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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Modulatory Effects of Plants with Therapeutic Potential in Neuropsychiatric Disorder

edited by

Alin Ciobica

submission deadline 31 Aug 2025 | Viewed by 1292 | Submission Open

Keywords: plant biodiversity; antioxidant effects; therapeutic potential; neuropsychiatric disorders; oxidative stress markers; inflammatory markers

(This special issue belongs to the Section Molecular Pharmacology)

Insights from Genetics, Epigenetics, and Microbiome Research in Obesity: Integrative Approaches to Understand Metabolic Disorders

edited by Shengping Yang

submission deadline 31 Aug 2025 | 1 articles | Viewed by 892 | Submission Open

Keywords: obesity; epigenetics; microbiom; genetics; bioinformatics

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Early Molecular Diagnosis and Comprehensive Treatment of Tumors

edited by

Chan-Yen Kuo

submission deadline 31 Aug 2025 | 2 articles | Viewed by 506 | Submission Open

Keywords: next-generation sequencing (NGS); novel biomarkers; precision medicine; targeted therapy; immunotherapy; integrative treatment; personalized cancer treatment

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Bioinformatics Research in Bacterial Genomics, Metagenomics and Metatranscriptomics: 2nd Edition

edited by

Vesselin Baev

submission deadline 31 Aug 2025 | 1 articles | Viewed by 449 | Submission Open

Keywords: bacterial genomics and functional analysis; genome-wide comparative genomics; bioinformatics methods and tools; metagenomics; metatranscriptomics

(This special issue belongs to the Section Molecular Microbiology)

Mechanisms and Pathophysiology of Obesity

edited by Padmamalini Baskaran

submission deadline 31 Aug 2025 | Viewed by 264 | Submission Open

Keywords: understanding genetic factors for obesity at the molecular level; understanding environmental factors for obesity at the molecular level; contribution of insulin resistance to obesity and ways to combat; circadian misalignment– molecular level understanding of its contribution to obesity and ways to mitigate it; effective and individualized obesity treatment strategies for stress; molecular understanding of the influence of parental obesity on childhood overweight; molecular mechanisms of maternal smoking on childhood obesity; therapeutic interventions for obesity through recombinant hormones; role of gut hormones in the treatment of obesity; development of new digital tools for weight management interventions

(This special issue belongs to the Section Molecular Medicine)

Cutting-Edge Microscopy and Electron Microscopy Innovations in Molecular Biology Research

edited by

Diana Torge

submission deadline 31 Aug 2025 | Viewed by 93 | Submission Open

Keywords: morphology; microscopy; transmission electron microscopy; molecular biology; medicine; dentistry

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Research in Osteoarthritis and Osteoarticular Diseases, 2nd Edition

edited by

Ye Liu

submission deadline 31 Aug 2025 | Viewed by 61 | Submission Open

Keywords: osteoarthritis; cartilage regeneration; bioinformatics; biomarkers; inflammation; cartilage; metabolic imbalance

(This special issue belongs to the Section Molecular Medicine)

The Role of the Immune System in the Progression of Chronic Liver Disease

edited by

Ana Maretti-Mira

submission deadline 10 Sep 2025 | 1 articles | Viewed by 3597 | Submission Open

Keywords: autoimmune hepatitis; epigenetics; fatty liver; inflammation; liver fibrosis; liver repair; therapeutic targets and interventions; transcriptomics; viral hepatitis

(This special issue belongs to the Section Molecular Medicine)

Novel Immunotherapy for Neurological Diseases

edited by

Michel-Edwar Mickael

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1526 | Submission Open

Keywords: T cells; immune; neurological disorders; Alzheimer's disease

(This special issue belongs to the Section Molecular Medicine)

Targeting Tumor Microenvironment for Cancer Therapy, 3rd Edition

edited by

Ming-Wei Lin

and

Cheng-Che Lee

submission deadline 30 Sep 2025 | 9 articles | Viewed by 12985 | Submission Open

Keywords: chemotherapy; cancer; tumor; tumor microenvironment; cancer stem cells; cancer therapy; cancer stemness; chemoresistance

