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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 10 May 2026 | Viewed by 654 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer

edited by

Yongye Huang

, Lin Yuan and Yang Yu

submission deadline 10 May 2026 | Viewed by 155 | Submission Open

Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics

Retinal Disorders: Cellular Mechanisms and Targeted Therapies

edited by

Takeshi Iwata

submission deadline 15 May 2026 | 5 articles | Viewed by 12677 | Submission Open

Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics

(This special issue belongs to the Section Cellular Pathology)

Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling

edited by Jianjie Ma, Long-Sheng Song,

Jingsong Zhou

and

Hua Zhu

submission deadline 15 May 2026 | 3 articles | Viewed by 3155 | Submission Open

Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 May 2026 | 1 articles | Viewed by 1709 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae

edited by

Yoshikazu Ohya

and Hisao Moriya

submission deadline 15 May 2026 | 2 articles | Viewed by 1457 | Submission Open

Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Placenta in Tissue Engineering and Regeneration

edited by

Gayathri Rajaraman

submission deadline 15 May 2026 | Viewed by 260 | Submission Open

Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration

The Metabolic Interactions and Pathways in Cancers

edited by Mohamed Elgendy

submission deadline 15 May 2026 | Viewed by 219 | Submission Open

Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy

Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma

edited by

Margot Martinez-Moreno

, Patricia L Sullivan and Jeremy J Reynolds

submission deadline 15 May 2026 | Viewed by 169 | Submission Open

Keywords: chordoma; targeted therapy; brachyury; tumor microenvironment; epigenetics; immunotherapy; biomarkers; drug resistance; translational oncology; radiation resistance

Molecular and Translational Advances in Metastatic Breast Cancer Research

edited by

Sravani Ramisetty

submission deadline 15 May 2026 | Viewed by 136 | Submission Open

Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis

The Role of Light in Ocular Health and Disease

edited by Krisztina Valter,

María Ana Contín

and

Monica Acosta

submission deadline 15 May 2026 | Viewed by 122 | Submission Open

Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics

Conditional Programming of Cells, Advanced Computational Methods, and Intelligent Systems in Prostate Cancer Research

edited by Ahmed Fadiel

submission deadline 15 May 2026 | Viewed by 92 | Submission Open

Keywords: prostate cancer; conditional programming; cellular reprogramming; computational biology; cell-state transitions; lineage plasticity; tumor microenvironment; ex vivo models; machine learning

Advances in Spermatogenesis—Second Edition

edited by

Zhibing Zhang

and Changmin Niu

submission deadline 15 May 2026 | Viewed by 66 | Submission Open

Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception

(This special issue belongs to the Section Reproductive Cells and Development)

Molecular Advances in Prenatal Exposure to Environmental Toxicants

edited by

Douglas M. Ruden

and

Sudipta Dutta

submission deadline 20 May 2026 | 4 articles | Viewed by 14296 | Submission Open

Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes

Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition

edited by

Mehrnoosh Saghizadeh Ghiam

and

Vivien Coulson-Thomas

submission deadline 20 May 2026 | 7 articles | Viewed by 11591 | Submission Open

Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β

(This special issue belongs to the Section Cell Signaling)

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 20 May 2026 | 1 articles | Viewed by 5708 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery

edited by Roberta Montanari and

Alberto Vitali

submission deadline 20 May 2026 | 1 articles | Viewed by 4257 | Submission Open

Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms

(This special issue belongs to the Section Cellular Biophysics)

The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses

edited by

Dimitrios Vlachakis

Tassos Georgakopoulos

and

Marios Agelopoulos

submission deadline 20 May 2026 | 3 articles | Viewed by 3852 | Submission Open

Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications

(This special issue belongs to the Section Cellular Pathology)

Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease

edited by

Israël Vlodavsky

and

Jin-Ping Li

submission deadline 20 May 2026 | 1 articles | Viewed by 1918 | Submission Open

Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation

(This special issue belongs to the Section Cell Signaling)

The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation

edited by

Vinay Shukla

submission deadline 20 May 2026 | 1 articles | Viewed by 1720 | Submission Open

Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation

(This special issue belongs to the Section Tissues and Organs)

Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies

edited by

Jorge Mata-Garrido

Raquel Francés

and Íñigo Casafont

submission deadline 20 May 2026 | Viewed by 334 | Submission Open

Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy

(This special issue belongs to the Section Cellular Metabolism)

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 20 May 2026 | Viewed by 267 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 20 May 2026 | Viewed by 189 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

(This special issue belongs to the Section Cell Microenvironment)

Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine

edited by Emanuela Mari

submission deadline 20 May 2026 | Viewed by 153 | Submission Open

Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome

(This special issue belongs to the Section Stem Cells)

Pathology and Therapies in Brain Tumor

edited by Bachuchu Lal

submission deadline 20 May 2026 | Viewed by 120 | Submission Open

Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models

(This special issue belongs to the Section Cellular Pathology)

Regulation of Iron Homeostasis

edited by

Huangen Ding

submission deadline 20 May 2026 | Viewed by 88 | Submission Open

Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins

Cellular and Molecular Basis of Sjögren’s Syndrome

edited by Muhammad Shahnawaz Soyfoo

submission deadline 20 May 2026 | Viewed by 75 | Submission Open

Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity

Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies

edited by Jayakumar R. Nair

submission deadline 20 May 2026 | Viewed by 62 | Submission Open

Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity

(This special issue belongs to the Section Cellular Pathology)

