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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Therapeutic Classes in Lung Cancer

edited by

Rajat Thawani

and

Rohit Singh

submission deadline 31 Dec 2026 | Viewed by 143 | Submission Open

Keywords: non-small-cell lung cancer; small-cell lung cancer; antibody– drug conjugates; bispecific antibodies; resistance mechanisms; precision oncology; immunotherapy combinations

(This special issue belongs to the Section Cancer Therapy)

Advances in Vaccines for the Treatment and Prevention of Cancer

edited by

Erika J Crosby

and Emilia Diego

submission deadline 31 Dec 2026 | Viewed by 135 | Submission Open

Keywords: cancer vaccines; neoantigens; tumor-specific antigens; mRNA vaccines; viral vector vaccines; dendritic cell vaccines; immunotherapy; adjuvants; biomarkers of vaccine response; personalized cancer vaccines

Chronic Lymphocytic Leukemia and Indolent B-Cell Lymphomas: Clonal Evolution, Microenvironment, and Immune Remodeling

edited by Franco Fais

submission deadline 31 Dec 2026 | Viewed by 132 | Submission Open

Keywords: chronic lymphocytic leukemia; indolent B-cell lymphomas; clonal evolution; tumor microenvironment; lymph node and bone marrow niche; B-cell receptor signaling; immune dysfunction; T-cell exhaustion; therapy resistance; intratumoral heterogeneity; metabolic reprogramming

Blood–Brain Barrier and Brain Metastases

edited by Liliana Santos

submission deadline 31 Dec 2026 | Viewed by 131 | Submission Open

Keywords: brain metastasis; blood– brain barrier; tumour microenvironment; cancer immunology; drug delivery; metastatic niche; targeted therapy

(This special issue belongs to the Section Cancer Metastasis)

Anal Squamous Cell Carcinoma (SCC)

edited by

Evie H. Carchman

submission deadline 31 Dec 2026 | Viewed by 121 | Submission Open

Keywords: HPV; anal cancer; screening; chemoradiotherapy; immunotherapy

Genomics, Epigenomics and Targeted Therapy of Oral Squamous Cell Carcinoma

edited by Mustafa Ozen

submission deadline 31 Dec 2026 | Viewed by 116 | Submission Open

Keywords: oral squamous cell carcinoma; genomics; epigenomics; targeted therapy; biomarkers; tumor microenvironment; precision medicine; translational research

Non-Contrast Breast Cancer MRI Screening: Diffusion-Weighted Imaging, DWIBS, and Clinical Implementation

edited by

Taro Takahara

submission deadline 31 Dec 2026 | Viewed by 92 | Submission Open

Keywords: non-contrast breast MRI; breast cancer screening; diffusion-weighted imaging; DWIBS; dense breasts; cancer detection rate; positive predictive value; quality control; remote interpretation; screening implementation

Advances in Inducement Factors, Precision Diagnostics, and Targeted Therapeutic Strategies for Basal Cell Carcinoma

edited by

Julia Welzel

submission deadline 31 Dec 2026 | Viewed by 90 | Submission Open

Keywords: basal cell carcinoma; inducement factors; precision diagnostics; molecular profiling; targeted therapy; hedgehog signaling pathway; biomarkers; non-invasive imaging; personalized medicine; diagnostic histopathology

Cancer Without Borders: International Perspectives on Prevention, Diagnosis and Treatment

edited by Km Monirul Islam

submission deadline 31 Dec 2026 | Viewed by 68 | Submission Open

Keywords: global oncology; cancer prevention; early detection; health disparities; cancer care delivery

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management (2nd Edition)

edited by

Roberto Fabiani

and

Irene Giacchetta

submission deadline 31 Dec 2026 | Viewed by 66 | Submission Open

Keywords: non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); prevention; risk management; mechanisms

Surgical Oncology for Hepato-Pancreato-Biliary Cancer: 2nd Edition

edited by Zaed Z. R. Hamady

submission deadline 31 Dec 2026 | Viewed by 63 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Empowered by Next-Generation AI: Paradigm Transformation in Cancer Radiotherapy

edited by

Jian-Rong Dai

and Kuo Men

submission deadline 31 Dec 2026 | Viewed by 61 | Submission Open

Keywords: radiotherapy; next-generation AI; LLM; RL; auto-segmentation; auto-planning; treatment adaptation; treatment outcome

(This special issue belongs to the Section Cancer Therapy)

