sik Min

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2025 | Submission Open

Keywords: spermatogenesis; steroidogenesis; sex hormones; sex hormone receptors; gonadotropin; germ cell differentiation; androgen; luteinizing hormone; follicle-stimulating hormone; glycoprotein hormone receptors

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Bioinformatics Research in Bacterial Genomics, Metagenomics and Metatranscriptomics: 2nd Edition

edited by

Vesselin Baev

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1794 | Submission Open

Keywords: bacterial genomics and functional analysis; genome-wide comparative genomics; bioinformatics methods and tools; metagenomics; metatranscriptomics

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Plant Adaptation and Stress Tolerance Under Changing Environmental Conditions

edited by

Naveed Ahmad

submission deadline 28 Feb 2026 | Viewed by 579 | Submission Open

Keywords: elevated CO2; drought– heat– salinity; carbon– nitrogen balance; TOR/SnRK1; hormone crosstalk; redox signaling; microbiome; single-cell/spatial omics; phenomics; genome editing; predictive breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Review Papers in Molecular Plant Science 2026

edited by

Zhaohui Chu

submission deadline 28 Feb 2026 | Viewed by 196 | Submission Open

Keywords: multi-omics; plant bioreactor; plant genomics; plant-pathogens interaction; crop domestication; crop yield traits

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring Symmetry and Asymmetry in Molecular Design for Anticancer and Antioxidant Therapies

edited by

Anca Stana

submission deadline 28 Feb 2026 | Viewed by 177 | Submission Open

Keywords: symmetry; asymmetry; antioxidant; anticancer; synergy; oxidative stress; cytotoxicity; molecular design; synthesis

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Research in Osteoarthritis and Osteoarticular Diseases, 2nd Edition

edited by

Ye Liu

submission deadline 28 Feb 2026 | Viewed by 148 | Submission Open

Keywords: osteoarthritis; cartilage regeneration; bioinformatics; biomarkers; inflammation; cartilage; metabolic imbalance

(This special issue belongs to the Section Molecular Medicine)

Epigenetics and Chromatin Remodeling in Cancer

edited by

Gianluca Tedaldi

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: epigenetics; chromatin remodeling; DNA methylation; histone modifications; non-coding RNAs; circulating tumor DNA; liquid biopsy; epigenetic therapy

(This special issue belongs to the Section Molecular Medicine)

Phagocytosis in Neurological Disorders: Molecular Mechanisms and Therapeutic Targets

edited by

Dimitrios I. Tsiptsios

and Konstantinos Anagnostopoulos

submission deadline 28 Feb 2026 | Viewed by 144 | Submission Open

Keywords: phagocytosis; endothelial cells; microglial cells; stroke; dementia; inflammation

(This special issue belongs to the Section Molecular Medicine)

Nanotechnology-Enhanced Photodynamic Therapy for Precision Medicines

edited by

Milutin Stepić

and

Iva A. Popović

submission deadline 28 Feb 2026 | Viewed by 132 | Submission Open

Keywords: photodynamic therapy; photosensitisers; targeting nanocarriers; multifunctional nanoplatforms; nanotheranostics; active targeting of cancer; molecular drug targeting; drug metabolism and toxicity; pharmacogenetic testing; cancer microenvironment remodelling

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Natural Product-Induced Immune Modulation: From Signaling Pathways to Therapeutic Targets

edited by Suyun Lyu

submission deadline 28 Feb 2026 | Viewed by 65 | Submission Open

Keywords: natural products; immunomodulation; immune responses; molecular mechanisms; immune cell activation; inflammation pathways; autoimmune diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Phytochemicals: Biological Activities and Applications

edited by

Mohammed Kara

submission deadline 28 Feb 2026 | Viewed by 61 | Submission Open

Keywords: plants; phytochemicals; natural compounds; molecular biology; antibiotics; anticancer

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Biology and Functional Roles of Tumor Suppressor Genes in Cancer

edited by

Yun Zhang

submission deadline 28 Feb 2026 | Viewed by 51 | Submission Open

Keywords: tumor suppressor genes; cancer biology; TP53; RB1; PTEN; genomic instability; tumor microenvironment; cancer therapy; epigenetic regulation; cell signaling

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Current Advances in Oxytocin Research, 2nd Edition

edited by

Claudia Camerino

submission deadline 28 Feb 2026 | Viewed by 51 | Submission Open

Keywords: oxytocin; thermoregulation; skeletal muscle; obesity; Prader– Willi syndrome

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innovative Models for SARS-CoV-2 Pathogenesis

edited by

Virginia Lotti

submission deadline 28 Feb 2026 | Viewed by 47 | Submission Open

Keywords: SARS-CoV-2; coronavirus; virus infection; pathogenesis; innovative models

(This special issue belongs to the Section Molecular Medicine)

Stem Cell-Derived Cells and Bioengineering: Molecular Bases in Regeneration and Disease Research

edited by Aylin Acun

submission deadline 28 Feb 2026 | Viewed by 44 | Submission Open

Keywords: stem cells; regenerative medicine; bioengineering; disease modeling; organoids; tissue engineering; decellularization; bioprinting

