Artificial Intelligence for Computer-Aided Detection in Biomedical Applications, 2nd Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 208

Special Issue Editor


E-Mail Website
Guest Editor
Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, China
Interests: bioinformatics; imaging informatics; clinical decision support
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of Artificial Intelligence (AI) in Computer-Aided Detection (CAD) has led to significant advancements in biomedical applications. AI encompasses the development of intelligent machines that can simulate human intelligence, enabling them to learn from large datasets and make predictions or decisions based on complex patterns and algorithms. CAD systems, on the other hand, aid healthcare professionals in the identification and analysis of various medical conditions, utilizing computer algorithms to improve accuracy and efficiency.

This Special Issue explores the integration of AI techniques within CAD systems to revolutionize biomedical applications. It aims to present work from researchers and practitioners from multidisciplinary backgrounds and discuss the latest advancements, challenges, and future prospects in this rapidly growing field.

Topics of interest within this Special Issue include, but are not limited to, the development and evaluation of novel AI algorithms for CAD in biomedical imaging, the application of machine learning techniques to enhance detection and diagnosis accuracy, the utilization of deep learning architectures in CAD systems, the integration of AI technologies into medical decision making, the impact of AI on CAD-assisted diagnosis and treatment planning, and ethical considerations surrounding the use of AI in biomedical applications.

The papers contributed to this Special Issue will provide valuable insights into the potential of AI-powered CAD systems in biomedical domains, paving the way for improved detection, diagnosis, prognosis, and personalized treatment strategies. Researchers and practitioners across fields such as computer science, biomedical engineering, radiology, medical imaging, and bioinformatics are encouraged to submit their original research, reviews, and case studies.

Dr. Lawrence Chan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial intelligence
  • computer-aided detection
  • CAD
  • biomedical applications
  • biomedical engineering
  • radiology
  • medical imaging
  • bioinformatics
  • deep learning
  • machine learning
  • disease diagnosis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 1612 KB  
Article
Multi-Phasic CECT Peritumoral Radiomics Predict Treatment Response to Bevacizumab-Based Chemotherapy in RAS-Mutated Colorectal Liver Metastases
by Feiyan Jiao, Yiming Liu, Zhongshun Tang, Shuai Han, Tian Li, Yuanpeng Zhang, Peihua Liu, Guodong Huang, Hao Li, Yongping Zheng, Zhou Li and Sai-Kit Lam
Bioengineering 2026, 13(2), 137; https://doi.org/10.3390/bioengineering13020137 (registering DOI) - 24 Jan 2026
Abstract
This study aims to investigate the predictive value of pre-treatment multi-phasic contrast-enhanced computed tomography (CECT) radiomic features for treatment resistance in patients with rat sarcoma virus (RAS)-mutated colorectal liver metastases (CRLMs) receiving bevacizumab-based chemotherapy. Seventy-three samples with RAS-mutated CRLMs receiving bevacizumab-combined chemotherapy regimens [...] Read more.
This study aims to investigate the predictive value of pre-treatment multi-phasic contrast-enhanced computed tomography (CECT) radiomic features for treatment resistance in patients with rat sarcoma virus (RAS)-mutated colorectal liver metastases (CRLMs) receiving bevacizumab-based chemotherapy. Seventy-three samples with RAS-mutated CRLMs receiving bevacizumab-combined chemotherapy regimens were evaluated. Radiomic features were extracted from arterial phase (AP), portal venous phase (PVP), AP-PVP subtraction image, and Delta phase (DeltaP, calculated as AP-to-PVP ratio) images. Three groups of radiomics features were extracted for each phase, including peritumor, core tumor, and whole-tumor regions. For each of the four phases, a two-sided independent Mann–Whitney U test with the Bonferroni correction and K-means clustering was applied to the remnant features for each phase. Subsequently, the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was then applied for further feature selection. Six machine learning algorithms were then used for model development and validated on the independent testing cohort. Results showed peritumoral radiomic features and features derived from Laplacian of Gaussian (LoG) filtered images were dominant in all the compared machine learning algorithms; NB models yielded the best-performing prediction (Avg. training AUC: 0.731, Avg. testing AUC: 0.717) when combining all features from different phases of CECT images. This study demonstrates that peritumoral radiomic features and LoG-filtered pre-treatment multi-phasic CECT images were more predictive of treatment response to bevacizumab-based chemotherapy in RAS-mutated CRLMs compared to core tumor features. Full article
Show Figures

Graphical abstract

Back to TopTop