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Regulation in Allergy and Immune Diseases, Immunodeficiencies, 2nd Edition

edited by

Kinga Lis

submission deadline 30 Sep 2025 | 3 articles | Viewed by 12640 | Submission Open

Keywords: allergy and hypersensitivity mechanisms; cross-reactivity in allergy; component resolved diagnostic (CRD); immunodeficiencies; experimental research methods in allergology; biochemical properties of allergens

(This special issue belongs to the Section Molecular Medicine)

Tumorigenesis and Tumor Microenvironment

edited by

Yaser Gamallat

submission deadline 30 Sep 2025 | 4 articles | Viewed by 10013 | Submission Open

Keywords: tumorigenesis; tumor growth; tumor progression; tumor metastasis; cancers

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Reproductive Biology and Germ Cell Development, 2nd Edition

edited by

Huafeng Wang

submission deadline 30 Sep 2025 | 5 articles | Viewed by 8812 | Submission Open

Keywords: reproduction; fertilization; sperm; oocyte; signaling; infertility

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Cerebrovascular Diseases: From Pathogenesis to Treatment

edited by

Adria Arboix

Teresa Gasull

and Francisco Purroy

submission deadline 30 Sep 2025 | 7 articles | Viewed by 7339 | Submission Open

Keywords: stroke; ischemic; hemorrhagic; neuronal death; molecular mechanisms; inflammation; epigenetics; ischemic tolerance; ferroptosis; free radicals; treatment

(This special issue belongs to the Section Molecular Medicine)

Human and Animal Infectious Diseases: Prevention, Diagnosis and Treatment, 2nd Edition

edited by

Sherif T.S. Hassan

submission deadline 30 Sep 2025 | 5 articles | Viewed by 5526 | Submission Open

Keywords: bacterial infections; fungal infections; viral infections; infectious microorganisms; molecular medicine techniques; diagnosis; treatment; and prevention approaches; molecular and physiological investigations; cellular and genetic studies; disease pathogenesis; computational methods; drug design and development

(This special issue belongs to the Section Molecular Medicine)

Molecular Research of Urological Diseases

edited by Juhyun Shin

submission deadline 30 Sep 2025 | 5 articles | Viewed by 5305 | Submission Open

Keywords: anticancer drugs; apoptosis mechanism; cell death and proliferation; bioinformatics; natural product

(This special issue belongs to the Section Molecular Medicine)

DNA Damage and Repair in Health and Diseases

edited by

Tomasz Popławski

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4690 | Submission Open

Keywords: DNA damage; DNA repair; DNA repair enzymes; genome stability; oxidative damage; cancers; autoimmune diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innate Immunity Responds to Virus Infection

edited by Zhenlu Chong

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2687 | Submission Open

Keywords: viral infection; cGAS-STING; RIG-I; toll-like receptors; IFN-I; IFN-III; JAK-STAT pathway; ubiquitination; cellular and molecular studies; animal model

(This special issue belongs to the Section Molecular Microbiology)

Microalga Biotechnology and Applications: Molecular and Cellular Mechanisms

edited by

Angel Llamas

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1859 | Submission Open

Keywords: microalgae; biotechnology; cyanobacteria; chlamydomonas; cellular stress; nutrient limitations; molecular mechanisms; omics technologies

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Targeted Therapeutic Approaches in Cancer: Combining Natural Compounds and Conventional Drugs

edited by

Alok Bhushan

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1013 | Submission Open

Keywords: natural compounds; cancer; repurposing; combination; polychemotherapy; pharmaceuticals; nutraceuticals; molecular targets; metabolomics; immunotherapy

(This special issue belongs to the Section Molecular Medicine)

Molecular Research on Virus-Related Infectious Disease

edited by Guangcai Duan and

Shuaiyin Chen

submission deadline 30 Sep 2025 | Viewed by 291 | Submission Open

Keywords: molecular diagnosis of viruses; viral genomics; host– virus interactions; molecular pathways; therapeutic targets; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Molecular Basis of Autoimmune Diseases

edited by

Ranjeet Singh Mahla

submission deadline 30 Sep 2025 | 1 articles | Viewed by 227 | Submission Open

Keywords: autoimmune diseases; immune regulation; molecular mechanisms; genetic predisposition; epigenetics; cytokines; biomarkers; immune checkpoints; targeted therapies; genomics; transcriptomics; proteomics; systems biology; inflammation; immune tolerance

