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Cancers
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Improving the Quality of Life in Patients with Gynecological Cancer
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Improving the Quality of Life in Patients with Gynecological Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 9654

Special Issue Editor

Dr. Vasilios Pergialiotis

E-Mail Website
Guest Editor
First Department of Obstetrics and Gynaecology, Alexandra Hospital, National and Kapodistrian University of Athens, 2 Lour Str., 11522 Athens, Greece
Interests: gynecologic oncology; minimally invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition

Special Issue Information

Dear Colleagues,

Gynecological cancer management has progressed significantly in recent decades, but optimizing perioperative outcomes and improving patients' quality of life still constitutes a clinical challenge. This Special Issue, titled "Improving the Quality of Life in Patients with Gynecological Cancer", welcomes the submission of articles related to new approaches and evidence-based medicine that contribute to the optimization of the care of patients during the perioperative continuum. Research domains include the application of minimally invasive surgical techniques, ERAS, immunonutrition, pain control, and psychological interventions to optimize postoperative outcomes and limit complications. We especially welcome studies in ovarian cancer and gynecologic oncology surgeries that include multi-disciplinary care aimed toward improved clinical outcomes and quality of life. All types of original research articles, review articles, and clinical trials that focus on improving our understanding of effective perioperative care are invited, with the goal of improving treatment and enhancing the quality of life for women with gynecological malignancies.

Dr. Vasilios Pergialiotis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecologic oncology
  • minimal invasive surgery
  • ovarian cancer
  • ERAS protocol
  • perioperative care
  • immunonutrition
  • cervical cancer

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Published Papers (2 papers)

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Research

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16 pages, 1292 KB  
Article
Implementation Rates and Predictors of Compliance with Enhanced Recovery After Surgery Protocols in Gynecologic Oncology: A Prospective Multi-Institutional Cohort Study
by Vasilios Pergialiotis, Dimitrios Haidopoulos, Alexandros Daponte, Dimitrios Tsolakidis, Stamatios Petousis, Ioannis Kalogiannidis, Dimitrios Efthymios Vlachos, Vasilios Lygizos, Maria Fanaki, George Delinasios, Panagiotis Tzitzis, Philipos Ntailianas, Vasilios Theodoulidis, Georgia Margioula Siarkou, Nikoletta Daponte and Nikolaos Thomakos
Cancers 2025, 17(24), 3991; https://doi.org/10.3390/cancers17243991 - 15 Dec 2025
Cited by 1 | Viewed by 759
Abstract
Background: The importance of integrating enhanced recovery after surgery protocols in gynecologic oncology has been proven in numerous studies. However, the actual adherence to protocol among institutions remains inconsistent in clinical practice, particularly among those without prior structured implementation. This pragmatic multicenter study [...] Read more.
Background: The importance of integrating enhanced recovery after surgery protocols in gynecologic oncology has been proven in numerous studies. However, the actual adherence to protocol among institutions remains inconsistent in clinical practice, particularly among those without prior structured implementation. This pragmatic multicenter study provides a preliminary report from the ongoing ERGO (Enhanced Recovery in Gynecologic Oncology) cohort study (ClinicalTrials.gov: NCT06655506) and aims to evaluate adherence to enhanced recovery protocols during the early phases of its adoption as well as identify factors that determine low uptake. Methods: Overall, 300 consecutive patients undergoing gynecologic oncology surgery across five institutions were included in the present study. Adherence to preoperative, intraoperative, and postoperative enhanced recovery elements was documented using standardized forms. Optimal adherence was predetermined as fulfillment of more than 70% of the enhanced recovery components included in the pathway. Multinomial analysis was used to identify predictors of adherence. Results: Overall, 70.3% of patients achieved optimal adherence; however, rates varied across centers (26.9–84.4%), reflecting the limited institutional familiarity with enhanced recovery pathways in most participating centers. The actual volume of cases handled was an important determinant of adherence, with high-volume units consistently demonstrating substantially higher compliance compared with lower-volume hospitals. Routine preoperative items demonstrated high uptake, whereas several intraoperative and early postoperative components showed low and heterogeneous implementation, which might be the result of anesthesiology-driven practices. Higher surgical complexity and poorer performance status independently predicted reduced adherence. Visual mapping confirmed that complex procedures resulted in lower adherence. Conclusions: The significant variability in enhanced recovery protocol adherence that was observed in our study indicates the need to institute structured workflows that help increase team familiarization, particularly in high-complexity cases and centers new to these elements. Full article
(This article belongs to the Special Issue Improving the Quality of Life in Patients with Gynecological Cancer)
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Review

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16 pages, 295 KB  
Review
Management of Endometrial Hyperplasia: A Comparative Review of Guidelines
by Eirini Boureka, Ioannis Tsakiridis, Georgios Kapetanios, Georgios Michos, Sonia Giouleka, Anastasios Liberis, Apostolos Mamopoulos, Themistoklis Dagklis and Ioannis Kalogiannidis
Cancers 2025, 17(19), 3143; https://doi.org/10.3390/cancers17193143 - 27 Sep 2025
Cited by 1 | Viewed by 8452
Abstract
Endometrial hyperplasia, presenting without atypia (EH) or as atypical hyperplasia (AH), is considered a precursor of endometrial cancer and affects women of reproductive or perimenopausal age, posing a major public health concern. The aim of this study was to review and compare the [...] Read more.
Endometrial hyperplasia, presenting without atypia (EH) or as atypical hyperplasia (AH), is considered a precursor of endometrial cancer and affects women of reproductive or perimenopausal age, posing a major public health concern. The aim of this study was to review and compare the most recently published influential guidelines providing recommendations on the management of endometrial hyperplasia. Thus, a comparative review of guidelines from the Royal College of Obstetricians and Gynecologists, the Society of Obstetricians and Gynecologists of Canada, and the American College of Obstetricians and Gynecologists was conducted. There is a consensus regarding the optimal management strategies for EH, with observation and medical treatment being the first-line options and surgical treatment with total hysterectomy offering a second line in specific cases. Moreover, there is agreement regarding patients with AH, with surgical treatment being the recommended approach, while medical therapy is preferred for women who seek fertility preservation. Notably, close surveillance with endometrial biopsies every 3 or 6 months is suggested unanimously, as well as long-term follow-up in high-risk patients. Controversy exists regarding the initial diagnostic approach, with RCOG and SOGC suggesting outpatient endometrial biopsy, while ACOG recommends diagnostic hysteroscopy, as well as the therapeutic regimens for the oral treatment of EH. Surgical techniques such as endometrial ablation, intraoperative frozen section analysis, intraoperative visual inspection of the uterus, and morcellation constitute areas of controversy among the reviewed guidelines, and the surveillance protocols for women with EH are addressed differently between RCOG and SOGC. Notably, RCOG is the only medical society offering recommendations regarding women under HRT and those on therapy for breast cancer. The development of consistent international practice protocols for timely management strategies and surveillance protocols is of paramount importance to safely guide clinical practice and subsequently improve women’s health. Full article
(This article belongs to the Special Issue Improving the Quality of Life in Patients with Gynecological Cancer)
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