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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oxidative Stress in Cancer Biology

edited by

Eugenia Yiannakopoulou

submission deadline 31 Oct 2025 | Viewed by 40 | Submission Open

Keywords: reactive oxygen species (ROS); redox homeostasis; oxidative DNA damage; antioxidant defense mechanisms; Nrf2 signaling pathway; mitochondrial dysfunction; tumor microenvironment; cancer cell survival and proliferation

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights and Unique Characteristics in Adolescent and Young Adult Oncology

edited by

Antonio Ruggiero

submission deadline 31 Oct 2025 | Viewed by 27 | Submission Open

Keywords: adolescent; young adult; biology; treatment; outcome

(This special issue belongs to the Section Molecular Medicine)

Protein Domains: Structure and Molecular Function

edited by Guangfeng Zhou

submission deadline 10 Nov 2025 | 4 articles | Viewed by 7951 | Submission Open

Keywords: protein structure; protein domains; domain classification; protein engineering; protein design; protein modeling; machine learning; deep learning; protein structure prediction; protein function prediction

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Neuropituitary Hormones in Metabolic Disorders

edited by

Claudia Camerino

submission deadline 10 Nov 2025 | Viewed by 53 | Submission Open

Keywords: oxytocin; vasopressin; thermoregulation; obesity; Prader– Willi syndrome; autism spectrum disorder; anorexia nervosa; craniopharyngioma; metabolic disorders; hypothalamic pituitary disorders; oxytocin-deficiency; vasopressin-deficiency

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Modulation of Oxidative Stress: A Global Perspective for Climate Change Adaptation

edited by

Tihomir Kovač

and

Tihana Marček

submission deadline 15 Nov 2025 | Viewed by 189 | Submission Open

Keywords: oxidative stress; modulation; climate change; environmental factors; adaption

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Biology in Dentistry: Innovations in Diagnosis, Treatment, and Biomaterials

edited by

Maria Maddalena Marrapodi

and Valentina Belli

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1732 | Submission Open

Keywords: oral microbiome; tissue regeneration; biomimetic materials

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Research on Virus-Induced Cellular and Molecular Responses

edited by

Rudian Zhang

submission deadline 30 Nov 2025 | 6 articles | Viewed by 10727 | Submission Open

Keywords: virus infectivity; infectious diseases; cellular stress; autophagy

(This special issue belongs to the Section Molecular Microbiology)

Natural Product in Skin Inflammation and Barrier Function Damage

edited by

Hsiu-Mei Chiang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6703 | Submission Open

Keywords: skin inflammation; barrier function damage; natural compounds; antioxidant properties; antiaging

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Radiation Oncology

edited by Allen Chen

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4063 | Submission Open

Keywords: molecular and cellular radiobiology; radiation physics; DNA damage and repair; radiation response; cancers

(This special issue belongs to the Section Molecular Medicine)

Tumor Immunology: From Molecular Mechanisms to Treatment

edited by

Deepika Awasthi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2512 | Submission Open

Keywords: cellular metabolism; metabolic reprogramming; immunometabolism; tumor microenvironment; immunotherapy; metabolites; immunosuppression; immune cells; tumor cells

(This special issue belongs to the Section Molecular Medicine)

Cardiovascular Disease: From Molecular Mechanisms to Therapeutic Innovations

edited by Andrea Marzullo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1964 | Submission Open

Keywords: cardiovascular pathophysiology; molecular biomarkers; inflammation and oxidative stress; therapeutic targets; lipid metabolism

(This special issue belongs to the Section Molecular Medicine)

Omics Analysis for Personalized Medicine

edited by

Golder N. Wilson

and

Tadeja Kuret

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1758 | Submission Open

Keywords: genomics; epigenomics; transcriptomics; proteomics; metabolomics; multi-omics; high throughput; personalized medicine; immune-mediated inflammatory diseases

(This special issue belongs to the Section Molecular Medicine)

