Machine Learning and Artificial Intelligence for Biomedical Applications, 4th Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 826

Special Issue Editors


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Guest Editor
Department of Economics, University of Foggia, 71122 Foggia, Italy
Interests: game theory and applications; finance; neural networks and applications; time-series models; behavioral finance; sustainability; multicriteria decision making; differential geometry; health economics
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Special Issue Information

Dear Colleagues,

In recent years, an increase in the accuracy of information technology has led to several scientific breakthroughs. The first researchers to benefit from improved hardware components have been the developers of artificial intelligence algorithms, who have been able to apply these algorithms in several scientific fields, including biomedicine. Biomedicine is a field of medicine that applies the principles of biology and natural sciences to the development of relevant technologies for healthcare. The combination of artificial intelligence algorithms and biomedicine has led to many applications, such as image analysis of human organs using magnetic resonance imaging (MRI); DNA/RNA sequencing and protein structure interactions and predictions; and analysis of different biosignals via methods involving electroencephalograms (EEGs), electromyography (EMGs), and electrocardiograms (ECGs).

In this context, machine learning algorithms enable us to learn from observational data and construct highly accurate artificial intelligence models to support the physician. However, obtaining models with high accuracy may not be enough, as AI-based biomedical decisions must be understandable to the physician. Therefore, it is necessary to equip machine learning methods with explainability capacity, leading to explainable artificial intelligence techniques that enable the physician to understand the decisions suggested by the models they use.

This is the fourth volume of our Special Issue series "Machine Learning and Artificial Intelligence for Biomedical Applications". Please feel free to download and read the first three volumes via the following links:
https://www.mdpi.com/journal/bioengineering/special_issues/39708P1H4A
https://www.mdpi.com/journal/bioengineering/special_issues/483SCWZ885
https://www.mdpi.com/journal/bioengineering/special_issues/3182T0HN52

Dr. Crescenzio Gallo
Prof. Dr. Luca Grilli
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial intelligence models
  • biomedicine
  • machine learning methods
  • artificial neural networks
  • precision medicine
  • personalized health care

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Published Papers (1 paper)

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Research

16 pages, 1022 KB  
Article
An Effective and Interpretable EEG-Based Depression Recognition Method Using Hybrid Feature Selection
by Xin Xu, Qiuyun Fan, Shanjing Ju and Ruoyu Du
Bioengineering 2026, 13(4), 410; https://doi.org/10.3390/bioengineering13040410 - 31 Mar 2026
Viewed by 522
Abstract
Recent studies on EEG-based automated depression detection have primarily depended on complex deep learning models. While these methods improve classification performance, their practical application is limited by high computational complexity, challenging training processes, and poor interpretability. This paper proposes an efficient method for [...] Read more.
Recent studies on EEG-based automated depression detection have primarily depended on complex deep learning models. While these methods improve classification performance, their practical application is limited by high computational complexity, challenging training processes, and poor interpretability. This paper proposes an efficient method for depression recognition, which extracts multi-domain features from preprocessed EEG signals and selects the most discriminative feature subset by integrating the rapid preliminary screening capability of RankSearch with the interactive optimization ability of the Genetic Algorithm (GA). Our approach first eliminates redundant features efficiently through RankSearch, then deeply explores inter-feature relationships via GA, significantly enhancing classification performance while maintaining feature-level interpretability. Using the optimized feature subset, we evaluate performance with multiple machine learning classifiers (Decision Tree, KNN, Random Forest, SVM, XGBoost). Experiments on the public HUSM dataset demonstrate superior performance under rigorous cross-validation (accuracy = 95.08%, sensitivity = 95.99%, specificity = 94.30%, F1-score = 95%, AUC = 0.9514), with feature importance analysis further confirming interpretability. Compared to existing models, our method achieves lower computational complexity and higher clinical practicality, offering a more efficient technical solution for objective depression diagnosis. Full article
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