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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Pharmacotherapeutic Strategies to Prevent Tumor Development, Progression and Treatment Resistance, 2nd Edition

edited by

Peter C. Hart

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8785 | Submission Open

Keywords: cancer; therapeutic resistance; drug tolerance; mechanisms of tumor development; mechanisms of tumor progression

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism of HPV’s Involvement in Cancers

edited by Xuesong Wen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8351 | Submission Open

Keywords: HPV; HPV carcinogenesis; viral interaction; HPV genotyping; head and neck cancer; immune balance; cervical cancer

(This special issue belongs to the Section Molecular Medicine)

Functional Genomics and Comparative Genomics Analysis in Plants, 3rd Edition

edited by

Quan Zou

, Ran Su and Qiangguo Jin

submission deadline 31 Dec 2025 | 9 articles | Viewed by 7159 | Submission Open

Keywords: de novo genome sequencing; pan-genomic analyses; genome re-sequencing; GWAS analyses; RNA-seq; metabolomics; gene family analyses; plant evolutionary analyses; bioinformatics; database

(This special issue belongs to the Section Molecular Plant Sciences)

Multiple Myeloma: From Molecular Mechanism to Diagnosis and Therapy

edited by

Jari Intra

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5433 | Submission Open

Keywords: multiple myeloma; blood cancer; immunopathogenesis; biomarker; immunoglobulin

(This special issue belongs to the Section Molecular Medicine)

Oral Cancer: Prophylaxis, Etiopathogenesis and Treatment, 2nd Edition

edited by

Violeta Popovici

and

Emma Adriana Ozon

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5243 | Submission Open

Keywords: oral carcinogenesis; biomarkers; cell signaling; natural products; phytochemicals; medicinal plants; essential oils; antimicrobial activity; cytotoxicity; phytotherapy; drug discovery; drug delivery; pharmaceutical formulation

(This special issue belongs to the Section Molecular Medicine)

Innovations in Marine Biotechnology and Molecular Biology

edited by Huarong Guo

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4971 | Submission Open

Keywords: marine animal; marine algae; marine microorganism; marine biotechnology; molecular biology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Phytochemicals in Cancer Chemoprevention and Treatment: 2nd Edition

edited by

Wojciech Trybus

Ewa Trybus

and

Aneta Wȩgierek-Ciuk

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4967 | Submission Open

Keywords: phytochemicals; chemoprevention; cancer therapy; oxidative stress; apoptosis; autophagy; mitotic catastrophe; cell cycle; cytotoxicity; DNA damage; molecular pathways

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights into Cancer Biomarkers: Identification and Practical Applications

edited by

Mihaela Chivu-Economescu

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4817 | Submission Open

Keywords: cancer biomarkers; liquid biopsy; early detection; progression; prognosis; treatment monitoring

(This special issue belongs to the Section Molecular Medicine)

New Immunological Therapeutic Strategies in Kidney Disease

edited by

Yasunari Matsuzaka

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4245 | Submission Open

Keywords: IgA nephritis; IL-23/IL-17 pathway; CAR T-cell therapy; mesenchymal stem cells; innate lymphoid cells

(This special issue belongs to the Section Molecular Medicine)

Advances in Molecular Therapies and Disease Associations in Diabetes

edited by

Hongbao Cao

and Shaolei Teng

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2811 | Submission Open

Keywords: diabetes; molecular therapies; comorbidities; genomics; proteomics; metabolomics; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Medicine)

The Molecular Basis of Immunotherapy in Cancer Treatment

edited by Hassan Dastsooz

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2702 | Submission Open

Keywords: immunotherapy; cancer; CAR-T cell therapy; monoclonal antibodies; immunomodulation; cytokines; immune evasion mechanisms

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in Molecular Medicine 2025

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Dec 2025 | 5 articles | Viewed by 2444 | Submission Open

Keywords: pathogenesis; angiogenesis; autoimmune diseases; inflammatory; cancer; cardiovascular diseases; development and differentiation; endocrinology; genetics; epigenetics; hematology; hypoxia research; immunology; infectious diseases; metabolic disorders; neuroscience of diseases; regenerative medicine; prevention; therapeutics; stem cell research

(This special issue belongs to the Section Molecular Medicine)

Molecular Breeding and Genetics Research in Plants—3rd Edition

edited by

Shimeles Tilahun

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2316 | Submission Open

Keywords: genetic basis; genomic selection/prediction; molecular breeding; biotic and abiotic stresses; qPCR

