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Emerging Trends in Nanobiotechnology and Nanomedicine

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 736

Special Issue Editors


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Guest Editor
Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941-902, RJ, Brazil
Interests: nanotechnology; microtechnology; neglected diseases; modified release; nanoparticles; nanoemulsions; liposomes
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Laboratório de Farmacotécnica Experimental (LabFE), Instituto de Tecnologia em Fármacos—Farmanguinhos, Fundação Oswaldo Cruz—Fiocruz, Rio de Janeiro, RJ, Brazil
2. Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941-902, RJ, Brazil
Interests: nanotechnology; microtechnology; neglected diseases; modified release; nanoparticles; nanoemulsions; polymers; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our next Special Issue on the ‘Emerging Trends in Nanobiotechnology and Nanomedicine’. This Special Issue aims to highlight the most recent advances in the application of nanotechnology in the areas of molecular biology and medicine. Nanotechnology involves the encapsulation of synthetic, natural, and biotechnological drugs in nanocarriers to promote the therapeutic effects in the treatment of cancer, infectious diseases (caused by viruses, bacteria, protozoa), immunological diseases, tissue regeneration, and antigens for vaccines.

Areas of research may include the following:

  • Functionalized nanocarriers for site-specific delivery of drugs, peptides, monoclonal antibodies, enzymes, hormones, antigens, and cytokines.
  • Promotion of the bioavailability of oral, skin, mucosa, and other tissues.
  • Development of nanoparticles (polymeric, lipid, metallic, ceramic, composite), liposomes, niosomes, polymeric micelles, nanoemulsions, and nanofibers containing biotechnologically active compounds and drugs for combined therapy.
  • Nanotheranostics for obtaining images and treating diseases.
  • Nanofibers containing biomolecules and drugs for tissue engineering and regeneration.
  • Assessment of biocompatibility and safety of materials for transactional research and clinical use.

Prof. Dr. Eduardo Ricci Junior
Dr. Ana Paula Dos Santos Matos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bionanotechnology
  • nanocarriers
  • cancer
  • infectious diseases
  • drug delivery
  • bioavailability

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Published Papers (1 paper)

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Research

23 pages, 10592 KB  
Article
Evaluation of Antitumor and Antimicrobial Photobiological Activity of Nanocarrier Containing Photosensitizer and Magnetic Nanoparticle
by Raphaela Aparecida Schuenck Rodrigues, Sandro Pinheiro da Costa, Veronica da Silva Cardoso, Alane Beatriz Vermelho, Ralph Santos-Oliveira, Franklin Chimaobi Kenechukwu and Eduardo Ricci-Junior
Curr. Issues Mol. Biol. 2026, 48(3), 324; https://doi.org/10.3390/cimb48030324 - 19 Mar 2026
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Abstract
Nanotechnology combined with photodynamic therapy (PDT) has been explored to enhance antitumor and antimicrobial photobiological activity. Aluminum phthalocyanine chloride (Al-Pc-Cl), with or without magnetic nanoparticles (MagNPs), was incorporated into polymeric nanoparticles (PNPs) to improve the PDT for treating tumors and infectious diseases. Three [...] Read more.
Nanotechnology combined with photodynamic therapy (PDT) has been explored to enhance antitumor and antimicrobial photobiological activity. Aluminum phthalocyanine chloride (Al-Pc-Cl), with or without magnetic nanoparticles (MagNPs), was incorporated into polymeric nanoparticles (PNPs) to improve the PDT for treating tumors and infectious diseases. Three batches of the nanoparticles (MagNPs, PNPs-PS and PNPs-PS-MagNPs) were developed and characterized in terms of size, PdI, morphology by TEM, release study, and antitumor (against A549 cells) and antimicrobial (against MRSA and C. albicans) photobiological activity. The developed nanoparticles were nanometric in size, with MagNPs, PNPs-PS, and PNPs-PS-MagNPs showing 33.6, 186.9, and 333.5 nm, respectively, maintained the magnetic properties (for MagNPs and PNPs-PS-MagNPs), and provided slow and sustained release of the photosensitizer. PNPs-PS and PNPs-PS-MagNPs showed excellent antitumor photobiological activity with cell viabilities of 42 and 34%, respectively, and were not cytotoxic in the dark, with cell viabilities above 70%. PNPs-PS showed strong antibacterial activity against MRSA with an IC50 of 8.26 μg/mL, which was lower to free Al-Pc-Cl with an IC50 of 14.22 μg/mL after I radiation. The results of the antifungal photobiological activity against C. albicans were excellent, with IC50 values of 3.75 and 3.5 μg/mL for PNPs-PS and PNPs-PS-MagNPs, respectively, values which were significantly lower with p < 0.05 than free PS (IC50 > 30 μg/mL) after irradiation with light and fluconazole (IC50 > 30 μg/mL), the reference antifungal agent. PNPs-PS showed promising results regarding antitumor, antibacterial, and antifungal photobiological activity. However, PNPs-PS-MagNPs showed weak results for antibacterial photobiological activity against MRSA but with promising results for tumor cells and C. albicans. Full article
(This article belongs to the Special Issue Emerging Trends in Nanobiotechnology and Nanomedicine)
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