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Medical Sciences Forum

Medical Sciences Forum is an open access journal dedicated to publishing findings resulting from academic conferences, workshops and similar events in all areas of medical sciences, for advances in basic, translational and clinical research and related disciplines.

The conference organizers and proceedings editors are responsible for managing the peer-review process and selecting papers for conference proceedings.

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All Articles (816)

Proceeding Paper

Bioinformatics Screening of Phenylpropanoids from Pyrostegia venusta in ER+ Breast Cancer

Ana Carolina Maldonado da Costa e Silva,
Samara Maria Piccirillo de Brito and
Silvio de Almeida-Junior
+ 6 authors

This study investigated the cytotoxic, antiproliferative, and molecular interaction profiles of the phenylpropanoids verbascoside and isoverbascoside from Pyrostegia venusta using in silico approaches. Computational predictions suggested differential cytotoxicity trends between tumor and non-tumor breast cell models compared with tamoxifen. QSAR analyses indicated antiproliferative potential, while docking studies revealed stable ligand–protein interactions with estrogen-related targets and PTEN. ADMET predictions suggested favorable metabolic characteristics, including limited CYP3A4 interaction. Overall, these results provide predictive insights that support further experimental investigation of these phenylpropanoids in ER⁺ breast cancer models.

26 January 2026

Identification of phenylpropanoids verbascoside (A) and isoverbascoside (B) from the floral extract of the plant Pyrostegia venusta (C).

Conference Report

Abstracts of the 3rd International Online Conference on Clinical Medicine

Emmanuel Andrès,
Kent Doi and
Francisco Guillén Grima

Kishore Muthukumar [...]

29 January 2026

Proceeding Paper

From Sweeteners to Sleeplessness: The Hidden Effects of Sucralose and Saccharin on the Gut–Brain Axis

Anxo Carreira-Casais and
Antia G. Pereira

Sweetener consumption has increased considerably in recent decades, driven by the growing demand from consumers of low-calorie products for weight control and, especially, from diabetic patients who require safe sweetener alternatives without affecting their glucose levels. However, the latest scientific evidence seems to indicate that the continued consumption of various sweeteners could significantly alter the gut microbiota, triggering consequences that go beyond metabolic health and could affect sleep quality. Among the most used non-caloric sweeteners in the food industry are sucralose and saccharin. Several studies have shown that prolonged consumption of these sweeteners can significantly alter the composition of the gut microbiota. In particular, its consumption might lead to a decrease in beneficial bacteria such as Lactobacillus and Bifidobacterium, along with an increase in potentially pathogenic microorganisms such as Clostridium difficile and Escherichia coli. This dysbiosis creates a chronic low-grade inflammatory environment and contributes to the deterioration of glucose metabolism, factors that negatively impact the regulation of the gut–brain axis. Consequently, these alterations could interfere with the neuroendocrine mechanisms involved in sleep, promoting the development of disorders such as insomnia, sleep fragmentation, and decreased subjective sleep quality. The aim of this narrative review is to synthesize the current scientific evidence on the impact of artificial sweeteners on the gut microbiota and their potential involvement in sleep disorders. The underlying biological mechanisms will be analyzed and the clinical relevance of these interactions discussed, laying the groundwork for future research that will contribute to the development of dietary recommendations and therapeutic strategies aimed at modulating the microbiota to improve sleep health.

20 January 2026