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Chemosensors, Volume 13, Issue 8

2025 August - 48 articles

Cover Story: The global increase in diabetes cases, especially in low-income countries, has accelerated advancements in glucose-sensing technologies. Traditional sensors, though highly specific, are often costly and prone to instability. As a cost-effective and portable solution, microfluidic paper-based analytical devices (µPADs) utilize cellulose paper for fluid transport and are easily fabricated through methods like wax printing, making them ideal for point-of-care testing (PoCT) use in resource-constrained settings. Current innovations include enzymatic, hybrid, and non-enzymatic systems, with artificial intelligence and machine learning (AI/ML) further enhancing their efficiency and accessibility. View this paper
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Articles (48)

  • Review
  • Open Access
1,689 Views
28 Pages

Nanoporous Layer Integration for the Fabrication of ISFET and Related Transistor-Based Biosensors

  • Cristian Ravariu,
  • Elena Manea,
  • Cătălin Pârvulescu and
  • Gabriel Dima

More and more chemosensors and biosensors are turning to electronic transistors, as they are ideal transducers, precise in current response, miniaturized in size and capable of providing sub-picomolar detection limits. Among these devices, ISFET tran...

  • Article
  • Open Access
805 Views
14 Pages

Three fluorophenyl-substituted cyclometalated Ir(III) complexes (Ir1Ir3) have been synthesized by changing the position of the fluorine atom. All complexes exhibit distinct aggregation-induced phosphorescence emission (AIPE) characteristics in...

  • Article
  • Open Access
1,197 Views
13 Pages

The analysis of historical pigments contributes significantly to understanding the materials and techniques used in artworks and in preserving cultural heritage. This work introduces a novel methodology for classifying historical pigments combining X...

  • Review
  • Open Access
1 Citations
2,304 Views
16 Pages

This review examines the emerging role of manganese-based nanoparticles (Mn-NPs) in detecting heavy metal pollutants in environmental matrices. Heavy metals such as cadmium, lead, zinc, and copper pose serious environmental and health concerns due to...

  • Review
  • Open Access
2 Citations
3,833 Views
37 Pages

Benzene, a well-established human carcinogen and major industrial pollutant, poses significant health risks through occupational exposure due to its no-threshold effect, leading to multi-system damage involving the hematopoietic, nervous, and immune...

  • Article
  • Open Access
2 Citations
1,315 Views
14 Pages

Breathprint-Based Endotyping of COPD and Bronchiectasis COPD Overlap Using Electronic Nose Technology: A Prospective Observational Study

  • Vitaliano Nicola Quaranta,
  • Mariafrancesca Grimaldi,
  • Silvano Dragonieri,
  • Alessio Marinelli,
  • Andrea Portacci,
  • Maria Rosaria Vulpi and
  • Giovanna Elisiana Carpagnano

Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome with multiple clinical and inflammatory phenotypes. The coexistence of bronchiectasis, known as bronchiectasis–COPD overlap (BCO), identifies a subgroup with increased mor...

  • Article
  • Open Access
823 Views
13 Pages

Addressing the lack of dynamic monitoring methods for assessing the combined toxicity of mixed pesticides, this study developed a fluorescent probe, CCHL, specifically responsive to leucine aminopeptidase (LAP). The probe utilized Cy7-COOH (CCH) as t...

  • Article
  • Open Access
1,239 Views
19 Pages

Fast, spark-free detection of hydrogen leaks is indispensable for large-scale hydrogen deployment, yet electronic sensors remain power-intensive and prone to cross-talk. Optical schemes based on surface plasmons enable remote read-out, but single-met...

  • Article
  • Open Access
2 Citations
1,483 Views
13 Pages

A Biosensor Based on Commercial R-SAW for Rapid and Sensitive Detection of E. coli

  • Li Lv,
  • Zhuoer Xu,
  • Yicheng Zhou,
  • Jayne Wu,
  • Xueyong Zhang and
  • Haochen Qi

Escherichia coli (E. coli) is one of the most common strains that produce Shiga toxin, which can contaminate food and water, causing serious diseases and even endangering life. Therefore, the detection of E. coli is crucial for protecting public heal...