(This special issue belongs to the Section Molecular Plant Sciences)

Applications of Natural and Pseudo-Natural Products in Drug Discovery and Development 2025

edited by

Hidayat Hussain

submission deadline 31 Dec 2025 | 5 articles | Viewed by 2072 | Submission Open

Keywords: natural products; pseudo-natural products; drug discovery; molecular level; in vitro studies; in vivo studies; computational methods; mode of action; computational methods

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Mechanism and Advances in Gynecological Pathology: From Bench to Bedside

edited by

Ahsanullah Unar

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2061 | Submission Open

Keywords: gynecological cancers; molecular pathology; biomarkers; genetic alterations; epigenetics; tumor microenvironment; personalized medicine; targeted therapy; endometriosis; ovarian cancer

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Functions of Long Non-Coding RNAs: Implications for Diseases and Therapy

edited by

Bodhisattwa Banerjee

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1993 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); gene regulation; molecular mechanisms; chromatin remodeling; epigenetic control; disease pathophysiology; biomarker discovery; therapeutic strategies; translational research

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Bioinformatics and Molecular Research on Alzheimer’s Disease

edited by Aristidis G. Vrahatis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 781 | Submission Open

Keywords: Alzheimer’ s disease; single-cell sequencing; molecular biomarkers; single-cell RNA-seq; single-cell ATAC-seq; spatial transcriptomics

(This special issue belongs to the Section Molecular Medicine)

New Advances in Plant Responses to Environmental Stresses

edited by

Fuyuan Zhu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 536 | Submission Open

Keywords: abiotic stress; functional proteomics; stress response; salt stress; heavy metal stress

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in piRNA Biology and Processing: Mechanisms and Applications

edited by

Yicheng Luo

submission deadline 31 Dec 2025 | Viewed by 360 | Submission Open

Keywords: piRNA; Piwi; transposable elements; epigenetics; genetics; development; cancer

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Design and Synthesis of Bioactive Peptides and Molecular Conjugates for Targeted Drug Delivery

edited by

Ashmeet Singh

submission deadline 31 Dec 2025 | Viewed by 242 | Submission Open

Keywords: peptides; non-covalent synthesis; fluorescent probes; biomaterials; stimuli-responsive; hydrogels; site specific; drug delivery

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Biomaterials for Disease Diagnosis and Therapy: Emerging Molecular Innovations and Applications

edited by Md Tipu Sultan

submission deadline 31 Dec 2025 | Viewed by 115 | Submission Open

Keywords: biomaterials; disease diagnosis; nanoparticles; hydrogels; scaffolds; bio 3D printing; bioink; biosensors; drug delivery; tissue engineering; biocompatibility; translational medicine; cancer; neurodegenerative disorders; disease model; 3D-printed microfluidic devices; organ on a chip; 3D-printed medical devices

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Targeted Therapies and Biomarker Discovery in Health and Disease

edited by

Rodrigo Pinheiro Araldi

submission deadline 31 Dec 2025 | Viewed by 97 | Submission Open

Keywords: multi-omics technologies; targeted therapies; biomarkers; oncology; neurology

(This special issue belongs to the Section Molecular Pharmacology)

Innovative Strategies in Overcoming Antimicrobial Resistance: From Phage Therapy to Combination

edited by Rajnikant Sharma

submission deadline 31 Dec 2025 | Viewed by 83 | Submission Open

Keywords: bacteriophages; phage therapy; antimicrobial resistance; phage engineering; phage-antibiotic combination; phage pharmacokinetics

(This special issue belongs to the Section Molecular Microbiology)

Advancements in Dendrimer Technology: From Molecular Biology Applications to Therapeutic Innovations

edited by

Jørn Bolstad Christensen

submission deadline 31 Dec 2025 | Viewed by 71 | Submission Open

Keywords: dendrimers; molecular biology applications; therapeutic innovations; nanomedicine; drug delivery

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Cancer Immunology: Molecular Tools, New Therapeutic Targets, Challenges, and Opportunities

edited by Pablo C. Ortiz-Lazareno

submission deadline 15 Jan 2026 | 1 articles | Viewed by 875 | Submission Open

Keywords: cancer immunology; immune response; immune evasion; immune checkpoints; immune response

(This special issue belongs to the Section Molecular Medicine)

Innovative Therapeutics and Biomarkers in Hepatocellular Carcinoma Research

edited by

Alok Raghav

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3937 | Submission Open

Keywords: hepatocellular carcinoma; biomarkers; therapeutics; imaging; artificial intelligence; diagnostics

