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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition

edited by

Arati Sharma

Dhimant Desai

and

Abhijit Date

submission deadline 1 Jun 2026 | 1 articles | Viewed by 6192 | Submission Open

Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation

(This special issue belongs to the Section Cancer Drug Development)

New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

edited by Vesna Bjelic-Radisic,

Maggie Banys-Paluchowski

and Constanze Elfgen

submission deadline 1 Jun 2026 | 3 articles | Viewed by 2566 | Submission Open

Keywords: oncoplastic breast surgery; breast reconstruction; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Proton Therapy of Cancer Treatment

edited by Minglei Kang, Benjamin Durkee and Kuo Men

submission deadline 1 Jun 2026 | 1 articles | Viewed by 428 | Submission Open

Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning

(This special issue belongs to the Section Cancer Therapy)

Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition)

edited by

Lubna Khaldi

and

Nektarios Koufopoulos

submission deadline 1 Jun 2026 | Viewed by 78 | Submission Open

Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in the Immunotherapy of Metastatic Cancer

edited by

Gianluca Tomasello

submission deadline 5 Jun 2026 | Viewed by 35 | Submission Open

Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Histopathology of Urological Cancers

edited by Vikas Mehta, Antoun Toubaji and Vijayalakshmi Ananthanarayanan

submission deadline 10 Jun 2026 | 3 articles | Viewed by 5918 | Submission Open

Keywords: renal cell carcinoma; prostate; testis Ggrm cell tumors; urothelial carcinoma; artificial intelligence; ductal adenocarcinoma of prostate; neuroendocrine differentiation of prostate carcinoma; next-generation sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Recent Studies on Oral Cancer: Diagnostic Technologies, Pathology, and Surgery

edited by

Luisa Limongelli

Gianfranco F. Favia

and

Fabio Dell’Olio

submission deadline 15 Jun 2026 | 2 articles | Viewed by 2155 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral potentially malignant disorders; diagnostic technologies; oral surgery; maxillo-facial surgery; oncology; radiology; immunohistochemistry; molecular biology

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer

edited by

Arezou A. Ghazani

submission deadline 15 Jun 2026 | 2 articles | Viewed by 2015 | Submission Open

Keywords: genome; cancers; oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Current Updates and Future Directions in Neuroendocrine Neoplasms (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs (2nd Edition)

edited by

Jaydira del Rivero

and Aman Chauhan

submission deadline 15 Jun 2026 | Viewed by 202 | Submission Open

Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Current Progress in Radiotherapy and Particle Therapy of Cancer

edited by

Carla Hajj

submission deadline 16 Jun 2026 | Viewed by 44 | Submission Open

Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy

(This special issue belongs to the Section Cancer Therapy)

p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition)

edited by

Lucília Saraiva

and

Marco M. Candeias

submission deadline 20 Jun 2026 | Viewed by 71 | Submission Open

Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Squamous Cell Carcinoma: From Pathogenesis to Treatment

edited by Carolin Götz

submission deadline 20 Jun 2026 | Viewed by 61 | Submission Open

Keywords: squamous cell carcinoma (SCC); oncological surgery; carcinogenesis; tumor microenvironment; HPV; immunotherapy; molecular targets; precision oncology; biomarkers; head and neck cancer; translational oncology

(This special issue belongs to the Section Cancer Pathophysiology)

Angiogenesis and Anti-Angiogenic Therapies in Cancer

edited by

Girolamo Ranieri

and Giovanni Mastrandrea

submission deadline 24 Jun 2026 | Viewed by 23 | Submission Open

Keywords: angiogenesis; anti-angiogenic therapies; cancer; tumor vasculature; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

Clinical and Translational Research in Head and Neck Cancer—2nd Edition

edited by Young J. Kim

submission deadline 25 Jun 2026 | Viewed by 14 | Submission Open

Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics

(This special issue belongs to the Section Clinical Research of Cancer)

Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers

edited by

Holli Loomans-Kropp

submission deadline 30 Jun 2026 | 9 articles | Viewed by 18607 | Submission Open

Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Prevention and Treatment of Liver Cancer

edited by Ewa Janczewska

submission deadline 30 Jun 2026 | 8 articles | Viewed by 16473 | Submission Open

Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization

(This special issue belongs to the Section Cancer Therapy)

New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy

edited by Kazunari Murakami and

Kazuhiro Mizukami

submission deadline 30 Jun 2026 | 6 articles | Viewed by 13497 | Submission Open

Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Therapy)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jun 2026 | 5 articles | Viewed by 8211 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

Clinical Diagnosis, Treatment, and Prognosis of Uveal Melanoma

edited by Josep Maria Caminal Mitjana

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7867 | Submission Open

Keywords: uveal melanoma; choroidal melanoma; gene expression profiling; immunotherapy; metastasis; radiotherapy; liquid biopsy; circulating tumor cells; brachytherapy; next-generation sequencing; proton therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Gynecologic Oncology: Clinical and Translational Research

edited by

Gennaro Daniele

, Pasquale Lombardi and Gaia Giannone

submission deadline 30 Jun 2026 | 5 articles | Viewed by 6352 | Submission Open

Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors

(This special issue belongs to the Section Cancer Therapy)

Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies

edited by

Juan Jose Segura-Sampedro

and

Constantino Fondevila

submission deadline 30 Jun 2026 | 4 articles | Viewed by 4889 | Submission Open

Keywords: abdominal oncologic surgery; minimally invasive techniques; laparoscopy; robotics; fluorescence; artificial intelligence; augmented vision; peritoneal carcinomatosis; intraperitoneal chemotherapy; liquid biopsy

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Regulation in Hematologic Malignancies

edited by Travis S. Johnson

submission deadline 30 Jun 2026 | 3 articles | Viewed by 4486 | Submission Open

Keywords: epigenetic regulation; hematologic malignancies; DNA methylation; non-coding RNA; therapeutic targeting

(This special issue belongs to the Section Tumor Microenvironment)

The Progress of Pancreatectomy for Pancreatic Cancer Treatment

edited by

Reinhold Függer

and

Matthias Biebl

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3494 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatectomy timing in multimodal regimen; minimally invasive pancreatectomy for PDAC; pancreatectomy and resectability; extended pancreatectomy; vascular resection and reconstruction; outcome research— pancreatectomy for cancer in unselected patient cohorts; interaction of postoperative complications and preoperative or adjuvant therapy; postoperative pancreatic fistula

(This special issue belongs to the Section Clinical Research of Cancer)

Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice

edited by

Maria Trovato

, Silvia Martina Ferrari and

Fausto Famà

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1360 | Submission Open

Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Neurofibromatosis

edited by Yunjia Chen and Yulong Fu

submission deadline 30 Jun 2026 | Viewed by 364 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1

(This special issue belongs to the Section Molecular Cancer Biology)

Understanding the Molecular Basis and Immunobiology of Renal Cell Carcinoma and Exploring Novel Therapeutic Strategies

edited by

Heba Khella

submission deadline 30 Jun 2026 | Viewed by 334 | Submission Open

Keywords: renal cell carcinoma; molecular basis; immunobiology; tumor microenvironment; immunotherapy; targeted therapy; metastasis; precision medicine; biomarkers; non-coding RNA; miRNA; prognosis; molecular diagnostics; translational research

(This special issue belongs to the Section Cancer Therapy)

Recent Updates on Treatment of Uveal Melanoma

edited by Richard D. Carvajal, Shaheer Khan and Brian Peter Marr

submission deadline 30 Jun 2026 | Viewed by 283 | Submission Open

Keywords: uveal melanoma; systemic therapies; surgical innovations; radiotherapy; genetic and molecular insights; translational research

