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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Insect–Derived Natural Products: Bioactivity Mechanisms and Applications

edited by

Xuepeng Chi

and Ying Wang

submission deadline 31 Oct 2026 | Viewed by 153 | Submission Open

Keywords: insect-derived bioactive compounds; natural products; molecular mechanisms; biosynthesis; drug discovery; biopesticides; antimicrobial peptides; functional applications; biotechnology; sustainable utilization

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Reparative Therapeutic Strategies in Neurodegenerative Diseases

edited by

Cesar Borlongan

and Amir Hadanny

submission deadline 31 Oct 2026 | Viewed by 150 | Submission Open

Keywords: neurodegeneration; cell death signaling; oxidative stress; mitochondrial dysfunction; brain repair

(This special issue belongs to the Section Molecular Medicine)

Recent Progress in Antiparasitic Drugs

edited by

Xiaofei Shang

submission deadline 31 Oct 2026 | Viewed by 137 | Submission Open

Keywords: parasitic diseases; antiparasitic drug; antiparasitic resistance; parasitic control; parasitic infections; antiparasitic targets

(This special issue belongs to the Section Molecular Pharmacology)

Antimicrobial or Antibiofilm Activity of Biodegradable Substances

edited by

Miyako Yoshida

submission deadline 20 Nov 2026 | 2 articles | Viewed by 5432 | Submission Open

Keywords: antibacterial; antibiofilm; antimicrobial; biodegradable; drug-resistance

(This special issue belongs to the Section Molecular Microbiology)

Novel Drugs and Natural Products Discovery—2nd Edition

edited by

Muhammad Khattab

submission deadline 25 Nov 2026 | 3 articles | Viewed by 1388 | Submission Open

Keywords: natural products; novel drugs; drug design

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Targeted Therapeutic Approaches in Cancer: Combining Natural Compounds and Conventional Drugs

edited by

Alok Bhushan

submission deadline 30 Nov 2026 | 6 articles | Viewed by 10757 | Submission Open

Keywords: natural compounds; cancer; repurposing; combination; polychemotherapy; pharmaceuticals; nutraceuticals; molecular targets; metabolomics; immunotherapy

(This special issue belongs to the Section Molecular Medicine)

Mechanistic Insights into the Antioxidant Activity of Bioorganic Molecules: A Chemical Perspective

edited by

Tatjana S. Radosavljević

submission deadline 30 Nov 2026 | 5 articles | Viewed by 9960 | Submission Open

Keywords: antioxidant mechanisms; bioorganic molecules; redox -active compounds; molecular reactivity; oxidative stress modulation

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Pathogenesis, Diagnosis and Treatment of Skin and Sexually Transmitted Diseases

edited by

Maria Eleni Manthou

, Efstratios Vakirlis and

Iasonas Dermitzakis

submission deadline 30 Nov 2026 | 6 articles | Viewed by 8719 | Submission Open

Keywords: pathogenesis; diagnosis; treatment; dermatology; STDs; molecular; immunology; inflammation; genomics; precision

(This special issue belongs to the Section Molecular Medicine)

Bioinformatics Research in Bacterial Genomics, Metagenomics and Metatranscriptomics: 2nd Edition

edited by

Vesselin Baev

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6402 | Submission Open

Keywords: bacterial genomics and functional analysis; genome-wide comparative genomics; bioinformatics methods and tools; metagenomics; metatranscriptomics

(This special issue belongs to the Section Molecular Microbiology)

Abiotic Stress in Plants

edited by

Edgar Omar Rueda-Puente

submission deadline 30 Nov 2026 | 5 articles | Viewed by 6128 | Submission Open

Keywords: plant growth; abiotic stress; abiotic stress tolerance; gene editing

(This special issue belongs to the Section Molecular Plant Sciences)

Gastrointestinal Cancers: From Pathogenesis to Treatment

edited by

Mingwei Lin

and

Cheng-Che Lee

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4558 | Submission Open

Keywords: gastric cancer; cancer stem cells (CSCs); Nrf2 signaling; chemoresistance; extracellular vesicles (EVs); redox homeostasis

(This special issue belongs to the Section Molecular Medicine)

Harnessing Genomic Data for Disease Understanding and Drug Discovery

edited by

Gaurav Tripathi

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4392 | Submission Open

Keywords: pharmacogenomics; genomics; transcriptomics; epigenomics; drug discovery

