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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiotherapy and the Tumor Microenvironment: From Basic Mechanisms to Clinical Translation
edited by Eleanor J. Cheadle and
submission deadline 31 Oct 2026 | Viewed by 111 | Submission Open
Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma; immunogenic cell death
The Role of Lifestyle Choices in Cancer Risk
edited by Itunu O. Sokale, Aaron P. Thrift and
submission deadline 31 Oct 2026 | Viewed by 111 | Submission Open
Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention
The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 106 | Submission Open
Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies
(This special issue belongs to the Section Tumor Microenvironment)
Metabolism and Precision Oncology
edited by Rays H.Y. Jiang and Gloria C. Ferreira
submission deadline 31 Oct 2026 | Viewed by 106 | Submission Open
Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting
(This special issue belongs to the Section Cancer Pathophysiology)
Molecular Imaging in Oncology: Recent Advances (2nd Edition) submission deadline 31 Oct 2026 | Viewed by 104 | Submission Open
Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry
(This special issue belongs to the Section Cancer Therapy)
AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive and Adaptive Cancer Treatment
edited by Zhen Tian and Chaoqiong Ma
submission deadline 31 Oct 2026 | Viewed by 101 | Submission Open
Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Opportunities and Challenges for Effective Cancer Immunotherapies
edited by
submission deadline 31 Oct 2026 | Viewed by 100 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; cellular therapy; tumor microenvironment; therapeutic resistance
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Circulating Tumor Cells (CTCs) for Cancer Diagnosis and Prognosis
edited by
submission deadline 31 Oct 2026 | Viewed by 97 | Submission Open
Keywords: CTCs; liquid biopsy; metastasis; biomarkers
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma (2nd Edition) submission deadline 31 Oct 2026 | Viewed by 84 | Submission Open
Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation
(This special issue belongs to the Section Cancer Therapy)
Innovations in Surgical and Management Strategies for Complex and Advanced Gastric Cancer submission deadline 31 Oct 2026 | Viewed by 84 | Submission Open
Keywords: advanced gastric cancer; surgical innovation; multimodal therapy; minimally invasive gastrectomy (robotic/laparoscopic); perioperative management; immunotherapy; precision medicine; peritoneal metastasis
(This special issue belongs to the Section Clinical Research of Cancer)
Oxidative Stress in Cancer: From Mechanisms to Therapeutic Strategies submission deadline 31 Oct 2026 | Viewed by 83 | Submission Open
Keywords: redox signaling; tumor microenvironment; senolytics; immunometabolism; gut microbiome; preventive oncology; drug delivery
(This special issue belongs to the Section Cancer Therapy)
Local, Systemic and Combined Therapy for Hepatocellular Carcinoma
edited by Xiaoqun Dong
submission deadline 31 Oct 2026 | Viewed by 82 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research
(This special issue belongs to the Section Cancer Therapy)
Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition submission deadline 31 Oct 2026 | Viewed by 81 | Submission Open
Keywords: acromegaly; adrenocorticotropic hormone; Cushing’ s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment
Advances in Imaging Techniques of Molecular Oncology (2nd Edition)
edited by
submission deadline 31 Oct 2026 | Viewed by 80 | Submission Open
Keywords: cancer; oncological imaging; molecular imaging; SPECT/TC; PET/CT; PET/MRI; DWI; DCE-MRI; nanotheranostics; artificial intelligence; radiomics; theranostics
(This special issue belongs to the Section Methods and Technologies Development)
Non-Pharmacological Interventions in Oncology Supportive and Palliative Care
edited by
submission deadline 31 Oct 2026 | Viewed by 69 | Submission Open
