The Role of Neutrophils in Tumor Progression and Metastasis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 1105
Special Issue Editors
Interests: chemokines; angiogenesis; metastasis
Special Issue Information
Dear Colleagues,
A growing body of evidence indicates that the interactions between neoplastic cells and inflammatory cells play an important role in tumor pathogenesis. These interactions are mediated by inflammatory cytokines and chemokines, leading to the recruitment of tumor-stromal-associated myeloid and endothelial cells that directly and indirectly promote tumor angiogenesis, progression, and metastasis. Neutrophils—the most abundant white blood cells in the circulation system—constitute a significant part of the tumor microenvironment, playing major roles in inflammation and cancer, and are highly involved in progression and metastasis. Additionally, abundant data suggest that neutrophils could be considered as emerging targets for multiple cancer types. This Special Issue will focus on the most recent advances in tumor-associated neutrophil recruitment, activation, and functions within the tumor microenvironment, regulating the progression and metastasis as well as development of TAN-targeted therapeutics.
Dr. Rakesh K. Singh
Dr. Leah M. Cook
Guest Editors
Manuscript Submission Information
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Keywords
- neutrophils
- innate immunity
- tumor
- microenvironment
- metastasis
- targeted therapeutics
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