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Article

Multicenter Study of the Risk Factors and Outcomes of Bloodstream Infections Caused by Carbapenem-Non-Susceptible Acinetobacter baumannii in Indonesia

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Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60115, Indonesia
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Department of Microbiology, Faculty of Medicine, Universitas Riau, Pekanbaru 28133, Indonesia
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Arifin Achmad General Hospital, Pekanbaru 28111, Indonesia
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Department of Clinical Microbiology, Faculty of Medicine, Universitas Brawijaya, Malang 65145, Indonesia
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Department of Clinical Microbiology, Dr. Saiful Anwar Hospital, Malang 65112, Indonesia
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Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya 60115, Indonesia
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Department of Medical Microbiology, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia
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Department of Biochemistry, Faculty of Medicine, Universitas Riau, Pekanbaru 28133, Indonesia
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Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60115, Indonesia
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Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia
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Author to whom correspondence should be addressed.
Academic Editors: Olga Perovic and Chakaya Muhwa Jeremiah
Trop. Med. Infect. Dis. 2022, 7(8), 161; https://doi.org/10.3390/tropicalmed7080161 (registering DOI)
Received: 27 June 2022 / Revised: 26 July 2022 / Accepted: 29 July 2022 / Published: 31 July 2022
(This article belongs to the Special Issue Global Burden of Antimicrobial Resistance (AMR))
The prevalence of bacteremia caused by carbapenem-non-susceptible Acinetobacter baumannii (CNSAB) continues to increase, and it is associated with a high mortality rate. Early recognition of infection and mortality determinants risk factors is necessary for adequate antibiotic administration. We aimed to determine the risk factors and outcomes of CNSAB bacteremia in Indonesia. A multicenter case-control study was conducted in three referral hospitals in Indonesia. Data were collected retrospectively from January 2019 to December 2021. Cases were defined as patients with bacteremia where CNSAB was isolated from the blood, while the controls were patients with bacteremia caused by carbapenem-susceptible A. baumannii (CSAB). Risk factors for bacteremia and mortality associated with CNSAB bacteremia were determined using univariates analysis (chi-squared and Student’s t-test or Mann–Whitney test) and multivariate logistic regression analysis. A total of 144 bacteremia patients were included, of whom 72 patients were for each case and control group. The final model of multivariate regression analysis revealed that bacteremia source from the lower respiratory tract (adjusted odds ratio (aOR): 3.24; 95% CI: 1.58–6.63, p = 0.001) and the use of central venous catheter (aOR: 2.56; 95% CI: 1.27–5.18; p = 0.009) were independent risk factors for CNSAB bacteremia. Charlson Comorbidity Index ≥ 4 (aOR: 28.56; 95% CI: 3.06–265.90, p = 0.003) and Pitt Bacteremia Score ≥ 4 (aOR: 6.44; 95% CI: 1.17–35.38; p = 0.032) were independent risk factors for mortality due to CNSAB bacteremia. Only high Pitt Bacteremia Score was an independent risk factor for mortality of CSAB bacteremia. In conclusion, we identified the risk factors for CNSAB-associated bacteremia and the risk factors for death, which are relevant for empiric therapy and infection control prevention, as well as prognosis evaluation of patients with bloodstream infections. View Full-Text
Keywords: Acinetobacter baumannii; bacteremia; carbapenem resistance; infectious disease; risk factor Acinetobacter baumannii; bacteremia; carbapenem resistance; infectious disease; risk factor
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MDPI and ACS Style

Anggraini, D.; Santosaningsih, D.; Endraswari, P.D.; Jasmin, N.; Siregar, F.M.; Hadi, U.; Kuntaman, K. Multicenter Study of the Risk Factors and Outcomes of Bloodstream Infections Caused by Carbapenem-Non-Susceptible Acinetobacter baumannii in Indonesia. Trop. Med. Infect. Dis. 2022, 7, 161. https://doi.org/10.3390/tropicalmed7080161

AMA Style

Anggraini D, Santosaningsih D, Endraswari PD, Jasmin N, Siregar FM, Hadi U, Kuntaman K. Multicenter Study of the Risk Factors and Outcomes of Bloodstream Infections Caused by Carbapenem-Non-Susceptible Acinetobacter baumannii in Indonesia. Tropical Medicine and Infectious Disease. 2022; 7(8):161. https://doi.org/10.3390/tropicalmed7080161

Chicago/Turabian Style

Anggraini, Dewi, Dewi Santosaningsih, Pepy Dwi Endraswari, Novira Jasmin, Fajri Marindra Siregar, Usman Hadi, and Kuntaman Kuntaman. 2022. "Multicenter Study of the Risk Factors and Outcomes of Bloodstream Infections Caused by Carbapenem-Non-Susceptible Acinetobacter baumannii in Indonesia" Tropical Medicine and Infectious Disease 7, no. 8: 161. https://doi.org/10.3390/tropicalmed7080161

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