Keywords: integrative palliative care; integrative therapies; non-pharmacological therapies; symptom management; palliative care; supportive care; massage; acupuncture; tai chi; virtual reality
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Skin and Hair Side Effects of Cancer Treatment
edited by Ian W. Tattersall
submission deadline 31 Oct 2026 | Viewed by 62 | Submission Open
Keywords: oncodermatology; toxicity management; supportive oncology
(This special issue belongs to the Section Cancer Therapy)
The Next Generation of Prognosis: Novel Biomarkers in AML and MDS
edited by , Andrija Bogdanovic and Ljubomir Jakovic
submission deadline 31 Oct 2026 | Viewed by 48 | Submission Open
Keywords: acute myeloid leukemia; myelodysplastic syndrome; biomarkers; minimal residual disease; novel prognostic factors; immune-related biomarkers; molecular targets; genomics; risk stratification
(This special issue belongs to the Section Clinical Research of Cancer)
Genetic Disorders and Cancer Susceptibility: Molecular Mechanisms, Risk Assessment, and Targeted Therapies
edited by Silmara de Lima
submission deadline 31 Oct 2026 | Viewed by 43 | Submission Open
Keywords: neurofibromatosis type-1; optic pathway glioma; retinal ganglion cell survival; myelination; vision loss; targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Targeted and Translational Therapies in Genitourinary Cancers: Addressing Unmet Clinical Needs Through Organ-Specific Innovation submission deadline 31 Oct 2026 | Viewed by 33 | Submission Open
Keywords: genitourinary cancer; therapeutic resistance; precision oncology; biomarker-guided therapy; antibody-drug conjugates; prostate cancer; renal cell carcinoma; bladder cancer; testicular cancer; novel modalities; organ-specific strategies
(This special issue belongs to the Section Cancer Therapy)
Current Treatment Options for Rectal Cancer
edited by Jesús Pedro Paredes Cotoré
submission deadline 31 Oct 2026 | Viewed by 7 | Submission Open
Keywords: rectal cancer; therapeutic approach; rectal surgery; neoadjuvant treatment; radiotherapy; immunotherapy; chemotherapy; quality of life
(This special issue belongs to the Section Cancer Therapy)
Novel Insights into Glioma Immunotherapy
edited by Tomasz Tykocki
submission deadline 5 Nov 2026 | Viewed by 71 | Submission Open
Keywords: glioma immunotherapy; tumor microenvironment; immune evasion; microglia; checkpoint inhibitors; CAR‑T; neoantigen vaccines
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Evaluating the Clinical Impact of Robotic Surgery in the Management of Colorectal Cancer
edited by and Miguel Leon-Arellano
submission deadline 15 Nov 2026 | Viewed by 160 | Submission Open
Keywords: robotic surgery; colorectal cancer; oncological outcomes; surgical technique; laparoscopic comparison; margin status; postoperative recovery; quality of life; intraoperative imaging; surgical navigation; learning curve; complications; cost-effectiveness; surgical training; technological innovation
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors
edited by Ciprian Brisc and Nadim Al Hajjar
submission deadline 15 Nov 2026 | Viewed by 59 | Submission Open
Keywords: gastrointestinal; hepatic and pancreatic tumors; metabolomics; endoscopy; ultrasound; elastography; molecular investigations and treatment; robotic surgery; laparoscopic surgery; early lesions; radiofrequency and microwave ablation; irreversible electroporation; cryoablation; targeted chemo- or radio-embolization
(This special issue belongs to the Section Cancer Therapy)
The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors: 2nd Edition submission deadline 20 Nov 2026 | Viewed by 68 | Submission Open
Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy
Cancer Cells Fostered Microenvironment in Metastasis (2nd Edition)
edited by
submission deadline 25 Nov 2026 | Viewed by 70 | Submission Open
Keywords: cancer cells; tumour microenvironment; metastasis; fibroblast; immune cells; extracellular ma-trix; adhesion; migration; invasion; drug resistance; target therapy