(This special issue belongs to the Section Cancer Therapy)

Cancer Inhibitory Receptors: Targeting Tumor Microenvironment Therapeutically

edited by

Vaishali Aggarwal

and Alok Kumar

submission deadline 30 Jun 2026 | Viewed by 268 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; tumor microenvironment; inhibitory receptors; immune system; T cells; malignant cells; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Neurofibromatosis Type 1 (NF1) Related Tumors (2nd Edition)

edited by

Daochun Sun

and

Sameer Farouk Sait

submission deadline 30 Jun 2026 | 1 articles | Viewed by 249 | Submission Open

Keywords: NF1; tumorigenesis; cancer stem cells; targeted therapy; tumor microenvironment; epigenetics; case report; metastasis; clinical trials

(This special issue belongs to the Section Tumor Microenvironment)

Role of BCL-2 Family Proteins in Cancer: Therapeutic Advancements and Challenges

edited by Sajid Khan

submission deadline 30 Jun 2026 | Viewed by 235 | Submission Open

Keywords: BCL-2 family proteins; apoptosis; BH3 mimetics; thrombocytopenia; proteolysis-targeting chimeras; drug resistance; combination therapy; targeted drug delivery

(This special issue belongs to the Section Cancer Therapy)

Innovative Treatments Based on Genomic Aberrations in Leukemia and Lymphoma

edited by

Vera Ulrike Bacher

and

Ashwini K. Yenamandra

submission deadline 30 Jun 2026 | Viewed by 233 | Submission Open

Keywords: leukemia; lymphoma; AI and predictive modeling; MRD; B-ALL; DLBCL; genomics; treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in Neoadjuvant Therapy for Urologic Cancer

edited by Carlo Messina

submission deadline 30 Jun 2026 | Viewed by 216 | Submission Open

Keywords: neoadjuvant treatment; bladder cancer; prostate cancer; renal cell carcinoma; penile cancers; immunotherapy; antibody– drug conjugates

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Epidemiology of Childhood Cancer

edited by Rafael Peris-Bonet,

Rebeca Ramis

and Adela Cañete

submission deadline 30 Jun 2026 | Viewed by 142 | Submission Open

Keywords: childhood cancer epidemiology; childhood cancer registries; environmental causes of childhood cancer; genetic epidemiology; molecular epidemiology; survival of children with cancer; quality of life; social determinants and inequalities; information technologies and statistical innovations

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Unveiling the Complexity of Hepato-Biliary-Pancreatic Cancers: From Pathogenesis to Management

edited by

Stefano Cacciatore

and Luiz Zerbini

submission deadline 30 Jun 2026 | Viewed by 99 | Submission Open

Keywords: hepatocellular carcinoma (HCC); cholangiocarcinoma; pancreatic ductal adenocarcinoma (PDAC); tumour microenvironment; molecular biomarkers; therapeutic resistance; cancer immunotherapy; early cancer detection; precision oncology; targeted therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Hepatocellular Carcinoma: Clinical Evidence and Emerging Therapeutic Benefits

edited by

Alessandro Loglio

submission deadline 30 Jun 2026 | Viewed by 70 | Submission Open

Keywords: artificial intelligence; downstaging; immunotherapy; multidisciplinary approaches; risk factors; nutrition

(This special issue belongs to the Section Cancer Therapy)

Arginine and Cancers: Molecular Mechanisms and Anticancer Therapy

edited by

Maria Francesca Baietti

submission deadline 30 Jun 2026 | Viewed by 55 | Submission Open

Keywords: arginine; cancer; therapy; immunotherapy; metabolism

(This special issue belongs to the Section Cancer Drug Development)

Advances in Pancreatic Cancer: Exploring Biomarkers and Prognostic Predictors

edited by

Makoto Abue

submission deadline 30 Jun 2026 | Viewed by 50 | Submission Open

Keywords: pancreatic cancer; biomarkers; diagnosis; prognosis; liquid biopsy; proteomics; metabolomics; tumor microenvironment; genetic aberrations/mutations; inflammatory markers

