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Bioengineering
Special Issues
Recent Advancements in Wound Healing and Repair
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Recent Advancements in Wound Healing and Repair

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 10218

Special Issue Editor

Dr. Wing Sum Siu

E-Mail Website
Guest Editor
Institute of Chinese Medicine, Chinese University of Hong Kong, Hong Kong 999077, China
Interests: bone; mesenchymal stem cell; osteoporosis

Special Issue Information

Dear Colleagues,

Recent advancements in wound healing and repair have introduced innovative approaches, paving the way for faster and more effective recovery. These developments encompass the use of bioactive dressings, growth factors, stem cell therapy, and tissue engineering to enhance tissue regeneration and minimize scarring. Emphasizing personalized medicine, researchers are crafting tailored treatment strategies that address the unique needs of each patient.

Key research areas in this field include identifying biomarkers for wound healing, developing novel therapies, and investigating the microbiome's role in the healing process. Additionally, advancements in imaging technologies and computer modeling are offering new insights into the mechanisms of wound healing, ultimately improving treatment outcomes.

Dr. Wing Sum Siu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • wound repair
  • bioactive dressings
  • stem cell therapy
  • tissue engineering
  • chronic wounds
  • biomaterials
  • imaging technologies
  • nanoparticles
  • antibacterial properties
  • biopolymers
  • wound dressing
  • cell and molecular biology

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Published Papers (5 papers)

