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Bioengineering
Special Issues
Advances in Wound Healing and Regenerative Medicine
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Advances in Wound Healing and Regenerative Medicine

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1271

Editors

Dr. Sik Namgoong

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Guest Editor
Department of Plastic Surgery, Korea University College of Medicine, Seoul 08308, Republic of Korea
Interests: wound healing; regenerative medicine; microsurgery; stem cell therapy; tissue engineering; diabetic ulcers
Prof. Dr. Shang-You Yang

E-Mail Website
Guest Editor
1. Department of Biological Sciences, Wichita State University, Wichita, KS 67260, USA
2. Department of Orthopaedic Surgery, University of Kansas School of Medicine-Wichita, Wichita, KS 67214, USA
Interests: polymeric biomaterials; wound healing; bone graft; biocompatibility
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to explore emerging perspectives in wound healing and regenerative medicine, bridging clinical needs and basic science innovations. We invite original research articles, reviews, and short communications focusing on novel strategies, materials, cellular therapies, and translational models that enhance tissue repair, angiogenesis, and functional regeneration. Topics may include, but are not limited to, tissue-engineered scaffolds, stem cell-based interventions, extracellular matrix remodeling, immune modulation, and the integration of microsurgery in regenerative approaches.

Wound healing and regenerative medicine represent rapidly evolving fields that aim to restore tissue integrity and function following injury or disease. Traditional wound management focuses on minimizing infection and promoting closure, but recent advances emphasize regenerative strategies that enhance tissue repair and reduce scarring. Emerging technologies—such as bioactive scaffolds, stem cell therapies, growth factor delivery systems, and gene editing—hold great promise for improving healing outcomes, particularly in chronic wounds, burns, and diabetic ulcers. Additionally, innovations in biomaterials, 3D bioprinting, and immunomodulation are reshaping therapeutic approaches by mimicking native tissue environments and accelerating regeneration.

We look forward to your contributions that will advance both the scientific community’s understanding and clinical applications in this rapidly evolving field.

Dr. Sik Namgoong
Prof. Dr. Shang-You Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • regenerative medicine
  • stem cells
  • tissue engineering
  • ECM
  • diabetic ulcers
  • microsurgical reconstruction
  • bioactive materials
  • cell-based therapy
  • translational models
  • DNA methylation
  • CRISPR technology
  • nanomedicine

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Published Papers (1 paper)

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22 pages, 381 KB  
Systematic Review
Intraoperative Autologous Adipose-Derived Therapies and PRP as Add-On in the Surgical Treatment of Cryptoglandular and Crohn’s Disease-Related Perianal Fistula—A Systematic Review
by Merel M. Verweij, Mustafa Uguten, Michiel T. J. Bak, Caroline D. M. Witjes, Annemarie C. de Vries, Ilse Molendijk, Joris A. van Dongen and Oddeke van Ruler
Bioengineering 2026, 13(4), 393; https://doi.org/10.3390/bioengineering13040393 - 28 Mar 2026
Viewed by 727
Abstract
Background: The treatment of perianal fistulas remains challenging, with low healing and high recurrence rates. Autologous adipose-derived regenerative therapies and platelet-rich plasma (PRP) have emerged as adjuncts to surgical intervention for cryptoglandular and Crohn’s disease (CD)-related perianal fistulas (PAF). This systematic review evaluates [...] Read more.
Background: The treatment of perianal fistulas remains challenging, with low healing and high recurrence rates. Autologous adipose-derived regenerative therapies and platelet-rich plasma (PRP) have emerged as adjuncts to surgical intervention for cryptoglandular and Crohn’s disease (CD)-related perianal fistulas (PAF). This systematic review evaluates the outcomes of these therapies as an add-on to surgical intervention. Methods: A systematic search was conducted in several online databases up to December 2025. Studies with ≥10 patients reporting on the use of intraoperative autologous adipose-derived therapies and/or PRP for the treatment of cryptoglandular or CD-related PAF, and clinical healing rates, were included. Other outcomes comprised radiologic healing (as defined in the study), recurrence rates and complications. The study quality was assessed with the Effective Public Health Practice Tool. Results: In total, 28 studies on individual cases were included (n = 1017 patients, range 10–219) (17 in cryptoglandular PAF, 8 in CD-related PAF and 3 in both entities). A total of 57% of the studies were rated low quality. In cryptoglandular PAF, reported healing rates with adipose-derived therapies ranged from 50% to 90% across studies of low to good methodological quality. For PRP, three of the four randomized trials demonstrated no superiority over standard care. In CD-related PAF, healing rates after treatment with adipose-derived therapies ranged from 40% to 80%. For PRP, three studies, of which two were low quality, reported highly variable healing rates (33–80%). Radiologic healing, reported in 10 studies, ranged from 38 to 76% in cryptoglandular and 33–75% in CD-related PAF. Recurrence rates remained <17% for adipose-derived therapies and <31% following treatment with PRP. Major complications occurred in <15% of the patients. Conclusions: High heterogeneity with regard to fistula complexities, outcome definitions and surgical method was observed in the available studies on autologous add-on therapies. This hinders an overall effectiveness analysis. The promising healing rates, low recurrence rates after healing and low complication rates warrant high-quality trials. Full article
(This article belongs to the Special Issue Advances in Wound Healing and Regenerative Medicine)
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