(This special issue belongs to the Section Cancer Biomarkers)

Emerging Therapies for Germ Cell Tumors

edited by

Ratnakar Singh

and Krinio Giannikou

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Urological Cancer: Epidemiology and Genetics

edited by Ilir Agalliu and Evan Kovac

submission deadline 30 Jun 2026 | Viewed by 46 | Submission Open

Keywords: environmental factors; lifestyle; genetic susceptibility; biomarkers; prostate cancer; bladder cancer; kidney cancer

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

A New Road for Cancer Drug Discovery

edited by

Navnath S. Gavande

and

Yubin Ge

submission deadline 30 Jun 2026 | Viewed by 45 | Submission Open

Keywords: cancer drug discovery; artificial intelligence in drug discovery and development; targeted therapy; precision oncology; targeted protein degrades; small-molecule therapeutics; immuno-oncology; undruggable targets; drug resistance mechanisms; combination therapy

(This special issue belongs to the Section Cancer Drug Development)

PARP Inhibitors in Cancer Therapy

edited by

Jie Jiang

and

Fu Gui

submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open

Keywords: PARP inhibitors; cancer therapy; DNA damage repair; drug discovery

(This special issue belongs to the Section Cancer Therapy)

Integrating Precision Medicine with Nanotechnology to Overcome Drug Resistance in Cancer

edited by Yan Li

submission deadline 30 Jun 2026 | Viewed by 34 | Submission Open

Keywords: precision medicine; nanotechnology; drug resistance

(This special issue belongs to the Section Methods and Technologies Development)

Nanocarriers in Cancer Therapy

edited by

Wenyi Gu

submission deadline 30 Jun 2026 | Viewed by 32 | Submission Open

Keywords: nanoparticles; cancer therapy; anticancer drug delivery

(This special issue belongs to the Section Methods and Technologies Development)

Radiation Therapy in Oncology

edited by Jerzy Wydmański

submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open

Keywords: radiotherapy; radiation injury; systemic therapy; immunotherapy; cancer; concurrent chemoradiotherapy; stereotactic radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Human Carcinogens—New Insights from Occupational Exposure

edited by

Enrico Oddone

and

Roberta Pernetti

submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open

Keywords: occupational carcinogens; chemical exposure; cancer prevention; artificial intelligence (AI); workplace health policy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Clinical Pathology of Lung Cancer (2nd Edition)

edited by

Letizia Gnetti

submission deadline 30 Jun 2026 | Viewed by 30 | Submission Open

Keywords: lung cancer; pathology; diagnosis; treatment; targeted therapies; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Genetic Alterations and Features in the Development of Gastrointestinal Cancer

edited by

Alexandra Voutsina

submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open

Keywords: gastrointestinal cancers; genetic alteration; epigenetic regulation; the mechanism of tumorigenesis; precision treatment

(This special issue belongs to the Section Molecular Cancer Biology)

Genomics and Genetics in Brain Cancer Treatment, Diagonals, and Prognosis

edited by

Nan Hu

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: genomics; genetics; brain tumor; brain cancer; glioblastoma multiform; glioma; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Updates on Anti-Cancer Drug Research

edited by

Ana Luísa De Sousa-Coelho

and Mónica Fernandes

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding RNAs; multi-omics data

(This special issue belongs to the Section Cancer Drug Development)

Long-Read Sequencing in Cancer (2nd Edition)

edited by

Luca Ermini

and Patrick Driguez

submission deadline 30 Jun 2026 | Viewed by 25 | Submission Open

Keywords: long-read sequencing; cancer genetics; genomics; transcriptomics; methylomics; cancer research

(This special issue belongs to the Section Molecular Cancer Biology)

Displaying special issue 1001-1050 on page 21 of 23.

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