Advances in Molecular Biology Methods in Hepatology Research, 2nd Edition
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 8066
Special Issue Editors
Interests: liver disease; fibrosis; biomarker; cytokines; chemokines; translational medicine
Special Issues, Collections and Topics in MDPI journals
Interests: molecular biology; liver fibrosis; drug discovery and development; advanced in vitro models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent advances in molecular and cellular biology methods have had profound implications in deciphering the complexities of hepatology research. Specifically, these advancements are helping us to understand how the liver functions and how diseases develop. They are also allowing us to identify novel therapies and drugs and reduce drug toxicity. The integration of genomic technologies such as next-generation sequencing (NGS), single-cell sequencing, CRISPR-Cas9, and epigenetic studies allows for a more thorough analysis of the liver's genomic landscape. Similarly, progress in single-cell proteomic techniques, including sensitive mass spectrometry and high-throughput proteomics, has enabled the identification and quantification of liver proteins at the cellular level. These technologies help scientists comprehend the molecular pathways involved in liver injury, fibrosis, and regeneration. In addition to genomic techniques, the progress in hepatic in vivo models and liver tissue engineering, utilizing technologies such as CRISPR-Cas9, has aided in the creation of humanized organoid models. These technologies, such as hepatic organoids, are scalable for high-throughput screening and can replicate intricate cellular interactions, providing further insights into the mechanisms underlying liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), hepatitis, and liver fibrosis. By generating patient-derived organoids, researchers can personalize disease models, uncover individualized disease mechanisms, and develop efficient toxicity screening platforms and precision therapeutics. Overall, these advancements in molecular biology have propelled hepatology research to new heights, providing additional opportunities for efficient diagnosis, treatment, and prevention strategies for hepatic diseases.
You can read the publications in the first volume here: https://www.mdpi.com/journal/cimb/special_issues/4L8BQQE181.
Prof. Dr. Ralf Weiskirchen
Dr. Dileep G. Nair
Guest Editors
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Keywords
- hepatic diseases
- molecular biology methods
- single-cell genomics
- single-cell proteomics
- hepatic organoids
- biomarkers
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