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Phytochemicals: Therapeutic Potential in Metabolic Disorders and Cancer

edited by

Mohamed Addi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 130 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer therapeutics; metabolic disorders; natural compounds; signal transduction; epigenetic regulation; oxidative stress; anti-inflammatory agents; plant-based

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Therapeutic Advances in Hypertension Management and Vascular Health

edited by

Federica Fogacci

Arrigo Francesco Giuseppe Cicero

and

Claudio Borghi

submission deadline 30 Sep 2025 | Viewed by 117 | Submission Open

Keywords: hypertension; vascular aging; endothelial dysfunction; gestational hypertension; metabolic disorders; therapeutic strategies in hypertension management

(This special issue belongs to the Section Molecular Medicine)

Post-Translational Modification Networks in Disease and Therapy: From Chromatin Regulation to Protein Stability

edited by

Zhe Yang

submission deadline 30 Sep 2025 | Viewed by 95 | Submission Open

Keywords: post-translational modifications; protein stability; chromatin regulation; phosphorylation; ubiquitination; methylation; acetylation; sumoylation; disease mechanisms; targeted therapy

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Research in Bioactivity of Natural Products, 3rd Edition

edited by

Magdalena Bartnik

and

Wirginia Kukula-Koch

submission deadline 30 Sep 2025 | Viewed by 70 | Submission Open

Keywords: molecular research; molecular properties; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Impacts of DNA Methylation as Epigenetic Drivers of Disease Onset and Progression

edited by Adam G. Marsh

submission deadline 30 Sep 2025 | Viewed by 67 | Submission Open

Keywords: epigenetics; DNA methylation; disease onset; disease progression; molecular mechanisms; molecular biomarkers; gene silencing; gene expression

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Nanotechnology-Enhanced Photodynamic Therapy for Precision Medicines

edited by

Milutin Stepić

and

Iva A. Popović

submission deadline 30 Sep 2025 | Viewed by 65 | Submission Open

Keywords: photodynamic therapy; photosensitisers; targeting nanocarriers; multifunctional nanoplatforms; nanotheranostics; active targeting of cancer; molecular drug targeting; drug metabolism and toxicity; pharmacogenetic testing; cancer microenvironment remodelling

(This special issue belongs to the Section Molecular Medicine)

Molecular Research on Free Radicals and Oxidative Stress—2nd Edition

edited by

Mosharraf Sarker

submission deadline 30 Sep 2025 | Viewed by 61 | Submission Open

Keywords: oxidative stress; free radicals; reactive oxygen species (ROS); gene regulation; antioxidants; mitochondrial dysfunction; insulin resistance; inflammation; autophagy

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecules at Play in Cardiovascular Diseases

edited by

Dumitru A. Iacobas

submission deadline 30 Sep 2025 | Viewed by 60 | Submission Open

Keywords: arrythmias; arteriosclerosis; congenital heart disease; coronary disease; diabetic cardiomyopathy; dilated cardiomyopathy; endocarditis; high blood pressure; hypertrophic cardiomyopathy; valvular heart diseases

(This special issue belongs to the Section Molecular Medicine)

Cancer Genetics and Pharmacology: Advancing Precision Therapeutics

edited by Baoming Wang

submission deadline 30 Sep 2025 | Viewed by 53 | Submission Open

Keywords: cancer genetics; epigenetic modifications; pharmacogenomics; personalized medicine

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Molecular Pathways Involved in Atopic Dermatitis: Implications for Targeted Therapy

edited by

Ciro Martins Gomes

submission deadline 30 Oct 2025 | Viewed by 73 | Submission Open

Keywords: atopic dermatitis; biological products; cytokines; Th2 cells; eczema; Janus kinase inhibitors

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Roles of Neutrophil Extracellular Traps in Immune Responses and Disease

edited by Sofía S. Jerez

submission deadline 30 Oct 2025 | Viewed by 43 | Submission Open

Keywords: neutrophils; NET; inflammation; chronic diseases; cell death

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Role of Natural Products in Inflammatory Diseases

edited by

Chingyuan Wu

submission deadline 31 Oct 2025 | 4 articles | Viewed by 12367 | Submission Open

Keywords: natural compounds; phytochemicals; bioactivity; IL-1; caspases; inflammasome; proinflammatory cytokines; psoriasis

