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Chemosensors
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Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025
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Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025

A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 7696

Special Issue Editors

Prof. Dr. Nicole Jaffrezic-Renault

E-Mail Website
Guest Editor
Institute of UTINAM, University of Franche-Comté, UMR-CNRS 6213, 16 Gray Road, 25030 Besançon, France
Interests: biosensors; gas sensing; biomedical and environmental applications
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jin-Ming Lin

E-Mail Website
Guest Editor
Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China
Interests: bio- and environmental analytical chemistry; microfluidics and mass spectrometry for cell analysis; chemiluminescence/fluorescence immunoassay for protein and DNA analysis; analytical methods for negative oxygen ions and reactive oxygen species (ROS); sample pretreatment for mass spectrometry and chromatography analysis; development of analytical instrumentation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to curate a collection of in-depth review papers encompassing comprehensive insights, analyses, and advancements in the field of chemical sensors, biosensors, and related analytical methods and systems. By selectively featuring review and systematic review manuscripts, this series aims to provide a rigorous and consolidated understanding of recent developments, offering valuable insights for researchers and practitioners in this field.

We sincerely welcome you all to contribute comprehensive review articles on a trending topic for peer review and possible publication.

Prof. Dr. Nicole Jaffrezic-Renault
Prof. Dr. Jin-Ming Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical devices and sensors
  • biosensors and imaging
  • optical chemical sensors
  • gas sensors
  • material-based chemical sensors
  • analytical methods and applications

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (7 papers)