  • Article
  • Open Access
4 Citations
2,395 Views
21 Pages

Development and Application of Analytical Methods to Quantitate Nitrite in Excipients and Secondary Amines in Metformin API at Trace Levels Using Liquid Chromatography–Tandem Mass Spectrometry

  • Ilyoung Ahn,
  • Soyeon Lee,
  • Min Ji Jung,
  • Yeongeun Jeong,
  • Ji Yun Kim,
  • Minjeong Kim,
  • Pan Soon Kim,
  • Byung-Hoon Lee,
  • Yong Moon Lee and
  • Kyung Hun Son

Nitrosamine impurities have provoked numerous global medicine recalls due to their possible presence during drug manufacturing or storage. Regarding formulation of nitrosamine impurities, a key risk involves reactions between nitrosating agents (nitr...

  • Article
  • Open Access
933 Views
13 Pages

Trichlorfon, an organophosphorus pesticide widely used in agriculture and other fields, poses a severe risk to both food safety and human health. We developed a photonic crystal film sensing platform for detecting trichlorfon, a hazardous organophosp...

  • Article
  • Open Access
1,033 Views
18 Pages

This study investigates the potential of transient potentiometric signals generated by an array of ion-selective electrodes (ISEs) as the basis for a potentiometric electronic tongue capable of identifying and quantifying a range of inorganic and org...

  • Article
  • Open Access
1,407 Views
14 Pages

Electrochemically Activated Screen-Printed Graphene Electrochemical Sensor for Daidzein Determination in Edible Peanut Oils

  • Matias Alberto Cárdenas,
  • Rubén Darío Alaníz,
  • Robert D. Crapnell,
  • Sebastian Noel Robledo,
  • Héctor Fernández,
  • Fernando Javier Arévalo,
  • Adrian Marcelo Granero,
  • Craig E. Banks and
  • Gastón Darío Pierini

In this work, we designed a novel and simple electrochemical approach for the determination of daidzein antioxidant (Dz) in peanut oil samples. The Dz determination was based on anodic stripping linear voltammetry using screen-printed graphene electr...

  • Article
  • Open Access
1,400 Views
18 Pages

This study presents a portable gas sensor system that achieves high performance while minimizing power consumption and production costs for biomedical applications. The proposed system integrates a low-power readout integrated circuit (ROIC) capable...

  • Review
  • Open Access
1,542 Views
25 Pages

Harnessing the Potential of Nanotechnology for Liquid Biopsy of Cancer

  • Prince Allawadhi,
  • Vishakha Singh,
  • Sachin Allwadhi,
  • Anil Kumar Banothu,
  • Kala Kumar Bharani and
  • Amit Khurana

Liquid biopsy offers dynamic and noninvasive analysis of cellular biomarkers, thereby presenting enormous potential for early detection of cancer, cancer staging, prediction of relapse, real-time examination of therapeutic efficacy, perception of the...

  • Editorial
  • Open Access
1,135 Views
6 Pages

Chemical sensors and biosensors, as a critical interdisciplinary field bridging analytical chemistry and chemical/biomedical engineering, have achieved remarkable progress over recent decades [...]

  • Review
  • Open Access
3 Citations
7,272 Views
34 Pages

Numerous research projects on biosensors have been conducted, and a substantial number of academic studies and conference papers on biosensors are published annually. However, only a few biosensors have been commercialized. In this review, we took bl...

  • Review
  • Open Access
2,857 Views
35 Pages

Sensors and Biosensors as Viable Alternatives in the Determination of Contaminants in Corn: A Review (2021–2025)

  • Lívia M. P. Teodoro,
  • Letícia R. G. Lacerda,
  • Penelopy Costa e Santos,
  • Lucas F. Ferreira and
  • Diego L. Franco

Corn is one of the most produced cereals in the world and exerts a significant economic impact on a billion-dollar market. It is utilized globally as a food source for humans and livestock and as a source of carbohydrates, fiber, vitamins, minerals,...

  • Review
  • Open Access
3 Citations
1,664 Views
20 Pages

Resistive-Based Nanostructured CeO2 Gas Sensors: A Review

  • Mahmoud Torkamani Cheriani,
  • Ali Mirzaei and
  • Jae-Hun Kim

Air pollution and the emission of toxic gases represent a critical global concern, posing significant threats to human health and environmental stability. Resistive gas sensors are widely employed to detect toxic gases, owing to their cost-effectiven...

  • Article
  • Open Access
4 Citations
1,190 Views
16 Pages

Silicon Nanowires Sensor Modified with Cu (II) Phthalocyanine Derivative for Phosphate Monitoring

  • Milaine Jebali,
  • Zina Fredj,
  • Sameh Daboussi,
  • Mounir Ben Ali and
  • Mohamed Hassen

This study reports the development of a highly sensitive electrochemical sensor for phosphate ion detection, utilizing silicon nanowires (SiNWs) as the transducing elements and a novel copper (II) phthalocyanine-acrylate polymer adduct (Cu (II) Pc-PA...

