Antibiotic Resistance: The Role of Aquatic Environments

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 784

Special Issue Editors


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Guest Editor
Environmental Health Science and Sustainability Program, Eastern Kentucky University, Richmond, KY 40475, USA
Interests: waterborne diseases; fecal indicator bacteria; antibiotic resistance; One Health

E-Mail Website
Guest Editor
USDA-ARS Environmental Microbial and Food Safety Laboratory, 10300 Baltimore Ave., Bldg. 303, Beltsville, MD 20705, USA
Interests: waterborne diseases; fecal indicator bacteria; antibiotic resistance; irrigation water quality; monitoring methodology

Special Issue Information

Dear Colleagues, 

Antibiotic resistance has become a growing concern worldwide, posing threats to both human and animal health. Water environments have been identified as crucial reservoirs and dissemination routes for antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs). The prevalence of antibiotic resistance in water environments has been attributed to various factors such as (1) contamination from runoff and wastewater effluent containing antibiotics or antibiotic-resistant bacteria; (2) the improper disposal, misuse and overuse of antibiotics; (3) inadequate wastewater treatment; (4) agricultural practices permitting the shedding of antibiotics or residues into the environment from livestock or manure; and (5) selective pressures from other contaminants or conditions in the environment that co-select for antibiotic resistance. 

Key topics covered in this issue will include: 

  1. Prevalence, distribution, and/or maintenance of antibiotic-resistant bacteria and resistance genes in various aquatic systems such as rivers, lakes, wastewater treatment plants, irrigation waters, drinking water distribution systems, and groundwater.
  2. Sources and reservoirs of antibiotic-resistant bacteria and resistance genes in water environments.
  3. Mechanisms of environmental dispersal and persistence of antibiotic-resistant bacteria and their resistance genes to and from aquatic environments.
  4. Environmental or ecological conditions favoring the emergence, maintenance, and/or spread of antibiotic resistance in natural and treated waters.
  5. Epidemiological studies associated with antibiotic resistance in water environments, including methods or tools for characterizing the burden of disease attributable to water-related antibiotic-resistant bacteria.
  6. Risk assessment methodologies for evaluating the impact of antibiotic resistance on human health, ecosystems, and agriculture.
  7. Surveillance strategies and testing methods for characterizing the prevalence and abundance of antibiotic-resistant bacteria and health-relevant antibiotic residues in water environments.
  8. The impact of source water quality and drinking water treatment strategies for selecting and/or removing antibiotic-resistant bacteria or resistance genes from water distribution systems.
  9. The role of water, sanitation, and hygiene (WaSH) factors and/or waterborne disease for facilitating the spread of antibiotic-resistant bacteria and resistance genes in water environments. 

Through a comprehensive understanding of the different aspects associated with antibiotic resistance in water environments, we hope that this Special Issue will contribute to raising awareness among researchers, policymakers, and the general public about this critical issue.

Prof. Dr. Jason W. Marion
Dr. Matthew D. Stocker
Guest Editors

Manuscript Submission Information

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Keywords

  • antibiotic resistance
  • water
  • wastewater
  • One Health
  • antibiotic misuse
  • antimicrobial resistance genes
  • microbiology
  • fecal indicator bacteria
  • mobile genetic elements
  • resistome
  • pollution
  • environment
  • water bodies
  • water treatment
  • waterborne disease
  • public health
  • risk assessment
  • sanitation
  • hygiene
  • aquatic environments

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Published Papers (1 paper)

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Review

39 pages, 6950 KiB  
Review
Emerging Trends in Antimicrobial Resistance in Polar Aquatic Ecosystems
by Melissa Bisaccia, Francesca Berini, Flavia Marinelli and Elisa Binda
Antibiotics 2025, 14(4), 394; https://doi.org/10.3390/antibiotics14040394 - 10 Apr 2025
Viewed by 559
Abstract
The global spread of antimicrobial resistance (AMR) threatens to plummet society back to the pre-antibiotic era through a resurgence of common everyday infections’ morbidity. Thus, studies investigating antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB) in urban, agricultural, and clinical settings, as well [...] Read more.
The global spread of antimicrobial resistance (AMR) threatens to plummet society back to the pre-antibiotic era through a resurgence of common everyday infections’ morbidity. Thus, studies investigating antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB) in urban, agricultural, and clinical settings, as well as in extreme environments, have become increasingly relevant in the One Health perspective. Since the Antarctic and Arctic regions are considered amongst the few remaining pristine environments on Earth, the characterization of their native resistome appears to be of the utmost importance to understand whether and how it is evolving as a result of anthropogenic activities and climate change. In the present review, we report on the phenotypic (e.g., disk diffusion test) and genotypic (e.g., PCR, metagenomics) approaches used to study AMR in the aquatic environment of polar regions, as water represents one of AMR main dissemination routes in nature. Their advantages and limits are described, and the emerging trends resulting from the analysis of ARB and ARGs diffusion in polar waters discussed. The resistome detected in these extreme environments appears to be mostly comparable to those from more anthropized areas, with the predominance of tetracycline, β-lactam, and sulfonamide resistance (and related ARGs). Indeed, AMR is, in all cases, more consistently highlighted in sites impacted by human and wildlife activities with respect to more pristine ones. Surprisingly, aminoglycoside and fluroquinolone determinants seem to have an even higher incidence in the Antarctic and Arctic aquatic environment compared to that from other areas of the world, corroborating the need for a more thorough AMR surveillance in these regions. Full article
(This article belongs to the Special Issue Antibiotic Resistance: The Role of Aquatic Environments)
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