The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 383

Special Issue Editors


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Guest Editor
Department of Oncology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Str., 200349 Craiova, Romania
Interests: medical oncology; colorectal cancer; gastric cancer; hepatocellular carcinoma; chemotherapy; immunotherapy; radiotherapy; internal medicine; palliative care

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Guest Editor
Department of Oncology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Str., 200349 Craiova, Romania
Interests: medical oncology; clinical trials; gastric cancer; pancreatic cancer; colorectal cancer; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine carcinoma; chemotherapy; immunotherapy; radiotherapy

Special Issue Information

Dear Colleagues,

This Special Issue, "The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer", aims to bridge the gap between cutting-edge laboratory research and clinical application. As gastrointestinal cancers remain a leading cause of cancer-related mortality globally, it is imperative to translate molecular and cellular findings into tangible patient outcomes. This Issue will explore key themes, including the latest advancements in understanding the molecular mechanisms of gastrointestinal tumorigenesis, the role of the microbiome in cancer progression, novel diagnostic endoscopic techniques, and the development of novel therapeutic strategies. It will also address the challenges in early detection and the integration of personalized medicine approaches in clinical settings. By fostering a multidisciplinary dialogue, this Issue seeks to highlight the importance of translational research in improving diagnostics, treatment protocols, and ultimately patient survival rates. Through comprehensive reviews, original research articles, and insightful commentary, this publication aims to serve as a valuable resource for researchers, clinicians, and healthcare professionals dedicated to combating gastrointestinal cancer.

Dr. Liliana Streba
Dr. Michael Schenker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • gastrointestinal cancer
  • tumorigenesis
  • microbiome
  • early detection
  • molecular mechanisms
  • personalized medicine
  • novel therapeutics
  • translational research
  • clinical application
  • diagnostic innovations

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Published Papers (1 paper)

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Research

19 pages, 15521 KiB  
Article
Small Bowel Tumors: A 7-Year Study in a Tertiary Care Hospital
by Sergiu Marian Cazacu, Dan Cârțu, Mihai Popescu, Liliana Streba, Bogdan Silviu Ungureanu, Vlad Florin Iovănescu, Mihai Cimpoeru, Cecil Sorin Mirea, Valeriu Marian Surlin, Stelian Mogoantă and Mirela Marinela Florescu
Cancers 2025, 17(9), 1465; https://doi.org/10.3390/cancers17091465 - 27 Apr 2025
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Abstract
(1) Background: Tumors of the small bowel represent 3–6% of gastrointestinal neoplasms and 3–6% of GI malignancies. The difficulties regarding the diagnosis are associated with larger tumors at the moment of the diagnosis and with advanced forms of malignant tumors, associated with a [...] Read more.
(1) Background: Tumors of the small bowel represent 3–6% of gastrointestinal neoplasms and 3–6% of GI malignancies. The difficulties regarding the diagnosis are associated with larger tumors at the moment of the diagnosis and with advanced forms of malignant tumors, associated with a dismal prognosis. (2) Methods: We performed an observational, retrospective, cohort study that included patients with small bowel tumors admitted to the Craiova County Emergency Clinic Hospital between 1 January 2017 and 31 December 2023. The data were collected from the analysis of the patient’s discharge documents from the Hippocrates computer system of the hospital and the evaluation of endoscopy databases. Patients under 16 years of age, those with no pathological confirmation of the malignancy, and those with insufficient data were excluded. (3) Results: A total of 80 cases of small bowel tumors were diagnosed; 72.5% were malignant, of which 10.3% were metastases. The most frequent primary malignant small bowel tumor was adenocarcinoma; two squamous cell carcinomas were noted. CT scans and upper digestive endoscopy represent the most frequent imaging methods for the diagnosis. The prognosis for malignant tumors was poor, with a 41% 5-year survival rate. (4) Conclusions: Small bowel tumors are rarely encountered, with 72.5% being malignant, and were diagnosed at large dimensions and in advanced stages for malignant tumors, with a dismal prognosis. Full article
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