Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer

Dear Colleagues,

Aging and cancer, two complex biological processes, share an intimate and paradoxical relationship. While advanced age is the single greatest risk factor for most cancers, the underlying cellular and molecular mechanisms driving this connection remain a central question in biomedical research. This interplay involves a delicate balance: hallmarks of aging, such as genomic instability, epigenetic alterations, and cellular senescence, can create a permissive environment for oncogenesis. Conversely, mechanisms that suppress cancer often overlap with those that promote aging.

In this Special Issue, original research articles, comprehensive reviews, communications, and systematic reviews are welcome. Research areas may include but are not limited to the following:

• Cellular senescence;
• Aging and cancer;
• Cellular reprogramming;
• Gene editing;
• Epigenetics;
• Cancer therapy;
• Oxidative stress;
• DNA damage response;
• Metabolism;
• Immune surveillance;
• Microenvironment;
• Protein aggregation.

We look forward to receiving your contributions.

Dr. Yongye Huang
Dr. Lin Yuan
Dr. Yang Yu
Guest Editors

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