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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Machine Learning and Artificial Intelligence in Leukemia

edited by Garrett M. Dancik and

Spiros Vlahopoulos

submission deadline 31 Jan 2027 | 1 articles | Viewed by 641 | Submission Open

Keywords: cancer genomics; genomic sequencing; biomarkers; predictive modeling; machine learning; artificial intelligence; leukemia; computer vision; natural language processing

(This special issue belongs to the Section Methods and Technologies Development)

Metals in Cancer: From Molecular Mechanisms to Innovative Therapeutics

edited by

Katarina Zivancevic

submission deadline 31 Jan 2027 | Viewed by 352 | Submission Open

Keywords: essential and toxic metals; metal-induced carcinogenesis; metal homeostasis; metallotherapeutics; oxidative stress; tumor microenvironment; immune modulation; metabolic reprogramming; therapy resistance; drug delivery systems

(This special issue belongs to the Section Molecular Cancer Biology)

Digital Health and Patient-Reported Outcomes in Cancer Care

edited by Joanne Droney

submission deadline 31 Jan 2027 | Viewed by 330 | Submission Open

Keywords: patient-reported outcome measures; digital health; remote symptom monitoring; outcome-based healthcare; health-related quality of life (HRQoL); shared decision-making; real-world data collection; data standardization; health equity in digital health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Blood Stem Cell and Hematological Malignancies (Second Edition)

edited by Dirk Loeffler

submission deadline 31 Jan 2027 | Viewed by 298 | Submission Open

Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation

(This special issue belongs to the Section Molecular Cancer Biology)

Redefining Cancer Through Its Microenvironment: Mechanisms, Modeling, and Targeting Strategies

edited by Leandro Marcelo Martinez

submission deadline 31 Jan 2027 | Viewed by 259 | Submission Open

Keywords: tumor microenvironment; solid cancer; hematologic malignancies; tumor initiation; tumor progression; therapeutic resistance; in-vitro models; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Nanomedicine for Cancer Treatment

edited by Youssef Wahib Naguib

submission deadline 31 Jan 2027 | Viewed by 256 | Submission Open

Keywords: cancer nanomedicine; CRISPR/CAS9 nanomedicine; immune checkpoint inhibitors; cancer immunotherapy; targeted therapeutics; targeted nanoparticles; cell-penetrating peptides

(This special issue belongs to the Section Cancer Drug Development)

Thoracic Surgical Oncology—Current Landscape and Future Directions

edited by Piergiorgio Solli and Alessia Stanzi

submission deadline 31 Jan 2027 | Viewed by 192 | Submission Open

Keywords: minimally invasive thoracic surgery; immunotherapy; liquid biopsy; lung cancer; mesothelioma; esophageal cancer; precision oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Molecular Biology and Genetics of Prostate Cancer

edited by

Grinu Mathew

and

Maher Y. Abdalla

submission deadline 31 Jan 2027 | Viewed by 135 | Submission Open

Keywords: prostate cancer; treatment resistance; tumor microenvironment; genomic alterations; therapy progression mechanisms

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular and Genetic Drivers of Cancer: Organelle Dysfunction, Cancer Stem Cells, and Tumor Progression

edited by

Babak Behnam

and Maziar Ashrafian-Bonab

submission deadline 31 Jan 2027 | Viewed by 105 | Submission Open

Keywords: cancer progression; organelle dysfunction; cancer stem cells; mitochondria; microtubules; organelle crosstalk; tumor metabolism; therapeutic resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Anticancer Drugs and Pharmacotherapy of Cancer

edited by

Yong Weon Yi

submission deadline 31 Jan 2027 | Viewed by 89 | Submission Open

Keywords: anticancer; therapeutics; target therapy; immune-oncology; mode of action; molecular mechanisms; targeted protein degradation; antibody-drug conjugates; cell therapy; cancer parmacology

(This special issue belongs to the Section Cancer Drug Development)

