2026 April - 111 articles
Recent evidence links lens epithelial cell (LEC) dysfunction and cellular senescence—an irreversible cell cycle arrest with a pro-inflammatory secretory phenotype—to age-related cataract (ARC) progression. This systematic review synthesiz...
Accurate feature selection is critical for machine learning in medical diagnosis, yet conventional methods often fail to capture complex non-linear relationships in biomedical data. This study introduces an advanced feature selection approach that in...
Retinal detachments following blunt ocular trauma are challenging to predict due to the complex and transient biomechanical responses of the globe. This study combines an in vitro weight-drop experiment and finite element analysis (FEA) to evaluate t...
EEG-based classification of mental disorders has increasingly relied on deep learning models, which are computationally intensive and difficult to interpret, limiting reproducibility and clinical deployment in resource-constrained or cross-site setti...
Background: The Global Positioning System (GPS) and wearable monitoring technologies are increasingly applied in sport science to quantify training load; however, data from female cross-country skiers in nations with emerging competitive programs rem...
Lupus nephritis (LN) stands out as one of the most critical complications of systemic lupus erythematosus (SLE), affecting almost 60% of the patient population. Even though more therapies have been made available for LN in the past decade, clinical o...
Early and accurate detection of skin cancer is critical for reducing mortality rates, particularly for malignant melanoma. Automated analysis of dermoscopic images has gained significant attention due to its potential to support clinical diagnosis an...
This study investigated whether tongue motor loss induced by bilateral transection of the hypoglossal nerves (Hx) alters anxiety- and/or depression-like behaviors in rats and examined the associated neuroendocrine changes. Male Sprague–Dawley r...
Peripheral facial palsy (PFP) causes pronounced facial asymmetry and functional impairment, highlighting the need for reliable, objective assessment. This study presents a novel, fully automated, reference-free method for quantifying facial symmetry...
Biofilm formation on denture base materials may contribute to oral diseases such as denture stomatitis and therefore represents an important factor in prosthodontic treatment. This in vitro study investigated biofilm formation on dental prosthetic ma...
Work-related shoulder disorders during overhead assembly represent a persistent occupational challenge. We evaluated a quasi-direct-drive (QDD) active upper-limb exoskeleton during simulated overhead work, providing simultaneous metabolic, electromyo...
Ventricular septal defect (VSD) occluders commonly rely on permanent nitinol frameworks, which may contribute to long-term mechanical mismatch and late complications. Here, we developed a tissue-compliant composite membrane by embedding a 3D-printed...
This paper evaluates the advantages of overlapping microwave ablation (OMWA) for the personalized treatment of large tumors, providing quantitative and technical references for conformal tumor eradication. A three-dimensional numerical model coupled...
Craniosynostosis is the premature fusion of skull bones due to loss of stem/progenitor cells located in non-mineralized tissue between growing cranial bones of infants. We generated scaffolds from a biodegradable biomaterial with small interconnected...
Background: Gait analysis offers a comprehensive assessment of locomotion and postural control, which are often altered in individuals with spinal deformities. After validating a stereophotogrammetric protocol for whole-body kinematics, including spi...
The anterior labral–ligamentous complex (ALLC), formed by the integration of the anterior inferior glenohumeral ligament and anterior glenoid labrum, plays a critical role in shoulder stability and represents a potential target for regenerative...
Background: Autologous serum eye drops (ASEDs) are produced without preservatives and need to be stored at 2–8 °C while in use. This study aims to analyze the behavior of specific bacteria and fungi in the case of contamination during the u...
Neopterin, a low-molecular-weight pteridine, is a biomarker of pro-inflammatory immune activity. Its levels rise in viral infections, transplant rejection, autoimmune, cardiovascular, and neurodegenerative diseases, and cancer. In healthy human serum...
Biological reactions are widely applied in processes such as bioenergy production, raw material manufacturing, and resource recovery from waste. As a main reactor type, the stirred-tank bioreactor exhibits prominent advantages of high mixing efficien...
Background: This study examined spherical and aspherical orthokeratology (Ortho-K) lens designs for myopia control and corneal optical stability over the course of a year. Methods: This retrospective analysis used data from a previously conducted two...
Cognitive impairment persists in people with HIV (PWH) despite effective combination antiretroviral therapy, possibly as a result of persistent alterations in white matter microstructural abnormalities in the brain. Noninvasive tensor-valued diffusio...
Background: Deep gluteal syndrome (DGS) has traditionally been attributed to sciatic nerve entrapment within the deep gluteal space. However, increasing evidence suggests that enthesopathy and soft tissue pathology of the short external rotators may...
Background: Despite the clinical significance of circumcision, traditional suturing is frequently compromised by intraoperative bleeding and lengthy recovery periods. While high-frequency electric welding (HFEW) presents a compelling alternative, its...
Recent studies on EEG-based automated depression detection have primarily depended on complex deep learning models. While these methods improve classification performance, their practical application is limited by high computational complexity, chall...
Fish waste disposal poses significant environmental and economic challenges, limiting sustainability in the marine food industry. Hence, sustainable valorization strategies are needed to enhance resource recovery while minimizing waste. As an approac...
