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Tropical Medicine and Infectious Disease, Volume 7, Issue 8

2022 August - 60 articles

Cover Story: Leishmaniasis is a neglected tropical disease that seriously influences global public health. Circular RNAs (circRNAs) are a new type of noncoding RNA that are involved in the regulation of biological and developmental processes. However, there is no published research on the function of circRNAs in leishmaniasis. This is the first study to explore the expression profiles of circRNAs in leishmaniasis. A total of 4664 significant differentially expressed circRNAs were identified and compared to those in control groups. Then, five hub genes (BRCA1, CREBBP, EP300, PIK3R1, and CRK) were identified. This study provides new evidence of the change in differentially expressed circRNAs and its potential function in leishmaniasis. These results may provide novel insights and evidence for the diagnosis and treatment of leishmaniasis. View this paper
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Articles (60)

  • Article
  • Open Access
19 Citations
4,505 Views
15 Pages

Evaluating Molecular Xenomonitoring as a Tool for Lymphatic Filariasis Surveillance in Samoa, 2018–2019

  • Brady McPherson,
  • Helen J. Mayfield,
  • Angus McLure,
  • Katherine Gass,
  • Take Naseri,
  • Robert Thomsen,
  • Steven A. Williams,
  • Nils Pilotte,
  • Therese Kearns and
  • Colleen L. Lau
  • + 1 author

Molecular xenomonitoring (MX), the detection of filarial DNA in mosquitoes using molecular methods (PCR), is a potentially useful surveillance strategy for lymphatic filariasis (LF) elimination programs. Delay in filarial antigen (Ag) clearance post-...

  • Article
  • Open Access
4 Citations
3,549 Views
14 Pages

Using Routinely Collected Health Records to Identify the Fine-Resolution Spatial Patterns of Soil-Transmitted Helminth Infections in Rwanda

  • Elias Nyandwi,
  • Tom Veldkamp,
  • Sherif Amer,
  • Eugene Ruberanziza,
  • Nadine Rujeni and
  • Ireneé Umulisa

Background. Soil-transmitted helminths (STH) are parasitic diseases with significant public health impact. Analysis is generally based on cross-sectional prevalence surveys; outcomes are mostly aggregated to larger spatial units. However, recent rese...

  • Article
  • Open Access
2 Citations
3,082 Views
14 Pages

Factors Affecting the Transition from Paper to Digital Data Collection for Mobile Tuberculosis Active Case Finding in Low Internet Access Settings in Pakistan

  • Christina Mergenthaler,
  • Jake D. Mathewson,
  • Abdullah Latif,
  • Hasan Tahir,
  • Vincent Meurrens,
  • Andreas van Werle,
  • Aamna Rashid,
  • Muhammad Tariq,
  • Tanveer Ahmed and
  • Ente Rood
  • + 1 author

Between September 2020 and March 2021, Mercy Corps piloted hybrid digital (CAPI) and paper-based (PAPI) data collection as part of its tuberculosis (TB) active case finding strategy. Data were collected using CAPI and PAPI at 140 TB chest camps in lo...

  • Article
  • Open Access
9 Citations
3,271 Views
10 Pages

Carbapenem-Resistant Organisms Isolated in Surgical Site Infections in Benin: A Public Health Problem

  • Carine Laurence Yehouenou,
  • Reza Soleimani,
  • Arsène A. Kpangon,
  • Anne Simon,
  • Francis M. Dossou and
  • Olivia Dalleur

An alarming worldwide increase in antimicrobial resistance is complicating the management of surgical site infections (SSIs), especially in low-middle income countries. The main objective of this study was to describe the pattern of carbapenem-resist...

  • Article
  • Open Access
10 Citations
3,159 Views
9 Pages

The Subjective Well-Being of Elderly Migrants in Dongguan: The Role of Residential Environment

  • Yuxi Liu,
  • Li Jia,
  • Junhui Xiao,
  • Qin Chen,
  • Qihui Gan,
  • Jie Huang,
  • Xianglei Zhu,
  • Chichen Zhang and
  • Chonghua Wan

To examine the association between community and individual-level residential environment in relation to subjective well-being (SWB) amongst 470 elderly migrants in China, this community-based survey was conducted. The manner and extent to which the...

