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Advances in Pleural and Peritoneal Mesothelioma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 821

Special Issue Editor


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Guest Editor
Unit of Pathological Anatomy, University Hospital of Pisa, Via Roma 67, 56126 Pisa, Italy
Interests: molecular pathology; lung cancer; mesothelioma; precision medicine; predictive biomarkers; molecular tests; next-generation sequencing
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Special Issue Information

Dear Colleagues,

Pleural and peritoneal mesotheliomas are rare, asbestos-related malignancies with an extremely poor prognosis and limited treatment options. Mesothelioma is a challenging tumor to diagnose and treat, and, currently, the histotype is the most reliable prognostic factor. However, recent studies on pleural mesothelioma have revealed genomic features that impact diagnosis, treatment response, and prognosis definition. Whereas there is data available regarding molecular characterization of peritoneal mesothelioma.

Molecular studies of both pleural and peritoneal mesothelioma are strongly warranted to define biomarkers useful to improve clinical practice.

This Special Issue welcomes original articles, reviews, and meta-analyses underlying advances in pleural and peritoneal mesothelioma from genetic landscape to treatment.

I look forward to receiving your contributions.

Dr. Rossella Bruno
Guest Editor

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Keywords

  • pleural mesothelioma
  • peritoneal mesothelioma
  • differential diagnosis
  • biomarkers
  • next-generation sequencing
  • gene expression

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Published Papers (1 paper)

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Research

14 pages, 2121 KB  
Article
Epithelioid Mesothelioma Cells Exhibit Increased Ferroptosis Sensitivity Compared to Non-Epithelioid Mesothelioma Cells
by Tatsuhiro Sato, Ikue Hasegawa, Haruna Ikeda, Taichi Ohshiro, Lisa Kondo-Ida, Satomi Mukai, Satoshi Ohte, Tohru Maeda and Yoshitaka Sekido
Cancers 2025, 17(24), 3983; https://doi.org/10.3390/cancers17243983 - 13 Dec 2025
Viewed by 402
Abstract
Background/Objectives: Mesothelioma is a highly aggressive tumor with a poor prognosis that typically develops after a long latency period following asbestos exposure. Although immunotherapy combined with chemotherapy is increasingly used, the efficacy of standard treatments remains limited. This study aimed to explore [...] Read more.
Background/Objectives: Mesothelioma is a highly aggressive tumor with a poor prognosis that typically develops after a long latency period following asbestos exposure. Although immunotherapy combined with chemotherapy is increasingly used, the efficacy of standard treatments remains limited. This study aimed to explore ferroptosis induction as a potential therapeutic strategy for mesothelioma. Methods: We first screened microbial culture extracts collected from soil and marine environments to identify compounds with selective cytotoxicity against mesothelioma cells. Gene expression profiling was performed to investigate the mechanism of cell death induced by the identified compound. To assess intrinsic ferroptosis susceptibility, patient-derived mesothelioma cell lines and immortalized mesothelial cell lines were treated with RSL3, a GPX4 inhibitor. Results: Screening identified brefeldin A as a compound that selectively induces cell death in mesothelioma cells. Gene expression profiling revealed transcriptional changes consistent with ferroptosis induction. Treatment with RSL3 demonstrated marked variability in ferroptosis sensitivity across cell lines; the subgroup showing high sensitivity to RSL3 did not exhibit significant genetic alterations in NF2 or BAP1, but contained a significantly higher proportion of epithelioid tumors in histological classification. Conclusions: Our findings highlight ferroptosis induction as a promising antitumor mechanism in mesothelioma, particularly in the epithelioid subtype. While GPX4 inhibitors such as RSL3 are effective in vitro, further studies are needed to overcome pharmacological limitations and define molecular determinants of ferroptosis susceptibility, which may inform future personalized therapeutic strategies. Full article
(This article belongs to the Special Issue Advances in Pleural and Peritoneal Mesothelioma)
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