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Research

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17 pages, 1676 KB  
Article
Promoting Re-Epithelialization in Diabetic Foot Wounds Using Integrative Therapeutic Approaches
by Lucia Bubulac, Iuliana-Raluca Gheorghe, Elisabeth Ungureanu, Claudia Florina Bogdan-Andreescu, Cristina-Crenguța Albu, Consuela-Mădălina Gheorghe, Ovidiu Mușat, Irina Anca Eremia, Cristina Aura Panea and Alexandru Burcea
Bioengineering 2025, 12(10), 1053; https://doi.org/10.3390/bioengineering12101053 - 29 Sep 2025
Abstract
Background: Diabetes mellitus is a heterogeneous chronic disease with an increasing global prevalence. In Romania, 11.6% of the population is affected, yet only 6.46% receive treatment. Among diabetic patients, 15–25% develop skin lesions that may progress to ulceration and necrosis, significantly impairing [...] Read more.
Background: Diabetes mellitus is a heterogeneous chronic disease with an increasing global prevalence. In Romania, 11.6% of the population is affected, yet only 6.46% receive treatment. Among diabetic patients, 15–25% develop skin lesions that may progress to ulceration and necrosis, significantly impairing quality of life and increasing the risk of complications. Methods: We conducted a prospective study including 28 patients (14 in the control group and 14 in the intervention group) with type I or II diabetes and chronic ulcers of the calf or foot (>4 cm2). The control group received standard therapy with debridement, dressings, antibiotics when indicated, and local and systemic ozone therapy. The intervention group was treated with an Integrative Therapeutic Protocol combining ozone therapy, pulsed electromagnetic field therapy (PEMF), colon hydrotherapy with probiotic supplementation, and an anti-inflammatory alkaline diet. Wound healing (reduction in ulcer surface area) was the primary endpoint; secondary endpoints included changes in glycemia and inflammatory biomarkers. Results: After 8 weeks, the intervention group achieved 86.2% re-epithelialization versus 58.2% in controls (p < 0.01). Significant improvements were also observed in blood glucose level (−38%), HbA1c (−25%), CRP (−26%), and fibrinogen (−28%) relative to baseline, with differences versus controls reaching statistical significance. Conclusions: The Integrative Therapeutic Protocol accelerated wound healing and improved glycemic and inflammatory profiles compared with ozone therapy alone. Although an alkaline diet was recommended, adherence and its specific contribution were not objectively monitored; therefore, this component should be interpreted with caution. Full article
(This article belongs to the Special Issue Recent Advancements in Wound Healing and Repair)
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13 pages, 2844 KB  
Article
Electrospun Nanofibers in Wound Healing: Real-World Evaluation of Spincare™ Technology
by Borza Ioan Lucian, Cornel Dragos Cheregi, Horgos Maur Sebastian, Bodog Ruxandra-Florina, Laura Maghiar, Brihan Ilarie, Huniadi Anca, Liliana Sachelarie and Sandor Mircea-Ioan
Bioengineering 2025, 12(5), 500; https://doi.org/10.3390/bioengineering12050500 - 9 May 2025
Cited by 2 | Viewed by 1896
Abstract
(1) Background: The increasing prevalence of chronic wounds, along with their significant healthcare burden, underscores the need for innovative and technologically advanced treatment strategies. Electrospun nanofiber-based dressings have emerged as a promising solution, mimicking the skin’s extracellular matrix and promoting efficient tissue regeneration. [...] Read more.
(1) Background: The increasing prevalence of chronic wounds, along with their significant healthcare burden, underscores the need for innovative and technologically advanced treatment strategies. Electrospun nanofiber-based dressings have emerged as a promising solution, mimicking the skin’s extracellular matrix and promoting efficient tissue regeneration. (2) Methods: This real-world, 10-month observational study conducted at CF Oradea Clinical Hospital enrolled 60 patients with chronic, non-healing wounds. Patients were randomly assigned to two groups: 30 received standard vacuum-assisted wound therapy, serving as the control group. In contrast, 30 received treatment with Spincare™, a novel electrospinning technology that delivers a personalized nanofiber matrix directly onto the wound. Symptom progression, pain levels, and treatment adaptation were assessed using standardized questionnaires. (3) Results: Patients treated with Spincare™ demonstrated faster wound healing, especially in the epithelialization phase, with significantly improved pain scores and quality of life measures. The technology was well-tolerated and reduced the need for repeated hospitalizations. (4) Conclusions: Spincare™ represents an effective and innovative electrospun nanofiber solution for chronic wound management, accelerating healing and enhancing patient outcomes, particularly in individuals with underlying conditions such as peripheral arterial disease. These findings support the integration of electrospinning-based therapies in modern wound care protocols. Full article
(This article belongs to the Special Issue Recent Advancements in Wound Healing and Repair)
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12 pages, 2825 KB  
Article
Comparison of Tissue-Engineered Dermis with Micronized Adipose Tissue and Artificial Dermis for Facial Reconstruction Following Skin Cancer Resection
by Kyu-Il Lee, Won-Seok Song, Seung-Kyu Han, Kyung-Chul Moon, Seong-Ho Jeong and Eun-Sang Dhong
Bioengineering 2025, 12(2), 145; https://doi.org/10.3390/bioengineering12020145 - 3 Feb 2025
Viewed by 1640
Abstract
Our group has previously demonstrated that tissue-engineered dermis containing cultured fibroblasts or adipose-derived stromal vascular fraction cells is superior to artificial dermis in terms of scar quality for covering facial defects. However, using these cells for clinical applications requires Food and Drug Administration [...] Read more.
Our group has previously demonstrated that tissue-engineered dermis containing cultured fibroblasts or adipose-derived stromal vascular fraction cells is superior to artificial dermis in terms of scar quality for covering facial defects. However, using these cells for clinical applications requires Food and Drug Administration approval and involves complex procedures for cell culture or isolation. This retrospective study aimed to compare effects of tissue-engineered dermis containing micronized adipose tissue (MAT) and artificial dermis for facial reconstruction. Tissue-engineered dermis consisting of MAT seeded on artificial dermis was applied in 30 cases, while artificial dermis without MAT was grafted in 35 cases. Healing time and severities of scar contraction, color mismatch, and landmark distortion at one year after healing were evaluated. Wounds in the tissue-engineered dermis group re-epithelialized in 30.0 ± 4.3 days compared to 34.3 ± 5.4 days in the artificial dermis group (p < 0.05). The average dE2000 score in color mismatch analysis was 4.9 ± 1.7 in the tissue-engineered dermis group and 5.1 ± 1.7 in the artificial dermis group (p = 0.57). The extent of scar contraction was 16.2 ± 12.3% in the tissue-engineered dermis group and 23.2 ± 12.8% in the artificial dermis group (p < 0.05). The average severity grade of landmark distortion was 0.20 ± 0.50 in the tissue-engineered dermis group and 0.50 ± 0.71 in the artificial dermis group (p < 0.05). These findings indicate that tissue-engineered dermis grafts containing MAT are superior to artificial dermis grafts for facial reconstruction in terms of healing time, scar contraction, and landmark distortion severity. However, there was no significant difference in color mismatch between the two groups. Full article
(This article belongs to the Special Issue Recent Advancements in Wound Healing and Repair)
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Review