Prognostic Biomarkers and Systemic Inflammation in Gastric Cancer: From Translational Research to Clinical Application

edited by

Konrad Matysiak

and Steve Kwon

submission deadline 31 Jan 2027 | Viewed by 48 | Submission Open

Keywords: gastric cancer; prognostic biomarkers; systemic inflammation; nutritional status; immune-inflammatory indices; survival prediction; clinical outcomes

Implementation of Physical Activity Promotion in Cancer Care (2nd Edition)

edited by Sarah Hardcastle

submission deadline 31 Jan 2027 | Viewed by 38 | Submission Open

Keywords: physical activity; cancer survivors; behavior change; interventions; cancer care; implementation; health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Multimodal Management of Bone Metastases: From Microenvironment Crosstalk to Precision Interventional Therapy

edited by

Zhengxue Quan

submission deadline 31 Jan 2027 | Viewed by 34 | Submission Open

Keywords: bone metastases; tumor microenvironment; precision therapy; molecular mechanisms; multimodal treatment; therapeutic targets

(This special issue belongs to the Section Cancer Metastasis)

Paradigm Shifts and Patient-Centered Outcomes of Breast Cancer Surgery

edited by Rakhshanda Layeequr Rahman, Cathy Graham and Jaime Alberty

submission deadline 31 Jan 2027 | Viewed by 12 | Submission Open

Keywords: shared decision-making; precision medicine; surgical de-escalation; minimally invasive surgery; clinical approaches with modern technologies; quality of life after breast surgery; economic impact of breast cancer surgery; financial toxicity

(This special issue belongs to the Section Methods and Technologies Development)

Progress and Precision in Surgical Treatment for Hepatobiliary and Pancreatic Cancers

edited by Ajith K. Siriwardena, Samik Kumar Bandyopadhyay and Louise M. Finch

submission deadline 1 Feb 2027 | Viewed by 140 | Submission Open

Keywords: liver surgery; pancreas surgery; robotic surgery; ablation; irreversible electroporation; liver tumours

Utilizing the DNA Damage Response Mechanism for Cancer Treatments

edited by

Daniel Chi-Wei Chen

submission deadline 15 Feb 2027 | 1 articles | Viewed by 458 | Submission Open

Keywords: DNA damage response; synthetic lethality; replication stress; DDR-targeted therapy; cancer metabolism; drug resistance; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Stereotactic Body Radiation Therapy for Thoracic and Abdominopelvic Tumors

edited by

Yin Zhang

and

Kai Ding

submission deadline 19 Feb 2027 | 2 articles | Viewed by 1837 | Submission Open

Keywords: stereotactic body radiation therapy (SBRT); adaptive radiation therapy (ART); image-guided radiation therapy (IGRT); motion management; thoracic tumors; abdominopelvic tumors

(This special issue belongs to the Section Methods and Technologies Development)

Sarcoma Management in Orthopaedic Oncology

edited by

Vasileios Kontogeorgakos

and Jendrik Hardes

submission deadline 20 Feb 2027 | 5 articles | Viewed by 7300 | Submission Open

Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Immunotherapy of Metastatic Cancer

edited by

Gianluca Tomasello

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1231 | Submission Open

Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

HIV-Associated Lymphoid Neoplasms (2nd Edition)

edited by

José-Tomás Navarro

and

Kai Hübel

submission deadline 20 Feb 2027 | 1 articles | Viewed by 983 | Submission Open

Keywords: B-cell lymphoma; HIV; AIDS; Epstein–Barr virus; epidemiology; pathogenesis; prognosis

(This special issue belongs to the Section Infectious Agents and Cancer)

Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition

edited by

William H. Gmeiner

submission deadline 20 Feb 2027 | Viewed by 472 | Submission Open

Keywords: colorectal cancer; chemotherapy; chemoprevention; targeted therapy; kinase inhibitor; immunotherapy

Digital Health Technologies in Oncology: 2nd Edition

edited by

Sorana D. Bolboacă

submission deadline 25 Feb 2027 | Viewed by 514 | Submission Open

Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics.