Current Advances and Challenges in Skin Cancers

edited by

Syril Keena T. Que

submission deadline 31 Dec 2026 | Viewed by 41 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; squamous cell carcinoma; artificial intelligence; immunotherapy; biomarkers

Cellular Plasticity in Cancer Progression

edited by Deemesh Oudit

submission deadline 31 Dec 2026 | Viewed by 40 | Submission Open

Keywords: cellular plasticity; epithelial-mesenchymal transition (EMT); cancer stem cells (CSCs); phenotypic plasticity; cell state transitions; lineage plasticity; tumour heterogeneity; dedifferentiation; drug-tolerant persistent cells; epigenetic reprogramming; phenotypic switching; transdifferentiation; cancer cell stemness; tumour microenvironment (TME); therapy resistance (adaptive/reversible resistance); single-cell RNA sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Carbon-Ion Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer

edited by

Hitoshi Ishikawa

submission deadline 31 Dec 2026 | Viewed by 30 | Submission Open

Keywords: prostate cancer; carbon-ion radiotherapy; androgen deprivation therapy; biochemical relapse-free survival; overall survival; salvage treatment

(This special issue belongs to the Section Cancer Therapy)

Tailoring Neoadjuvant Strategies for Breast Cancer Subtypes

edited by Dajiang Guo and Julia Y. Tsang

submission deadline 31 Dec 2026 | Viewed by 18 | Submission Open

Keywords: neoadjuvant therapy; breast cancer subtypes; precision medicine; immunotherapy; targeted therapy; endocrine therapy; liquid biopsies; predictive biomarkers; survival outcome; pathological complete response

Contemporary Pathology of Genitourinary Cancers

edited by Gang Wang and

Charles C. Guo

submission deadline 31 Dec 2026 | Submission Open

Keywords: pathology; genitourinary cancers; diagnostic; molecular; biomarkers

(This special issue belongs to the Section Cancer Pathophysiology)

Evolving Landscape in the Management of Liver Malignancies

edited by Ioannis A. Ziogas and

Dimitrios Moris

submission deadline 1 Jan 2027 | Viewed by 273 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; colorectal liver metastasis; liver resection; liver transplantation; transplant oncology; locoregional therapies; immunotherapy; molecular profiling

Nursing and Supportive Care for Cancer Survivors

edited by

Michela Piredda

submission deadline 2 Jan 2027 | 3 articles | Viewed by 5988 | Submission Open

Keywords: cancer survivorship; oncology nursing; symptom management; quality of life; supportive care; psycho-existential distress; pain catastrophizing; palliative care; caregiver support; advanced cancer; patient-centred care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Systematic Reviews and Meta-Analyses on Skin Cancer

edited by

Stan N. Tolkachjov

submission deadline 5 Jan 2027 | Viewed by 200 | Submission Open

Keywords: skin cancer; dermatologic oncology; Mohs micrographic surgery; cutaneous oncology; systematic review

Nutrition in Cancer Care: From Generalized to Personalized Adjunctive Therapy

edited by

Mitsuyoshi Urashima

submission deadline 6 Jan 2027 | 3 articles | Viewed by 1614 | Submission Open

Keywords: anthropometry; body mass index (BMI); body surface area (BSA); personalized medicine; therapeutic drug monitoring (TDM); pharmacokinetics; nutritional status; chemotherapy optimization; vitamin D; adjunctive therapy

The Advances in Proton Therapy in Head-and-Neck Cancers

edited by

Nancy Lee

and Edward Christopher Dee

submission deadline 8 Jan 2027 | Viewed by 513 | Submission Open

Keywords: proton therapy; head-and-neck cancer; clinical outcomes; toxicity reduction; multinational studies; reirradiation; skull base tumors; salivary gland cancers; prospective and retrospective cohorts

(This special issue belongs to the Section Cancer Therapy)

Tumor Microenvironment in Ovarian Cancer Progression, Dissemination, Recurrence: Biology and Therapeutic Opportunities

edited by

Ralf-Peter Czekay

Paul J. Higgins

and

Dong-Joo Cheon

submission deadline 10 Jan 2027 | Viewed by 376 | Submission Open

Keywords: transperitoneal carcinomatosis; malignant ascites; chemoresistance; metabolic adaptations; regulation of immune response; tumor– stroma interaction; tumor– peritoneal interaction

(This special issue belongs to the Section Tumor Microenvironment)

