Stereotactic Body Radiation and Stereotactic Ablative Radiotherapy Therapy for Cancers 2nd edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 844

Special Issue Editors


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Guest Editor
Department of Radiation Physics, Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: SBRT/SABR; motion mitigation; 3D scintillation dosimetry and in vivo dosimetry; proton radiography and CT; FLASH RT
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Guest Editor
Department of Radiation Oncology, Miami Cancer Institute, Miami, FL 33176, USA
Interests: radiation oncology; radiotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Within the last decade, the radiation oncology community has witnessed increased adoption of hypofractionated, high-precision radiation therapy using stereotactic body radiation therapy (SBRT) or stereotactic ablative radiotherapy (SABR) across many disease sites such as Liver, Pancreas, Lung, and Prostate on the basis of clinical evidence demonstrating both efficacy and safety. The indication of SBRT/SABR is poised to greatly expand in the coming years for the management of oligometastatic disease. Technological advancements in precision patient alignment, in-room imaging, tumor motion management, and treatment machine deliveries have also emerged and followed suit.

Therefore, this Special Issue will include articles on all types of stereotactic modalities and treatments (SBRT, SABR, and others) using ultra-hypofractionated and hypofractionated high-dose-per-fraction regimens, including original research describing clinical outcomes and novel treatment planning and delivery approaches.

Submissions on the potential and use of AI and machine learning for SBRT/SABR treatment planning, tracking and alignment, and delivery are also welcome.

Prof. Dr. Sam Beddar
Dr. Michael D. Chuong
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiation therapy (oncology)
  • stereotactic body radiation therapy (SBRT) and stereotactic ablative radiotherapy (SABR)
  • ultra-hypofractionated and hypofractionated studies
  • ablative/dose-escalated studies
  • SBRT, SABR, and cyberknife technology
  • MRI guidance
  • tumor motion techniques and management
  • frame and frameless immobilization devices
  • SBRT/SABR dose constraints and toxicities
  • artificial intelligence/machine learning

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Published Papers (1 paper)

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Research

11 pages, 713 KiB  
Article
Ablative Five-Fraction CT Versus MR-Guided Stereotactic Body Radiation Therapy for Pancreatic Cancer: In Silico Evaluation of Interfraction Anatomic Changes as a Rationale for Online Adaptive Replanning
by Adeel Kaiser, Nicole Luther, Kathryn E. Mittauer, Amna Gul, Robert A. Herrera, Mukesh K. Roy, Ashley Fellows, Amy Rzepczynski, Will Deere, Matthew D. Hall, Rupesh Kotecha, Nema Bassiri-Gharb, Alonso N. Gutierrez and Michael D. Chuong
Cancers 2025, 17(13), 2061; https://doi.org/10.3390/cancers17132061 - 20 Jun 2025
Viewed by 594
Abstract
Background/Objectives: Non-ablative stereotactic body radiation therapy (SBRT) is commonly employed for locally advanced pancreatic cancer (LAPC) using computed tomography-guided radiotherapy (CTgRT) without online adaptive radiation therapy (oART). The safe delivery of ablative SBRT has been demonstrated using stereotactic magnetic resonance-guided online adaptive radiation [...] Read more.
Background/Objectives: Non-ablative stereotactic body radiation therapy (SBRT) is commonly employed for locally advanced pancreatic cancer (LAPC) using computed tomography-guided radiotherapy (CTgRT) without online adaptive radiation therapy (oART). The safe delivery of ablative SBRT has been demonstrated using stereotactic magnetic resonance-guided online adaptive radiation therapy (SMART). We performed an in silico comparison of non-adapted CTgRT versus SMART to better understand the potential benefit of oART for ablative pancreatic SBRT. Methods: We retrospectively evaluated original and daily adapted SMART plans that were previously delivered for 20 consecutive LAPC cases (120 total plans across all patients) treated on a 0.35 T MR-linac prescribed to 50 Gy (gross disease) and 33 Gy (elective sites) simultaneously in five fractions. Six comparative CTgRT plans for each patient (one original, five daily treatment) were retrospectively generated with the same prescribed dose and planning parameters as the SMART plans assuming no oART availability. The impact of daily anatomic changes on CTgRT and SMART plans without oART was evaluated across each treatment day MRI scan acquired for SMART. Results: Ninety percent of cases involved the pancreatic head. No statistically significant differences were seen between CTgRT and SMART with respect to target coverage. Nearly all (96%) fractions planned on either CT or MRI platforms exceeded at least one GI organ at risk (OAR) constraint without oART. Significant differences favoring SMART over non-adaptive CTgRT were observed for the duodenum V35 Gy ≤ 0.5 cc (34.2 vs. 41.9 Gy, p = 0.0035) and duodenum V40 Gy ≤ 0.03 cc (37 vs. 52.5 Gy, p = 0.0006) constraints. Stomach V40 Gy trended towards significance favoring SMART (37 vs. 40.3 Gy, p = 0.057) while no significant differences were seen. Conclusions: This is the first study that quantifies the frequency and extent of GI OAR constraint violations that would occur during ablative five-fraction SBRT using SMART vs. CTgRT. GI OAR constraint violations are expected for most fractions without oART whereas all constraints can be achieved with oART. As such, these data suggest that oART should be required for ablative five-fraction pancreatic SBRT. Full article
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