Non-Coding and Coding RNAs in Targeted Cancer Therapy

edited by

César López-Camarillo

and

Macrina B. Silva-Cázares

submission deadline 25 May 2026 | 4 articles | Viewed by 8866 | Submission Open

Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets

(This special issue belongs to the Section Cell and Gene Therapy)

Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory

edited by

Avik Roy

submission deadline 25 May 2026 | 2 articles | Viewed by 5495 | Submission Open

Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition

edited by

Dimitrios Kouroupis

and

Thomas M. Best

submission deadline 25 May 2026 | 2 articles | Viewed by 3973 | Submission Open

Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering

(This special issue belongs to the Section Stem Cells)

Recent Advances in Astrocyte Neuron Communication

edited by

Stefano Ferroni

and

Francesco Formaggio

submission deadline 25 May 2026 | Viewed by 1012 | Submission Open

Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity

(This special issue belongs to the Section Cellular Neuroscience)

Cell Therapy for Retinal Diseases

edited by

Girish Kumar Srivastava

and

Yogeswaran Lokanathan

submission deadline 25 May 2026 | Viewed by 423 | Submission Open

Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration

(This special issue belongs to the Section Tissues and Organs)

Cell Signaling in Neurodegenerative Disease

edited by

Rijwan Uddin Ahammad

, Yasuhiro Funahashi,

Akira Sobue

Xinjian Zhang

and Md-nadim Hossain

submission deadline 25 May 2026 | Viewed by 363 | Submission Open

Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience

(This special issue belongs to the Section Cellular Neuroscience)

Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury

edited by

Daniel J. Hellenbrand

and Angela R. Filous

submission deadline 25 May 2026 | Viewed by 172 | Submission Open

Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia

Cellular and Molecular Insights into Female Reproductive Biology

edited by

Mohamed Ali

submission deadline 25 May 2026 | Viewed by 158 | Submission Open

Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis

(This special issue belongs to the Section Reproductive Cells and Development)

Metabolic Regulation of Cell Behavior and Implications for Aging

edited by

Eloy Bejarano

and José Antonio Rodríguez Navarro

submission deadline 25 May 2026 | Viewed by 131 | Submission Open

Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy

Brain Function and Structure: Mapping Complexity in Neuronal Cells

edited by

José Antonio Del Río Fernández

submission deadline 25 May 2026 | Viewed by 96 | Submission Open

Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience

Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy

edited by

Ali R. Jazirehi

submission deadline 25 May 2026 | Viewed by 81 | Submission Open

Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis

Human DNA Replication/Repair Factors

edited by

Shuming Zhang

and

Michal Goldberg

submission deadline 25 May 2026 | Viewed by 71 | Submission Open

Keywords: DNA replication; replisome; DNA polymerase; helicase; replication fork; DNA repair; replication stress; DNA damage response; homologous recombination; replication-coupled DNA repair

From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies

edited by

Francesca Bianchi

Elena Dozio

and

Lucia La Sala

submission deadline 29 May 2026 | Viewed by 275 | Submission Open

Keywords: obesity; inflammasomes; immune system; microbiota

(This special issue belongs to the Section Tissues and Organs)

Advanced Research in Neurogenesis and Neuroinflammation

edited by

Muskan Gupta

submission deadline 30 May 2026 | 5 articles | Viewed by 2949 | Submission Open

Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions

(This special issue belongs to the Section Cellular Neuroscience)

Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance

edited by

Katrina F. Cooper

and Kleiton Silva

submission deadline 30 May 2026 | Viewed by 112 | Submission Open

Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders

(This special issue belongs to the Section Autophagy)

Therapeutic Targeting of Myeloid Cells in Tumor

edited by Mirko Farina and

Giovanni Micheloni

submission deadline 30 May 2026 | Viewed by 67 | Submission Open

Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development

Protein–Protein Interaction in Health and Disease

edited by

Riccardo Sgarra

and

Sara Petrosino

submission deadline 30 May 2026 | Viewed by 60 | Submission Open

Keywords: protein– protein interactions; mass spectrometry; cross-linking; disease mechanisms; structural biology; proteomics; therapeutic targets; protein complexes

(This special issue belongs to the Section Cell Signaling)

Genome Editing in Biomedicine

edited by

Fu-Lei Tang

submission deadline 30 May 2026 | Viewed by 60 | Submission Open

Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)

(This special issue belongs to the Section Cell and Gene Therapy)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 May 2026 | 11 articles | Viewed by 24234 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cellular Neuroscience)

Proteomic Applications in Ageing and Neurodegenerative Conditions

edited by

Thomas Wishart

Rachel A. Kline

and

Dominic Kurian

submission deadline 31 May 2026 | 4 articles | Viewed by 19594 | Submission Open

(This special issue belongs to the Section Cell Methods)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 31 May 2026 | 7 articles | Viewed by 18096 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition

edited by

Hideki Sudo

submission deadline 31 May 2026 | 4 articles | Viewed by 14436 | Submission Open

Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy

(This special issue belongs to the Section Cellular Pathology)

Displaying special issue 351-400 on page 8 of 13.

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