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Insights into Pathogen–Host Interactions and Therapeutic Development

edited by

Sherif T.S. Hassan

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4270 | Submission Open

Keywords: bacterial infections; fungal infections; viral infections; infectious microorganisms; molecular medicine techniques; diagnosis, treatment, and prevention approaches; molecular and physiological investigations; cellular and genetic studies; disease pathogenesis; computational methods; drug design and development

(This special issue belongs to the Section Molecular Microbiology)

Molecular Basis of Autoimmune Diseases

edited by

Ranjeet Singh Mahla

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4002 | Submission Open

Keywords: autoimmune diseases; immune regulation; molecular mechanisms; genetic predisposition; epigenetics; cytokines; biomarkers; immune checkpoints; targeted therapies; genomics; transcriptomics; proteomics; systems biology; inflammation; immune tolerance

(This special issue belongs to the Section Molecular Medicine)

Natural Products and Their Derivatives as Antitumor Agents

edited by

Branislav Nastasijevic

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2388 | Submission Open

Keywords: anticancer drug screening; derivatives of natural compounds; targeted cancer therapy; multi-target therapy; cancer drug resistance; drug repurposing; anticancer drug bioavailability; antiproliferative activity; natural products as radiosensitizers; natural products as radioprotectors; natural remedies for chemotherapy side effects

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular and Immunological Research on Colorectal Cancer: Pathogenesis, Microenvironment, and Future Therapies

edited by Mónica G Mendoza-Rodríguez

submission deadline 30 Nov 2026 | 3 articles | Viewed by 2281 | Submission Open

Keywords: colorectal cancer (CRC); tumor microenvironment; chemotherapy resistance; inflammation-related signalling; biotherapeutics; immune response; cancer progression

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Gene Expression and Regulation in Cancer

edited by

Karolina Bajdak-Rusinek

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2153 | Submission Open

Keywords: cancer gene expression; oncogenic regulatory mechanisms; gene regulation targeted therapy; tumor phenotypes; cancer diagnostics and treatment

(This special issue belongs to the Section Molecular Medicine)

Autophagy Dysfunction in Neurodegenerative Disease

edited by

Federica Morani

and

Stefano Doccini

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1562 | Submission Open

Keywords: autophagy; neurodegeneration; neurodegenerative diseases; autophagy dysfunction; lysosome; autophagosome; mitophagy

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Phytochemical-Based Therapeutics: Emerging Mechanisms and Biomedical Applications

edited by

Yoon-Jin Lee

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1097 | Submission Open

Keywords: phytochemicals; therapeutic mechanisms; natural products; signal transduction; bioactivity; drug delivery; translational research; biomedical applications

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Multifactorial Causes of Insulin Resistance in Obesity, 2nd Edition

edited by Bogdana Virgolici

submission deadline 30 Nov 2026 | 3 articles | Viewed by 931 | Submission Open

Keywords: obesity; inflammation; oxidative stress; insulin resistance; caloric restriction

(This special issue belongs to the Section Molecular Medicine)

Nutrition and Immune Function in Disease: From Mechanisms to Precision Medicine

edited by

Liang Chen

submission deadline 30 Nov 2026 | 1 articles | Viewed by 674 | Submission Open

Keywords: nutrition–immune interactions; immunometabolism; inflammation; sarcopenia; precision medicine

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in Cancer Treatment and Anticancer Drugs

edited by

Roberto Campagna

and Valentina Schiavoni

submission deadline 30 Nov 2026 | 1 articles | Viewed by 432 | Submission Open

Keywords: anticancer drugs; molecular mechanisms; drug resistance; targeted therapy; signaling pathways; tumor biology; precision oncology; epigenetics; cancer metabolism; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Exploring Novel Therapeutic Targets for Neuropsychiatric Disorders: Current Research and Future Direction

edited by Claudia Bregonzio

submission deadline 30 Nov 2026 | Viewed by 416 | Submission Open

Keywords: microvascular alterations; Parkinson’s disease; Alzheimer disease; schizophrenia; depression

(This special issue belongs to the Section Molecular Medicine)

Extracellular Proteostasis and Chaperone Networks in Neurodegeneration

edited by

Nicholas J. Geraghty

submission deadline 30 Nov 2026 | Viewed by 275 | Submission Open

Keywords: protein aggregation; extracellular chaperone; receptor-mediated endocytosis; protein clearance; neuronal stress response; protein trafficking; clusterin; haptoglobin; α2-macroglobulin

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Nanomedicines in Cancers Targeting and Therapy

edited by

Wei Jiang

submission deadline 30 Nov 2026 | Viewed by 232 | Submission Open

Keywords: nanomedicine; tumor targeting; cancer therapy; drug delivery vehicle; biomedical