(This special issue belongs to the Section Cancer Metastasis)
Treatment and Prognosis of Pediatric Medulloblastoma
edited by Marwa Ismail
submission deadline 25 Nov 2026 | Viewed by 65 | Submission Open
Keywords: pediatric medulloblastoma; proteomics; radiogenomics
(This special issue belongs to the Section Pediatric Oncology)
Infectious Pathogens and Cancer
edited by
submission deadline 25 Nov 2026 | Viewed by 60 | Submission Open
Keywords: infectious cancer pathogens; related topics in immunology; virology; epidemiology; (therapeutic) vaccines; oncogenesis; screening; therapy
(This special issue belongs to the Section Infectious Agents and Cancer)
Radiologic Staging and Surgical Decision-Making in the Era of Neoadjuvant Therapy for Breast Cancer
edited by
submission deadline 25 Nov 2026 | Viewed by 58 | Submission Open
Keywords: radiologic staging; neoadjuvant therapy; breast cancer; breast-conserving surgery; mastectomy; targeted axillary dissection; sentinel lymph node biopsy; axillary lymph node dissection; magnetic resonance imaging; surgical de-escalation
(This special issue belongs to the Section Cancer Therapy)
New Findings in Targeting Cancer Proteins (Second Edition) submission deadline 30 Nov 2026 | 1 articles | Viewed by 3377 | Submission Open
Keywords: monoclonal antibodies; protein target; immunotherapy; signaling blockade; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence and Machine Learning in Lung Cancer submission deadline 30 Nov 2026 | 1 articles | Viewed by 1507 | Submission Open
Keywords: artificial intelligence; machine learning; lung cancer screening; low-dose CT; early detection
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
In Vitro and In Vivo Pharmacology for Glioma Drug Discovery submission deadline 30 Nov 2026 | 1 articles | Viewed by 635 | Submission Open
Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence
(This special issue belongs to the Section Cancer Drug Development)
Advances in Nanoparticle and Exosome Technology for Delivery of Payloads in CNS Tumors
edited by
submission deadline 30 Nov 2026 | Viewed by 172 | Submission Open
Keywords: glioblastoma; brain metastasis; nanoparticles; exosomes; viral therapy; delivery of payload; imaging probes
(This special issue belongs to the Section Cancer Drug Development)
New Approaches to Surgical Treatment and Care for Urological Cancer
edited by and Bente Thoft Jensen
submission deadline 30 Nov 2026 | Viewed by 154 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; penile cancer; patient perspective; patient education; enhanced recovery after surgery (ERAS) protocols; prehabilitation rehabilitation; sexual health
(This special issue belongs to the Section Clinical Research of Cancer)
New Clinical Insights into Gastrointestinal Cancers
edited by Dai Shida
submission deadline 30 Nov 2026 | Viewed by 139 | Submission Open
(This special issue belongs to the Section Clinical Research of Cancer)
After Cancer Remission: Tracking Minimal Residual Disease and Relapse submission deadline 30 Nov 2026 | Viewed by 103 | Submission Open
Keywords: minimal residual disease (MRD); cancer relapse; liquid biopsy; circulating tumor DNA (ctDNA); biomarkers; molecular monitoring; post-remission surveillance; translational oncology; multi-omics; personalized cancer care; precision medicine
Intraoperative Radiotherapy in Cancer Treatment
edited by
submission deadline 30 Nov 2026 | Viewed by 101 | Submission Open
Keywords: intraoperative radiation therapy; image-guided IORT; IOERT; kV-IORT; HDR-IORT; FLASH
(This special issue belongs to the Section Cancer Therapy)
Acute Myeloid Leukemia: Novel Therapeutic Agents and Clinical Trials
edited by Wieslaw W. Jedrzejczak
submission deadline 30 Nov 2026 | Viewed by 100 | Submission Open
Keywords: acute leukemia; targeted therapy; antibody– drug conjugates
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in the Management of Pelvic Tumors: 2nd Edition
edited by Giorgia Gaia and
submission deadline 30 Nov 2026 | Viewed by 79 | Submission Open
Keywords: pelvic cancer; prostate cancer; bladder cancer; uterine cancer; ovarian cancer; rectal cancer; anal cancer