  • Article
  • Open Access
11 Citations
3,170 Views
11 Pages

A Web of Science-Based Bibliometric Analysis of Global Noma Publications

  • Diego Azañedo,
  • Fabriccio J. Visconti-Lopez and
  • Akram Hernández-Vásquez

The World Health Organization recognizes noma as a global health problem and has suggested prioritizing research into this disease. A bibliographic search of original articles published in the Web of Science database up to 2022 was performed. A bibli...

  • Article
  • Open Access
6 Citations
3,611 Views
20 Pages

Transmission Dynamics and Genomic Epidemiology of Emerging Variants of SARS-CoV-2 in Bangladesh

  • Md. Abu Sayeed,
  • Jinnat Ferdous,
  • Otun Saha,
  • Shariful Islam,
  • Shusmita Dutta Choudhury,
  • Josefina Abedin,
  • Mohammad Mahmudul Hassan and
  • Ariful Islam

With the progression of the global SARS-CoV-2 pandemic, the new variants have become more infectious and continue spreading at a higher rate than pre-existing ones. Thus, we conducted a study to explore the epidemiology of emerging variants of SARS-C...

  • Article
  • Open Access
54 Citations
104,501 Views
13 Pages

Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents

  • Suyanee Mansanguan,
  • Prakaykaew Charunwatthana,
  • Watcharapong Piyaphanee,
  • Wilanee Dechkhajorn,
  • Akkapon Poolcharoen and
  • Chayasin Mansanguan

This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13–18 years from two...

  • Article
  • Open Access
9 Citations
3,678 Views
12 Pages

First Molecular Identification of Bulinus africanus in Lake Malawi Implicated in Transmitting Schistosoma Parasites

  • Mohammad H. Alharbi,
  • Cynthia Iravoga,
  • Sekeleghe A. Kayuni,
  • Lucas Cunningham,
  • E. James LaCourse,
  • Peter Makaula and
  • J. Russell Stothard

The freshwater snail genus Bulinus plays a vital role in transmitting parasites of the Schistosoma haematobium group. A hybrid schistosome between S. haematobium and S. mattheei has been recently detected using DNA-based identification methods in sch...

  • Article
  • Open Access
1 Citations
4,222 Views
12 Pages

Contributory Factors to Successful Tuberculosis Treatment in Southwest Nigeria: A Cross-Sectional Study

  • Olanrewaju Oladimeji,
  • Kelechi Elizabeth Oladimeji,
  • Mirabel Nanjoh,
  • Lucas Banda,
  • Olukayode Ademola Adeleke,
  • Teke Apalata,
  • Jabu Mbokazi and
  • Francis Leonard Mpotte Hyera

Tuberculosis (TB) is one of the oldest human diseases, and preventing treatment failure is critical. This is because TB cases pose a risk to the immediate and remote communities due to the potential for spread, particularly for multidrug-resistant (M...

  • Article
  • Open Access
2 Citations
2,437 Views
8 Pages

Co-Radiation of Leptospira and Tenrecidae (Afrotheria) on Madagascar

  • Yann Gomard,
  • Steven M. Goodman,
  • Voahangy Soarimalala,
  • Magali Turpin,
  • Guenaëlle Lenclume,
  • Marion Ah-Vane,
  • Christopher D. Golden and
  • Pablo Tortosa

Leptospirosis is a bacterial zoonosis caused by pathogenic Leptospira that are maintained in the kidney lumen of infected animals acting as reservoirs and contaminating the environment via infected urine. The investigation of leptospirosis through a...

  • Article
  • Open Access
3 Citations
3,491 Views
16 Pages

Knowledge of International Standards for Tuberculosis Care among Private Non-NTP Providers in Lagos, Nigeria: A Cross-Sectional Study

  • Victor Abiola Adepoju,
  • Kelechi Elizabeth Oladimeji,
  • Olusola Adedeji Adejumo,
  • Oluwatoyin Elizabeth Adepoju,
  • Ademola Adelekan and
  • Olanrewaju Oladimeji

Studies specifically evaluating tuberculosis knowledge among private non-NTP providers using the International Standards for Tuberculosis Care (ISTC) framework are scarce. We evaluated the knowledge of ISTC among private non-NTP providers and associa...

  • Case Report
  • Open Access
2 Citations
2,888 Views
6 Pages

Gemella morbillorum is a facultative anaerobic, catalase-negative and non-spore forming Gram-positive cocci. It can be found as part of the normal oropharyngeal flora, in the gastrointestinal tract and the female genital tract. However, it can be a c...