(This special issue belongs to the Section Molecular Medicine)

Innovative and Advanced Approaches in Drug Design and Discovery

edited by

Mohammed Bouachrine

submission deadline 30 Nov 2026 | Viewed by 227 | Submission Open

Keywords: drug design; drug discovery; molecular docking; virtual screening; molecular modeling; artificial intelligence; machine learning; cheminformatics; ADMET prediction; target identification

(This special issue belongs to the Section Molecular Pharmacology)

Pharmacology of Neuroprotection: Strategies, Compounds, and Drug Repurposing—a Regional Perspective from Bulgaria

edited by

Stela Dragomanova

submission deadline 30 Nov 2026 | Viewed by 213 | Submission Open

Keywords: neurodegenerative diseases; neuroprotection; multi-target pharmacology; natural compounds and drug repurposing; biological therapies and translational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Integrative Multi-Omics and Transcriptomic Profiling of Reproductive Tract Disorders: From Molecular Mechanisms to Precision Medicine

edited by

Ahsanullah Unar

submission deadline 30 Nov 2026 | Viewed by 207 | Submission Open

Keywords: multi-omics; transcriptomics; reproductive tract disorders; gynecological cancers; male infertility; single-cell sequencing; spatial transcriptomics; machine learning; precision medicine; biomarkers

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanisms of Therapy and Stress Responses in Cancer Cells and Normal Tissues

edited by

Ratan Sadhukhan

submission deadline 30 Nov 2026 | Viewed by 185 | Submission Open

Keywords: cancer therapeutics; radiotherapy; DNA damage; cellular stress response; genome integrity; DNA repair; tumor cells; normal tissue toxicity

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Potential Applications of Bioactive Plants and Their Natural Products

edited by

Mónica Lizeth Chávez-González

submission deadline 30 Nov 2026 | Viewed by 138 | Submission Open

Keywords: bioactive plants; natural products; molecular mechanisms; phytochemicals; secondary metabolites; functional applications; plant-derived bioactives

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

State-of-the-Art Molecular Skin Research in the Republic of Korea

edited by

Sullim Lee

submission deadline 30 Nov 2026 | Viewed by 105 | Submission Open

Keywords: natural products; bioactive compounds; skin biology; dermatological health; skin aging; skin barrier; keratinocytes; dermal fibroblasts; pigmentation; inflammation; oxidative stress; extracellular matrix (ECM); collagen; matrix metalloproteinases (MMPs); cellular senescence; signal transduction; molecular mechanisms; cosmeceuticals; functional ingredients; phytochemicals; marine-derived compounds; microbial metabolites

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Intervertebral Disc Degeneration and Regeneration

edited by

Koji Akeda

, Nobuyuki Fujita and Akira Shinohara

submission deadline 10 Dec 2026 | Viewed by 360 | Submission Open

Keywords: intervertebral disc degeneration; disc regenerative therapy; biomechanics of the spine; molecular mechanisms; degenerative lumbar disorders

(This special issue belongs to the Section Molecular Medicine)

New Advances in Muscle Physiology and Biophysics

edited by

Massimo Reconditi

submission deadline 25 Dec 2026 | Viewed by 49 | Submission Open

Keywords: muscle; actin; myosin; titin; sarcomere; muscle energetics; muscle aging; exercise; excitation-contraction coupling

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Research on Metabolic Aberration-Driven Carcinogenesis

edited by John Joseph Byrnes

submission deadline 30 Dec 2026 | 1 articles | Viewed by 1322 | Submission Open

Keywords: metabolic disorders; carcinogenic mutations; carcinogenesis; obesity-associated cancers; metabolic signaling

(This special issue belongs to the Section Molecular Medicine)

Latest Review Papers in Molecular Biology 2026

edited by

Madhav Bhatia

submission deadline 31 Dec 2026 | 12 articles | Viewed by 16358 | Submission Open

Keywords: molecular biology; molecular plant sciences; molecular cell biology; molecular medicine; molecular pathology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Natural Phytochemicals as Modulators of Cellular Pathways and Therapeutic Targets in Disease Models

edited by

Jui-Hung Yen

submission deadline 31 Dec 2026 | 5 articles | Viewed by 11625 | Submission Open

Keywords: phytochemicals; cellular signaling pathways; disease models; therapeutic targets; synergistic effects; natural products; bioactive modulators

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Featured Papers in Bioinformatics and Systems Biology

edited by

Howard H. Yang

submission deadline 31 Dec 2026 | 5 articles | Viewed by 8364 | Submission Open

Keywords: bioinformatics; omics; genomics and transcriptomics sequence analyses; dynamic modeling

