Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Molecular Insights to Cancer Treatments: Progress in Translational Science
edited by , Dhanir Tailor and
submission deadline 30 Apr 2026 | Viewed by 66 | Submission Open
Keywords: cancer biology; therapeutics; molecular targets; translational research
(This special issue belongs to the Section Cancer Therapy)
The Changing Paradigms in the Management of Thyroid Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open
Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open
Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance
(This special issue belongs to the Section Methods and Technologies Development)
Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)
edited by Shi-Ming Tu, Louis L. Pisters and
submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open
Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness
(This special issue belongs to the Section Cancer Pathophysiology)
New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers
edited by Patriciu Achimas-Cadariu and
submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open
Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers
Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open
Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology
(This special issue belongs to the Section Cancer Metastasis)
Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open
Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft
(This special issue belongs to the Section Cancer Therapy)
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies
edited by Giuseppe Marulli
submission deadline 30 Apr 2026 | Viewed by 16 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery
(This special issue belongs to the Section Cancer Therapy)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 30 Apr 2026 | Viewed by 16 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
CT/MRI/PET in Cancer submission deadline 30 Apr 2026 | Viewed by 13 | Submission Open
Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration
(This special issue belongs to the Section Methods and Technologies Development)
PARP Inhibitors in Cancers: 2nd Edition submission deadline 30 Apr 2026 | Viewed by 7 | Submission Open
Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 6 | Submission Open
Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA
(This special issue belongs to the Section Infectious Agents and Cancer)
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 May 2026 | 3 articles | Viewed by 4603 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)
edited by Kouji Izumi
submission deadline 1 May 2026 | Viewed by 2 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent
(This special issue belongs to the Section Cancer Therapy)
Rehabilitation Opportunities in Cancer Survivorship
edited by and Alejandro Heredia-Ciuro
submission deadline 8 May 2026 | 1 articles | Viewed by 1616 | Submission Open
Keywords: cancer; rehabilitation; sequelae; disability; impairment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Hepatocellular Carcinoma Progression and Metastasis
edited by
submission deadline 10 May 2026 | Submission Open
Keywords: hepatocellular carcinoma; tumor progression; metastasis; liver cancer; angiogenesis; epithelial– mesenchymal transition; tumor microenvironment; molecular pathways; biomarkers; targeted therapy; systemic therapy
(This special issue belongs to the Section Cancer Metastasis)
Endoscopic Advances in Gastrointestinal Oncology
edited by Eduardo Rodrigues-Pinto
submission deadline 15 May 2026 | 1 articles | Viewed by 1814 | Submission Open
Keywords: endoscopic oncology; endoscopic screening; endoscopic resection; endoscopic palliation; staging
(This special issue belongs to the Section Cancer Therapy)
Gene Editing and Delivery for Cancer Therapy (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 43 | Submission Open
Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science
(This special issue belongs to the Section Cancer Therapy)
Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)
edited by and
submission deadline 15 May 2026 | Viewed by 40 | Submission Open
Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET
(This special issue belongs to the Section Molecular Cancer Biology)
Mass Spectrometry and Cancers submission deadline 15 May 2026 | Viewed by 1 | Submission Open
Keywords: cancer; biomolecular; mass spectrometry
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Surgical Management of Colorectal Cancer
edited by Gyung-mo Son
submission deadline 20 May 2026 | 8 articles | Viewed by 14795 | Submission Open
Keywords: colorectal cancer; surgical management; minimally invasive surgery; laparoscopic surgery; robotic surgery; single port surgery; emergency surgery; image-guided surgery; enhanced recovery after surgery (ERAS); systemic metastasis in colorectal cancer (involving the liver; lung; peritoneum; etc.)