  • Article
  • Open Access
4 Citations
3,819 Views
22 Pages

Trace the History of HIV and Predict Its Future through Genetic Sequences

  • Zhen Wang,
  • Zhiyuan Zhang,
  • Chen Zhang,
  • Xin Jin,
  • Jianjun Wu,
  • Bin Su,
  • Yuelan Shen,
  • Yuhua Ruan,
  • Hui Xing and
  • Jie Lou

Traditional methods of quantifying epidemic spread are based on surveillance data. The most widely used surveillance data are normally incidence data from case reports and hospital records, which are normally susceptible to human error, and sometimes...

  • Review
  • Open Access
11 Citations
8,189 Views
16 Pages

Vector-Borne Tularemia: A Re-Emerging Cause of Cervical Lymphadenopathy

  • Kaja Troha,
  • Nina Božanić Urbančič,
  • Miša Korva,
  • Tatjana Avšič-Županc,
  • Saba Battelino and
  • Domen Vozel

Tularemia is a zoonosis caused by the highly invasive bacterium Francisella tularensis. It is transmitted to humans by direct contact with infected animals or by vectors, such as ticks, mosquitos, and flies. Even though it is well-known as a tick-bor...

  • Review
  • Open Access
7 Citations
4,049 Views
12 Pages

The gastrointestinal tract plays an important role in the pathogenesis of COVID-19. The angiotensin-converting enzyme 2 receptor and the transmembrane protease serine 2 receptor bind and activate SARS-CoV-2 and are present in high concentrations thro...

  • Systematic Review
  • Open Access
45 Citations
5,150 Views
23 Pages

Global Prevalence of Antifungal-Resistant Candida parapsilosis: A Systematic Review and Meta-Analysis

  • Dina Yamin,
  • Mutiat Hammed Akanmu,
  • Abbas Al Mutair,
  • Saad Alhumaid,
  • Ali A. Rabaan and
  • Khalid Hajissa

A reliable estimate of Candida parapsilosis antifungal susceptibility in candidemia patients is increasingly important to track the spread of C. parapsilosis bloodstream infections and define the true burden of the ongoing antifungal resistance. A sy...

  • Systematic Review
  • Open Access
15 Citations
3,700 Views
14 Pages

C-Reactive Protein-to-Albumin Ratio and Clinical Outcomes in COVID-19 Patients: A Systematic Review and Meta-Analysis

  • Hernán J. Zavalaga-Zegarra,
  • Juan J. Palomino-Gutierrez,
  • Juan R. Ulloque-Badaracco,
  • Melany D. Mosquera-Rojas,
  • Enrique A. Hernandez-Bustamante,
  • Esteban A. Alarcon-Braga,
  • Vicente A. Benites-Zapata,
  • Percy Herrera-Añazco and
  • Adrian V. Hernandez

C-reactive protein-to-albumin ratio (CAR) is an independent risk factor in cardiovascular, cerebrovascular, and infectious diseases. Through this study, we investigated the CAR values with respect to the severity and mortality of COVID-19 patients. W...

  • Article
  • Open Access
2 Citations
2,506 Views
9 Pages

Autochthonous West Nile Virus Infection Outbreak in Humans (Asti, Piedmont, Italy, August–October 2018) and Long-Term Sequelae Follow-Up

  • Tommaso Lupia,
  • Valentina Libanore,
  • Silvia Corcione,
  • Valentina Fornari,
  • Barbara Rizzello,
  • Roberta Bosio,
  • Giacomo Stroffolini,
  • Paolo Bigliano,
  • Silvia Fontana and
  • Francesco Giuseppe De Rosa
  • + 6 authors

West Nile virus (WNV) infection is a reemerging zoonosis recently provoking significant outbreaks throughout Europe. During the summer of 2018, the number of WNV infections rose with a peak of new diagnoses of West Nile neuro-invasive disease (WNND)....

  • Article
  • Open Access
2 Citations
2,919 Views
11 Pages

The COVID-19 pandemic caused significant damage to global healthcare systems. Previous studies regarding COVID-19’s impact on outpatient numbers focused only on a specific department, lacking research data for multiple departments in general ho...