(This special issue belongs to the Section Molecular Medicine)

Molecular Approaches in Early Detection and Targeted Therapies for Pancreatic Cancer

edited by

Hassan Mubarak Ishqi

submission deadline 25 Jan 2026 | Viewed by 83 | Submission Open

Keywords: pancreatic cancer; early detection; molecular biomarkers; targeted therapy; genomics; tumor microenvironment; precision medicine; transcriptomics; proteomics; cancer diagnostics

(This special issue belongs to the Section Molecular Medicine)

Advanced Molecular Research on Hypertensive Disorders of Pregnancy (HDPs)

edited by

Melissa Wilson

submission deadline 31 Jan 2026 | 7 articles | Viewed by 8938 | Submission Open

Keywords: DNA; RNA; protein; microbiome; hypertensive disorders of pregnancy; preeclampsia; epidemiology; meta-analysis

(This special issue belongs to the Section Molecular Medicine)

Radiation-Induced Cellular and Molecular Responses

edited by

Carlo Aprile

submission deadline 31 Jan 2026 | 2 articles | Viewed by 8917 | Submission Open

Keywords: radiation; radiobiology; space radiobiology; heavy ions carcinogenesis; LinearNonTreshold; radionuclide therapy; alpha emitters; beta emitters; radiobiology

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in Plant Stress Tolerance

edited by

Sajid Ali

submission deadline 31 Jan 2026 | 9 articles | Viewed by 8342 | Submission Open

Keywords: plant stress tolerance; molecular mechanisms; stress-responsive gene; signal transduction pathways; epigenetic modifications; phytohormones (ethylene; ABA; SA; JA); reactive oxygen species (ROS); plant– microbe interactions; microbial plant bio-stimulants; omics approaches (genomics; transcriptomics; proteomics; and metabolomics)

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment, 2nd Edition

edited by Haibo Dong and

Wei Guo

submission deadline 31 Jan 2026 | 5 articles | Viewed by 6411 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); alcohol-associated liver disease (ALD); lipotoxicity; bile acid metabolism; novel biomarker identification; organelle dysfunction and communication; inflammation and oxidative stress; cell signaling and cell death pathways; lipid metabolism and dysregulation; epigenetic modifications (DNA/RNA/non-coding RNA); therapeutic targets and interventions

(This special issue belongs to the Section Molecular Medicine)

Tumor Microenvironment: Crosstalk Between Epigenetics, Metabolism and Immunity

edited by

Liang Chen

submission deadline 31 Jan 2026 | 4 articles | Viewed by 3425 | Submission Open

Keywords: tumor microenvironment; epigenetic modifications; metabolic reprogramming; immune escape; tumor metastasis; therapeutic resistance

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Food-Derived Natural Products and Their Biological Activities—2nd Edition

edited by

Yanfang Li

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3238 | Submission Open

Keywords: food compounds; natural products; biologically active compounds; oxidative stress; anticancer; functionality of foods

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights into Pathogenesis and Targeted Therapy of Gynaecological Cancers

edited by

Stergios Boussios

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3169 | Submission Open

Keywords: ovarian cancers; cervical cancers; endometrial cancers; targeted therapy; molecular markers; immunotherapy

(This special issue belongs to the Section Molecular Medicine)

Exploring Molecular Pathways in Skin Health and Diseases

edited by

Sullim Lee

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2992 | Submission Open

Keywords: skin health; skin aging; skin disease; molecular pathways; oxidative stress; immune response; inflammatory skin diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights: Mechanisms Underlying the Biological Activities of Natural Products—2nd Edition

edited by

Premalatha Balachandran

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2304 | Submission Open

Keywords: natural products; molecular mechanisms; biological activities; pharmacodynamics; drug discovery; therapeutic potential; signaling pathways; target identification; pharmacological properties; bioactive compounds

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Advances in Phytochemical Research: Molecular Pathways in Health and Disease

edited by

Christiana Charalambous

and

Christiana Neophytou

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1286 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer signaling pathways; anti-inflammatory properties; anti-oxidant properties; apoptosis; cardiovascular disorders; metabolic syndromes; chemoprevention

(This special issue belongs to the Section Molecular Medicine)

