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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Mediastinum—Pandora’s Box
edited by
submission deadline 1 Jul 2026 | Viewed by 425 | Submission Open
Keywords: mediastinum; thymus; imaging; surgery; thymoma; germ cell tumors
Advancing CAR-T Cell Therapy: The Next Evolution in Breast Cancer Treatment submission deadline 1 Jul 2026 | Viewed by 115 | Submission Open
Keywords: CAR-T cell therapy; breast cancer; triple-negative breast cancer (TNBC); HER2-positive breast cancer; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Role of Opioid Therapy for Cancers
edited by Brian Le and
submission deadline 1 Jul 2026 | Viewed by 21 | Submission Open
Keywords: opioids; palliative care; chronic cancer pain
(This special issue belongs to the Section Cancer Therapy)
Perioperative Management and Cancer Outcome (2nd Edition)
edited by
submission deadline 9 Jul 2026 | Viewed by 87 | Submission Open
Keywords: perioperative management; cancer treatment outcomes; onco-anesthesiology; preoperative risk assessment; enhanced recovery after surgery (ERAS); pain management; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Clinicopathological Study of Gynecologic Cancer (2nd Edition)
edited by
submission deadline 10 Jul 2026 | 1 articles | Viewed by 948 | Submission Open
Keywords: gynecological oncology; gynecological cancer; female cancer; uterine cancer; ovarian cancer; endometrial cancer; cancerogenesis; cancer biology; cell transformation; cancer pathology; cancer biology
(This special issue belongs to the Section Clinical Research of Cancer)
Chemotherapy for Metastatic Head and Neck Squamous Cell Carcinomas
edited by Ken Saijo
submission deadline 15 Jul 2026 | 1 articles | Viewed by 352 | Submission Open
Keywords: head and neck squamous cell carcinomas; HNSCC; immune checkpoint inhibitor; biomarker; chemotherapy
(This special issue belongs to the Section Cancer Metastasis)
Penile Cancer and Rare Urogenital Malignancies: From Biology to Clinical Management
edited by and Marcin Matuszewski
submission deadline 15 Jul 2026 | Viewed by 73 | Submission Open
Keywords: penile cancer; urethral carcinoma; upper tract urothelial carcinoma; rare urogenital tumors; surgical management; systemic therapy; epidemiology
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Hodgkin Lymphoma (HL)
edited by
submission deadline 15 Jul 2026 | Viewed by 60 | Submission Open
Keywords: classic Hodgkin lymphoma; diagnostic challenges; tumour microenvironment; variability in disease extent; TME-targeted therapies; personalized treatment; relapsed/refractory cHL
(This special issue belongs to the Section Cancer Pathophysiology)
Tumor Microenvironment of Breast Cancer—2nd Edition
edited by
submission deadline 15 Jul 2026 | Viewed by 52 | Submission Open
Keywords: breast cancer; tumor microenvironment; TME; stromal cells
(This special issue belongs to the Section Tumor Microenvironment)
Pancreatic Cancer: Genomics, Therapy and Survival
edited by Hisanobu Ogata
submission deadline 15 Jul 2026 | Viewed by 31 | Submission Open
Keywords: pancreas; cancer; treatment; oncolytic virus; stromal cell; cancer-associated fibroblast (CAF)
(This special issue belongs to the Section Cancer Therapy)
Robotic Versus Laparoscopic Surgery for Colorectal Cancer
edited by Richard Garfinkle and Nicholas P. McKenna
submission deadline 15 Jul 2026 | Viewed by 24 | Submission Open
Keywords: colon cancer; rectal cancer; colorectal cancer; robotic surgery; laparoscopic surgery; transanal surgery; minimally invasive surgery
(This special issue belongs to the Section Methods and Technologies Development)
Personalizing Head and Neck Cancer Care
edited by and
submission deadline 17 Jul 2026 | Viewed by 6 | Submission Open
Keywords: head and neck cancer; personalized treatment; targeted therapy; prehabilitation; quality of life
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Current Status and Clinical Developments in Lung Cancer: What to Expect from Emerging Drugs? (2nd Edition) submission deadline 20 Jul 2026 | 1 articles | Viewed by 1139 | Submission Open
Keywords: lung cancer; immunotherapy; immune checkpoint inhibitors (ICIs); target therapy; tyrosine kinase inhibitors (TKIs); cancer biomarkers
(This special issue belongs to the Section Cancer Therapy)
HIV-Associated Lymphoid Neoplasms (2nd Edition) submission deadline 20 Jul 2026 | Viewed by 68 | Submission Open
Keywords: B-cell lymphoma; HIV; AIDS; Epstein– Barr virus; epidemiology; pathogenesis; prognosis
(This special issue belongs to the Section Infectious Agents and Cancer)
Novel Diagnostic and Therapeutic Approaches in Urologic Oncology
edited by
submission deadline 21 Jul 2026 | Viewed by 56 | Submission Open