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16 pages, 1010 KB  
Review
Applications of Adipose Tissue Micrografts (ATM) and Dermis Micrografts (DMG) in Wound Healing: A Scoping Review of Clinical Studies
by Konstantinos Zapsalis, Orestis Ioannidis, Elissavet Anestiadou, Maria Pantelidou, Konstantinos Siozos, Christos Xylas, Georgios Gemousakakis, Angeliki Cheva, Chryssa Bekiari, Antonia Loukousia, Savvas Symeonidis, Stefanos Bitsianis, Manousos-Georgios Pramateftakis, Efstathios Kotidis, Ioannis Mantzoros and Stamatios Angelopoulos
Bioengineering 2025, 12(9), 948; https://doi.org/10.3390/bioengineering12090948 - 31 Aug 2025
Viewed by 718
Abstract
Adipose tissue micrografts (ATM) and dermis micrografts (DMG) have emerged as promising autologous therapies in regenerative wound care, leveraging mechanically disaggregated cell–matrix constructs to modulate the wound microenvironment and promote tissue repair. This scoping review systematically analyzed clinical studies investigating ATMs and DMGs [...] Read more.
Adipose tissue micrografts (ATM) and dermis micrografts (DMG) have emerged as promising autologous therapies in regenerative wound care, leveraging mechanically disaggregated cell–matrix constructs to modulate the wound microenvironment and promote tissue repair. This scoping review systematically analyzed clinical studies investigating ATMs and DMGs in acute and chronic wounds. Eight studies, comprising randomized controlled trials, observational studies, and case series, were identified, involving diverse wound types such as burns, ulcers, surgical dehiscence, and posttraumatic defects. All interventions utilized mechanical disaggregation (Rigenera® system) to produce micrografts, which were applied via perilesional injection, scaffold-assisted delivery, or topical administration. Outcomes consistently demonstrated accelerated re-epithelialization, enhanced angiogenesis, improved scar remodeling, and low complication rates. In select studies, micrografts were combined with platelet-rich fibrin or stromal vascular fraction, suggesting potential synergistic effects. While one randomized trial showed superior healing outcomes with DMGs over collagen scaffolds, others yielded mixed results, likely reflecting heterogeneity in methodology and outcome measures. Overall, the available clinical evidence supports the safety, feasibility, and biological activity of micrograft-based therapies. However, larger, standardized, and mechanistically driven studies are required to validate their efficacy and define optimal protocols across wound etiologies. Full article
(This article belongs to the Special Issue Recent Advancements in Wound Healing and Repair)
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16 pages, 581 KB  
Review
Review on Current Advancements in Facilitation of Burn Wound Healing
by Wing Sum Siu, Hui Ma and Ping Chung Leung
Bioengineering 2025, 12(4), 428; https://doi.org/10.3390/bioengineering12040428 - 18 Apr 2025
Cited by 2 | Viewed by 4516
Abstract
Burns are common injuries, but their treatment remains challenging due to the complex nature of the wound healing process. Burn wounds are classified into different categories based on their size and depth. Treatment modalities vary significantly across these categories, primarily focusing on the [...] Read more.
Burns are common injuries, but their treatment remains challenging due to the complex nature of the wound healing process. Burn wounds are classified into different categories based on their size and depth. Treatment modalities vary significantly across these categories, primarily focusing on the inflammation, proliferation, and remodeling phases of burn wound healing. This review summarizes current research on various approaches to enhance burn wound recovery, including advancements in wound dressings, the use of platelet-rich plasma, stem cells, their soluble factors primarily in the form of secretomes or extracellular vesicles, and nano-technologies. Additionally, advancements in modernized traditional medicine are discussed to give a new aspect for burn wound healing. This review also summarizes the barriers in translating bench research to clinical practice in burn wound treatment methods. For an effective translation, researchers and industrial partners should work more closely, while regulatory bodies should streamline the approval procedure. Full article
(This article belongs to the Special Issue Recent Advancements in Wound Healing and Repair)
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