Spectroscopic Techniques for Chemical Analysis

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Analytical Methods, Instrumentation and Miniaturization".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 400

Special Issue Editors


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Guest Editor
College of Electrical and Electronic Engineering, Wenzhou University, Wenzhou 325035, China
Interests: food quality control and safety; spectroscopic detection; spectral multivariate analysis; machine/deep learning

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Guest Editor
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Interests: research on the rapid non-destructive determination of food and agricultural products; research on the nanobiosensor detection of food safety; research on the on-line monitoring technology of food processing

Special Issue Information

Dear Colleagues,

We are excited to announce a Special Issue on "Spectroscopic Techniques for Chemical Analysis". As the demand rises for rapid food quality control and safety, the need for rapid analysis methods is growing exponentially. Spectroscopic methods, such as UV, visible, NIR, MIR, and Raman spectroscopy, can quickly detect contaminants, assess fruit quality and nutrition, and ensure products meet standards, thus realizing gradation and boosting consumer confidence. Spectroscopic techniques, paired with machine learning or deep learning, provide a promising, rapid, non-destructive way to obtain accurate chemical fingerprints of food and agricultural products and other daily consumption goods.

This Special Issue aims to present novel advances in the broad field of spectroscopic analysis, from farm to fork, covering all aspects of edible food quality, monitoring, and improvement. It involves spectroscopic studies of nutritional, sensory, sanitary, and technological properties. New advances made in the laboratory, novel strategies for spectroscopic edible food analysis in farm or food processing, and inventive chemometrics and multi-variate and statistical data analysis approaches are strongly welcomed. In this Special Issue, we aim to publish original research results and review papers.

Dr. Leiming Yuan
Dr. Quansheng Chen
Guest Editors

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Keywords

  • spectroscopic techniques
  • chemometrics
  • machine/deep learning
  • chemical composition analysis
  • UV/VIS/NIR/MID spectroscopy
  • raman spectroscopy
  • quality control and safety
  • edible food
  • daily consumption of goods
  • non-destrucitve determination

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Published Papers (1 paper)

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Research

15 pages, 6078 KiB  
Article
Developing a Quantitative Profiling Method for Detecting Free Fatty Acids in Crude Lanolin Based on Analytical Quality by Design
by Sihan Liu, Shaohua Wu, Hao Zhang and Xingchu Gong
Chemosensors 2025, 13(4), 126; https://doi.org/10.3390/chemosensors13040126 - 3 Apr 2025
Viewed by 258
Abstract
In this study, a quantitative profiling method for detecting free fatty acids in crude lanolin based on the Quality by Design (QbD) concept was developed. High-performance liquid chromatography (HPLC) equipped with a charged aerosol detector (CAD) and a Proshell 120 EC C18 column [...] Read more.
In this study, a quantitative profiling method for detecting free fatty acids in crude lanolin based on the Quality by Design (QbD) concept was developed. High-performance liquid chromatography (HPLC) equipped with a charged aerosol detector (CAD) and a Proshell 120 EC C18 column was employed for the separation of crude lanolin components. Initially, the analytical target profile and critical method attributes were defined. Potential critical method parameters, including column temperature, flow rate, isocratic run time, gradient end organic phase ratio, and gradient time, were identified using fishbone diagrams and single-factor experiments. The definitive screening design (DSD) was then utilized to screen and optimize these parameters. Stepwise regression was applied to establish quantitative models between the critical method attributes and the method parameters. Subsequently, the method operable design region (MODR) was calculated and was successfully verified. The analytical conditions established were configured with 0.1% formic acid in water and 0.1% formic acid in acetonitrile serving as the mobile phases. The flow rate was set at 0.8 mL/min, and the column temperature was maintained at 35 °C with the evaporation tube temperature also set at 35 °C. An injection volume of 10 μL was used for each analysis. The gradient elution conditions were as follows: from 0 to 30 min, 75% of solvent B was used, and from 30 to 60 min, the proportion of solvent B was increased from 75% to 79%. Ten components, including 12-hydroxystearic acid, 2-hexyldecanoic acid, and palmitic acid, were identified by mass spectrometry, and seven common peaks were found in the fingerprints. The contents of palmitic acid, oleic acid, and stearic acid in the crude lanolin were quantitatively determined. Both the fingerprint and quantitative analysis methods were validated. The method was applied to analyze 15 batches of crude lanolin from different sources. The new established quantitative profiling method for free fatty acids can be potentially used for industrial applications to enhance the quality control of crude lanolin. Full article
(This article belongs to the Special Issue Spectroscopic Techniques for Chemical Analysis)
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