Keywords: urologic oncology; liquid biopsy; immunotherapy; artificial intelligence; targeted therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Current Advances in Surgical and Systemic Treatment of Breast Cancer submission deadline 23 Jul 2026 | Viewed by 41 | Submission Open
Keywords: breast cancer; breast surgery; oncoplastic surgery; systemic therapy; biomarkers; targeted therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Image Assisted High Precision Radiation Oncology
edited by Christopher Njeh and Senthamizhchelvan Srinivasan
submission deadline 25 Jul 2026 | Viewed by 51 | Submission Open
Keywords: image-guided radiation therapy (IGRT); MR-guided radiation therapy (MRgRT); adaptive radiation therapy (ART); radiomics and AI in imaging; multi-modal imaging (CT; MRI; PET); treatment planning and verification; real-time tracking and motion management; stereotactic radiotherapy (SBRT/SRS); imaging biomarkers; dose accumulation and image registration
(This special issue belongs to the Section Methods and Technologies Development)
Precision Medicine and Targeted Therapies in Neuroblastoma
edited by
submission deadline 30 Jul 2026 | 1 articles | Viewed by 890 | Submission Open
Keywords: pediatric oncology; solid tumors; targeted therapies; biomarkers of response; novel combination therapies; tumor microenvironment; integrative diagnostics; theranostics; telomere maintenance mechanisms; neuroblastoma
(This special issue belongs to the Section Clinical Research of Cancer)
Cutting-Edge Nanomedicine Advancements in Cancer Disease submission deadline 30 Jul 2026 | Viewed by 254 | Submission Open
Keywords: active targeting; breast cancer; drug delivery; liposomes; lung cancer; metallic nanoparticles; polymeric nanoparticles; theragnostic
(This special issue belongs to the Section Methods and Technologies Development)
Flow Cytometry and Molecular Studies in Hematological Malignancies
edited by Kirill A. Lyapichev
submission deadline 30 Jul 2026 | Viewed by 123 | Submission Open
Keywords: flow cytometry; molecular studies; hematological neoplasms; lymphoma; leukemia
(This special issue belongs to the Section Molecular Cancer Biology)
Machine Learning and Artificial Intelligence in Cancer Diagnostic and Monitoring
edited by
submission deadline 30 Jul 2026 | Viewed by 54 | Submission Open
Keywords: machine learning; artificial intelligence; implementation; fairness; uncertainty
(This special issue belongs to the Section Methods and Technologies Development)
Multidisciplinary Approach to Bladder Cancer Treatment and Care
edited by Bente Thoft Jensen and
submission deadline 30 Jul 2026 | Viewed by 47 | Submission Open
Keywords: non-muscle-invasive bladder cancer; muscle-invasive bladder cancer; health-related quality of life; nutrition; prehabilitation; sexual health; nursing leadership; implementation; new technologies
(This special issue belongs to the Section Cancer Therapy)
Resection and Reconstruction for Breast Cancer
edited by Radoslaw Tarkowski and
submission deadline 30 Jul 2026 | Viewed by 41 | Submission Open
Keywords: oncoplastic breast surgery; breast reconstruction; breast cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Surgical Management of Ovarian Cancer
edited by Lina Salman
submission deadline 30 Jul 2026 | Viewed by 29 | Submission Open
Keywords: ovarian cancer; surgical management; complications; HIPEC; survival
(This special issue belongs to the Section Clinical Research of Cancer)
Evolving Understanding of the Epidemiology of Thyroid Cancer submission deadline 31 Jul 2026 | 2 articles | Viewed by 4475 | Submission Open
Keywords: thyroid cancer; epidemiology; incidence; time trends; mortality
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Circulating Tumor Cells (CTCs) and the Implementation of Liquid Biopsy (2nd Edition)
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1610 | Submission Open
Keywords: liquid biopsy; metastatic biomarkers; CTCs isolation technologies; tumor heterogeneity; clinical CTC applications
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Treatment and Prognosis of Breast Cancer
edited by Roxana Popescu and
submission deadline 31 Jul 2026 | Viewed by 562 | Submission Open
Keywords: breast cancer; targeted therapy; personalized therapy; alternative approach; tumor biology; gynecologic oncology
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Developments on PET-CT in Multiple Myeloma
edited by Carmelo Caldarella
submission deadline 31 Jul 2026 | Viewed by 115 | Submission Open
Keywords: PET/CT; multiple myeloma; novel radiopharmaceuticals; radiomics; theranostics
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Mechanisms of Resistance to Cancer Therapies submission deadline 31 Jul 2026 | Viewed by 62 | Submission Open
Keywords: therapy resistance; cancer heterogeneity; drug resistance mechanisms; targeted therapy resistance; immunotherapy resistance; tumor microenvironment; epigenetic reprogramming; biomarkers of resistance; clonal evolution