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Review

22 pages, 2235 KiB  
Review
Resistive-Based Nanostructured CeO2 Gas Sensors: A Review
by Mahmoud Torkamani Cheriani, Ali Mirzaei and Jae-Hun Kim
Chemosensors 2025, 13(8), 298; https://doi.org/10.3390/chemosensors13080298 - 9 Aug 2025
Viewed by 26
Abstract
Air pollution and the emission of toxic gases represent a critical global concern, posing significant threats to human health and environmental stability. Resistive gas sensors are widely employed to detect toxic gases, owing to their cost-effectiveness, high stability, sensitivity, and swift dynamics. Among [...] Read more.
Air pollution and the emission of toxic gases represent a critical global concern, posing significant threats to human health and environmental stability. Resistive gas sensors are widely employed to detect toxic gases, owing to their cost-effectiveness, high stability, sensitivity, and swift dynamics. Among various sensing materials, comparatively less attention has been paid to CeO2 despite its good catalytic activity and high stability. In this review paper, we are focusing on CeO2 gas sensors in pristine, doped, decorated, and composite forms. Using numerous examples, we have shown the great potential of CeO2 for gas sensing. The main features of CeO2 as a gas sensor include excellent environmental stability, the abundance of oxygen vacancies, high mechanical strength, cost-effectiveness, and good catalytic activity. However, low electrical conductivity is the main shortage of CeO2 as a gas sensor. With a high emphasis on the sensing mechanism, we believe that this review paper is highly useful for researchers working in this field. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025)
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16 pages, 3021 KiB  
Review
Microfluidic Paper-Based Sensors and Their Applications for Glucose Sensing
by Phan Gia Le and Sungbo Cho
Chemosensors 2025, 13(8), 293; https://doi.org/10.3390/chemosensors13080293 - 7 Aug 2025
Viewed by 216
Abstract
Recently, the incidence of diabetes has increased across all socioeconomic groups, with a notable increase in developing countries. Although advances in medical devices have enhanced healthcare accessibility, these benefits remain largely out of reach for individuals residing in remote areas. Concurrently, a variety [...] Read more.
Recently, the incidence of diabetes has increased across all socioeconomic groups, with a notable increase in developing countries. Although advances in medical devices have enhanced healthcare accessibility, these benefits remain largely out of reach for individuals residing in remote areas. Concurrently, a variety of devices have been created to detect glucose biomarkers. Among these, microfluidic paper-based sensors have received substantial attention due to their affordability, disposability, and ease of production. Research on microfluidic paper-based glucose sensors has become particularly prominent owing to their considerable potential and wide applicability, especially in the integration of artificial intelligence and machine learning in glucose sensor processing. This review aims to examine recent advancements and progress in the development of microfluidic paper-based glucose sensors over the past five years, highlighting their advantages, limitations, and prospects. The sensors combined with artificial intelligence and machine learning have potential for future applications. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025)
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36 pages, 22778 KiB  
Review
Enzyme-Based Single Solid-State Nanochannel Biosensors
by L. Miguel Hernández Parra, Omar Azzaroni and Waldemar A. Marmisollé
Chemosensors 2025, 13(8), 275; https://doi.org/10.3390/chemosensors13080275 - 25 Jul 2025
Viewed by 276
Abstract
Sensing technologies play a critical role in healthcare, not only for diagnosis and treatment but especially for prevention and early intervention. Recent advances in biology, medicine, and materials science have expanded the landscape of measurable biological markers and enabled the development of nanotechnology-based [...] Read more.
Sensing technologies play a critical role in healthcare, not only for diagnosis and treatment but especially for prevention and early intervention. Recent advances in biology, medicine, and materials science have expanded the landscape of measurable biological markers and enabled the development of nanotechnology-based biosensing platforms. Among the most prominent strategies in biosensing are those that take inspiration from nature, particularly through the integration of biological components such as enzymes. This review focuses on the intersection between enzymatic catalysis and single solid-state nanochannel (SSN) technologies as a promising approach for the development of advanced biosensing devices. We provide an overview of the historical background, current state of the art, and major achievements in enzyme-based biosensors and artificial nanochannel platforms, highlighting their synergistic potential. Particular attention is given to the challenges associated with enzyme integration into artificial environments, including stability and functionality retention, and the strategies employed to overcome them. Finally, we discuss the prospects and limitations of combining enzymes with SSNs, aiming to inspire future research in this emerging and multidisciplinary field. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025)
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23 pages, 3823 KiB  
Review
Electrochemical Strategies for MicroRNA Quantification Leveraging Amplification and Nanomaterials: A Review
by Alexander Hunt and Gymama Slaughter
Chemosensors 2025, 13(7), 242; https://doi.org/10.3390/chemosensors13070242 - 6 Jul 2025
Viewed by 579
Abstract
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and have emerged as critical biomarkers in various diseases, including cancer. Their stability in bodily fluids and role as oncogenes or tumor suppressors make them attractive targets for non-invasive diagnostics. However, conventional detection [...] Read more.