Molecular and Pharmacological Insights into Bioactive Compounds: Pathways to Therapeutics

edited by

Mosharraf Sarker

and

Talat Nasim

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1110 | Submission Open

Keywords: bioactive compounds; natural products; drug discovery; pharmacology; therapeutic pathways; molecular mechanisms; signal transduction; medicinal chemistry; target identification

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Phytochemicals: Therapeutic Potential in Metabolic Disorders and Cancer

edited by

Mohamed Addi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 996 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer therapeutics; metabolic disorders; natural compounds; signal transduction; epigenetic regulation; oxidative stress; anti-inflammatory agents; plant-based

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Autophagy and the Ubiquitin–Proteasome System: Regulators of Protein Homeostasis, Cell Death, and Disease Pathogenesis

edited by

Lei Dong

submission deadline 31 Jan 2026 | 1 articles | Viewed by 943 | Submission Open

Keywords: autophagy; ubiquitin– proteasome system; protein homeostasis; autophagosome; cell death regulation; cancer; Alzheimer's disease

(This special issue belongs to the Section Molecular Medicine)

Advances in Multi-Omics for Functional Genomics Studies and Molecular Breeding, 2nd Edition

edited by Chen Chen

submission deadline 31 Jan 2026 | 2 articles | Viewed by 831 | Submission Open

Keywords: sequencing technologies; plant genomics; transcriptomics; proteomics; metabolomics; epigenomics; single-cell sequencing; functional genomics; transformation methods; gene identification

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Hormones, Development, and Stress Tolerance

edited by

Zhaohui Chu

and

Wei Yang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 729 | Submission Open

Keywords: plant hormones; abiotic stress; auxins; jasmonic acid; signal pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Real-World Evidence Research of Respiratory Diseases and Infections, 2nd Edition

edited by

Chingyuan Wu

submission deadline 31 Jan 2026 | Viewed by 318 | Submission Open

Keywords: respiratory diseases; pathogenesis; vaccines; therapies; COVID-19

(This special issue belongs to the Section Molecular Medicine)

Cutting-Edge Microscopy and Electron Microscopy Innovations in Molecular Biology Research

edited by

Diana Torge

submission deadline 31 Jan 2026 | Viewed by 221 | Submission Open

Keywords: morphology; microscopy; transmission electron microscopy; molecular biology; medicine; dentistry

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Impacts of DNA Methylation as Epigenetic Drivers of Disease Onset and Progression

edited by Adam G. Marsh

submission deadline 31 Jan 2026 | Viewed by 145 | Submission Open

Keywords: epigenetics; DNA methylation; disease onset; disease progression; molecular mechanisms; molecular biomarkers; gene silencing; gene expression

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Molecular Biology Methods in Hepatology Research, 2nd Edition

edited by

Ralf Weiskirchen

and

Dileep G. Nair

submission deadline 31 Jan 2026 | Viewed by 78 | Submission Open

Keywords: hepatic diseases; molecular biology methods; single-cell genomics; single-cell proteomics; hepatic organoids; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Allergic Diseases: Molecular Pathways and Pathogenesis

edited by

Jing Gao

submission deadline 31 Jan 2026 | Viewed by 75 | Submission Open

Keywords: allergic diseases; allergic responses; allergic inflammation; immune response; genetics and susceptibility

(This special issue belongs to the Section Molecular Medicine)

Unraveling the Role of Epigenetics and Molecular Genetics in Disease Progression via the Gut–Brain Axis

edited by Yong-Chan Kim

submission deadline 31 Jan 2026 | Viewed by 70 | Submission Open

Keywords: prion diseases; Parkinson’ s disease; Alzheimer’ s disease; neurodegenerative disease; inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; brain– gut axis; bioinformatics; polymorphism

(This special issue belongs to the Section Molecular Medicine)

Molecular Dynamics Simulations in Structural Biology: From Proteins to Complex Biomolecular Systems

edited by

Ana E. Ledesma

submission deadline 31 Jan 2026 | Viewed by 64 | Submission Open

Keywords: protein; molecular docking; dynamic simulation; biomolecular systems; molecular interactions; structural modification; enzyme activity; biological function; antioxidant activity; infrared spectroscopy

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular and Cellular Mechanisms of Vascular Function and Dysfunction: Roles of the Endothelium and G-Protein Coupled Receptors

edited by John J. McGuire

submission deadline 31 Jan 2026 | Viewed by 57 | Submission Open

Keywords: endothelium; endothelial cells; vascular smooth muscle; platelets; G-protein coupled receptor; signal transduction; metabolic dysfunction; diabetes; inflammation; angiogenesis

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

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