Tumor Microenvironment in Ovarian Cancer Progression, Dissemination, Recurrence: Biology and Therapeutic Opportunities
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 3
Special Issue Editors
Interests: ovarian cancer; PAI-1; regulation of cell adhesion; tumor metabolism; tumor–stroma interaction
Special Issues, Collections and Topics in MDPI journals
Interests: tumor microenvironment; tissue fibrosis; desmoplastic cancers; SERPINE1; transcriptomics/proteomics
Special Issues, Collections and Topics in MDPI journals
Interests: ovarian cancer; tumor–stroma interaction; extracellular matrix; lipid metabolism; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We invite researchers and clinicians to submit original research articles and reviews for a forthcoming Special Issue on ovarian cancer highlighting the latest advances in pathophysiology, progression, and treatment of advanced-stage ovarian cancer.
Ovarian malignancies remain a leading cause of cancer death, primarily due to late diagnosis and the complex nature of disease progression. Despite advances in cytoreductive surgery and chemotherapy, recurrence rates remain high, underscoring the urgent need for novel insights and therapeutic approaches.
This Special Issue will explore the biological mechanisms and clinical implications of advanced ovarian cancer, particularly in the following contexts:
- Malignant ascites: its role in dissemination, immunosuppression, and therapeutic resistance
- Metabolic reprogramming: alterations in energy metabolism and nutrient utilization that support tumor progression
- Cell–cell interactions: how tumor and stromal cells communicate within the peritoneal environment
- Intracellular signaling pathways: key mediators that drive transcoelomic dissemination, proliferation, and chemoresistance
We are particularly interested in manuscripts that use cutting-edge techniques, including single-cell analyses, organoid models, multi-omics approaches, and translational studies that bridge basic science and clinical application.
Dr. Ralf-Peter Czekay
Dr. Paul J. Higgins
Dr. Dong-Joo Cheon
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- transperitoneal carcinomatosis
- malignant ascites
- chemoresistance
- metabolic adaptations
- regulation of immune response
- tumor–stroma interaction
- tumor–peritoneal interaction
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