Biobased Gels for Drugs and Cells

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 429

Special Issue Editors


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Guest Editor
Nanotechnologies Unit, Luxembourg Institute of Science and Technology, L-4362 Esch Sur Alzette, Luxembourg
Interests: biomaterials; hydrogels; nanoparticles; microparticles; drug delivery; growth factor delivery; tissue engineering; bioprinting; antimicrobial coatings

E-Mail Website
Guest Editor
Nanotechnologies Unit, Luxembourg Institute of Science and Technology, L-4362 Esch Sur Alzette, Luxembourg
Interests: biomaterials; sustainable materials; antimicrobial coatings; delivery systems; hydrogels; nanoparticles; microparticles; formulation

Special Issue Information

Dear Colleagues,

Biobased gels are materials made from renewable biological resources, including plants, microbes, and organic debris. These gels are distinguished by their capacity to absorb water and swell, resulting in a hydrophilic network that may encapsulate a variety of molecules. Biobased gels have gained popularity due to their sustainability and prospective uses in a variety of sectors, including biomedicine. They offer significant advantages, including their ease of availability, biodegradability, low toxicity, and enhanced sustainability. Furthermore, these gels create an ideal environment for cell growth, making them particularly suitable for biomedical applications.

This Special Issue of Gels invites contributions exploring the synthesis, chemical modification, and characterization of biobased gels; cell–biobased hydrogel interactions; and various applications of biobased gels, particularly their potential in drug delivery and cell-related applications. We invite researchers to submit original research articles, perspectives, case studies, reviews, and critical reviews that highlight the use of biobased gels in drug delivery and cell-based therapies.

Dr. Resmi Anand
Dr. David Duday
Guest Editors

Manuscript Submission Information

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Keywords

  • biobased gel
  • drug delivery
  • cell encapsulation
  • biomaterials
  • cell–biomaterial interactions
  • chitosan
  • gelatin
  • alginate
  • lignin
  • cellulose

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Published Papers (1 paper)

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Research

22 pages, 13023 KiB  
Article
Liposomes-in-Gel as the Docetaxel Delivery for the Effective Treatment of Psoriasis by Inhibiting the Proliferation of Blood Vessels
by Ruoyang Jia, Yinyin Liu, Yifang Wu, Si Shen, Keang Cao, Xue Chen, Yang Wu, Wang Shen, Lu Wang, Bin Sun, Yongli Zhang and Hongmei Xia
Gels 2025, 11(4), 228; https://doi.org/10.3390/gels11040228 - 22 Mar 2025
Viewed by 260
Abstract
Psoriasis is a chronic skin disease caused by the interaction of multiple factors that leads to the abnormal growth of stratum corneum cells and has been called an immortal cancer. Docetaxel has been trialed for the treatment of psoriasis due to its superior [...] Read more.
Psoriasis is a chronic skin disease caused by the interaction of multiple factors that leads to the abnormal growth of stratum corneum cells and has been called an immortal cancer. Docetaxel has been trialed for the treatment of psoriasis due to its superior ability to induce apoptosis, but its insolubility and low bioavailability have hampered its development. Here, docetaxel (DTX)-loaded liposomes-in-gel (DTX-LP-G) as the transdermal delivery was investigated to the treatment of psoriasis via modulating the IL6-HIF-1α-VEGF axis. The results demonstrated that DTX-LP-G cumulatively released a much higher amount of drug into the skin than that from DTX-loaded liposomes (DTX-LPs) and DTX-loaded gel (DTX-G). DTX-LP-G was also the most efficient in scavenging hydrogen peroxide free radicals in vitro. In a mouse model of psoriasis, DTX-LP-G acted as a preliminary therapeutic agent for psoriasis in terms of apparent evaluation, splenomegaly, suppression of MDA content in skin tissue, and down-regulated the expression of IL6, HIF-1α, and VEGF to control the proliferation of vessels, except for a less pronounced effect on the stratum corneum. In addition, enrichment analysis can speculate that DTX also treated psoriasis by resisting the production of keratin-forming cells. Full article
(This article belongs to the Special Issue Biobased Gels for Drugs and Cells)
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