Multiscale Mechanics of Biomaterials

Dear Colleagues,

Biomaterials always show structural variations across multiple length scales, which further determine their mechanical behavior. A comprehensive understanding of the multiscale mechanics of biomaterials is essential for revealing their complex behavior, understanding the pathological mechanisms of specific diseases, and facilitating biomaterial fabrication and tissue engineering. Mechanical behaviors at different scales have been characterized using various experimental methods, including atomic force microscopy, nanoindentation, and uniaxial or biaxial tension/compression testing. However, the connections between different length scales—especially how mechanical behavior at the microscale affects the global or structural behavior of tissues—still require more investigation. The development of advanced testing techniques at the micro and nano scales, along with progress in computational modeling and machine learning methods, offers new opportunities to explore and better understand the complex mechanical behavior of biomaterials across scales. These approaches help reveal the structure-function relationships that are often difficult to capture through experiments alone. This Special Issue aims to attract original research papers focusing on mechanical characterization of biomaterials across multiple length scales using innovative experimental, simulation, and machine learning techniques, as well as their application in biomedical engineering, such as early diagnosis of diseases, biomaterial fabrication, and tissue engineering.

Dr. Pengfei Dong
Prof. Dr. Linxia Gu
Dr. Yi Hua
Guest Editors

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