  • Article
  • Open Access
2 Citations
2,601 Views
13 Pages

Coordination and Management of COVID-19 in Africa through Health Operations and Technical Expertise Pillar: A Case Study from WHO AFRO One Year into Response

  • Nsenga Ngoy,
  • Ishata Nannie Conteh,
  • Boniface Oyugi,
  • Patrick Abok,
  • Aminata Kobie,
  • Peter Phori,
  • Cephas Hamba,
  • Nonso Ephraim Ejiofor,
  • Kaizer Fitzwanga and
  • Abdou Salam Gueye
  • + 11 authors

Background: following the importation of the first Coronavirus disease 2019 (COVID-19) case into Africa on 14 February 2020 in Egypt, the World Health Organisation (WHO) regional office for Africa (AFRO) activated a three-level incident management su...

  • Article
  • Open Access
5 Citations
3,528 Views
9 Pages

Low Prevalence of Syndromic Respiratory Tract Infections among Returning Hajj Pilgrims Amidst the COVID-19 Pandemic: A Post-Hajj Survey

  • Hashim A. Mahdi,
  • Fadi S. Qashqari,
  • Sumyya H. Hariri,
  • Shahad Bamerdah,
  • Shahad A. Altayyar,
  • Hazim M. Almalki,
  • Fayez A. Alwadani,
  • Renan A. Alabbasi,
  • Mohammed H. Alqahtani and
  • Harunor Rashid
  • + 3 authors

This study estimates the point prevalence of symptomatic respiratory tract infections (RTIs) among returned Hajj pilgrims and their contacts in 2021. Using the computer-assisted telephone interview (CATI) technique, domestic pilgrims were invited to...

  • Review
  • Open Access
3 Citations
3,704 Views
17 Pages

The Northern Territory (NT) is a geographically remote region of northern and central Australia. Approximately a third of the population are First Nations Australians, many of whom live in remote regions. Due to the physical environment and climate,...

  • Article
  • Open Access
78 Citations
8,776 Views
17 Pages

Dengue Incidence Trends and Its Burden in Major Endemic Regions from 1990 to 2019

  • Na Tian,
  • Jin-Xin Zheng,
  • Zhao-Yu Guo,
  • Lan-Hua Li,
  • Shang Xia,
  • Shan Lv and
  • Xiao-Nong Zhou

Background: Dengue has become one of the major vector-borne diseases, which has been an important public health concern. We aimed to estimate the disease burden of dengue in major endemic regions from 1990 to 2019, and explore the impact pattern of t...

  • Article
  • Open Access
16 Citations
2,909 Views
7 Pages

Gender and Cutaneous Leishmaniasis in Israel

  • Michal Solomon,
  • Inbal Fuchs,
  • Yael Glazer and
  • Eli Schwartz

Leishmaniasis is estimated to be more common in males than in females. Our purpose was to evaluate differences in preponderance in relation to sex and gender across cutaneous and mucocutaneous leishmaniasis in Israel. An observational study was perfo...

  • Review
  • Open Access
9 Citations
4,379 Views
12 Pages

Narrative Review of the Control and Prevention of Knowlesi Malaria

  • Ahmad Hazim Mohammad,
  • Nurul Athirah Naserrudin,
  • Syed Sharizman Syed Abdul Rahim,
  • Jenarun Jelip,
  • Azman Atil,
  • Mohd Fazeli Sazali,
  • Adora J. Muyou,
  • Priya Dharishini Kunasagran,
  • Nornazirah Ahmad Kamarudin and
  • Mohd Rohaizat Hassan
  • + 3 authors

Despite the reduction in the number of cases of human malaria throughout the world, the incidence rate of knowlesi malaria is continuing to rise, especially in Southeast Asia. The conventional strategies for the prevention and control of human malari...

  • Case Report
  • Open Access
10 Citations
2,987 Views
10 Pages

Using Community Engagement and Geographic Information Systems to Address COVID-19 Vaccination Disparities

  • Tsu-Yin Wu,
  • Xining Yang,
  • Sarah Lally,
  • Alice Jo Rainville,
  • Olivia Ford,
  • Rachel Bessire and
  • Jessica Donnelly

The COVID-19 pandemic has exacerbated existing health disparities and had a disproportionate impact on racial and ethnic minority groups in the United States. Limited COVID-19 data for Asian Americans have led to less attention for this population; n...

