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Gels, Volume 11, Issue 7

July 2025 - 93 articles

Cover Story: The solid-state form of active pharmaceutical ingredients (APIs) critically impacts their functionality and manufacturability. Polymorphs, solvates, salts, and cocrystals exhibit unique physicochemical behaviours affecting solubility, stability, and bioavailability. Supramolecular gels, formed through the self-assembly of low-molecular-weight gelators (LMWGs), provide microenvironments and confined spaces favourable for controlling API crystallization through specific intermolecular interactions. This study explores the synergistic effects of FmocFF organogels and solvent selection on controlling the polymorphic outcomes of nilutamide, demonstrating gel-mediated crystallization as a broadly applicable platform technology for pharmaceutical solid form discovery under mild conditions. View this paper
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Articles (93)

  • Review
  • Open Access
3 Citations
3,275 Views
35 Pages

21 July 2025

Hydrogels have emerged as multifunctional biomaterials in cardiac surgery, offering promising solutions for myocardial regeneration, adhesion prevention, valve engineering, and localized drug and gene delivery. Their high water content, biocompatibil...

  • Review
  • Open Access
6 Citations
4,701 Views
29 Pages

Oleogels: Uses, Applications, and Potential in the Food Industry

  • Abraham A. Abe,
  • Iolinda Aiello,
  • Cesare Oliviero Rossi and
  • Paolino Caputo

21 July 2025

Oleogels are a subclass of organogels that present a healthier alternative to traditional saturated and trans solid fats in food products. The unique structure and composition that oleogels possess make them able to provide desirable sensory and text...

  • Article
  • Open Access
3 Citations
1,935 Views
32 Pages

Tumor Organoids Grown in Mixed-Composition Hydrogels Recapitulate the Plasticity of Pancreatic Cancers

  • Ioritz Sorzabal-Bellido,
  • Xabier Morales,
  • Iván Cortés-Domínguez,
  • Maider Esparza,
  • Lucía Grande,
  • Pedro Castillo,
  • Silvia Larumbe,
  • María Monteserín,
  • Shruthi Narayanan and
  • Mariano Ponz-Sarvise
  • + 2 authors

21 July 2025

Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit pronounced phenotypic plasticity, alternating between a treatment-sensitive classical phenotype and a more aggressive basal-like state associated with drug resistance and poor prognosis. The freq...

  • Article
  • Open Access
1 Citations
999 Views
14 Pages

21 July 2025

Yogurt fortified with polyphenols, as a new type of functional yogurt, exhibits high quality and good antioxidant activity. However, the effects of black garlic polyphenols (BGP) on the quality of solidified yogurt have been scarcely reported. Theref...

  • Article
  • Open Access
902 Views
17 Pages

A Poly(Acrylic Acid)-Based Hydrogel Crosslinked with Hydroxypropylcellulose as a Clarifying Agent in Nickel(II) Solutions

  • Rubén Octavio Muñoz-García,
  • Cesar Alexis Ruiz-Casillas,
  • Diego Alberto Lomelí-Rosales,
  • Jorge Alberto Cortés-Ortega,
  • Juan Carlos Sánchez-Díaz and
  • Luis Emilio Cruz-Barba

21 July 2025

Poly(acrylic acid) (PAA) and hydroxypropylcellulose (HPC) hydrogels were synthesized in the absence of a crosslinker. Chemical crosslinking between PAA and HPC was demonstrated through free radical polymerization by a precipitation reaction in aceton...

  • Review
  • Open Access
5 Citations
2,273 Views
31 Pages

Sustainable Hydrogels for Medical Applications: Biotechnological Innovations Supporting One Health

  • Silvia Romano,
  • Sorur Yazdanpanah,
  • Orsolina Petillo,
  • Raffaele Conte,
  • Fabrizia Sepe,
  • Gianfranco Peluso and
  • Anna Calarco

21 July 2025

The One Health paradigm—recognizing the interconnected health of humans, animals, and the environment—promotes the development of sustainable technologies that enhance human health while minimizing ecological impact. In this context, bio-...

  • Article
  • Open Access
1 Citations
737 Views
24 Pages

A Study on the Performance of Gel-Based Polyurethane Prepolymer/Ceramic Fiber Composite-Modified Asphalt

  • Tengteng Guo,
  • Xu Guo,
  • Yuanzhao Chen,
  • Chenze Fang,
  • Jingyu Yang,
  • Zhenxia Li,
  • Jiajie Feng,
  • Hao Huang,
  • Zhi Li and
  • Haijun Chen
  • + 1 author

20 July 2025

In order to solve various problems in traditional roads and extend their service life, new road materials have become a research hotspot. Polyurethane prepolymers (PUPs) and ceramic fibers (CFs), as materials with unique properties, were chosen due t...

  • Article
  • Open Access
1,635 Views
23 Pages

19 July 2025

Antimicrobial resistance in infected chronic wounds present significant risk of complications (e.g., amputations, fatalities). This research aimed to formulate honey-loaded hydrocolloid film comprising gelatin and HPMC, for potential treatment of inf...

  • Article
  • Open Access
1,245 Views
15 Pages

Rheological and Physical Properties of Mucilage Hydrogels from Cladodes of Opuntia ficus-indica: Comparative Study with Pectin

  • Federica Torregrossa,
  • Matteo Pollon,
  • Giorgia Liguori,
  • Francesco Gargano,
  • Donatella Albanese,
  • Francesca Malvano and
  • Luciano Cinquanta

19 July 2025

The physical and rheological properties of mucilage hydrogels derived from the cladodes of Opuntia ficus-indica (L. Mill) were compared with those of commercial pectin for potential applications in the food industry. All hydrogels—formulated by...

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Gels - ISSN 2310-2861