  • Article
  • Open Access
1 Citations
1,521 Views
13 Pages

Development and Validation of an HPLC-MS/MS Method for Quantifying Deoxynivalenol and Zearalenone Biomarkers in Dried Porcine Blood Spots

  • Isadora Fabris Laber,
  • Cristina Tonial Simões,
  • Cristiane Rosa da Silva,
  • Luara Medianeira de Lima Schlösser,
  • Janine Alves Sarturi,
  • Luriane Medianeira Carossi Leal,
  • Renê Valmor Theobald and
  • Carlos Augusto Mallmann

Deoxynivalenol (DON) and zearalenone (ZEN) are common mycotoxins in animal feeds, and their metabolites can be detected in exposed animals. Traditional methods focus on mycotoxin detection in feed, whereas biomarker-based approaches are used for eval...

  • Article
  • Open Access
1 Citations
1,385 Views
16 Pages

Taiwan accounts for 90% of the total oolong tea production and enjoys a good global reputation for its quality. In recent years, oolong tea from neighboring countries has been imported into Taiwan and sold as Taiwanese oolong at high prices. This stu...

  • Article
  • Open Access
1 Citations
1,096 Views
12 Pages

A High-Precision Hydrogen Sensor Array Based on Pt-Modified SnO2 for Suppressing Humidity and Oxygen Interference

  • Meile Wu,
  • Zhixin Wu,
  • Hefei Chen,
  • Zhanyu Wu,
  • Peng Zhang,
  • Lin Qi,
  • He Zhang and
  • Xiaoshi Jin

Humidity and oxygen have significant impacts on the accuracy of hydrogen detection, especially for metal oxide semiconductor sensors at room temperature. Addressing this challenge, this study employs a screen-printed 1 × 2 resistive sensor arra...

  • Review
  • Open Access
1 Citations
3,284 Views
16 Pages

Recently, the incidence of diabetes has increased across all socioeconomic groups, with a notable increase in developing countries. Although advances in medical devices have enhanced healthcare accessibility, these benefits remain largely out of reac...

  • Article
  • Open Access
2,634 Views
16 Pages

Amino acids (AAs), a type of nitrogen-based organic compounds in the atmosphere, are directly and indirectly related to climate change, and as their link to allergic diseases becomes more known, the need for quantitative analysis of ultrafine dust (P...

  • Article
  • Open Access
1 Citations
933 Views
14 Pages

A pH-Responsive Liquid Crystal-Based Sensing Platform for the Detection of Biothiols

  • Xianghao Meng,
  • Ronghua Zhang,
  • Xinfeng Dong,
  • Zhongxing Wang and
  • Li Yu

Biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), are crucial for physiological regulation and their imbalance poses severe health risks. Herein, we developed a pH-responsive liquid crystal (LC)-based sensing platform fo...

  • Article
  • Open Access
714 Views
15 Pages

Application of a Low-Cost Electronic Nose to Differentiate Between Soils Polluted by Standard and Biodegradable Hydraulic Oils

  • Piotr Borowik,
  • Przemysław Pluta,
  • Miłosz Tkaczyk,
  • Krzysztof Sztabkowski,
  • Rafał Tarakowski and
  • Tomasz Oszako

Detection of soil pollution by petroleum products is necessary to remedy threats to economic and human health. Pollution by hydraulic oil often occurs through leaks from forestry machinery such as harvesters. Electronic noses equipped with gas sensor...

  • Article
  • Open Access
1 Citations
1,069 Views
16 Pages

Optimized SILAR Growth of Vertically Aligned ZnO Nanorods for Low-Temperature Acetone Detection

  • Brahim Ydir,
  • Amine Ajdour,
  • Mouad Soumane,
  • Iulia Antohe,
  • Gabriel Socol,
  • Luiza-Izabela Toderascu,
  • Driss Saadaoui,
  • Imade Choulli,
  • Radouane Leghrib and
  • Houda Lahlou

Vertically oriented morphologies of the semiconducting metal oxide (SMO) surface provide a simple and effective means of enhancing gas sensor performance. We successfully synthesized explicitly aligned ZnO nanorods using a simple automated SILAR tech...

