News and How Much to Improve in Management of Soft Tissue Sarcomas

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 887

Special Issue Editors


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Guest Editor
Surgery Department, Hospital Universitario Sant Pau, Universidad Autonoma de Barcelona, 08035 Barcelona, Spain
Interests: sarcoma; liposarcoma

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Guest Editor
Hepatobiliary Surgery and Liver Transplant Unit, Gregorio Marañón University Hospital, 28007 Madrid, Spain
Interests: sarcoma

Special Issue Information

Dear Colleagues,

Soft tissue sarcomas (STSs) are rare, heterogeneous (>150 subtypes), and of mesenchymal origin. They represent less than 1% of adult tumors and can be located anywhere in the body. Under these conditions, a multidisciplinary approach to sarcomas is mandatory. During the last decades, due to the advancement in chemotherapy and surgical techniques, the survival rate has reached approximately 50% in patients with sarcoma. However, survival rates have not improved during the last 20 years. New biomarkers and therapeutic strategies are necessary to further improve prognosis. Likewise, focus on these patients in reference centers is of vital importance to ensure a correct diagnosis and personalized treatment with a correct incorporation of new diagnostic–therapeutic technologies, and thus to improve the medium- and long-term prognosis of these patients.

We are pleased to invite you to collaborate in this Special Issue of the Soft Tissue Sarcomas. This Special Issue will explore how the sarcomas subgroup relates to the scope of the journal.

In this Special Issue, we propose an approach to the recent progress in diagnosis and treatment and the greater impact on the prognosis of the most prevalent subtypes of sarcomas.

Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: immunotherapy in sarcomas, IA and sarcomas, 3D imaging in sarcomas, new surgical approaches in sarcomas, pelvic sarcomas, sarcomas of the cava veins and others venous locations, retroperitoneal sarcomas, medical gestion and referent centers in sarcomas, treatment of desmoid tumors, treatment approaches to metastasic sarcomas, the state-of-the-art in the medical management of sarcomas, etc.

We look forward to receiving your contributions.

Dr. Vicente Artigas-Raventós
Dr. José Manuel Asencio
Guest Editors

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Keywords

  • soft tissue sarcomas
  • prevalent types
  • multidisciplinary board
  • reference centers
  • news diagnosis methods and treatments
  • implication of IA and 3D in sarcomas
  • implication of minimally aggressive surgical techniques

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Published Papers (1 paper)

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29 pages, 342 KiB  
Guidelines
Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations
by Raquel Lopes-Brás, Paula Muñoz, Eduardo Netto, Juan Ángel Fernández, Mario Serradilla-Martín, Pablo Lozano, Miguel Esperança-Martins, Gerardo Blanco-Fernández, José Antonio González-López, Francisco Cristóbal Muñoz-Casares, Isabel Fernandes, José Manuel Asencio-Pascual and Hugo Vasques
Cancers 2025, 17(8), 1295; https://doi.org/10.3390/cancers17081295 - 11 Apr 2025
Viewed by 664
Abstract
Liver metastases from soft tissue sarcoma (STS) (excluding gastrointestinal stromal tumors) are rare and more commonly arise from retroperitoneal and intra-abdominal primary sites. Chemotherapy remains the mainstay of treatment for disseminated disease, but its effectiveness is limited and patients typically have a dismal [...] Read more.
Liver metastases from soft tissue sarcoma (STS) (excluding gastrointestinal stromal tumors) are rare and more commonly arise from retroperitoneal and intra-abdominal primary sites. Chemotherapy remains the mainstay of treatment for disseminated disease, but its effectiveness is limited and patients typically have a dismal prognosis with short survival. However, when metastases are confined to the liver (without pulmonary involvement), some patients may benefit from local techniques, either surgical or nonsurgical, that can provide long periods of disease-free survival. Due to the rarity of STS, especially with liver metastases, and the heterogeneity of histologies and biological behavior, there is a lack of standardized treatment guidelines and universally accepted criteria for this specific setting. To fill this gap, a multidisciplinary working group of experts in sarcoma and liver surgery reviewed the literature and available evidence and developed a set of clinical recommendations to be voted and discussed in the I Ibero-American Consensus on the Management of Metastatic Sarcoma, held at the III Spanish-Portuguese Update Meeting on the Treatment of Sarcomas in May 2024. Herein, the voting results of this meeting and the resulting consensus recommendations are presented, and their applicability, strengths, and limitations are discussed. Full article
(This article belongs to the Special Issue News and How Much to Improve in Management of Soft Tissue Sarcomas)
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