Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa

Fonte, Luis; Acosta, Armando; Sarmiento, María E.; Norazmi, Mohd Nor; Ginori, María; de Armas, Yaxsier; Calderón, Enrique J.

doi:10.3390/tropicalmed7080157

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Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa

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Department of Parasitology, Institute of Tropical Medicine “Pedro Kourí”, Havana 11400, Cuba

School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia

Department of Teaching, Polyclinic “Plaza de la Revolución”, Havana 11300, Cuba

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Department of Clinical Microbiology Diagnostic, Hospital Center of Institute of Tropical Medicine “Pedro Kourí”, Havana 11400, Cuba

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Department of Pathology, Hospital Center of Institute of Tropical Medicine “Pedro Kourí”, Havana 11400, Cuba

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Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, 41013 Sevilla, Spain

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Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain

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Depatamento de Medicina, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain

Authors to whom correspondence should be addressed.

Academic Editors: Peter A. Leggat, John Frean and Lucille Blumberg

Trop. Med. Infect. Dis. 2022, 7(8), 157; https://doi.org/10.3390/tropicalmed7080157

Received: 27 June 2022 / Revised: 26 July 2022 / Accepted: 27 July 2022 / Published: 30 July 2022

(This article belongs to the Special Issue COVID-19: Current Status and Future Prospects)

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Abstract

There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection. View Full-Text

Keywords: pulmonary fibrosis; postacute COVID-19 syndrome; tuberculosis; helminth coinfection; sub-Saharan Africa

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MDPI and ACS Style

Fonte, L.; Acosta, A.; Sarmiento, M.E.; Norazmi, M.N.; Ginori, M.; de Armas, Y.; Calderón, E.J. Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa. Trop. Med. Infect. Dis. 2022, 7, 157. https://doi.org/10.3390/tropicalmed7080157

AMA Style

Fonte L, Acosta A, Sarmiento ME, Norazmi MN, Ginori M, de Armas Y, Calderón EJ. Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa. Tropical Medicine and Infectious Disease. 2022; 7(8):157. https://doi.org/10.3390/tropicalmed7080157

Chicago/Turabian Style

Fonte, Luis, Armando Acosta, María E. Sarmiento, Mohd Nor Norazmi, María Ginori, Yaxsier de Armas, and Enrique J. Calderón. 2022. "Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa" Tropical Medicine and Infectious Disease 7, no. 8: 157. https://doi.org/10.3390/tropicalmed7080157

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Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa

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