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular and Omics Insights into Microbiome–Host Interactions in Health and Disease

edited by

Shweta Kuba

submission deadline 31 Dec 2026 | 1 articles | Viewed by 5985 | Submission Open

Keywords: microbiome; host–microbe interactions; multi-omics; molecular mechanisms; health and disease

(This special issue belongs to the Section Molecular Microbiology)

Multi-Omics Integration for Precision Medicine: From Pathogenesis, Diagnosis to Treatment

edited by

Sanghun Lee

, Brian Kwan and Kangjin Kim

submission deadline 31 Dec 2026 | 7 articles | Viewed by 4402 | Submission Open

Keywords: multi-omics integration; precision medicine; systems biology; biomarker discovery; genomics and transcriptomics; proteomics and metabolomics; disease pathogenesis; personalized therapy; machine learning in biology; translational research

(This special issue belongs to the Section Molecular Medicine)

Repurposing and Innovation: Drug Research in Neuroprotection

edited by

Stela Dragomanova

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3552 | Submission Open

Keywords: neuroprotection; drug repurposing; natural-derived compounds; neurodegenerative diseases; pharmacological innovation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Neuropsychiatry: Target Discovery for Mental Disorders

edited by Fenfen Ge and Yue Wang

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3421 | Submission Open

Keywords: molecular targets; neuropsychiatric disorders; genetic and epigenetic regulation; transcriptomics; pharmacogenomics; brain–immune interactions; neural circuits and synaptic plasticity; biomarker discovery; omics approaches; precision psychiatry

(This special issue belongs to the Section Molecular Medicine)

Molecular Roles of Neutrophil Extracellular Traps in Immune Responses and Disease

edited by Sofía S. Jerez and

Michaela Shishmanova-Doseva

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3022 | Submission Open

Keywords: neutrophils; NET; inflammation; chronic diseases; cell death

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Vascular Biology in Health and Diseases

edited by

Nilanjana Maulik

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2928 | Submission Open

Keywords: vascular biology; vascular disease; endothelium; cardiovascular disease (CVD); pathological mechanisms

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms of Plant Stress Responses and Development

edited by

Abdul Wakeel Umar

submission deadline 31 Dec 2026 | 4 articles | Viewed by 2642 | Submission Open

Keywords: plant stress physiology; hormonal signaling networks; abiotic stress tolerance; transcriptional regulation; epigenetics and chromatin dynamics; multi-omics integration; secondary metabolite biosynthesis; developmental plasticity; signal transduction; ROS and redox regulation; synthetic biology; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms, Diet and Therapeutic Interventions in Neurological Disorders

edited by

Giulia Accardi

and

Francesco Cacciabaudo

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2287 | Submission Open

Keywords: neurodegeneration; metabolic interventions; intermittent fasting; Mediterranean diet; molecular biomarkers; neuroinflammation; mitochondrial dysfunction; precision nutrition

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights and Unique Characteristics in Adolescent and Young Adult Oncology

edited by

Antonio Ruggiero

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2039 | Submission Open

Keywords: adolescent; young adult; biology; treatment; outcome

(This special issue belongs to the Section Molecular Medicine)

Molecular Pathways and Therapeutic Targets in Endometriosis

edited by

Edgar Ricardo Vázquez-Martínez

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1518 | Submission Open

Keywords: endometriosis; pathophysiology; gene expression; signaling pathway; epigenetics; steroid hormone; inflammation; therapeutic target; drug discovery; natural compound

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Insights into the Musculoskeletal System, Joints and Spine

edited by Seon-Jin Yoon

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1434 | Submission Open

Keywords: musculoskeletal system; joints; spine; pain-related nerve system; genetics; sequencing; human; animal; cell

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Cancer-Associated Remodeling of Functional Molecular Pathways

edited by

Dumitru Iacobas

submission deadline 31 Dec 2026 | 4 articles | Viewed by 1388 | Submission Open

Keywords: metabolism alteration; alteration of genetic information processing; alteration of environmental information processing; alterations of cellular processes; alterations of organismal systems

(This special issue belongs to the Section Molecular Medicine)

Immune Signatures and Biomarkers for Precision Medicine in Inflammatory Bowel Disease

edited by

Andreas C. Lazaris

and

Nikolaos Martinos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1221 | Submission Open

Keywords: inflammatory bowel disease; ulcerative colitis; Crohn’s disease; cytokines; IL-10; IL-23; biomarkers; precision medicine; immune profiling; histologic remission

(This special issue belongs to the Section Molecular Medicine)

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