Advancing CAR-T Cell Therapy: The Next Evolution in Breast Cancer Treatment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 1 July 2026 | Viewed by 129
Special Issue Editors
Interests: biochemistry; molecular biology; molecular immunology; cancer; tumor microenvironment; obesity; cancer immunology; cell therapy (CAR-NK and CAR_T cell therapy)
Special Issues, Collections and Topics in MDPI journals
2. School of Human Sciences, The University of Western Australia, Nedlands, Perth, WA 6009, Australia
3. Trichy SRM Medical College Hospital and Research Centre, SRM Nagar, Trichy—Chennai Highways, Irungalur, Trichy 621 105, India
Interests: wnt signaling; secreted frizzled related protein 4; cancer; cancer stem cells; angiogenesis; apoptosis; redox signaling; molecular modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The success of CAR-T cell therapy in hematologic malignancies has ignited interest in applying this powerful immunotherapeutic approach to solid tumors, including breast cancer. However, breast cancer poses unique biological and clinical challenges, such as antigen heterogeneity, the immunosuppressive tumor microenvironment (TME), limited T-cell infiltration, and safety concerns related to off-tumor toxicity. Despite these hurdles, emerging innovations in CAR-T cell engineering, target discovery, and combination therapies have begun to open new avenues for breast cancer treatment, particularly in difficult-to-treat subtypes like triple-negative breast cancer (TNBC) and HER2-positive breast cancer.
The purpose of this Special Issue is to advance the understanding and development of CAR-T cell therapy for breast cancer by providing a platform to showcase cutting-edge research, innovative therapeutic strategies, and clinical progress in this rapidly evolving field. By bringing together contributions that address the unique challenges of applying CAR-T cell therapy to solid tumors—such as tumor heterogeneity, immune evasion, and the suppressive tumor microenvironment.
This Special Issue welcomes reviews as well as original research articles, which should be submitted by 1 July 2026.
Dr. Nethaji Muniraj
Dr. Arun Dharmarajan
Guest Editors
Manuscript Submission Information
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Keywords
- CAR-T cell therapy
- breast cancer
- triple-negative breast cancer (TNBC)
- HER2-positive breast cancer
- tumor microenvironment
- immunotherapy
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