Antibiotic Adjuvants for Overcoming and Preventing Antimicrobial Resistance
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 121
Special Issue Editor
Interests: synergy; antimicrobials; AMR; Pseudomonas aeruginosa; Staphylococcus aureus; adjuvants; nanoparticles; natural compounds; wound infections
Special Issue Information
Dear Colleagues,
Antimicrobial resistance (AMR) has emerged as one of the most pressing challenges in modern medicine, increasingly compromising the effectiveness of existing antibiotics and threatening the management of bacterial infections, particularly in vulnerable patient populations. Prolonged and repeated exposure of bacteria to antibiotics accelerates the selection of resistant phenotypes, ultimately limiting therapeutic options and contributing to increased morbidity and mortality.
Antibiotic adjuvants have gained significant attention as a strategy to restore and preserve antibiotic efficacy. By targeting resistance mechanisms or enhancing antibiotic activity, adjuvants can potentiate antibacterial effects, resensitize resistant pathogens, and reduce the likelihood of resistance emergence. Compounds of diverse origin, including natural products, synthetic molecules, repurposed drugs, and nanomaterials, represent a versatile platform for the development of resistance-modifying strategies.
This Special Issue invites original research articles and reviews addressing antibiotic adjuvants that enhance antibacterial activity against resistant pathogens. Particular emphasis will be placed on mechanistic insights into antibiotic-adjuvant interactions and on strategies aimed at limiting bacterial tolerance and resistance development.
We especially encourage studies targeting intrinsic resistance mechanisms, including biofilm formation, efflux pump activity, and cell envelope-associated barriers, and exploring adjuvant-based approaches to restore antibiotic susceptibility.
Dr. Marta Krychowiak-Maśnicka
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antibiotic adjuvants
- antimicrobial resistance
- resistance-modifying agents
- drug repurposing
- biofilm-associated resistance
- efflux pump inhibitors
- antibiotic synergy
- intrinsic resistance
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