  • Article
  • Open Access
1 Citations
961 Views
17 Pages

A novel near-infrared (NIR) squaraine-based chemosensor, SQ-68, has been designed and synthesized for the sensitive and selective detection of Cu2+ and Ag+ ions, offering a compact solution for multi-analyte sensing. SQ-68 demonstrates high selectivi...

  • Article
  • Open Access
1 Citations
1,054 Views
14 Pages

Mid-Infrared Spectroscopy with Variable Selection for the Rapid Quantification of Amylose Content in Starch

  • Jingyue Qiao,
  • Hongwei Wang,
  • Jianing Bai,
  • Yimin Liu,
  • Xiaocheng Liu,
  • Yanyan Zhang and
  • Leiming Yuan

Amylose content significantly influences the technological, quality, and nutritional properties of starchy foods. This study developed a rapid, non-destructive method to quantify amylose content in starch using mid-infrared (MIR) spectroscopy combine...

  • Review
  • Open Access
2 Citations
9,287 Views
29 Pages

Methods for GC/MS Analysis of the Most Commonly Seized Drugs of Abuse and Their Metabolites in Biological Samples

  • Ivan Kojić,
  • Violeta M. Đurović,
  • Yulia A. Smyatskaya,
  • Nemanja Brkljača,
  • Angi E. Skhvediani,
  • Andrey V. Vasin,
  • Ksenija Stojanović and
  • Saša D. Đurović

Gas chromatography with mass spectrometry (GC-MS) is a common analytical technique used for identifying and quantifying drugs of abuse, as well as their metabolites, extracted from biological samples. Depending on the properties of the analyzed compo...

  • Review
  • Open Access
13 Citations
4,762 Views
37 Pages

Environmental monitoring plays a key role in understanding and mitigating the effects of climate change, pollution, and resource mismanagement. The growth of printed sensor technologies offers an innovative approach to addressing these challenges due...

  • Article
  • Open Access
1 Citations
2,648 Views
13 Pages

Morphine is an opioid extracted from the poppy plant and highly effective for moderate to severe pain management. Development of techniques to measure the concentration of this highly addictive drug in various matrices is very important. This work wa...

  • Article
  • Open Access
1,530 Views
13 Pages

A Long-Wavelength Fluorescent Probe for Efficient Dual-Color Imaging of Boronic-Acid-Containing Agents in Living Cells

  • Shinya Takada,
  • Honghuo Du,
  • Naoya Kondo,
  • Anna Miyazaki,
  • Fumiko Hara,
  • Shizuyo Horiyama,
  • Takashi Temma and
  • Masayori Hagimori

In boron neutron capture therapy (BNCT), the intracellular localization and concentration of boron-10 atoms significantly influence therapeutic efficacy. Although various boronic-acid-targeted fluorescent probes have been developed to evaluate BNCT a...

  • Article
  • Open Access
4 Citations
1,020 Views
15 Pages

Application of Graphite Electrodes Prepared from Waste Zinc−Carbon Batteries for Electrochemical Detection of Xanthine

  • Milan B. Radovanović,
  • Ana T. Simonović,
  • Marija B. Petrović Mihajlović,
  • Žaklina Z. Tasić and
  • Milan M. Antonijević

Waste from zinc−carbon batteries poses a serious environmental protection problem. One of the main problems is also the reliable and rapid determination of some compounds that may be present in food and beverages consumed worldwide. This study...

  • Article
  • Open Access
1,168 Views
15 Pages

In this study, we propose a bidirectional chemical sensor platform based on a reconfigurable ion-sensitive field-effect transistor (R-ISFET) architecture. The device incorporates Ni-silicide Schottky barrier source/drain (S/D) contacts, enabling ambi...

  • Review
  • Open Access
9 Citations
4,211 Views
21 Pages

A Review of Fluorescent pH Probes: Ratiometric Strategies, Extreme pH Sensing, and Multifunctional Utility

  • Weiqiao Xu,
  • Zhenting Ma,
  • Qixin Tian,
  • Yuanqing Chen,
  • Qiumei Jiang and
  • Liang Fan

pH is a critical parameter requiring precise monitoring across scientific, industrial, and biological domains. Fluorescent pH probes offer a powerful alternative to traditional methods (e.g., electrodes, indicators), overcoming limitations in miniatu...

  • Article
  • Open Access
719 Views
18 Pages

This work aims to solve the problem of product quality fluctuations caused by batch-to-batch variations in the adsorption capacity of activated carbon during the production of traditional Chinese medicine (TCM) injections. In this work, Shenqi Fuzhen...

