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New Discoveries and Mechanistic Insights in Future Cancer Therapies

A Special Issue of Current Issues in Molecular Biology (ISSN 1467-3045) belonging to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 1046

Editor


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Guest Editor
School of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
Interests: molecular biology of cancer; tumor pathology; molecular diagnosis; new drug research and development; health medical data analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is one of the most prevalent and deadly diseases worldwide. Drug repurposing is a viable strategy for discovering new drugs in approved drugs by defining new indications.

We tried to summarize articles that inhibit cancer growth and are sensitive to anti-cancer drugs in vitro and in vivo, as well as explain the underlying chemoprevention patterns. We welcome articles on the development of new pharmacologically active compounds and the continued use of natural products such as synthetic and existing drugs as new drug developments. We welcome your original articles illuminating the challenges and opportunities in chemopreventive drug development. These can include new positioning of cancer therapeutics, selective optimization and reduction in side effects, sources and applications of synthetic drugs or drug metabolites as new drugs, drug delivery systems, and applications of nanomaterials. The manuscript collection will be published as a Special Issue of the journal.

Prof. Dr. Yi-Chiang Hsu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer therapeutics
  • tumor antigens
  • vaccine
  • nanotechnology

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Published Papers (1 paper)

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Review

20 pages, 2977 KB  
Review
Current Perspectives on 2D and 3D Cell Culture Models in Cancer Research: Molecular Determinants of Tumor Biology and Therapeutic Response
by Selma Yıldırım, Juan Gómez-Salgado, Luis El Khoury-Moreno and Özkan Özden
Curr. Issues Mol. Biol. 2026, 48(9), 914; https://doi.org/10.3390/cimb48090914 - 6 Sep 2026
Viewed by 266
Abstract
Cancer remains a major global health challenge, requiring innovative diagnostic and therapeutic strategies. Cell culture models are essential tools in cancer research. While traditional two-dimensional (2D) cultures are widely used because of their accessibility and simplicity, they inadequately represent the tumor microenvironment. This [...] Read more.
Cancer remains a major global health challenge, requiring innovative diagnostic and therapeutic strategies. Cell culture models are essential tools in cancer research. While traditional two-dimensional (2D) cultures are widely used because of their accessibility and simplicity, they inadequately represent the tumor microenvironment. This review provides a molecular perspective on the biological differences between 2D and 3D cancer models, emphasizing extracellular matrix signaling, mechanotransduction, metabolic adaptation, tumor heterogeneity, and therapeutic resistance rather than a general comparison of culture systems. It discusses the limitations of 2D models and highlights the advantages of 3D systems, including spheroids and organoids, for more accurately recapitulating the tumor microenvironment and improving the predictive value of anticancer drug testing. This narrative review synthesizes current evidence on the roles of 2D and 3D cell culture methods in oncology. The literature was searched in PubMed, Google Scholar, and Web of Science from 2015 to 2026 using keywords including “2D cell culture,” “3D cell culture,” “spheroids,” “organoids,” and “cancer.” Studies were eligible for inclusion if they addressed cancer research using 2D or 3D cell culture models and provided relevant experimental, preclinical, or translational evidence, particularly regarding tumor microenvironment, extracellular matrix signaling, cellular interactions, therapeutic response, or molecular mechanisms. Studies unrelated to cancer or 2D/3D culture models, duplicate records, and publications lacking relevant primary data were excluded. Study selection was performed by screening titles and abstracts followed by full-text assessment according to the predefined eligibility criteria. Seminal studies were also included when considered relevant to the conceptual framework of the review. Findings were synthesized narratively without quantitative analysis. 2D cultures limit cell–cell and cell–extracellular matrix interactions, reducing the applicability of findings to in vivo conditions. In contrast, 3D cultures better reproduce oxygen and nutrient gradients and cellular interactions, providing a more realistic representation of the tumor microenvironment. Recent advances in 3D systems have improved predictive accuracy for drug screening and personalized medicine. Both 2D and 3D culture methods possess unique strengths and limitations. Used in complementary ways, they can improve the translation of in vitro findings to in vivo and clinical applications, accelerating progress in cancer research and therapeutic development. Full article
(This article belongs to the Special Issue New Discoveries and Mechanistic Insights in Future Cancer Therapies)
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