Multiscale Mechanics of Biomaterials

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 781

Special Issue Editors


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Guest Editor
Department of Biomedical Engineering and Science, Florida Institute of Technology, Melbourne, FL, USA
Interests: multiscale biomechanics; image-based modeling; cardiovascular diseases; orthodontic design; machine learning/AI for biomechanics

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Guest Editor
Department of Biomedical Engineering and Science, Florida Institute of Technology, Melbourne, FL, USA
Interests: stent optimization; abusive head trauma; ocular injury; mutiscale materials characterization; simulation-driven AI/ML
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biomedical Engineering, University of Mississippi, University, MS, USA
Interests: biomechanics; finite element modeling; glaucoma; traumatic brain injury
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials always show structural variations across multiple length scales, which further determine their mechanical behavior. A comprehensive understanding of the multiscale mechanics of biomaterials is essential for revealing their complex behavior, understanding the pathological mechanisms of specific diseases, and facilitating biomaterial fabrication and tissue engineering. Mechanical behaviors at different scales have been characterized using various experimental methods, including atomic force microscopy, nanoindentation, and uniaxial or biaxial tension/compression testing. However, the connections between different length scales—especially how mechanical behavior at the microscale affects the global or structural behavior of tissues—still require more investigation. The development of advanced testing techniques at the micro and nano scales, along with progress in computational modeling and machine learning methods, offers new opportunities to explore and better understand the complex mechanical behavior of biomaterials across scales. These approaches help reveal the structure-function relationships that are often difficult to capture through experiments alone. This Special Issue aims to attract original research papers focusing on mechanical characterization of biomaterials across multiple length scales using innovative experimental, simulation, and machine learning techniques, as well as their application in biomedical engineering, such as early diagnosis of diseases, biomaterial fabrication, and tissue engineering.

Dr. Pengfei Dong
Prof. Dr. Linxia Gu
Dr. Yi Hua
Guest Editors

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Keywords

  • multiscale mechanics
  • atomic force microscopy
  • machine learning
  • biomaterials
  • finite element method

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Published Papers (1 paper)

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Research

12 pages, 1607 KB  
Article
Spatiotemporal Mapping of Biomechanical Stress Predicts Region-Specific Retinal Injury in a Murine Model of Blunt Ocular Trauma
by Jianing Wang, Ji An Lee, Yingnan Zhai, Kourosh Shahraki, Pengfei Dong, Donny W. Suh and Linxia Gu
Bioengineering 2026, 13(4), 431; https://doi.org/10.3390/bioengineering13040431 - 7 Apr 2026
Viewed by 442
Abstract
Retinal detachments following blunt ocular trauma are challenging to predict due to the complex and transient biomechanical responses of the globe. This study combines an in vitro weight-drop experiment and finite element analysis (FEA) to evaluate the mechanical pathways leading to traumatic retinal [...] Read more.
Retinal detachments following blunt ocular trauma are challenging to predict due to the complex and transient biomechanical responses of the globe. This study combines an in vitro weight-drop experiment and finite element analysis (FEA) to evaluate the mechanical pathways leading to traumatic retinal detachment and to predict the spatial likelihood of injury. In the in vitro model, a cylindrical weight was impacted onto freshly enucleated mouse eyes (16 weeks old) supported on a rigid metal plate. Following impact, the eyes were sectioned and stained using hematoxylin and eosin (H&E) for histological assessment. A finite element model of a mouse eye, including the cornea, sclera, lens, zonule, vitreous body, aqueous humor, and retina, was reconstructed from the histological section and used to simulate the whole sequence of compression and rebound following the blunt impact. The simulation demonstrated that the lens retained a high momentum. It generated an alternating compressive (up to −6.57 × 10−3 MPa) and tensile (up to 1.62 × 10−3 MPa) radial stress at the posterior pole and sustained compressive stress at the peripheral region (up to −3.12 × 10−3 MPa) and tensile-compressive stress variation at the equatorial region of the retina. In addition, the regions experiencing tensile stress overlapped with the region exhibiting retinal detachment in the in vitro experiment. These findings highlight the spatiotemporal mapping of biomechanical stress to predict traumatic retinal detachment following blunt impact and provide an understanding of early biomechanical response following ocular trauma. Full article
(This article belongs to the Special Issue Multiscale Mechanics of Biomaterials)
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