Novel Treatments for Ocular and Periocular Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 437

Special Issue Editor


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Guest Editor
Ophthalmology Department, Loyola University of Chicago, Chicago, IL, USA
Interests: ocular; ophthalmology

Special Issue Information

Dear Colleagues,

Ocular cancers, though rare, affect patients in all age groups, significantly affecting their vision and survival. Thus, understanding ocular cancers is vital for effective management of the disease. Ocular cancers affect almost every structure of the eye and manifest in various tissues, ranging from intraocular tumors, including retinoblastoma and uveal melanoma, to tumors affecting the ocular surface, such as conjunctival and lacrimal gland carcinomas, as well as orbital tumors. Further, ocular tumors can be primary in nature arising from ocular tissue such as the retinoblastoma or metastasized from distant organs including lymphomas. Given the complexity and diversity of cancers affecting the eye and the stake of losing vision, treating ocular cancers has demanded specialized expertise and advancement in ocular cancer targeted treatments as well as diagnosis. In this Special Issue dedicated to ocular cancers, we request cancer researchers to share their invaluable work to bring together a comprehensive body of research that reflects the current status and advances made in understanding of pathology, detection, diagnosis, and treatment of ocular cancers to benefit both our scientific and non-scientific readers.

Dr. Vidhya R. Rao
Guest Editor

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Keywords

  • ocular cancer
  • intraocular tumor
  • retinoblastoma
  • uveal melanoma

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Published Papers (1 paper)

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Research

12 pages, 1941 KiB  
Article
Breast Cancer Orbital Metastases: Clinical and Histopathological Characteristics, Imaging Features, and Disease-Related Survival in a Multicentric Retrospective Case Series
by Sofia Peschiaroli, Adriana Iuliano, Giovanni Cuffaro, Francesco M. Quaranta Leoni, Tommaso Tartaglione, Monica Maria Pagliara, Maria Grazia Sammarco, Carmela Grazia Caputo, Angela Santoro, Matteo Barchitta, Vittoria Lanni, Diego Strianese and Gustavo Savino
Cancers 2025, 17(11), 1875; https://doi.org/10.3390/cancers17111875 - 3 Jun 2025
Viewed by 57
Abstract
Background: This study aims to analyze the clinical, radiological, and histopathological features, as well as the long-term follow-up, of patients with breast carcinoma orbital metastases. Methods: The study was a multicentric retrospective observational case series. The medical records of 32 female [...] Read more.
Background: This study aims to analyze the clinical, radiological, and histopathological features, as well as the long-term follow-up, of patients with breast carcinoma orbital metastases. Methods: The study was a multicentric retrospective observational case series. The medical records of 32 female patients affected by breast carcinoma orbital metastases referred to three tertiary referral centers from January 2016 to December 2023 were reviewed. The demographic characteristics of the population, clinical ophthalmological presentation, histological features, orbital metastasis latency, disease-related survival (DRS), and mortality rate were analyzed. Results: The median age of the patients was 62.50 years (interquartile range (IQR): 74.50–57.50). The prevalent histotype of the orbital metastases of breast cancer was lobular carcinoma (75.00% of cases). The median orbital metastasis latency time was 39.50 months (IQR: 134.00–10.25). The median disease-related survival (DRS) during the observational period was 35 months, and the 24-month survival rate was 70.73%. The overall mortality rate in our population was 50%. Conclusions: The most frequent histotype of breast cancer orbital metastasis is lobular carcinoma. The primary tumor precedes the onset of orbital metastasis in most cases and usually presents as a mass occupying space and infiltrating the orbit. Orbital metastases are a sign of an advanced stage of the disease, which has a high mortality rate and a low DRS. Full article
(This article belongs to the Special Issue Novel Treatments for Ocular and Periocular Cancers)
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