Epidemiology of and Antibiotic Therapy for Helicobacter pylori Infection
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: 28 February 2026 | Viewed by 107
Special Issue Editor
Special Issue Information
Dear Colleagues,
The goal of Helicobacter pylori eradication is to completely eliminate the bacteria as part of the treatment or prevention of peptic ulcers, MALT lymphoma, atrophic gastritis, idiopathic iron deficiency anemia, and ITP, and it should also be considered in many cases of dyspepsia. The first choice today is usually a 10-14-day quadruple therapy with bismuth (PPI + bismuth + tetracycline + metronidazole). Where antibiotic resistance is low and there has been no previous use of macrolides, clarithromycin-based triple therapy (PPI + amoxicillin + clarithromycin) may be given, but it is becoming less popular due to its decreasing effectiveness. In case of failure, levofloxacin- or rifabutin-containing "salvage" treatment or personalized therapy based on resistance testing is recommended. The key to success is the right dose, sufficient duration, and good adherence; side effects (abdominal discomfort, diarrhea, taste disturbance) are common but can be mitigated by probiotics. To confirm cure, a ¹³C-urea breath test or stool antigen test is required 4 weeks after antibiotics and at least 2 weeks after PPI discontinuation. Reinfection is rare in adults. Acid reducers and bismuth should be avoided prior to diagnosis as they may cause false-negative results. In special situations (allergies, pregnancy, childhood), individual assessment and adherence to guidelines are necessary. Eradication reduces ulcer recurrence and the risk of gastric cancer in the long term.
Dr. Peter Birinyi
Guest Editor
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Keywords
- Helicobacter pylori infection
- bismuth citrate
- metronidazole
- tetracycline
- amoxicillin
- clarithromycin
- proton pump inhibitor
- amoxicillin
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