  • Article
  • Open Access
6 Citations
3,113 Views
11 Pages

Expression Profile Analysis of Circular RNAs in Leishmaniasis

  • Zhongqiu Li,
  • Wenbo Zeng,
  • Yufeng Yang,
  • Peijun Zhang,
  • Zhengbing Zhou,
  • Yuanyuan Li,
  • Yunhai Guo and
  • Yi Zhang

Leishmaniasis is a neglected tropical disease that seriously influences global public health. Among all the parasitic diseases, leishmaniasis is the third most common cause of morbidity after malaria and schistosomiasis. Circular RNAs (circRNAs) are...

  • Case Report
  • Open Access
2 Citations
2,800 Views
5 Pages

Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant

  • Makoto Kondo,
  • Kohei Nishikawa,
  • Shohei Iida,
  • Takehisa Nakanishi,
  • Koji Habe and
  • Keiichi Yamanaka

Ten years ago, a 56-year-old woman with a history of IgA nephropathy who received a living-donor kidney transplant across ABO barriers was managed with immunosuppressive drugs. The kidney transplant donor was her father who had poor kidney function....

  • Article
  • Open Access
15 Citations
3,216 Views
9 Pages

Individual Risk Factors of Mycetoma Occurrence in Eastern Sennar Locality, Sennar State, Sudan: A Case-Control Study

  • Rowa Hassan,
  • Kebede Deribe,
  • Hope Simpson,
  • Stephen Bremner,
  • Osama Elhadi,
  • Mustafa Alnour,
  • Ahmed Hassan Fahal,
  • Melanie Newport and
  • Sahar Bakhiet

Mycetoma is a serious chronic subcutaneous granulomatous inflammatory disease that is endemic in tropical and subtropical regions, where it impacts profoundly on patients, families, and communities. Individual-level risk factors for the disease are p...

  • Article
  • Open Access
2 Citations
3,154 Views
8 Pages

Seropositivity of Leptospira spp. Antibodies among Febrile Patients Attending Outpatient Clinics in Mwanza, Tanzania: Should It Be Included in Routine Diagnosis?

  • Mariam M. Mirambo,
  • Vitus Silago,
  • Betrand Msemwa,
  • Helmut Nyawale,
  • Mlekwa G. Mgomi,
  • Julius M. Madeu,
  • William S. Nasson,
  • Gabriel Emmanuel,
  • John Moses and
  • Stephen E. Mshana
  • + 7 authors

Leptospirosis is a zoonotic neglected tropical disease with a worldwide distribution caused by the pathogenic spirochetes of the genus Leptospira. Despite being a widespread disease in tropical regions, it has never been considered in the routine dia...

  • Article
  • Open Access
6 Citations
4,496 Views
19 Pages

Optimal Validated Multi-Factorial Climate Change Risk Assessment for Adaptation Planning and Evaluation of Infectious Disease: A Case Study of Dengue Hemorrhagic Fever in Indonesia

  • Lia Faridah,
  • Djoko Santoso Abi Suroso,
  • Muhammad Suhardjono Fitriyanto,
  • Clarisa Dity Andari,
  • Isnan Fauzi,
  • Yonatan Kurniawan and
  • Kozo Watanabe

(1) Background: This paper will present an elaboration of the risk assessment methodology by Deutsche Gesellschaft für Internationale Zusammenarbeit GmbH (GIZ), Eurac Research and United Nations University Institute for Environment and Human Sec...

  • Article
  • Open Access
21 Citations
7,087 Views
14 Pages

The efforts towards effective control of the COVID-19 pandemic may affect the incidence of dengue. This study aimed to investigate temporal variations and spatial clusters of dengue in Thailand before and during the COVID-19 pandemic. Reported dengue...

  • Article
  • Open Access
8 Citations
3,899 Views
16 Pages

Epidemiological Profile of a Human Hepatitis E Virus Outbreak in 2018, Chattogram, Bangladesh

  • Kei Owada,
  • Joyantee Sarkar,
  • Md. Kaisar Rahman,
  • Shahneaz Ali Khan,
  • Ariful Islam,
  • Mohammad Mahmudul Hassan and
  • Ricardo J. Soares Magalhães

Hepatitis E virus (HEV) is a waterborne zoonotic disease that can result in a high fatality rate in pregnant women and infants. In 2018, a large HEV outbreak emerged in Chattogram, Bangladesh, resulting in 2800 cases and a significant public health r...