Contemporary Advances in Esophageal and Upper Gastrointestinal Cancer Management

edited by

Giovanni Maria Garbarino

and Carlo Castoro

submission deadline 10 Jan 2027 | Viewed by 37 | Submission Open

Keywords: esophageal surgery; gastric surgery; upper gastrointestinal cancer; minimally invasive surgery; robotic surgery; artificial intelligence; radiomics; neoadjuvant therapy; surgical quality assessment; fluorescence-guided surgery

(This special issue belongs to the Section Methods and Technologies Development)

Perioperative Management and Anesthetic Strategies for Improving Cancer Prognosis

edited by

Juan P. Cata

Lucillia Bezu

and

Nicolas Villablanca Uribe

submission deadline 13 Jan 2027 | Viewed by 432 | Submission Open

Keywords: perioperative care; anesthesia; cancer; oncological outcomes

Nanocarriers as an Emerging Platform for Cancer Therapy

edited by

Andrea Markus

and Fernanda Ramos-Gomes

submission deadline 15 Jan 2027 | 1 articles | Viewed by 1325 | Submission Open

Keywords: nanoparticles; cancer therapy; nanomedicine; theranostics; chemotherapy; nanocarriers; drug delivery; nanotechnology

(This special issue belongs to the Section Cancer Therapy)

New Insights into Thymic Tumors

edited by Till Ploenes

submission deadline 15 Jan 2027 | 1 articles | Viewed by 928 | Submission Open

Keywords: thymic tumors; thymic carcinoma; thymomas; new daignostic and therapeutic approaches; myasthenia gravis

Advancing CAR-T Cell Therapy: The Next Evolution in Breast Cancer Treatment

edited by

Nethaji Muniraj

and

Arun Dharmarajan

submission deadline 15 Jan 2027 | Viewed by 414 | Submission Open

Keywords: CAR-T cell therapy; breast cancer; triple-negative breast cancer (TNBC); HER2-positive breast cancer; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Three-Dimensional In Vitro Modeling for the Study of Epithelial Cancers

edited by

Sherif M. Karam

and George Wai Cheong Yip

submission deadline 15 Jan 2027 | Viewed by 378 | Submission Open

Keywords: 3D cancer model; 3D cancer stem cell culture; 3D tumor invasion model; cancer-on-a-chip; cancer spheroids; carcinogenesis organoid model; bioprinted cancer tissue; microfluidic platform for cancer; scaffold-based cancer model

(This special issue belongs to the Section Methods and Technologies Development)

Mass Spectrometry and Cancers

edited by

Rita Casadonte

and

Kristina Schwamborn

submission deadline 15 Jan 2027 | Viewed by 348 | Submission Open

Keywords: cancer; biomolecular; mass spectrometry

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

AI and Machine Learning in Cancer Multi-Omics: Identification of Biomarkers, Disease-Related Processes and Drug Targets

edited by Graham Ball

submission deadline 15 Jan 2027 | Viewed by 331 | Submission Open

Keywords: artificial intelligence; machine learning; multi-omics integration; biomarker discovery; precision oncology; drug target identification; computational cancer biology

(This special issue belongs to the Section Methods and Technologies Development)

Pancreatic Cancer: Genomics, Therapy and Survival

edited by Hisanobu Ogata

submission deadline 15 Jan 2027 | Viewed by 280 | Submission Open

Keywords: pancreas; cancer; treatment; oncolytic virus; stromal cell; cancer-associated fibroblast (CAF)

(This special issue belongs to the Section Cancer Therapy)

Flow Cytometry in Acute Leukemia: From Diagnosis to Disease Monitoring

edited by

Donatella Raspadori

and

Paola Pacelli

submission deadline 15 Jan 2027 | Viewed by 229 | Submission Open

Keywords: acute leukemia; ALL; AML; flow cytometry; NGF; leukemia stem cells (LSCs; minimal residual disease (MRD)

(This special issue belongs to the Section Methods and Technologies Development)

Improving the Quality of Life in Patients with Gynecological Cancer

edited by Vasilios Pergialiotis

submission deadline 20 Jan 2027 | 2 articles | Viewed by 11666 | Submission Open

Keywords: gynecologic oncology; minimal invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition; cervical cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 30 Jan 2027 | 2 articles | Viewed by 5278 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