(This special issue belongs to the Section Molecular Medicine)

Advances in Drug Design and Drug Discovery

edited by

Arjun Singh

submission deadline 28 Feb 2026 | Viewed by 42 | Submission Open

Keywords: drug discovery; drug design; artificial intelligence; structure-based drug design; omics; biologics; precision medicine; drug repurposing

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms Driving Cancer Progression and Metastasis

edited by

Karolina Bajdak-Rusinek

submission deadline 28 Feb 2026 | Viewed by 35 | Submission Open

Keywords: cancer progression; metastasis; epithelial– mesenchymal transition (EMT); tumor plasticity; tumor microenvironment; signaling pathways; therapy resistance

(This special issue belongs to the Section Molecular Medicine)

Multiomics of Cancer Research in Human and Animals

edited by

Kyuhyung Choi

submission deadline 28 Feb 2026 | Viewed by 33 | Submission Open

Keywords: multiomics; cancer; epigenomics; proteomics; metabolomics

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Role of Microglia in Neuroinflammation and Neurodegenerative Diseases

edited by

Shunqi Wang

submission deadline 28 Feb 2026 | Viewed by 19 | Submission Open

Keywords: microglia; neuroinflammation; neurodegeneration; synaptic pruning; microglial activation states; innate immune signaling; TLR signaling; TREM2; CX3CR1; NF-κ B; glia– neuron interactions; neuroimmune crosstalk; therapeutic targeting of microglia

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Innovations in Antimicrobial Resistance

edited by

Rúben Fernandes

submission deadline 28 Feb 2026 | Viewed by 14 | Submission Open

Keywords: antimicrobial resistance (AMR); molecular mechanisms; genomics; personalized medicine; resistance mechanisms; translational research

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights and Therapeutic Advances in Hematological Disorders, 2nd Edition

edited by

Eleni Gavriilaki

submission deadline 28 Feb 2026 | Viewed by 12 | Submission Open

Keywords: acute leukemia; myeloproliferative neoplasms; lymphoma; multiple myeloma; hemoglobinopathies; hemophilia

(This special issue belongs to the Section Molecular Medicine)

Mechanisms and Pathophysiology of Obesity

edited by Padmamalini Baskaran

submission deadline 20 Mar 2026 | 4 articles | Viewed by 4272 | Submission Open

Keywords: understanding genetic factors for obesity at the molecular level; understanding environmental factors for obesity at the molecular level; contribution of insulin resistance to obesity and ways to combat; circadian misalignment– molecular level understanding of its contribution to obesity and ways to mitigate it; effective and individualized obesity treatment strategies for stress; molecular understanding of the influence of parental obesity on childhood overweight; molecular mechanisms of maternal smoking on childhood obesity; therapeutic interventions for obesity through recombinant hormones; role of gut hormones in the treatment of obesity; development of new digital tools for weight management interventions

(This special issue belongs to the Section Molecular Medicine)

Molecular Biology in Drug Design and Precision Therapy

edited by

Cristina Manuela Dragoi

Ion-Bogdan Dumitrescu

and

Alina Crenguta Nicolae

submission deadline 31 Mar 2026 | 12 articles | Viewed by 20099 | Submission Open

Keywords: molecular biology; drug design; molecular targets; disease mechanisms; structural biology; computational chemistry; pharmacology; precision medicine; molecular pathways; personalized therapy; drug research

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Regulation in Allergy and Immune Diseases, Immunodeficiencies, 2nd Edition

edited by

Kinga Lis

submission deadline 31 Mar 2026 | 4 articles | Viewed by 18001 | Submission Open

Keywords: allergy and hypersensitivity mechanisms; cross-reactivity in allergy; component resolved diagnostic (CRD); immunodeficiencies; experimental research methods in allergology; biochemical properties of allergens

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Multifactorial Causes of Insulin Resistance in Obesity

edited by Bogdana Virgolici

submission deadline 31 Mar 2026 | 7 articles | Viewed by 16125 | Submission Open

Keywords: obesity; inflammation; oxidative stress; insulin resistance; caloric restriction

(This special issue belongs to the Section Molecular Medicine)

Natural Products as Potential Sources of Antidiabetic Compounds, 2nd Edition

edited by

Hidayat Hussain

submission deadline 31 Mar 2026 | 6 articles | Viewed by 11653 | Submission Open

Keywords: natural products; natural product derivatives; antidiabetic agents; α -glucosidase inhibitors; amylase inhibitors; PTP1B inhibitors; DPP-4 inhibitors; molecular level; kinetic studies; in vitro studies; in vivo studies; computational methods; mode of action

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Research in Bioactivity of Natural Products, 3rd Edition

edited by

Magdalena Bartnik

and

Wirginia Kukula-Koch

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3775 | Submission Open

Keywords: molecular research; molecular properties; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Early Molecular Diagnosis and Comprehensive Treatment of Tumors

edited by

Chan-Yen Kuo

submission deadline 31 Mar 2026 | 5 articles | Viewed by 3670 | Submission Open

Keywords: next-generation sequencing (NGS); novel biomarkers; precision medicine; targeted therapy; immunotherapy; integrative treatment; personalized cancer treatment

