The Advance of Proton Therapy in Head-and-Neck Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 1
Special Issue Editors
Interests: radiation oncology; reirradiation; proton therapy; dose de-escalation; nasopharynx cancer; head and neck cancers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proton therapy has emerged as a critical advancement in the management of head-and-neck cancers, offering highly conformal dose distributions that enable improved organ-at-risk sparing relative to conventional photon-based radiation. As global experience grows, there is an increasing need to consolidate contemporary evidence and highlight clinical outcomes across diverse disease sites, practice settings, and patient populations. This Special Issue, “The Advance of Proton Therapy in Head-and-Neck Cancers”, seeks high-quality prospective and retrospective studies that clarify the role of proton therapy in both routine and complex clinical scenarios.
We welcome multidisciplinary contributions that evaluate treatment efficacy, toxicity mitigation, functional outcomes, cost and value considerations, and patterns of care. Submissions incorporating multinational or multi-institutional cohorts are particularly encouraged, as they provide insights into real-world practice variation and expand the generalizability of findings. While common subsites such as oropharyngeal, nasopharyngeal, and laryngeal cancers remain central areas of investigation, we also invite studies focused on less frequently examined entities—including sinonasal tumors, skull base malignancies, salivary gland cancers, and rare histologies—where proton therapy may offer distinct advantages.
Through this Special Issue, we aim to advance the clinical understanding of proton therapy, inform evidence-based practice, and stimulate collaborative research to improve outcomes for patients with head-and-neck cancers worldwide.
Dr. Nancy Lee
Guest Editor
Dr. Edward Christopher Dee
Co-Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- proton therapy
- head-and-neck cancer
- clinical outcomes
- toxicity reduction
- multinational studies
- reirradiation
- skull base tumors
- salivary gland cancers
- prospective and retrospective cohorts
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