Advanced Research in Glioblastoma and Neuroblastoma

edited by

Maria G. Bottone

submission deadline 30 Nov 2025 | 1 articles | Viewed by 983 | Submission Open

Keywords: glioblastoma; neuroblastoma; neuropharmaceuticals; drug design; blood– brain barrier; molecular therapeutics; brain-tumor biomarkers

(This special issue belongs to the Section Molecular Medicine)

Effects of Nanoparticles on Living Organisms, 3rd Edition

edited by

Yoshitaka Miyamoto

submission deadline 30 Nov 2025 | 1 articles | Viewed by 716 | Submission Open

Keywords: nanoparticles; particulate matter; medicine; prevention; diagnosis; drug delivery; environment; nanoparticles functionalization; in vitro/in vivo evaluation; 3D model; ADME; toxicity; biomedical applications; respiratory and cardiovascular diseases; immunological; inflammatory; and allergic diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Keys to Bioactivity: Pharmacophore and SAR Exploration in Organic Compounds

edited by

Claudiu N. Lungu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 373 | Submission Open

Keywords: structure– activity relationship; pharmacophore; chirality; bioactive molecules; morphogenesis; protein targets; membrane interaction; natural products; synthetic organic compounds; drug discovery

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

The Green Revolution in Cancer Research: Bioactive Substances from Plants as Promising Therapeutics

edited by Johura Ansary

submission deadline 30 Nov 2025 | Viewed by 130 | Submission Open

Keywords: bioactive compound; cancer research; plant-derived; anti-cancer properties; therapeutic strategies

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Mechanistic Insights into the Antioxidant Activity of Bioorganic Molecules: A Chemical Perspective

edited by

Tatjana S. Radosavljević

submission deadline 30 Nov 2025 | Viewed by 74 | Submission Open

Keywords: antioxidant mechanisms; bioorganic molecules; redox -active compounds; molecular reactivity; oxidative stress modulation

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Exploring Novel Therapeutic Targets for Neuropsychiatric Disorders: Current Research and Future Direction

edited by Claudia Bregonzio

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: microvascular alterations; Parkinson’ s disease; Alzheimer disease; schizophrenia; depression

(This special issue belongs to the Section Molecular Medicine)

Natural Phytochemicals as Modulators of Cellular Pathways and Therapeutic Targets in Disease Models

edited by

Jui-Hung Yen

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: phytochemicals; cellular signaling pathways; disease models; therapeutic targets; synergistic effects; natural products; bioactive modulators

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms and Biomarker Discovery in Neurodegenerative Disorders

edited by

George P. Paraskevas

submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; cerebrospinal fluid (CSF) biomarkers; positron emission tomography (PET); seeding amplification assay (SAA); plasma biomarkers

(This special issue belongs to the Section Molecular Medicine)

Advancements in Biomedical Optics and Brain Metabolism

edited by Jennifer M. Lynch

submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open

Keywords: biomedical optics; brain metabolism; optical neuroimaging; cerebral blood flow; near-infrared spectroscopy; diffuse correlation spectroscopy; neurocritical care; noninvasive monitoring; optical biomarkers; brain health

(This special issue belongs to the Section Molecular Medicine)

Novel Pharmacological Strategies and Molecular Mechanisms in Nonclinical Research

edited by

Vanessa Mateus

submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open

Keywords: molecular pharmacology; drug targets; signal transduction pathways; nonclinical models; receptor-ligand interactions; pharmacogenomics; preclinical drug development; gene expression modulation; mechanism of action; translational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Bioactives in Inflammation, 2nd Edition

edited by

Chan-Yen Kuo

submission deadline 30 Nov 2025 | Viewed by 24 | Submission Open

Keywords: anti-inflammation; bioactives; drug research and development; inflammatory diseases; natural products; signaling; synthesized compounds

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Harnessing Genomic Data for Disease Understanding and Drug Discovery

edited by

Gaurav Tripathi

submission deadline 30 Nov 2025 | Viewed by 20 | Submission Open

Keywords: pharmacogenomics; genomics; transcriptomics; epigenomics; drug discovery