  • Article
  • Open Access
5 Citations
2,901 Views
16 Pages

Pathological Abnormalities Observed on Ultrasonography among Fishermen Associated with Male Genital Schistosomiasis (MGS) along the South Lake Malawi Shoreline in Mangochi District, Malawi

  • Sekeleghe A. Kayuni,
  • Mohammad H. Al-Harbi,
  • Peter Makaula,
  • Boniface Injesi,
  • Bright Mainga,
  • Fanuel Lampiao,
  • Lazarus Juziwelo,
  • E. James LaCourse and
  • J. Russell Stothard

Schistosome eggs cause granulomata and pathological abnormalities, detectable with non-invasive radiological techniques such as ultrasonography which could be useful in male genital schistosomiasis (MGS). As part of our novel MGS study among fisherme...

  • Systematic Review
  • Open Access
7 Citations
3,372 Views
15 Pages

Malaria and influenza are co-endemic in several geographical areas, and differentiation of their clinical features is difficult. The present study aimed to qualitatively and quantitatively analyze the prevalence and characteristics of malaria and inf...

  • Article
  • Open Access
8 Citations
3,582 Views
18 Pages

Assessment of Knowledge, Attitudes, and Practices towards Rift Valley Fever among Livestock Farmers in Selected Districts of Malawi

  • Henson Kainga,
  • James Mponela,
  • Linda Basikolo,
  • Marvin Collen Phonera,
  • Prudence Mpundu,
  • Muso Munyeme,
  • Edgar Simulundu and
  • Ngonda Saasa

Rift Valley fever (RVF) is a mosquito-borne viral zoonosis whose cases go unreported in endemic areas without active surveillance. Information on the knowledge, attitude, and practice of RVF among livestock farmers remains speculative in Malawi. A cr...

  • Systematic Review
  • Open Access
17 Citations
12,622 Views
17 Pages

A Systematic Scoping Review on Migrant Health Coverage in Thailand

  • Andrea König,
  • Jamila Nabieva,
  • Amin Manssouri,
  • Khatia Antia,
  • Peter Dambach,
  • Andreas Deckert,
  • Olaf Horstick,
  • Stefan Kohler and
  • Volker Winkler

(1) Background: Thailand is a major migrant receiving country and pioneer of migrant health policy in the ASEAN region. However, on the ground, coverage of migrants is faced with multiple barriers. (2) Objectives: We aim to scope and analyse the type...

  • Article
  • Open Access
3 Citations
2,371 Views
12 Pages

Surveillance Quality Indicators Highlight the Need for Improving Tuberculosis Diagnostics and Monitoring in a Hyperendemic Area of the Brazilian Amazon Region

  • Juliana Conceição Dias Garcez,
  • Daniele Melo Sardinha,
  • Emilyn Costa Conceição,
  • Gabriel Fazzi Costa,
  • Ianny Ferreira Raiol Sousa,
  • Cristal Ribeiro Mesquita,
  • Wellington Caldas do Carmo,
  • Yan Corra Rodrigues,
  • Luana Nepomuceno Gondim Costa Lima and
  • Karla Valéria Batista Lima

The city of Ananindeua, State of Pará, Brazil, is a hyperendemic area for tuberculosis (TB). The present study describes the population characteristics and epidemiological indicators of TB cases from Ananindeua, from 2018 to 2020. The TB cases...

  • Review
  • Open Access
37 Citations
7,950 Views
12 Pages

Both directly and indirectly transmitted infectious diseases in humans are spatial-related. Spatial dimensions include: distances between susceptible humans and the environments shared by people, contaminated materials, and infectious animal species....

  • Article
  • Open Access
2 Citations
3,160 Views
21 Pages

Rickettsia prowazekii, the bacterial cause of epidemic typhus in humans, proliferates mainly within the microvascular endothelial cells. Previous studies have shown that murine macrophage-like RAW264.7 cells are rapidly damaged if they are pretreated...