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Peptidases in Cancer

edited by

Natalia A. Ignatenko

submission deadline 25 Feb 2027 | Viewed by 284 | Submission Open

Keywords: signaling proteases; proteolytic pathways; proteases and tumor microenvironment; protease diagnostic and therapeutic modalities in cancer

(This special issue belongs to the Section Molecular Cancer Biology)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 28 Feb 2027 | 2 articles | Viewed by 6074 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 28 Feb 2027 | 3 articles | Viewed by 5992 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

Novel Diagnostic and Therapeutic Approaches in Urologic Oncology

edited by

Whi-An Kwon

submission deadline 28 Feb 2027 | 1 articles | Viewed by 5497 | Submission Open

Keywords: urologic oncology; liquid biopsy; immunotherapy; artificial intelligence; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 28 Feb 2027 | 4 articles | Viewed by 5317 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Integrating Chemotherapy and Immunotherapy for Head and Neck Cancer

edited by Ken Saijo

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2821 | Submission Open

Keywords: head and neck squamous cell carcinomas; HNSCC; immune checkpoint inhibitor; biomarker; chemotherapy

(This special issue belongs to the Section Cancer Metastasis)

Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration

edited by

Ken Kudura

and Robert Förster

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2075 | Submission Open

Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy

(This special issue belongs to the Section Methods and Technologies Development)

Transformative Genomic Technologies Shaping the Future of Precision Approaches for Haematological Malignancies

edited by

Chung Hoow Kok

and

Barbara McClure

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1946 | Submission Open

Keywords: multi-omics; risk stratification; bioinformatics; AI/machine learning; hematological malignancies; biomarkers; targeted therapeutics; genomics; cancer cell biology

Role of Inflammation in Cancer

edited by

Li Yang

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1261 | Submission Open

Keywords: cancer; inflammation; immune cells; cytokines; anti-inflammatory; tumor microenvironment; immunotherapy; immune-related adverse events; targeted therapy; chemotherapy and chemoprevention

Surgery for Head and Neck Cancer

edited by

Boban M. Erovic

Blazen Marijic

and Stefan Grasl

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1167 | Submission Open

Keywords: head and neck cancer; oncologic surgery; minimally invasive surgery; transoral robotic surgery; neck dissection; reconstructive surgery; multidisciplinary treatment; functional outcomes

(This special issue belongs to the Section Cancer Therapy)

Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics

edited by Mohamed I. Elsaid,

Electra D. Paskett

and Vinod Rustgi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1070 | Submission Open

Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cellular Senescence, Aging and the Tumor Microenvironment in Cancer

edited by Jabed Iqbal and Jeremy Wee Kiat Ng

submission deadline 28 Feb 2027 | 1 articles | Viewed by 781 | Submission Open

Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression

edited by Andrej Veljković,

Gordana Kocic

and

Aleksandra Klisic

submission deadline 28 Feb 2027 | Viewed by 390 | Submission Open

Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets

(This special issue belongs to the Section Tumor Microenvironment)

Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine

edited by

Daniel Gündel

and

Sophie Stotz

submission deadline 28 Feb 2027 | Viewed by 307 | Submission Open

Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Robotic and Thoracoscopic Surgery for Lung Cancer

edited by Benjamin Wei

submission deadline 28 Feb 2027 | Viewed by 200 | Submission Open

Keywords: robotic; thoracoscopic; lobectomy; segmentectomy; wedge resection; lymph node dissection; neoadjuvant therapy; immunotherapy; spread through air spaces; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Non-Coding RNAs in Bone Tumors: Pathogenesis, Diagnostic Biomarkers, and Therapeutic Perspectives

edited by Albert Roessner

submission deadline 28 Feb 2027 | Viewed by 139 | Submission Open

Keywords: bone tumors; non-coding RNAs; pathogenesis; biomarkers; non-coding RNA therapeutics