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Drug Delivery: Molecular Mechanisms, Therapeutic Applications, and Technologies

edited by

Wenhao Wang

and

Zhengwei Huang

submission deadline 30 Nov 2025 | Viewed by 18 | Submission Open

Keywords: drug delivery; stimulus-responsive drug delivery systems; controlled-release drug delivery systems; theranostics; carrier– biological system interactions; delivery barriers; molecular mechanisms

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Repurposing and Innovation: Drug Research in Neuroprotection

edited by

Stela Dragomanova

submission deadline 30 Nov 2025 | Viewed by 16 | Submission Open

Keywords: neuroprotection; drug repurposing; natural-derived compounds; neurodegenerative diseases; pharmacological innovation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biology and Biochemistry of Cannabis

edited by Craig M. Schluttenhofer

submission deadline 30 Nov 2025 | Viewed by 12 | Submission Open

Keywords: cannabis sativa; molecular biology; phytochemical pathways; cannabinoid receptors; genomics; neurobiology; immunomodulation; plant– microbe interactions

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Future Challenges of Targeted Therapy of Cancers: 2nd Edition

edited by

Simona Gurzu

submission deadline 10 Dec 2025 | 3 articles | Viewed by 4685 | Submission Open

Keywords: biomarkers; tumor tissue; individualized therapy; gene profile; epithelial– mesenchymal transition; immunotherapy; angiogenesis; metastases; oncology; pathology

(This special issue belongs to the Section Molecular Medicine)

Latest Review Papers in Molecular Biology 2025

edited by

Madhav Bhatia

submission deadline 31 Dec 2025 | 11 articles | Viewed by 11435 | Submission Open

Keywords: molecular biology; molecular plant sciences; molecular cell biology; molecular medicine; molecular pathology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Technological Advances Around Next-Generation Sequencing Application

edited by

Gaurav Tripathi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 10540 | Submission Open

Keywords: next-generation sequencing; single-cell sequencing; long-read sequencing; metagenomics; epigenomics; cancer genomics; clinical applications; liquid biopsy; CRISPR-Cas9; precision medicine; personalized healthcare

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanism of HPV’s Involvement in Cancers

edited by Xuesong Wen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5968 | Submission Open

Keywords: HPV; HPV carcinogenesis; viral interaction; HPV genotyping; head and neck cancer; immune balance; cervical cancer

(This special issue belongs to the Section Molecular Medicine)

Effects of Environmental Factors on Cardiovascular Disease: From Molecular Effects to Possible Future Clinic Application

edited by

Angelika Edyta Charkiewicz

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3102 | Submission Open

Keywords: environmental factors; cardiovascular diseases; disease and chronic risk; health status; healthy eating; healthy lifestyle; physical activity; alcohol consumption reduction; tobacco cessation; public health; population health; psychosocial factors; dietary recommendations; nutrient intake; health outcomes

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

New Immunological Therapeutic Strategies in Kidney Disease

edited by

Yasunari Matsuzaka

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1848 | Submission Open

Keywords: IgA nephritis; IL-23/IL-17 pathway; CAR T-cell therapy; mesenchymal stem cells; innate lymphoid cells

(This special issue belongs to the Section Molecular Medicine)

Advances in Pharmacotherapeutic Strategies to Prevent Tumor Development, Progression and Treatment Resistance, 2nd Edition

edited by

Peter C. Hart

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1650 | Submission Open

Keywords: cancer; therapeutic resistance; drug tolerance; mechanisms of tumor development; mechanisms of tumor progression

(This special issue belongs to the Section Molecular Pharmacology)

Phytochemicals in Cancer Chemoprevention and Treatment: 2nd Edition

edited by

Wojciech Trybus

Ewa Trybus

and

Aneta Wȩgierek-Ciuk

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1166 | Submission Open

Keywords: phytochemicals; chemoprevention; cancer therapy; oxidative stress; apoptosis; autophagy; mitotic catastrophe; cell cycle; cytotoxicity; DNA damage; molecular pathways