(This special issue belongs to the Section Cancer Therapy)
Viral Oncogenes and Their Role in Cancer Pathogenesis
edited by and Yosef Sabo
submission deadline 21 May 2026 | 2 articles | Viewed by 3722 | Submission Open
Keywords: viral oncogenes; cancer pathogenesis; cellular regulation; tumorigenesis mechanisms; antiviral and anticancer strategies
(This special issue belongs to the Section Infectious Agents and Cancer)
Inhibitors in Thyroid Carcinoma (2nd Edition) submission deadline 24 May 2026 | Viewed by 53 | Submission Open
Keywords: thyroid carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; sorafenib; lenvatinib
(This special issue belongs to the Section Tumor Microenvironment)
Genetics of Ovarian Cancer (2nd Edition) submission deadline 30 May 2026 | Viewed by 34 | Submission Open
Keywords: epithelial ovarian cancer; genomics; epigenetics; translational research; biomarkers; DNA damage response; PARP inhibitors
(This special issue belongs to the Section Cancer Pathophysiology)
Updates on Depression Among Cancer Patients (2nd Edition)
edited by Wen-Yu Hu, and
submission deadline 30 May 2026 | Viewed by 16 | Submission Open
Keywords: depression; psychotherapy; oncology nursing
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Prostate Cancer and Inflammation
edited by Takuji Hayashi
submission deadline 31 May 2026 | 1 articles | Viewed by 1275 | Submission Open
Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Role of Circulating Tumor Cells in Colorectal Cancer
edited by
submission deadline 31 May 2026 | Viewed by 188 | Submission Open
Keywords: circulating tumor cells (CTC); colorectal cancer (CRC); liquid biopsy; biomarkers; tumor progression; personalized medicine; molecular profiling; metastasis; diagnostic techniques; prognostic evaluation
(This special issue belongs to the Section Cancer Biomarkers)
Gut Microbiome, Diet and Cancer Risk
edited by
submission deadline 31 May 2026 | Viewed by 48 | Submission Open
Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Mutagenesis and DNA Methylation in Aging
edited by Steven S. Smith
submission deadline 31 May 2026 | Viewed by 38 | Submission Open
Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns
(This special issue belongs to the Section Molecular Cancer Biology)
The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine
edited by Aftab Alam
submission deadline 31 May 2026 | Viewed by 37 | Submission Open
Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Clinical and Translational Research of Urological Cancer submission deadline 31 May 2026 | Viewed by 34 | Submission Open
Keywords: urological cancer; bladder cancer; surgery; conservative treatment; immunotherapy; radical cystectomy; artifical intelligence
(This special issue belongs to the Section Clinical Research of Cancer)
Developments in the Management of Gastrointestinal Malignancies (2nd Edition)
edited by Zachary J. Brown
submission deadline 31 May 2026 | Viewed by 12 | Submission Open
Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic
(This special issue belongs to the Section Cancer Therapy)
Emerging Nanotechnology and Advanced Materials for Cancer Therapy
edited by
submission deadline 31 May 2026 | Viewed by 8 | Submission Open
Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology
(This special issue belongs to the Section Methods and Technologies Development)
Infectious Agents and Oesophageal Cancer (2nd Edition)
edited by and Mohammed Rabiei
submission deadline 31 May 2026 | Viewed by 6 | Submission Open
Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma
(This special issue belongs to the Section Infectious Agents and Cancer)
Targeted Therapy in Gastrointestinal Cancer (2nd Edition)
edited by and
submission deadline 31 May 2026 | Viewed by 4 | Submission Open
Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development
(This special issue belongs to the Section Cancer Therapy)
Role of Cytokines in Cancer (2nd Edition) submission deadline 31 May 2026 | Viewed by 3 | Submission Open
Keywords: inflammation; tumor microenvironment; cytokines
(This special issue belongs to the Section Tumor Microenvironment)
Proton Therapy of Cancer Treatment
edited by Minglei Kang, Benjamin Durkee and Kuo Men
submission deadline 1 Jun 2026 | Viewed by 144 | Submission Open
Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning
(This special issue belongs to the Section Cancer Therapy)
Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition) submission deadline 1 Jun 2026 | Viewed by 9 | Submission Open
Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Current Updates and Future Directions in Neuroendocrine Neoplasms (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs (2nd Edition)
edited by and Aman Chauhan
submission deadline 15 Jun 2026 | Viewed by 136 | Submission Open
Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic management
(This special issue belongs to the Section Cancer Therapy)
Current Progress in Radiotherapy and Particle Therapy of Cancer
edited by
submission deadline 16 Jun 2026 | Viewed by 14 | Submission Open
Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy
(This special issue belongs to the Section Cancer Therapy)
p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition) submission deadline 20 Jun 2026 | Viewed by 51 | Submission Open
Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Epidemiology of Childhood Cancer
edited by Rafael Peris-Bonet, and Adela Cañete
submission deadline 30 Jun 2026 | Viewed by 119 | Submission Open
Keywords: childhood cancer epidemiology; childhood cancer registries; environmental causes of childhood cancer; genetic epidemiology; molecular epidemiology; survival of children with cancer; quality of life; social determinants and inequalities; information technologies and statistical innovations
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Arginine and Cancers: Molecular Mechanisms and Anticancer Therapy submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open
Keywords: arginine; cancer; therapy; immunotherapy; metabolism
(This special issue belongs to the Section Cancer Drug Development)
Hepatocellular Carcinoma: Clinical Evidence and Emerging Therapeutic Benefits
edited by
submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open
Keywords: artificial intelligence; downstaging; immunotherapy; multidisciplinary approaches; risk factors; nutrition
(This special issue belongs to the Section Cancer Therapy)
Clinical Therapy and Surgical Treatment for Head and Neck Cancer
edited by Boban M. Erovic
submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open
Keywords: 3D planning; head and neck cancer; sarcomas; microvascular reconstruction; osteonecrosis
(This special issue belongs to the Section Cancer Therapy)
Nanocarriers in Cancer Therapy
edited by
submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open
Keywords: nanoparticles; cancer therapy; anticancer drug delivery
(This special issue belongs to the Section Methods and Technologies Development)
Chemotherapy for Metastatic Head and Neck Squamous Cell Carcinomas
edited by Ken Saijo
submission deadline 15 Jul 2026 | Viewed by 4 | Submission Open
Keywords: head and neck squamous cell carcinomas; HNSCC; immune checkpoint inhibitor; biomarker; chemotherapy
(This special issue belongs to the Section Cancer Metastasis)
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