Advances in Pathology of Lymphoma and Leukemia—Second Edition

edited by

Siba El Hussein

submission deadline 28 Feb 2027 | Viewed by 90 | Submission Open

Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis

(This special issue belongs to the Section Cancer Pathophysiology)

Emerging Roles of HDACs in Cancer Metabolism, Plasticity and Therapeutic Response

edited by Changmin Peng

submission deadline 28 Feb 2027 | Viewed by 68 | Submission Open

Keywords: HDAC biology; cancer metabolism; therapeutic resistance; post-translational modifications; cancer plasticity

(This special issue belongs to the Section Molecular Cancer Biology)

Photodiagnosis and Photodynamic Therapy for CNS Tumors

edited by

Jiro Akimoto

submission deadline 28 Feb 2027 | Viewed by 59 | Submission Open

Keywords: photo-diagnosis; photodynamic therapy; central nervous system tumors; photosensitizer

Signaling Molecules for Brain Tumors

edited by

Meenakshisundaram Kandhavelu

submission deadline 28 Feb 2027 | Viewed by 25 | Submission Open

Keywords: brain tumor; signaling molecules; tumor microenvironment; sensor; diagnosis and treatment; tumor microenvironment; synthesis and characterization; small drug molecules; gene expression; computational studies

(This special issue belongs to the Section Molecular Cancer Biology)

Quality of Life and Management of Pediatric Cancer (2nd Edition)

edited by

Luca Giacomelli

and

Momcilo Jankovic

submission deadline 28 Feb 2027 | Viewed by 15 | Submission Open

Keywords: pediatric palliative care; oncology; quality of life; early management

(This special issue belongs to the Section Pediatric Oncology)

Feature Papers in Section “Methods and Technologies Development” in 2026

edited by

Maxim V. Berezovski

submission deadline 1 Mar 2027 | 3 articles | Viewed by 2551 | Submission Open

Keywords: artificial intelligence (AI); medical imaging; clinical diagnostics; oncology biomarkers; precision medicine; big data integration; early cancer detection; radiomics; therapy response prediction; translational technology

(This special issue belongs to the Section Methods and Technologies Development)

Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition)

edited by

Lubna Khaldi

and

Nektarios Koufopoulos

submission deadline 1 Mar 2027 | 1 articles | Viewed by 1117 | Submission Open

Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Endoscopic Management of Esophageal Cancer

edited by Hugo Uchima and

Cristina Bugés Sánchez

submission deadline 1 Mar 2027 | 1 articles | Viewed by 735 | Submission Open

Keywords: endoscopic submucosal dissection (ESD); esophageal squamous cell carcinoma; Barrett’s esophagus

(This special issue belongs to the Section Cancer Therapy)

Precise and Personalized Radiation Therapy for Cancer Treatment

edited by Thomas Weissmann and

Michael Goldstein

submission deadline 1 Mar 2027 | Viewed by 206 | Submission Open

Keywords: radiation research; artificial intelligence; cancer; adaptive radiotherapy; stereotactic radiotherapy; radiotherapy; (radio)-immunotherapy; (radio)-chemotherapy; precision radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Symptom Management in Cancer Care

edited by Lena Lee and Joosun Shin

submission deadline 5 Mar 2027 | Viewed by 337 | Submission Open

Keywords: symptom burden; symptom management; health service; palliative care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical, Immune, and Microbial Markers of Response to Systemic Therapy in Skin Cancer

edited by

Robin Reschke

submission deadline 14 Mar 2027 | Viewed by 242 | Submission Open

Keywords: melanoma; cutaneous squamous cell carcinoma; immunotherapy; immune checkpoint inhibitors; tumor microenvironment; microbiome; predictive biomarkers

Proton Therapy of Cancer Treatment

edited by Minglei Kang, Benjamin Durkee and Kuo Men

submission deadline 15 Mar 2027 | 5 articles | Viewed by 8598 | Submission Open

Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 1151-1200 on page 24 of 25.

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