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Functions of Long Non-Coding RNAs: Implications for Diseases and Therapy

edited by

Bodhisattwa Banerjee

submission deadline 31 Dec 2025 | 1 articles | Viewed by 769 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); gene regulation; molecular mechanisms; chromatin remodeling; epigenetic control; disease pathophysiology; biomarker discovery; therapeutic strategies; translational research

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Feature Papers in Molecular Medicine 2025

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Dec 2025 | 1 articles | Viewed by 713 | Submission Open

Keywords: pathogenesis; angiogenesis; autoimmune diseases; inflammatory; cancer; cardiovascular diseases; development and differentiation; endocrinology; genetics; epigenetics; hematology; hypoxia research; immunology; infectious diseases; metabolic disorders; neuroscience of diseases; regenerative medicine; prevention; therapeutics; stem cell research

(This special issue belongs to the Section Molecular Medicine)

Advances in Bioinformatics and Molecular Research on Alzheimer’s Disease

edited by Aristidis G. Vrahatis

submission deadline 31 Dec 2025 | Viewed by 197 | Submission Open

Keywords: Alzheimer’ s disease; single-cell sequencing; molecular biomarkers; single-cell RNA-seq; single-cell ATAC-seq; spatial transcriptomics

(This special issue belongs to the Section Molecular Medicine)

Design and Synthesis of Bioactive Peptides and Molecular Conjugates for Targeted Drug Delivery

edited by

Ashmeet Singh

submission deadline 31 Dec 2025 | Viewed by 161 | Submission Open

Keywords: peptides; non-covalent synthesis; fluorescent probes; biomaterials; stimuli-responsive; hydrogels; site specific; drug delivery

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Applications of Natural and Pseudo-Natural Products in Drug Discovery and Development 2025

edited by

Hidayat Hussain

submission deadline 31 Dec 2025 | Viewed by 56 | Submission Open

Keywords: natural products; pseudo-natural products; drug discovery; molecular level; in vitro studies; in vivo studies; computational methods; mode of action; computational methods

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

New Advances in Plant Responses to Environmental Stresses

edited by

Fuyuan Zhu

submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open

Keywords: abiotic stress; functional proteomics; stress response; salt stress; heavy metal stress

(This special issue belongs to the Section Molecular Plant Sciences)

Biomaterials for Disease Diagnosis and Therapy: Emerging Molecular Innovations and Applications

edited by Md Tipu Sultan

submission deadline 31 Dec 2025 | Viewed by 9 | Submission Open

Keywords: biomaterials; disease diagnosis; nanoparticles; hydrogels; scaffolds; bio 3D printing; bioink; biosensors; drug delivery; tissue engineering; biocompatibility; translational medicine; cancer; neurodegenerative disorders; disease model; 3D-printed microfluidic devices; organ on a chip; 3D-printed medical devices

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innovative Strategies in Overcoming Antimicrobial Resistance: From Phage Therapy to Combination

edited by Rajnikant Sharma

submission deadline 31 Dec 2025 | Viewed by 4 | Submission Open

Keywords: bacteriophages; phage therapy; antimicrobial resistance; phage engineering; phage-antibiotic combination; phage pharmacokinetics

(This special issue belongs to the Section Molecular Microbiology)

Latest Review Papers in Molecular Plant Science 2026

edited by

Zhaohui Chu

submission deadline 28 Feb 2026 | Viewed by 69 | Submission Open

Keywords: multi-omics; plant bioreactor; plant genomics; plant-pathogens interaction; crop domestication; crop yield traits

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Trends for Genome-Wide Association Studies in Complex Disease Genetics

edited by

Xiaowei Wu

submission deadline 31 Mar 2026 | Viewed by 74 | Submission Open

Keywords: GWAS; polygenic risk scores; rare variants; structural variants; multi-omics; Mendelian randomization; population structure and relatedness; machine learning; Bayesian models; stochastic models

(This special issue belongs to the Section Bioinformatics and Systems Biology)

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