(This special issue belongs to the Section Molecular Cancer Biology)
Hematopoietic Stem Cells and Cancer Immunotherapy
edited by Harinad B. Maganti
submission deadline 31 Jul 2026 | Viewed by 61 | Submission Open
Keywords: hematopoietic stem cell; transplantation; leukemia; cell biology; CAR-T cell therapies; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Biologic Advancements in Childhood and Adolescent Cancers: From Disease Mechanisms to Precision Therapies
edited by and Eleni Tsotridou
submission deadline 31 Jul 2026 | Viewed by 60 | Submission Open
Keywords: pediatric oncology; precision therapies; molecular vulnerabilities; biomarker-driven trials; disease mechanisms
(This special issue belongs to the Section Pediatric Oncology)
Clinical Trials for Hepatobiliary and Pancreatic Cancer Diagnosis and Treatment (2nd Edition)
edited by
submission deadline 31 Jul 2026 | Viewed by 56 | Submission Open
Keywords: biliary cancer; liver cancer; pancreatic cancer; clinical trial; diagnosis; surgery; neoadjuvant therapy; adjuvant therapy; radiotherapy; chemotherapy; targeted therapy; precision medicine; immunotherapy; biliary and duodenal stent; psycho-oncology; palliative and supportive care
(This special issue belongs to the Section Clinical Research of Cancer)
Hybrid Molecular Imaging Approaches in Cancer: PET/CT, PET/MRI, and Beyond
edited by
submission deadline 31 Jul 2026 | Viewed by 56 | Submission Open
Keywords: PET/CT; PET/MRI; hybrid molecular imaging; radiomics and artificial intelligence; conventional PET Radiotracers; emerging PET Radiotracers; cancer imaging
(This special issue belongs to the Section Methods and Technologies Development)
Novel Insights into Glioblastoma and Brain Metastases (2nd Edition) submission deadline 31 Jul 2026 | Viewed by 55 | Submission Open
Keywords: glioblastoma; brain metastasis; surgery; radiation; chemotherapy; blood– brain barrier; immunotherapy; novel targets; oncogenes; tumor heterogeneity; drug discovery
(This special issue belongs to the Section Cancer Metastasis)
The Emerging Role of Multiplexed Imaging for Cancer Diagnosis and Therapy (2nd Edition)
edited by and
submission deadline 31 Jul 2026 | Viewed by 53 | Submission Open
Keywords: multiplexed imaging; cancer diagnosis; molecular imaging; novel contrast agents; targeted radionuclide tracers theragnostics; personalized cancer therapy; therapeutic monitoring; imaging biomarkers; clinical translation
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Perioperative Care and Pain Management in Cancer Patients: From Basic Science to Clinical Practice—2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 53 | Submission Open
Keywords: perioperative care; cancer anesthesia; analgesia; pain management
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Tumorigenesis and Tumor Microenvironment—Insights and Interventions (TTMII) submission deadline 31 Jul 2026 | Viewed by 52 | Submission Open
Keywords: tumorigenesis; tumor microenvironment; intervention; stress biology; aging; mortalin; CARF; ashwagandha; propolis; curcumin; natural compounds
(This special issue belongs to the Section Tumor Microenvironment)
Nanomedicine for Cancer Treatment
edited by Youssef Wahib Naguib
submission deadline 31 Jul 2026 | Viewed by 51 | Submission Open
Keywords: cancer nanomedicine; CRISPR/CAS9 nanomedicine; immune checkpoint inhibitors; cancer immunotherapy; targeted therapeutics; targeted nanoparticles; cell-penetrating peptides
(This special issue belongs to the Section Cancer Drug Development)
Mechanisms of Therapy Resistance in Cancers—2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open
Keywords: ATP-binding cassette transporters; cancer stem cells; extracellular ATP; repair of DNA damage; immunotherapy resistance
(This special issue belongs to the Section Cancer Drug Development)
Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer
edited by Abirami Sivapiragasam and Roberto A. Leon Ferre
submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open
Keywords: tumor microenvironment; breast cancer; immune cell– tumor interaction; immunotherapy; T cells; macrophages; dendritic cells; single-cell transcriptomics; spatial transcriptomics; artificial intelligence; prognostic biomarkers; predictive biomarkers; personalized therapy
(This special issue belongs to the Section Tumor Microenvironment)
Microsatellite Instability in Colorectal Cancer
edited by and Vicente Alonso-Orduña
submission deadline 31 Jul 2026 | Viewed by 40 | Submission Open
Keywords: microsatellite instability; colorectal cancer; immune checkpoint inhibitors; immune signatures
(This special issue belongs to the Section Tumor Microenvironment)
Current Applications and Cutting-Edge Innovations in Neuroendoscopy: Where Are We and Where Are We Going?