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

The Significance of Transcription Factors, miRNAs, and lncRNAs in Anticancer Drug Development, 2nd Edition

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3183 | Submission Open

Keywords: transcription factors; microRNAs (miRNAs); long non-coding RNAs (lncRNAs); anticancer drugs; cancer; coactivators

(This special issue belongs to the Section Molecular Medicine)

Targeted Therapeutic Approaches in Cancer: Combining Natural Compounds and Conventional Drugs

edited by

Alok Bhushan

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2300 | Submission Open

Keywords: natural compounds; cancer; repurposing; combination; polychemotherapy; pharmaceuticals; nutraceuticals; molecular targets; metabolomics; immunotherapy

(This special issue belongs to the Section Molecular Medicine)

Effects of Nanoparticles on Living Organisms, 3rd Edition

edited by

Yoshitaka Miyamoto

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2024 | Submission Open

Keywords: nanoparticles; particulate matter; medicine; prevention; diagnosis; drug delivery; environment; nanoparticles functionalization; in vitro/in vivo evaluation; 3D model; ADME; toxicity; biomedical applications; respiratory and cardiovascular diseases; immunological; inflammatory; and allergic diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Therapeutic Effects of Natural Bioactive Compounds in the Management of Human Diseases: 2nd Edition

edited by

Rossana Morabito

and

Sara Spinelli

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1192 | Submission Open

Keywords: natural bioactive compound; human health; chronic diseases; molecular target; oxidative stress; inflammation; cancer; diabetes

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Basis of Autoimmune Diseases

edited by

Ranjeet Singh Mahla

submission deadline 31 Mar 2026 | 1 articles | Viewed by 744 | Submission Open

Keywords: autoimmune diseases; immune regulation; molecular mechanisms; genetic predisposition; epigenetics; cytokines; biomarkers; immune checkpoints; targeted therapies; genomics; transcriptomics; proteomics; systems biology; inflammation; immune tolerance

(This special issue belongs to the Section Molecular Medicine)

Precision Molecular Oncology: From Tumor Biomarker Discovery to Next-Generation Drug Delivery

edited by

Farhadul Islam

submission deadline 31 Mar 2026 | Viewed by 709 | Submission Open

Keywords: precision oncology; molecular pathology; personalized treatment; tumor marker; biomarkers; multi-omics; drug discovery; nanocarriers; drug delivery; clinical management

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Therapeutic Advances in Hypertension Management and Vascular Health

edited by

Federica Fogacci

Arrigo Francesco Giuseppe Cicero

and

Claudio Borghi

submission deadline 31 Mar 2026 | Viewed by 216 | Submission Open

Keywords: hypertension; vascular aging; endothelial dysfunction; gestational hypertension; metabolic disorders; therapeutic strategies in hypertension management

(This special issue belongs to the Section Molecular Medicine)

Emerging Trends for Genome-Wide Association Studies in Complex Disease Genetics

edited by

Xiaowei Wu

submission deadline 31 Mar 2026 | Viewed by 179 | Submission Open

Keywords: GWAS; polygenic risk scores; rare variants; structural variants; multi-omics; Mendelian randomization; population structure and relatedness; machine learning; Bayesian models; stochastic models

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Research on Free Radicals and Oxidative Stress—2nd Edition

edited by

Mosharraf Sarker

submission deadline 31 Mar 2026 | Viewed by 179 | Submission Open

Keywords: oxidative stress; free radicals; reactive oxygen species (ROS); gene regulation; antioxidants; mitochondrial dysfunction; insulin resistance; inflammation; autophagy

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Scoliosis and Spinal Disorders: Molecular Biomarkers and Therapeutic Strategies

edited by

Angelos Kaspiris

submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open

Keywords: intracellular interactions during the progression of spinal disorders; molecular signaling in scoliosis; growth factor expression in spinal disorders and deformities; biomarkers; molecular-driven treatment

(This special issue belongs to the Section Molecular Medicine)

Featured Papers in Bioinformatics and Systems Biology

edited by

Howard H. Yang

submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open

Keywords: bioinformatics; omics; genomics and transcriptomics sequence analyses; dynamic modeling

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Insights into Gut Biology: Stem Cells, Organoids, and Microbiota–Immune Interactions

edited by

Shaoyi Zhang

submission deadline 31 Mar 2026 | Viewed by 53 | Submission Open

Keywords: intestinal stem cells; intestinal organoids; gut– microbiota interaction; mucosal immunology; molecular mechanisms; gut epithelial regeneration; microbiota– immune crosstalk; organoid disease models; intestinal homeostasis; molecular gut biology

(This special issue belongs to the Section Molecular Microbiology)

Molecular Studies of Bioactive Compounds and Their Therapeutic Potential

edited by Sanja Radman and

Ivana Carev

submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open

Keywords: bioactive compounds; molecular mechanisms; structural elucidation; molecular targets; omics approaches

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

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