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and have emerged as critical biomarkers in various diseases, including cancer. Their stability in bodily fluids and role as oncogenes or tumor suppressors make them attractive targets for non-invasive diagnostics. However, conventional detection methods, such as Northern blotting, RT-PCR, and microarrays, are limited by low sensitivity, lengthy protocols, and limited specificity. Electrochemical biosensors offer a promising alternative, providing high sensitivity, rapid response times, portability, and cost-effectiveness. These biosensors translate miRNA hybridization events into quantifiable electrochemical signals, often leveraging redox-active labels, mediators, or intercalators. Recent advancements in nanomaterials and signal amplification strategies have further enhanced detection capabilities, enabling sensitive, label-free miRNA quantification. This review provides a comprehensive overview of the recent advances in electrochemical biosensing of miRNAs, emphasizing innovative redox-based detection strategies, probe immobilization techniques, and hybridization modalities. The critical challenges and future perspectives in advancing electrochemical miRNA biosensors toward clinical translation and point-of-care diagnostics are discussed. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025)
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33 pages, 4183 KiB  
Review
Recent Advances on Fluorescent Sensors for Detection of Pathogenic Bacteria
by Xu Tang, Qi Qi, Binrong Li, Zhi Zhu, Jian Lu and Lei Liu
Chemosensors 2025, 13(5), 182; https://doi.org/10.3390/chemosensors13050182 - 13 May 2025
Viewed by 3419
Abstract
Pathogenic bacteria are one of the main causes of diseases and have become an important public health problem threatening human health and socio-economic development. Therefore, it is particularly important to develop an efficient and convenient detection method. Fluorescence detection has become a highly [...] Read more.
Pathogenic bacteria are one of the main causes of diseases and have become an important public health problem threatening human health and socio-economic development. Therefore, it is particularly important to develop an efficient and convenient detection method. Fluorescence detection has become a highly concerned analytical technology, which has gradually emerged in the aspect of pathogen detection, and is favored by researchers. In this review, we summarized a series of sensing strategies for pathogen detection based on fluorescence response signals in recent years, including single molecule fluorescent probes, biosensors, nanocomposite sensors and strategies for integrating different recognition elements with nanomaterials, along with the advantages and disadvantages of various design strategies. Based on the existing research reports, the existing problems and future research challenges of fluorescent sensor technology are proposed. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025)
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20 pages, 5758 KiB  
Review
Innovative Microfluidic Technologies for Rapid Heavy Metal Ion Detection
by Muhammad Furqan Rauf, Zhenda Lin, Muhammad Kamran Rauf and Jin-Ming Lin
Chemosensors 2025, 13(4), 149; https://doi.org/10.3390/chemosensors13040149 - 18 Apr 2025
Cited by 1 | Viewed by 1505
Abstract
Heavy metal ion (HMI) contamination poses significant threats to public health and environmental safety, necessitating advanced detection technologies that are rapid, sensitive, and field-deployable. While conventional methods like atomic absorption spectroscopy (AAS) and inductively coupled plasma mass spectrometry (ICP-MS) remain prevalent, their limitations—including [...] Read more.
Heavy metal ion (HMI) contamination poses significant threats to public health and environmental safety, necessitating advanced detection technologies that are rapid, sensitive, and field-deployable. While conventional methods like atomic absorption spectroscopy (AAS) and inductively coupled plasma mass spectrometry (ICP-MS) remain prevalent, their limitations—including high costs, complex workflows, and lack of portability—underscore the urgent need for innovative alternatives. This review consolidates advancements in the last five years in microfluidic technologies for HMI detection, emphasizing their transformative potential through miniaturization, integration, and automation. We critically evaluate the synergy of microfluidics with cutting-edge materials (e.g., graphene and quantum dots) and detection mechanisms (electrochemical, optical, and colorimetric), enabling ultra-trace detection at parts-per-billion (ppb) levels. We highlight novel device architectures, such as polydimethylsiloxane (PDMS)-based labs-on-chip (LOCs), paper-based microfluidics, 3D-printed systems, and digital microfluidics (DMF), which offer unparalleled portability, cost-effectiveness, and multiplexing capabilities. Additionally, we address persistent challenges (e.g., selectivity and scalability) and propose future directions, including AI integration and sustainable fabrication. By bridging gaps between laboratory research and practical deployment, this review provides a roadmap for next-generation microfluidic solutions, positioning them as indispensable tools for global HMI monitoring. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025)
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25 pages, 8266 KiB  
Review
Challenges and Applications of Bio-Sniffers for Monitoring Volatile Organic Compounds in Medical Diagnostics
by Yang Wang, Xunda Zhou, Siying Mao, Shiwei Chen and Zhenzhong Guo
Chemosensors 2025, 13(4), 127; https://doi.org/10.3390/chemosensors13040127 - 3 Apr 2025
Viewed by 1173
Abstract
Bio-sniffers represent a novel detection technology that demonstrates significant potential in medical diagnostics. Specifically, they assess disease conditions and metabolic status through the detection of volatile organic compounds (VOCs) in exhaled breath. Unlike conventional methods such as gas chromatography-mass spectrometry (GC-MS) and gas [...] Read more.
Bio-sniffers represent a novel detection technology that demonstrates significant potential in medical diagnostics. Specifically, they assess disease conditions and metabolic status through the detection of volatile organic compounds (VOCs) in exhaled breath. Unlike conventional methods such as gas chromatography-mass spectrometry (GC-MS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS), bio-sniffers provide rapid, sensitive, and portable detection capabilities. In this review, we examine the metabolic pathways and detection methods of specific VOCs in the human body, and their roles as disease biomarkers, and focus on the detection principles, performance characteristics, and medical applications of two bio-sniffer types: electrical and optical sensors. Finally, we systematically discuss the current challenges facing bio-sniffers in VOC monitoring, outline future development directions, and provide suggestions for improving sensitivity and reducing environmental interference. Full article
(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025)
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