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanisms and Innovative Therapeutic Approaches in Inflammatory Diseases, Pioneering Precision Medicine Solutions

edited by

Hector A. Cabrera-Fuentes

Klaus T. Preissner

and

Elisabeth Deindl

submission deadline 31 Oct 2025 | 12 articles | Viewed by 8853 | Submission Open

Keywords: inflammatory diseases; autoimmune disorders; cytokine signaling; oxidative stress; therapies

(This special issue belongs to the Section Molecular Medicine)

Complex Molecular Mechanism of Monogenic Diseases: 3rd Edition

edited by

Grzegorz Wegrzyn

submission deadline 31 Oct 2025 | 2 articles | Viewed by 7497 | Submission Open

Keywords: cystic fibrosis; sickle cell disease; duchenne muscular dystrophy; inherited monogenic disease; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Novel Drugs and Natural Products Discovery

edited by

Muhammad Khattab

submission deadline 31 Oct 2025 | 6 articles | Viewed by 6248 | Submission Open

Keywords: natural products; novel drugs; drug design

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Biology of Viral Replication and Associated Disease Outcomes

edited by Usama Ashraf

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4566 | Submission Open

Keywords: viruses; replication; immunity; pathogenesis; antivirals; immune modulator

(This special issue belongs to the Section Molecular Microbiology)

Natural Product Drug Activity and Biomedicine Application

edited by

Anna Makuch-Kocka

submission deadline 31 Oct 2025 | 5 articles | Viewed by 4283 | Submission Open

Keywords: natural products; signaling pathways; epignetic regulation; cell communication; molecular biology

(This special issue belongs to the Section Molecular Pharmacology)

Challenges and Advances in Bioinformatics and Computational Biology

edited by Haijun Gong

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2722 | Submission Open

Keywords: bioinformatics; computational biology; genomics; proteomics; metabolomics; multi-omics; machine learning; AI; big data; molecular diagnostics; personalized medicine; data visualization

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanism and Regulation in Neuroinflammation, 2nd Edition

edited by Hung-Pei Tsai

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2618 | Submission Open

Keywords: microglia; glial cells; cytokines; blood– brain barrier; traumatic brain injury; aging; Alzheimer's disease; parkinson's disease; amyotrophic lateral sclerosis; multiple sclerosis

(This special issue belongs to the Section Molecular Medicine)

Intestinal Inflammation: From Molecular Mechanisms to Therapeutic Strategies

edited by

Raffaele Pellegrino

and

Antonietta Gerarda Gravina

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1026 | Submission Open

Keywords: inflammatory bowel disease; celiac disease; Crohn's Disease; ulcerative colitis; colitis; hemorrhoidal disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Gut Microbiota in Health, Immunity and Disease

edited by

Ahmad Ud Din

submission deadline 31 Oct 2025 | 1 articles | Viewed by 494 | Submission Open

Keywords: gut microbiome; immune system; probiotics; prebiotics; microbial metabolites; microbiota– host interactions; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

Mitochondrial Genomes 2025: Unraveling the Threads of Evolution and Function

edited by Hongyi Liu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 341 | Submission Open

Keywords: mitogenomes; mitochondria genomes; molecular evolution

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

The Emerging Role of Molecular and Serum Biomarkers in Osteoporosis

edited by

Francesca Salamanna

and

Stefania Pagani

submission deadline 31 Oct 2025 | Viewed by 246 | Submission Open

Keywords: osteoporosis; biomarkers; PINP; CTX; bone metabolism

(This special issue belongs to the Section Molecular Medicine)

Natural Products in Biomedicine and Pharmacotherapy, 2nd Edition

edited by

Ahmed Ezat El Zowalaty

submission deadline 31 Oct 2025 | Viewed by 184 | Submission Open

Keywords: natural products; genetic engineering; pharmacotherapy; anticancer; antimicrobials

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Epigenetic Changes in Cancer: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Priscilla Brebi-Mieville

submission deadline 31 Oct 2025 | Viewed by 167 | Submission Open

Keywords: epigenetic mechanisms in cancer; epigenetic-based therapies; precision oncology and epigenetics; epigenetic drug development; tumor heterogeneity and epigenetics; epigenetic reprogramming

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Pathogenesis, Diagnosis and Treatment of Skin and Sexually Transmitted Diseases

edited by