Anionic polysaccharides are sugars with a negative charge. Common examples include alginic acid, hyaluronic acid, pectin, chondroitin sulfate, and heparin. These molecules are bioactive and widely used in medicine, food, and cosmetics. On their own,...
Low-frequency pulsed magnetic fields (LFPMFs) are a recently developed modality for managing pain and promoting wound healing. The term LFPMF is used to describe low-intensity fields in wound and tissue studies, and is referred to as magnetic periphe...
The present study demonstrates that the corrosion behavior of dental cobalt–chromium (Co–Cr) alloys is strongly influenced by the interaction between microstructure, manufacturing technique, and oral chemical environment. A comparative in...
Selectively modulating specific brain-rhythm bands with physical stimuli helps both to reveal neural mechanisms and to provide non-pharmacological treatment avenues for brain disorders. This study proposes and implements a multi-channel transcranial...
Recently, photoacoustic (PA) imaging has made a significant impact on biomedical imaging, providing detailed information on tissue structure and function by integrating optical and acoustic techniques. PA imaging can provide functional information at...
This study addresses the challenge of the difficult identification of organ structures in the standard sections of fetal abdominal ultrasounds. A deep learning-based multi-task model named SEG-FAUSP was developed to segment the core anatomical struct...
Radiation-induced bone injury, characterized by oxidative stress damage and impaired osteogenesis, lacks effective treatments. Exosome-based therapies have recently emerged as a safe and effective modality for radiation damage, and their functional c...
To design novel heart valve bioprostheses, it is extremely important to predict leaflet failure and fatigue for 10–20 years, as the aortic valve opens and closes approximately 40 million times per year. Most studies devoted to aortic valve leaf...
(1) Background: Postoperative anterior cruciate ligament reconstruction often involves quadriceps strength asymmetry, leading to abnormal lower limb biomechanics during running. While previous studies have examined the relationship between isokinetic...
Background: Artificial intelligence-based computer-aided detection (AI-CAD) systems are increasingly being used in endovascular practice to support time-sensitive detection, triage and prioritization tasks in imaging and procedural workflows. Despite...
Ultrasound imaging is a crucial tool for guiding radiation therapy, particularly for cancers such as pancreatic cancer, where tumors exhibit respiration-induced motion. While flexible ultrasound transducers offer improved anatomical conformity and re...
Irreversible anterior segment blindness with preserved retinal integrity (e.g., dense corneal opacity) remains a major clinical challenge because effective sight-restoring options are limited. Here, we describe an intraocular micro-light-emitting dio...
Lung cancer is one of the most common causes of death from cancer around the world, and catching it early through computed tomography (CT) scans can drastically improve survival. However, automated classification of pulmonary nodule candidates is har...
Low-field magnetic stimulation (LFMS) has been proposed as a non-invasive approach for modulating cortical oscillations through electromagnetic coupling. Frequency-aligned enhancement of alpha-band activity is of interest due to its association with...
Background: The treatment of perianal fistulas remains challenging, with low healing and high recurrence rates. Autologous adipose-derived regenerative therapies and platelet-rich plasma (PRP) have emerged as adjuncts to surgical intervention for cry...
Critical-sized bone defects pose significant challenges in orthopedic surgery. The introduction of 3D printing technology in bone grafting offers a promising solution by creating customized grafts that mimic the natural bone structure. This study aim...
Low-count positron emission tomography (PET) is inherently affected by Poisson-dominated noise, which degrades image contrast, structural delineation, and quantitative reliability. This study systematically evaluated residual learning-based deep neur...
Background: The phase of electroencephalogram (EEG) signals critically influences cortical reactivity to external inputs. Phase-dependent effects and their sensitivity to stimulation intensity have been observed at suprathreshold levels, while subthr...
Radiation-associated soft tissue fibrosis represents a progressive structural remodeling process characterized by extracellular matrix accumulation, septal thickening, and reduced tissue compliance, which complicates reconstructive interventions. Rel...
Background: Hallux valgus (HV) is a complex forefoot deformity influenced by interactions between osseous alignment, ligamentous restraint, and muscle–tendon forces. While the biomechanical role of ligament laxity and bone geometry has been ext...
This study examines the influence of photobioreactor (PBR) configuration on the cultivation performance of Chlorococcum sp. using aquaculture wastewater as the growth medium. Four systems were compared: horizontal without aeration (H-Plain), horizont...
Technologies for home movement rehabilitation after stroke are rapidly expanding. However, for consumers, the number and nature of available products are unclear, and the information provided by device manufacturers varies widely. To understand this...
Background: Severe jaw atrophy limits traditional endosseous implantation, often necessitating complex regenerative procedures. Advances in digital planning and 3D printing have reintroduced custom-made subperiosteal (juxta-osseous) implants as a via...
Accurate assessment of hypoxia-related fetal risk during labour is essential for improving perinatal outcomes while avoiding unnecessary operative interventions. Although deep learning has shown promise for automated fetal risk assessment, most exist...
Telemedicine, driven by the Internet of Things (IoT) and wireless connectivity, is essential for managing cardiovascular diseases, where hypertension remains the primary risk factor. In preclinical research, rabbits are superior biological models com...
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