  • Review
  • Open Access
3 Citations
2,526 Views
33 Pages

The increasing demand for rapid, sensitive, and eco-friendly methods for the detection of trace heavy metals in environmental samples, attributed to their serious threats to health and the environment, has spurred considerable interest in the develop...

  • Article
  • Open Access
980 Views
13 Pages

Radical TTM-DMODPA for Ascorbic Acid Non-Catalytic Visual Detection

  • Qingmei Zhong,
  • Huixiang Zong,
  • Xiaohui Xie,
  • Xiaomei Rong and
  • Chuan Yan

Ascorbic acid (AA) plays a multidimensional role in human physiological and pathological processes, and the detection of its urinary concentration facilitates the diagnosis of metabolic or kidney diseases. Visual detection exhibits minimal reliance o...

  • Article
  • Open Access
1,258 Views
11 Pages

The development of rapid detection methods to identify mercury ions in aqueous solutions is crucial for effectively monitoring environmental contamination. Fluorescent chemical sensors offer a fast and reliable approach to detect and analyze these me...

  • Review
  • Open Access
1 Citations
1,808 Views
36 Pages

Enzyme-Based Single Solid-State Nanochannel Biosensors

  • L. Miguel Hernández Parra,
  • Omar Azzaroni and
  • Waldemar A. Marmisollé

Sensing technologies play a critical role in healthcare, not only for diagnosis and treatment but especially for prevention and early intervention. Recent advances in biology, medicine, and materials science have expanded the landscape of measurable...

  • Article
  • Open Access
1,212 Views
18 Pages

Urban Precipitation Scavenging and Meteorological Influences on BTEX Concentrations: Implications for Environmental Quality

  • Kristina Kalkan,
  • Vitaly Efremov,
  • Dragan Milošević,
  • Mirjana Vukosavljev,
  • Nikolina Novakov,
  • Kristina Habschied,
  • Kresimir Mastanjević and
  • Brankica Kartalović

This study provides an assessment of BTEX compounds—benzene, toluene, ethylbenzene, and xylene isomers—in urban precipitation collected in the city of Novi Sad, Republic of Serbia, during autumn and winter 2024, analyzed by gas chromatogr...

  • Article
  • Open Access
1,081 Views
15 Pages

Ligand Differentiation Ability of Insect Odorant Receptors in Heterologously Expressed Cells as Potential Biosensor Elements

  • Rui Zhou,
  • Yuji Sukekawa,
  • Sawako Niki,
  • Eri Kuroda,
  • Ryohei Kanzaki,
  • Shigehiro Namiki and
  • Hidefumi Mitsuno

The extensive diversity of volatile organic compounds, along with their minor structural variations, presents significant challenges in the development of chemosensory-based biosensors. Previously, we generated sensor cells expressing insect odorant...

  • Article
  • Open Access
1,109 Views
13 Pages

Water quality should be tested to ensure it is acceptable for the healthy growth of plants and animals, and water hardness is one of the important testing indexes. Herein, a novel approach was proposed to achieve high accuracy and rapid quantitative...

  • Review
  • Open Access
3 Citations
2,795 Views
63 Pages

Electrochemical Nanosensors Applied to the Assay of Some Food Components—A Review

  • Aurelia Magdalena Pisoschi,
  • Florin Iordache,
  • Loredana Stanca,
  • Petronela Mihaela Rosu,
  • Nicoleta Ciocirlie,
  • Ovidiu Ionut Geicu,
  • Liviu Bilteanu and
  • Andreea Iren Serban

Nanomaterials’ special features enable their extensive application in chemical and biochemical nanosensors for food assays; food packaging; environmental, medicinal, and pharmaceutical applications; and photoelectronics. The analytical strategi...

  • Article
  • Open Access
1,781 Views
16 Pages

Rare Earth Element Detection and Quantification in Coal and Rock Mineral Matrices

  • Chet R. Bhatt,
  • Daniel A. Hartzler and
  • Dustin L. McIntyre

As global demand for rare earth elements (REEs) increases, maintaining the production and supply chain is critical. Technologies capable of being used in the field and in situ in the subsurface for rapid REE detection and quantification facilitates t...

  • Article
  • Open Access
979 Views
19 Pages

In this study, we systematically investigated the adsorption behavior of a titanium-based metal–organic framework (MOF) sensing layer on five primary alcohol homologs using the quartz crystal microbalance (QCM) technique. Unexpectedly, response...

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Chemosensors - ISSN 2227-9040