Natural Polyphenols in Cardiovascular Disease Prevention: Molecular Mechanisms and Therapeutic Perspectives
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioorganic Chemistry and Medicinal Chemistry".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 26
Special Issue Editor
Special Issue Information
Dear Colleague,
Polyphenols and other naturally derived bioactive compounds have emerged as promising agents in the prevention and management of cardiovascular diseases (CVDs), which remain a leading cause of morbidity and mortality worldwide. These compounds exert a wide range of molecular effects, including antioxidant, anti-inflammatory, vasodilatory, and lipid-lowering actions, all of which are critically involved in cardiovascular health. Recent advances in molecular biology have provided new insights into the ways in which polyphenols modulate key cellular pathways, gene expression, and signaling mechanisms involved in atherogenesis, endothelial function, and cardiac remodeling.
This Special Issue aims to gather original research articles and reviews that explore the molecular mechanisms by which natural polyphenols and related phytochemicals exert their cardioprotective effects. Contributions that investigate bioavailability, structure–activity relationships, synergistic effects with conventional therapies, and emerging delivery systems are particularly welcome. We also encourage submissions focusing on translational aspects and in vivo studies that bridge the gap between experimental evidence and clinical application. This collection will provide a comprehensive overview of the current molecular understanding of natural compounds in cardiovascular prevention, highlighting new therapeutic strategies and future research directions.
Dr. Pasquale Perrone
Guest Editor
Manuscript Submission Information
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Keywords
- polyphenols
- phytochemicals
- cardiovascular diseases
- cardiovascular
- protective
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