  • Article
  • Open Access
25 Citations
6,320 Views
10 Pages

Prognostic Indicators for the Early Prediction of Severe Dengue Infection: A Retrospective Study in a University Hospital in Thailand

  • Mayuna Srisuphanunt,
  • Palakorn Puttaruk,
  • Nateelak Kooltheat,
  • Gerd Katzenmeier and
  • Polrat Wilairatana

This study aimed to develop simple diagnostic guidelines which would be useful for the early detection of severe dengue infections. Retrospective data of patients with dengue infection were reviewed. Patients with diagnosed dengue infection were cate...

  • Article
  • Open Access
13 Citations
3,249 Views
13 Pages

Multicenter Study of the Risk Factors and Outcomes of Bloodstream Infections Caused by Carbapenem-Non-Susceptible Acinetobacter baumannii in Indonesia

  • Dewi Anggraini,
  • Dewi Santosaningsih,
  • Pepy Dwi Endraswari,
  • Novira Jasmin,
  • Fajri Marindra Siregar,
  • Usman Hadi and
  • Kuntaman Kuntaman

The prevalence of bacteremia caused by carbapenem-non-susceptible Acinetobacter baumannii (CNSAB) continues to increase, and it is associated with a high mortality rate. Early recognition of infection and mortality determinants risk factors is necess...

  • Article
  • Open Access
26 Citations
4,595 Views
10 Pages

West Nile Virus Lineage 2 Overwintering in Italy

  • Giulia Mencattelli,
  • Federica Iapaolo,
  • Andrea Polci,
  • Maurilia Marcacci,
  • Annapia Di Gennaro,
  • Liana Teodori,
  • Valentina Curini,
  • Valeria Di Lollo,
  • Barbara Secondini and
  • Giovanni Savini
  • + 7 authors

In January 2022, West Nile virus (WNV) lineage 2 (L2) was detected in an adult female goshawk rescued near Perugia in the region of Umbria (Italy). The animal showed neurological symptoms and died 15 days after its recovery in a wildlife rescue cente...

  • Review
  • Open Access
17 Citations
4,216 Views
11 Pages

Antimicrobial Stewardship in Tropical Infectious Diseases: Focusing on Dengue and Malaria

  • Ashley Siribhadra,
  • Thundon Ngamprasertchai,
  • Pinyo Rattanaumpawan,
  • Saranath Lawpoolsri,
  • Viravarn Luvira and
  • Punnee Pitisuttithum

Acute undifferentiated febrile illness (AUFI) is the presenting symptom of various tropical and infectious diseases. Viral infection is generally the most common cause of AUFI, accounting for 8–11.8% of cases; thus, antibiotics might be unneces...

  • Opinion
  • Open Access
4 Citations
2,407 Views
8 Pages

Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa

  • Luis Fonte,
  • Armando Acosta,
  • María E. Sarmiento,
  • Mohd Nor Norazmi,
  • María Ginori,
  • Yaxsier de Armas and
  • Enrique J. Calderón

There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have s...

  • Article
  • Open Access
10 Citations
7,604 Views
14 Pages

Hydroquinine is an organic compound that is closely related to quinine-derivative drugs and contains anti-malarial and anti-arrhythmia activities. It has been also found in abundance in some natural extracts that possess antibacterial properties. How...

  • Article
  • Open Access
11 Citations
3,204 Views
9 Pages

Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger

  • Ibrahima Issa,
  • Mahaman Moustapha Lamine,
  • Veronique Hubert,
  • Amadou Ilagouma,
  • Eric Adehossi,
  • Aboubacar Mahamadou,
  • Neil F. Lobo,
  • Demba Sarr,
  • Lisa M. Shollenberger and
  • Ibrahim Maman Laminou
  • + 2 authors

The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on that of artemisinin but also on that of partner molecules. This study aims to evaluate the prevalence of mutations in the Pfdhfr, Pfdhps, and Pfmdr1 genes from is...

  • Perspective
  • Open Access
23 Citations
4,324 Views
8 Pages

Long-Acting Injectable Drugs for HIV-1 Pre-Exposure Prophylaxis: Considerations for Africa

  • Enos Moyo,
  • Grant Murewanhema,
  • Godfrey Musuka and
  • Tafadzwa Dzinamarira

Sub-Saharan Africa carries the highest burden of HIV-1 and AIDS. About 39% of all new infections in the world in 2020 were in this region. Oral PrEP was found to be very effective in reducing the risk of HIV-1 transmission. However, its effectiveness...

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Trop. Med. Infect. Dis. - ISSN 2414-6366