Pancreatic Cancer: Clinical Standards, Unmet Needs and Future Directions
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 732
Special Issue Editor
Interests: precision cancer medicine; precision immuno-oncoloy; precision oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pancreatic cancer is a highly complex and heterogeneous disease, with the worst prognosis among leading cancer types. Late diagnosis, minimal residual disease (MRD) following surgical resections and resistance to current standard neoadjuvant and/or adjuvant chemotherapy are the causes of alarmingly high recurrence rates (80–90%).
To overcome these unmet challenges, breakthrough patient-centric research focuses on the development of prognostic and predictive biomarkers to eliminate MRD through meaningful therapy. Towards this direction, this Special Issue invites a wide spectrum of clinicians such as surgical and medical oncologists, as well as researchers aiming to develop comprehensive rational treatment with targeted therapy and immunotherapy. Considering the limitations of chemotherapy and targeted therapy, research interest concentrates on how to enhance the natural capacity of immune cells within the tumor microenvironment (TME). Harnessing multiomics technologies at bulk and particularly single-cell resolution, the goal of cancer immunotherapy, encompassing immune checkpoint inhibitors (ICIs), adoptive cellular therapy and mRNA vaccines, could be achieved over the next decade. Indeed, phase II/III trials are ongoing, evaluating the clinical utility of next-generation bispecific antibodies for dual checkpoint inhibition. Moreover, on the basis of the successful mRNA cancer vaccines in phase I clinical trials, a global randomized trial will take place soon. The development of tumor and liquid biopsy biomarkers can further improve the efficacy of these immunotherapies by enabling precision immunotherapy.
Prof. Dr. Dimitrios H. Roukos
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- standard clinical management
- surgery
- neoadjuvant and/or adjuvant treatment
- cancer immunotherapy
- targeted therapy
- detection and elimination of MRD
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
