Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 24 December 2025 | Viewed by 22
Special Issue Editors
Interests: functional genomics; morphological profiling; Saccharomyces cerevisiae; fermentation; agrichemicals
Special Issue Information
Dear Colleagues,
Functional genomics aims to systematically elucidate gene functions and the molecular basis of phenotypic traits and disease susceptibility. Saccharomyces cerevisiae has long served as a central model organism in this field, owing to its genetic tractability and the wealth of experimental resources available. Recent advances, including large-scale phenotypic libraries (~5,000 deletion strains across >7,500 conditions) and transcriptomic datasets for over 1,500 strains, have provided unprecedented insights into gene regulatory networks and diverse cellular features—such as morphology, protein localization, and intracellular environments.
The field is now rapidly expanding beyond traditional knockout approaches. Emerging directions include gene overexpression systems, machine learning-guided predictions of uncharacterized ORFs, and the causal inference of drug-response phenotypes. Particular attention is being paid toward rare, condition-specific phenotypes that may offer novel biological insights.
Today, the functional genomics of S. cerevisiae are increasingly being recognized as a versatile platform for integrative biology, with broad applications in drug discovery, disease modeling, and industrial biotechnology. This Special Issue highlights recent developments in functional genomics and morphological profiling in yeast, and invites contributions that address new methodologies, biological discoveries, and conceptual advances shaping the future of this field.
Prof. Dr. Yoshikazu Ohya
Prof. Dr. Hisao Moriya
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- functional genomics
- morphological profiling
- Saccharomyces cerevisiae
- overexpression
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