Genetic Determinism and Singularity: Fundamentals of Genomic, Predictive and Personalized Medicine of Thyroid Cancer

edited by Ginesa Maria Garcia-Rostan

submission deadline 30 Jan 2027 | Viewed by 126 | Submission Open

Keywords: screening; molecular pathogenesis; metastases; progression; dedifferentiation; prognostic biomarkers; targeted therapies; molecular heterogeneity and therapy resistance; follicular-cell-derived thyroid carcinomas; C-cell-derived thyroid carcinomas

Novel Treatments for Ocular and Periocular Cancers

edited by

Vidhya R. Rao

submission deadline 31 Jan 2027 | 4 articles | Viewed by 8045 | Submission Open

Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma

(This special issue belongs to the Section Cancer Therapy)

Innovations in Microsurgical Techniques for Breast Cancer Reconstruction

edited by

Babak J. Mehrara

and Robert J. Allen

submission deadline 31 Jan 2027 | 4 articles | Viewed by 6976 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair

(This special issue belongs to the Section Methods and Technologies Development)

CT/MRI/PET in Cancer

edited by

Dávid Sipos

Ritter Zsombor

and

Elif Hindié

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5524 | Submission Open

Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration

(This special issue belongs to the Section Methods and Technologies Development)

The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine

edited by Aftab Alam

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5484 | Submission Open

Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Plasma and Cancer Treatment

edited by

Michael Keidar

and

Vikas Soni

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3811 | Submission Open

Keywords: cold atmospheric plasma (CAP); cancer treatment; plasma medicine; reactive oxygen species (ROS); apoptosis; tumor; non-thermal plasma; plasma oncology; cancer and molecular biology; clinical translation; in vivo/preclinical

(This special issue belongs to the Section Cancer Therapy)

Biologic Advancements in Childhood and Adolescent Cancers: From Disease Mechanisms to Precision Therapies

edited by

Emmanouel Hatzipantelis

and Eleni Tsotridou

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2473 | Submission Open

Keywords: pediatric oncology; precision therapies; molecular vulnerabilities; biomarker-driven trials; disease mechanisms

(This special issue belongs to the Section Pediatric Oncology)

Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers

edited by

Andrea Belli

, Matteo Serenari and

Benedetto Ielpo

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2276 | Submission Open

Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy

(This special issue belongs to the Section Cancer Therapy)

New Perspectives in Skin Cancer: From Biology to Therapy

edited by Marija Buljan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1240 | Submission Open

Keywords: skin cancer; melanoma and non-melanoma skin cancer; tumor biology; early diagnosis; targeted therapy; immunotherapy; epidemiology

Lung Cancer: Diagnosis and Targeted Therapy

edited by Myung-Ju Ahn and

Kyung Jong Lee

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1211 | Submission Open

Keywords: lung cancer; modern diagnostics; screening; imaging; pathologic and molecular profiling; biomarkers; targeted therapies; next-generation TKIs; antibody– drug conjugates (ADCs); drug resistance

Means of Improving Gastric Cancer Response to Chemotherapy and Immunotherapy

edited by

Beate Rau

and

Kazuo Kobayashi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1161 | Submission Open

Keywords: gastric cancer; chemotherapy response; immunotherapy; treatment adherence; adverse event management; oncology pharmacy; pharmacist intervention; oral anticancer agents; medication safety

Advances in the Use of PET/CT and MRI in Prostate Cancer: 2nd Edition

edited by Carmelo Caldarella

submission deadline 31 Jan 2027 | 2 articles | Viewed by 934 | Submission Open

Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals

(This special issue belongs to the Section Methods and Technologies Development)

Thyroid Cancer: Diagnosis, Prognosis and Treatment—3rd Edition

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 31 Jan 2027 | 1 articles | Viewed by 773 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

Advances in Peripheral Nerve Tumors

edited by

Cordula Matthies

submission deadline 31 Jan 2027 | 1 articles | Viewed by 762 | Submission Open

Keywords: electrophysiology; malignant peripheral nerve sheath tumors; nerve sheath collision tumors; neurofibromas; neurofibromatosis type 1; NF2-associated schwannomatosis; non-NF2-associated schwannomatosis; schwannomas; untypical neurofibromas of uncertain biological potential

Machine Learning and Artificial Intelligence in Leukemia

edited by Garrett M. Dancik and

Spiros Vlahopoulos

submission deadline 31 Jan 2027 | 1 articles | Viewed by 622 | Submission Open

Keywords: cancer genomics; genomic sequencing; biomarkers; predictive modeling; machine learning; artificial intelligence; leukemia; computer vision; natural language processing

(This special issue belongs to the Section Methods and Technologies Development)

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