(This special issue belongs to the Section Cancer Therapy)
Advances in Adoptive Cell Therapy for Cancer
edited by Andrew Furness
submission deadline 30 Nov 2026 | Viewed by 47 | Submission Open
Keywords: CAR-T cells; adoptive cell therapy; tumor microenvironment; immunotherapy; translational oncology
Update in Pathology of Gynaecologic Cancer
edited by
submission deadline 30 Nov 2026 | Viewed by 45 | Submission Open
Keywords: gynaecological; cancer; pathology; diagnosis
(This special issue belongs to the Section Cancer Pathophysiology)
HMGA Oncoproteins in Cancer
edited by and Sabrina Battista
submission deadline 30 Nov 2026 | Viewed by 42 | Submission Open
Keywords: HMGA1; HMGA2; chromatin architecture; oncogenic signaling; tumor progression; biomarkers; therapeutic targeting
(This special issue belongs to the Section Molecular Cancer Biology)
Innovations and Current Evidence in Radiotherapy for Urological Cancers
edited by
submission deadline 30 Nov 2026 | Viewed by 29 | Submission Open
Keywords: radiotherapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; testicular cancer; penile cancer; palliative; metastases; salvage
(This special issue belongs to the Section Cancer Therapy)
New Advances of Brain Metastasis in Oncology submission deadline 5 Dec 2026 | Viewed by 46 | Submission Open
Keywords: brain mets; BBB; brain microenvironment; molecular mechanism; immune; cytokines; drugs
(This special issue belongs to the Section Cancer Metastasis)
Advances in Hormone-Based Breast Cancer Treatment submission deadline 5 Dec 2026 | Viewed by 40 | Submission Open
Keywords: DNA damage; checkpoint inhibitor; retinoid; PARP1; estrogen/estrogen receptors; androgen/androgen receptors; glucocorticoid/glucocorticoid receptors; tumor classification
(This special issue belongs to the Section Cancer Therapy)
HCC Associated with Viral Liver Infections (HBV, HCV, and HDV) and Other Rare Conditions
edited by
submission deadline 11 Dec 2026 | Viewed by 9 | Submission Open
Keywords: hepatocellular carcinoma; viral infections; hepatocarcinogenesis; chronic liver damage; epidemiology; etiopathogenesis; diagnostic approaches; therapeutic strategies
(This special issue belongs to the Section Infectious Agents and Cancer)
Clinical Treatment and Prognostic Factors of Urologic Cancer
edited by
submission deadline 15 Dec 2026 | 13 articles | Viewed by 40900 | Submission Open
Keywords: prostate cancer; bladder cancer; urothelial carcinoma; upper urinary tract tumors; kidney cancer; renal cell carcinoma; testicular tumors; molecular markers; diagnosis; systemic treatment
(This special issue belongs to the Section Cancer Therapy)
The Evolving Landscape of Squamous Cell Carcinoma of the Anal Canal: State of the Art, Current Challenges and Future Perspectives
edited by and Francesco Vasuri
submission deadline 15 Dec 2026 | Viewed by 102 | Submission Open
Keywords: squamous cell anal carcinoma; anal cancer; HIV; HPV
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Treatment-Induced Metabolic and Inflammatory Responses in Cancer
edited by
submission deadline 15 Dec 2026 | Viewed by 40 | Submission Open
Keywords: radiation therapy; chemotherapy; immunotherapy; normal tissue toxicity; metabolic reprogramming; chronic inflammation; lipid dysregulation; treatment resistance; inflammatory signaling
Studies on Molecular Mechanism in the Tumor Microenvironment submission deadline 15 Dec 2026 | Viewed by 10 | Submission Open
Keywords: molecular mechanisms; tumor microenvironment; non-coding RNAs
(This special issue belongs to the Section Tumor Microenvironment)
Cancer Genetics and Epigenetics: Their Roles and Clinical Implications (2nd Edition)
edited by and
submission deadline 20 Dec 2026 | 1 articles | Viewed by 644 | Submission Open
Keywords: cancer genetics; cancer epigenetics; carcinogenesis; cancer prognosis; cancer therapeutics; genetic mutations; DNA methylation; histone modifications; RNA methylation
(This special issue belongs to the Section Molecular Cancer Biology)
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