edited by Giuseppe Roberto Giammalva, Giovanni Tringali and Giuseppe Cinalli
submission deadline 31 Jul 2026 | Viewed by 34 | Submission Open
Keywords: neuroendoscopy; endoventricular surgery; skull base surgery; endoscopic assisted neurosurgery; innovations
(This special issue belongs to the Section Methods and Technologies Development)
Pheochromocytoma and Paraganglioma: Molecular Insights and Clinical Frontiers
edited by
submission deadline 31 Jul 2026 | Viewed by 21 | Submission Open
Keywords: pheochromocytoma and paraganglioma; hereditary cancer syndromes; genetic mutations; genotype– phenotype correlations; functional imaging; molecular diagnostics; biomarkers; precision oncology; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Surgical and Non-Surgical Convergence in Hepatocellular Carcinoma
edited by
submission deadline 31 Jul 2026 | Viewed by 20 | Submission Open
Keywords: hepatocellular carcinoma; conversion therapy; HCC treatment boundaries; surgical– non-surgical convergence; multidisciplinary HCC management
(This special issue belongs to the Section Cancer Therapy)
Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) in Patients with Cancers
edited by Caterina Alati and Martina Pitea
submission deadline 31 Jul 2026 | Viewed by 12 | Submission Open
Keywords: hematopoietic stem cell; hematologic malignancies; transplantation; immunotherapy
(This special issue belongs to the Section Transplant Oncology)
Epigenetics: A New Approach to Cancer Therapy
edited by
submission deadline 31 Jul 2026 | Viewed by 10 | Submission Open
Keywords: epigenetics; targets; cancer; tumor; signaling regulation; inhibitors; drugs
(This special issue belongs to the Section Cancer Therapy)
Cancer After Kidney Transplant
edited by Sławomir Lizakowski
submission deadline 31 Jul 2026 | Viewed by 9 | Submission Open
Keywords: immunosuppression; virus-associated cancer; skin cancer; graft survival; kidney transplantation; post-transplantation lymphoproliferative disorder
(This special issue belongs to the Section Transplant Oncology)
Advances in Dermato-Oncology
edited by Carmen Cantisani
submission deadline 31 Jul 2026 | Viewed by 8 | Submission Open
Keywords: melanoma; line-field confocal optical coherence tomography (LC-OCT); confocal microscopy; dermoscopy; non-melanoma skin cancers; treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Novel Therapies in Metastatic Castration-Resistant Prostate Cancer
edited by Kathryn E. Meier
submission deadline 1 Aug 2026 | 1 articles | Viewed by 3091 | Submission Open
Keywords: signal transduction inhibitors; targeted therapies; immunotherapy; radiopharmaceuticals; PARP inhibitors; biomarker-based approaches
(This special issue belongs to the Section Cancer Therapy)
Clinical Trials and Evolving Treatment Paradigms in Urologic Cancers
edited by
submission deadline 1 Aug 2026 | Viewed by 25 | Submission Open
Keywords: urologic cancers; clinical trials; prostate cancer; bladder cancer; kidney cancer; testicular cancer; systemic therapy; meta-analysis; biomarkers; oncology innovation
(This special issue belongs to the Section Clinical Research of Cancer)
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