Advancements in the Diagnosis and Surgical Treatment of Prostate Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 25 December 2025 | Viewed by 1182

Special Issue Editors


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Guest Editor
Department of Urology, St. Elisabeth Hospital Straubing, 94315 Straubing, Germany
Interests: urological robotic-assisted surgery; diagnosis of urologic cancer; surgical therapies for benign prostatic hyperplasia; urological laparoscopy; conventional urological surgery

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Guest Editor
Department of Urology, Carl Gustav Carus University Dresden, 01307 Dresden, Germany
Interests: prostate cancer; bladder cancer; renal cell cancer; uro-oncology; surgery; robotic; medical therapy; clinical management
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Special Issue Information

Dear Colleagues,

Diagnostic and therapeutic approaches for localized prostate cancer (PCa) have substantially improved over the past two decades. The implementation of targeted biopsy, based on MRI/ultrasound fusion, for suspicious prostate lesions has led to better discrimination of clinically significant PCa. This approach has also allowed for a more precise surgical intervention, balancing oncological safety and maximal preservation of functionality. The introduction of robot-assisted radical prostatectomy (RARP) in the 2000s quickly became a globally accepted standard of care. Since then, it has undergone several evolutionary steps based on further innovations, resulting in the development and establishment of new systems.

Despite overall satisfactory oncological and functional outcomes, some scientific questions remain unanswered, providing room for robust data analyses presented in international journals and major urological congresses. Unanswered questions include the impact of learning curves and the necessary case volumes to achieve stable and reproducible quality, applicable to both diagnostic fusion therapy and various modifications of RARP. The significance of pelvic lymph node dissection continues to be controversial, particularly considering that symptomatic lymphoceles are nearly the only quantitatively relevant complication after RARP. Another question lacking sufficient evidence is whether single-port procedures or RARP with "new systems" can achieve comparable oncological and functional safety.

The scope of this Special Issue is intentionally broad, as, in the spirit of the German poet Theodor Fontane, 'the inseparably connected diagnosis and treatment of localized prostate cancer truly represent a wide field'. We invite academically and clinically active urologists from around the world to contribute their results and perspectives in the form of original research articles and systematic review articles for discussion.

Dr. Christian Peter Gilfrich
Prof. Dr. Christian Thomas
Guest Editors

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Keywords

  • robotic-assisted radical prostatectomy
  • significance of pelvic lymph node dissection in the context of radical prostatectomy
  • complications of surgical therapy for prostate cancer
  • magnetic resonance imaging/ultrasound-guided target biopsy of the prostate
  • comparison of various robotic systems for radical prostatectomy
  • learning curves
  • hospital volume
  • prostate cancer centers

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Published Papers (1 paper)

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Research

12 pages, 757 KiB  
Article
Information Behaviour and Knowledge of Patients Before Radical Prostatectomy
by Christopher Hirtsiefer, Anna Vogelgesang, Fabian Falkenbach, Mona Kafka, Annemarie Uhlig, Tim Nestler, Cem Aksoy, Iva Simunovic, Johannes Huber, Isabel Heidegger, Markus Graefen, Marianne Leitsmann, Christian Thomas and Martin Baunacke
Cancers 2025, 17(2), 300; https://doi.org/10.3390/cancers17020300 - 17 Jan 2025
Viewed by 662
Abstract
Background/Objectives: Robot-assisted and open radical prostatectomy (RARP and ORP) are established procedures for localized prostate cancer, with comparable oncological and functional outcomes. Little is known about patients’ knowledge of both procedures. This study aimed to examine comparatively the informational behaviour and knowledge of [...] Read more.
Background/Objectives: Robot-assisted and open radical prostatectomy (RARP and ORP) are established procedures for localized prostate cancer, with comparable oncological and functional outcomes. Little is known about patients’ knowledge of both procedures. This study aimed to examine comparatively the informational behaviour and knowledge of patients undergoing ORP vs. RARP. Methods: This prospective, multicentre study included patients who underwent RARP or ORP prior to presurgery counselling. The questionnaires gathered information about patients’ information-seeking behaviours and their assessment of outcomes for RARP vs. ORP. We investigated risk factors for the misperception of procedure outcomes. Results: A total of 508 patients were included (307 RARP (60%); 201 ORP (40%)). The most common sources of information were outpatient urologists (84%), urologic departments (67%) and the internet (57%). Compared with ORP, RARP patients more often received the same amount of information about both procedures (60% vs. 40%, p < 0.001). Compared with ORP, RARP patients wrongfully considered their procedure to be superior in terms of oncological and functional outcomes. In the multivariable analysis, age > 66 years (OR 2.1, p = 0.02), no high school degree (OR 1.9, p = 0.04), unbalanced information search (OR 2.4, p = 0.02), RARP patient status (OR 8.9, p < 0.001), and treatment at a centre offering only one procedure (OR 3.5, p < 0.001) were independent predictors of misperception. Conclusions: RARP patients wrongfully considered their intervention to be oncologically and functionally more beneficial than ORP patients perceived it to be. This may be due to unbalanced sources of information. Urologists and surgical centres must address this misperception to enable patients to make informed decisions. Full article
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