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Bioengineering
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Biomaterials for Cartilage and Bone Tissue Engineering: Third Edition
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Biomaterials for Cartilage and Bone Tissue Engineering: Third Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1869

Editor

Dr. Francesca Scalera

E-Mail Website
Guest Editor
CNR NANOTEC—Institute of Nanotechnology, Campus Ecotekne, Via Monteroni, 73100 Lecce, Italy
Interests: biomaterials; bone; cartilage; hydrogel; bioinks; tissue engineering; bioprinting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the realm of clinical orthopedics, the successful regeneration of weight-bearing bone defects and critical-sized cartilage defects remains challenging; however, a valid solution to this is tissue engineering. This Special Issue is therefore dedicated to recent developments in biomaterials for scaffolds that repair and regenerate tissues such as bones, cartilage, tendons, meniscus, and ligaments, from synthesis to production methods. The scope of this Special Issue includes, but is not limited to, cell–biomaterial surface interactions and bone cell mechanotransduction.

I hope that this Special Issue will provide the scientific community with novel insights into this ever-expanding field of research. Scientific contributions to this Special Issue may be submitted in the form of original articles or reviews. I look forward to receiving your manuscripts.

Dr. Francesca Scalera
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cartilage
  • bone
  • scaffolds
  • stem cells
  • tissue engineering

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Published Papers (2 papers)

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Research

29 pages, 5475 KB  
Article
Synergistic Effects of Calcium Phosphate Biomaterials Combined with Honey on Osteochondral Regeneration: A Qualitative Study in an Animal Model
by Pavol Rusnák, Katarína Vdoviaková, Ján Danko, Lenka Krešáková, Filip Humeník, Ľubomír Medvecký, Mária Giretová, Radoslava Štulajterová, Kristína Čurgali, Štefan Tóth, Jozef Bíreš, Filip Korim, Zuzana Čriepoková, Peter Očenáš, Roman Totkovič and Tatiana Špakovská
Bioengineering 2026, 13(5), 585; https://doi.org/10.3390/bioengineering13050585 - 20 May 2026
Viewed by 564
Abstract
Osteochondral defects of the knee represent a significant clinical challenge due to the limited regenerative capacity of the osteochondral unit. The aim of this study was to evaluate the therapeutic potential of calcium phosphate-based biomaterials combined with honey in a porcine model. Osteochondral [...] Read more.
Osteochondral defects of the knee represent a significant clinical challenge due to the limited regenerative capacity of the osteochondral unit. The aim of this study was to evaluate the therapeutic potential of calcium phosphate-based biomaterials combined with honey in a porcine model. Osteochondral defects were surgically induced and treated with a custom-prepared composite material. Tissue regeneration was assessed using integrated macroscopic and microscopic evaluation, supported by multimodal imaging techniques. The outcomes were compared with both a spontaneous healing group and a control site with native cartilage. The composite biomaterial significantly enhanced osteochondral regeneration, with results comparable to healthy cartilage. Notably, improved structural organization and more advanced healing responses were observed in the treated group compared to spontaneous healing. The beneficial effects are attributed to the anti-inflammatory, antimicrobial, antioxidant, and immunomodulatory properties of honey, which may enhance the regenerative microenvironment and support tissue repair. These findings highlight the potential of calcium phosphate-based biomaterials combined with honey as a promising strategy for osteochondral defect treatment, improving structural, biological, and biomechanical aspects of healing. Full article
(This article belongs to the Special Issue Biomaterials for Cartilage and Bone Tissue Engineering: Third Edition)
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14 pages, 3573 KB  
Article
Initial In Vivo Analyses of Small Pore Polymer Scaffolds for Creation of an Artificial Cranial Stem Cell Niche
by Elizabeth Soulas, W. Benton Swanson, Hwa Kyung Nam, Kelsey Gruber, Yuji Mishina and Nan E. Hatch
Bioengineering 2026, 13(4), 420; https://doi.org/10.3390/bioengineering13040420 - 2 Apr 2026
Viewed by 658
Abstract
Craniosynostosis is the premature fusion of skull bones due to loss of stem/progenitor cells located in non-mineralized tissue between growing cranial bones of infants. We generated scaffolds from a biodegradable biomaterial with small interconnected pores (125–250 μm diameter), previously shown to maintain stemness [...] Read more.
Craniosynostosis is the premature fusion of skull bones due to loss of stem/progenitor cells located in non-mineralized tissue between growing cranial bones of infants. We generated scaffolds from a biodegradable biomaterial with small interconnected pores (125–250 μm diameter), previously shown to maintain stemness of a mesenchymal cell population, to further develop a method for the creation of an artificial cranial bone stem cell niche. Polymer scaffolds of consistent pore size were fabricated using a molecular-sieved sugar sphere casting technique with poly-l-lactic acid. A rectangular surgical defect within the parietal bone of juvenile mice was created. The three groups included sham animals with surgery but no scaffold, experimental animals with surgery plus an implanted cell-free scaffold, and experimental animals with surgery plus an implanted bone mesenchymal cell-seeded scaffold. Healing at the surgical site was evaluated at 4 and 12 weeks after surgery by micro-CT and histology. Surgical site bone volume fraction and bone mineral density were significantly greater at twelve than four weeks in the sham group but not in either of the scaffold groups. At twelve weeks, the surgical site bone volume fraction and bone mineral density were significantly lower in the cell-seeded scaffold as compared to the sham animal group. At twelve weeks, the anterior and middle cranial vault widths were significantly greater in the cell-seeded scaffold as compared to the sham animal group on the surgery side of the skulls. Less mineralization was evident within the cell-seeded than the cell-free scaffolds by histology. Based on these findings, scaffolds of sufficiently small pore size seeded with autologous bone mesenchymal stem cells could function as an artificial cranial stem cell niche to inhibit surgical-site mineralization and promote cranial growth. Full article
(This article belongs to the Special Issue Biomaterials for Cartilage and Bone Tissue Engineering: Third Edition)
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