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New Perspectives in Skin Cancer: From Biology to Therapy

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 15 June 2026 | Viewed by 1093

Special Issue Editor


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Guest Editor
Department of Dermatology and Venereology, University Hospital Centre Sestre Milosrdnice, 10000 Zagreb, Croatia
Interests: dermato-oncology; dermoscopy; melanoma; skin cancer

Special Issue Information

Dear Colleagues,

Skin cancer represents the most frequently diagnosed malignancy worldwide, with both melanoma and non-melanoma skin cancers showing a striking and continuous increase in incidence and prevalence over recent decades. This rapid rise constitutes a growing global health burden, driven by demographic changes, ultraviolet exposure, and improved awareness and detection. In parallel, the past few years have witnessed substantial progress in our understanding of skin tumor biology, as well as major advances in early diagnostic strategies and therapeutic approaches. Notably, the introduction of targeted therapies and immunotherapies has significantly improved clinical outcomes for selected patient groups.

This Special Issue of Cancers aims to cover the full spectrum of skin cancer research, from molecular and cellular mechanisms of carcinogenesis to innovations in early diagnosis, prognostic assessment, and state-of-the-art therapeutic strategies. We welcome original research and reviews that contribute to this rapidly evolving field.

Dr. Marija Buljan
Guest Editor

Nika Filipović
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin cancer
  • melanoma and non-melanoma skin cancer
  • tumor biology
  • early diagnosis
  • targeted therapy
  • immunotherapy
  • epidemiology

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Published Papers (1 paper)

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Research

14 pages, 1613 KB  
Article
A Treatment Decision Model for Cutaneous Squamous Cell Carcinoma Based on Bayesian Networks
by Eenas Ghura, Jan Gaebel, Thomas Neumuth, Andreas Dietz, Gunnar Wichmann and Matthaeus Stoehr
Cancers 2026, 18(4), 704; https://doi.org/10.3390/cancers18040704 - 21 Feb 2026
Viewed by 767
Abstract
Background: One of the most prevalent non-melanoma skin cancers (NMSCs) is cutaneous squamous cell carcinoma (cSCC), which is typically treated surgically. For patients with advanced or inoperable disease, systemic therapies—particularly immune checkpoint inhibitors—have become increasingly important. The anti-PD-1 monoclonal antibody Cemiplimab was approved [...] Read more.
Background: One of the most prevalent non-melanoma skin cancers (NMSCs) is cutaneous squamous cell carcinoma (cSCC), which is typically treated surgically. For patients with advanced or inoperable disease, systemic therapies—particularly immune checkpoint inhibitors—have become increasingly important. The anti-PD-1 monoclonal antibody Cemiplimab was approved for the treatment of advanced cSCC, providing patients who are unable to receive conventional therapy with additional options. Methods: In this study, we developed a clinical decision support tool based on Bayesian networks (BNs) to help clinicians choose the most suitable treatment strategies for cSCC. The model can manage missing or uncertain data and includes patient-specific clinical, histological, and genetic information, such as tumor type, stage, and PD-L1 expression. Results: Using data from 66 patients with either basal cell carcinoma (BCC) or cSCC, we retrospectively validated the model by comparing the treatment recommendations from the tool with the actual choices made by multidisciplinary tumor boards. The model demonstrated an overall accuracy of 95.5% and statistical significance with a p-value of <0.001. Conclusions: Our results suggest that BNs are a valuable tool for representing complex clinical decision-making processes. Full article
(This article belongs to the Special Issue New Perspectives in Skin Cancer: From Biology to Therapy)
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