Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Plant, Algae and Fungi Cell Biology".
Deadline for manuscript submissions: 24 December 2025 | Viewed by 309
Special Issue Editors
Interests: functional genomics; morphological profiling; Saccharomyces cerevisiae; fermentation; agrichemicals
Special Issue Information
Dear Colleagues,
Functional genomics aims to systematically elucidate gene functions and the molecular basis of phenotypic traits and disease susceptibility. Saccharomyces cerevisiae has long served as a central model organism in this field, owing to its genetic tractability and the wealth of experimental resources available. Recent advances, including large-scale phenotypic libraries (~5,000 deletion strains across >7,500 conditions) and transcriptomic datasets for over 1,500 strains, have provided unprecedented insights into gene regulatory networks and diverse cellular features—such as morphology, protein localization, and intracellular environments.
The field is now rapidly expanding beyond traditional knockout approaches. Emerging directions include gene overexpression systems, machine learning-guided predictions of uncharacterized ORFs, and the causal inference of drug-response phenotypes. Particular attention is being paid toward rare, condition-specific phenotypes that may offer novel biological insights.
Today, the functional genomics of S. cerevisiae are increasingly being recognized as a versatile platform for integrative biology, with broad applications in drug discovery, disease modeling, and industrial biotechnology. This Special Issue highlights recent developments in functional genomics and morphological profiling in yeast, and invites contributions that address new methodologies, biological discoveries, and conceptual advances shaping the future of this field.
Prof. Dr. Yoshikazu Ohya
Prof. Dr. Hisao Moriya
Guest Editors
Manuscript Submission Information
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Keywords
- functional genomics
- morphological profiling
- Saccharomyces cerevisiae
- overexpression
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